Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Genetic Variants in Interleukin-2 and Risk of Lymphoma among Children in Korea

  • Song, Nan (Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine or College of Pharmacy, Seoul National University) ;
  • Han, So-Hee (Department of Preventive Medicine, Seoul National University) ;
  • Lee, Kyoung-Mu (Department of Environmental Health, Korea National Open University) ;
  • Choi, Ji-Yeob (Department of Biomedical Sciences, Graduate School, Seoul National University) ;
  • Park, Sue-K (Department of Preventive Medicine, Seoul National University) ;
  • Jeon, Su-Jee (Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine or College of Pharmacy, Seoul National University) ;
  • Lee, Yun-Hee (Department of Biomedical Sciences, Graduate School, Seoul National University) ;
  • Ahn, Hyo-Seop (Cancer Research Institute, Seoul National University) ;
  • Shin, Hee-Young (Cancer Research Institute, Seoul National University) ;
  • Kang, Hyoung-Jin (Cancer Research Institute, Seoul National University) ;
  • Koo, Hong-Hoe (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Seo, Jong-Jin (Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Choi, Ji-Eun (Department of Pediatrics, Seoul Metropolitan Boramae Hospital) ;
  • Kang, Dae-Hee (Department of Preventive Medicine, Seoul National University)
  • Published : 2012.02.29
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Abstract

To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma ($P_{trend}$ <0.05) in six genes ($IL1RN$, $IL2$, $IL12RB1$, $JAK3$, $TNFRSF13B$, and $XRCC3$). The most significant association was seen for $IL2$ variant rs2069762 ($OR_{TG+GG}$ vs. TT=3.43 (1.29-9.11), $P_{trend}$=0.002, min$P$=0.005). These findings suggest that common genetic variants in $IL2$ might play a role in the pathogenesis of childhood lymphoma.

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References

  1. Baris S, Celkan T, Batar B, et al (2009). Association between genetic polymorphism in DNA repair genes and risk of B-cell lymphoma. Pediatr Hematol Oncol, 26, 467-72. https://doi.org/10.3109/08880010903096201
  2. Cerhan JR, Wang S, Maurer MJ, et al (2007). Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Blood, 109, 5439-46. https://doi.org/10.1182/blood-2006-11-058040
  3. Chan KK, Shen L, Au WY, et al (2010). Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells. J Pathol, 221, 164-74. https://doi.org/10.1002/path.2699
  4. Chen BE, Sakoda LC, Hsing AW, et al (2006). Resamplingbased multiple hypothesis testing procedures for genetic case-control association studies. Genet Epidemiol, 30, 495-507. https://doi.org/10.1002/gepi.20162
  5. Cozen W, Gill PS, Salam MT, et al (2008). Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma. Blood, 111, 3377-82. https://doi.org/10.1182/blood-2007-08-106872
  6. Howlader N, Noone AM, Krapcho M, et al(2011). SEER Cancer Statistics Review, 1975-2008, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/ csr/1975_2008/, based on November 2010 SEER data submission, posted to the SEER web site.
  7. Packer BR, Yeager M, Burdett L, et al (2006). SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes. Nucleic Acids Res, 34, D617-21. https://doi.org/10.1093/nar/gkj151
  8. Rothman N, Skibola CF, Wang SS, et al (2006). Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. Lancet Oncol, 7, 27-38. https://doi.org/10.1016/S1470-2045(05)70434-4
  9. Seidemann K, Zimmermann M, Book M, et al (2005). Tumor necrosis factor and lymphotoxin alfa genetic polymorphisms and outcome in pediatric patients with non-Hodgkin's lymphoma: results from Berlin-Frankfurt- Munster Trial NHL-BFM. 95, J Clin Oncol, 23, 8414-21. https://doi.org/10.1200/JCO.2005.01.2179
  10. Skinnider BF, Mak TW (2002). The role of cytokines in classical Hodgkin lymphoma. Blood, 99, 4283-97. https://doi.org/10.1182/blood-2002-01-0099

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