• 제목/요약/키워드: Sequential analysis.

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Effectiveness of Rapid Response Team on In-hospital Mortality in Patients with Hematologic Malignancy (혈액암 환자의 원내 사망률에 미치는 신속대응팀의 효용성)

  • Park, So-Jung;Hong, Sang-Bum;Lim, Chae-Man;Koh, Youn-Suck;Huh, Jin-Won
    • Quality Improvement in Health Care
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    • v.27 no.2
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    • pp.18-29
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    • 2021
  • Purpose: Patients with hematologic malignancy (HM) typically have a high mortality rate when their condition deteriorates. The chronic progressive course of the disease makes it difficult to assess the effect of intervention on acute events. We investigated the effectiveness of a rapid response team (RRT) on in-hospital mortality in patients with HM. Methods: We retrospectively analyzed the data of patients with HM who admitted to the medical intensive care unit between 2006 and 2015. Clinical outcomes before and after RRT implementation were evaluated. Results: A total of 228 patients in the pre-RRT period and 781 patients in the post-RRT period were included. The overall in-hospital mortality was 55.4%. Patients in the post-RRT period had improved survival; however, they required more vasopressor therapy, continuous renal replacement therapy, and extracorporeal membrane oxygenation. Multivariate analysis revealed that in-hospital mortality was associated with RRT activation (hazard ratio [HR], 0.634; 95% confidence interval [CI], 0.498-0.807; p < .001), neurological disease (HR, 2.007; 95% CI, 1.439-2.800; p < .001), sequential organ failure assessment score (HR, 1.085; 95% CI, 1.057-1.112; p < .001), need for continuous renal replacement therapy (HR, 1.608; 95% CI, 1.206-1.895; p< .001), mechanical ventilation (HR, 1.512; 95% CI, 1.206-1.895; p< .001), vasopressor (HR, 1.598; 95% CI, 1.105-2.311; p = .013), and extracorporeal membrane oxygenation (HR, 1.728; 95% CI, 1.105-2.311; p = .030). Conclusion: RRT activation may be associated with improved survival in patients with HM.

An Analysis of The Effect of a Port on The Living Conditions of Its Neighborhood Area (항만이 인근지역 생활여건에 미친 영향 분석)

  • Kim, Chang Soo
    • Journal of Korea Port Economic Association
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    • v.37 no.4
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    • pp.71-87
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    • 2021
  • This study aims to reveal how a port affects the living conditions of its neighborhood area with a case study of Pusan New Port and to suggest several implications to port policy. PLS-SEM reflective measurement model satisfies the criteria on reliability and validity, and also structural model meets the criteria in terms of R2, path coefficients' significance and predictive relevance(Q2). The results of PLS-SEM support the hypotheses of this study: The expansion of Pusan New Port contributes to the improvement of living conditions of Gangseo-gu(nearby area) through its significant and sequential effects on the employment and population increase of Gangseo-gu. The originality of this study can be found in enunciating that a port plays a role as a driving force of the betterment of living conditions of its nearby Gu-level area. In terms of policy, central and local governments and port related companies should cooperate with each other to reinforce the acceptability of port policy through the improvement of the living conditions of port neighborhood area. To evaluate comprehensively the influence of a port on its neighborhood area, a further study needs to identify how a port affects the quality of life of the area or what kinds of socio-economic effects a port has on the area.

The Influence of Employees' Belief about Emotional Expression on Attitudes toward Professional Psychological Help Seeking: the Mediating Effetcs of Ambivalence over Emotional Expressiveness and Psychological Flexibility (직장인의 정서표현신념이 전문적도움추구태도에 미치는 영향: 정서표현양가성과 심리적유연성의 이중매개효과)

  • Ha, Serena;Lee, Su-Lim
    • The Journal of the Korea Contents Association
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    • v.21 no.11
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    • pp.748-760
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    • 2021
  • The purpose of the study is to examine the mediating effects of ambivalence over emotional expression and psychological flexibility on the relationship between employees' beliefs about emotional expression and attitudes toward seeking professional psychological help. The subjects of this study were 346 employees(male: 176, female:170) over the age of 19. Questionnaires including beliefs about emotional expression, ambivalence over emotional expression, psychological flexibility, attitude toward seeking professional psychological help were conducted and the collected data were analyzed by using SPSS and Macro. A summary of the results as follows. First, in the results of the correlation analysis on the primary factors had a significant correlation. Second, psychological flexibility had a mediating effect in the relationship between beliefs about emotional expression and attitude toward seeking psychological help while mediating effect of ambivalence over emotional expression was not significant. Lastly, the sequential mediating effect of ambivalence over emotional expression and psychological flexibility between beliefs about emotional expression and attitudes toward seeking professional psychological help was significant.

The Effects of Youth Instructors' Competence and Job Environment on Their Burnout (청소년지도사의 역량과 직무환경이 소진에 미치는 영향)

  • Park, Woon-Ju
    • The Journal of the Korea Contents Association
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    • v.22 no.3
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    • pp.236-249
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    • 2022
  • The purpose of this study is to understand the influence of the competence of juvenile counselors and their working environment upon exhaustion. This study is expected to allow the exploration of various support strategies to prevent exhaustion, by investigating the impact of competence and working environment as juvenile counselors experience exhaustion. For this study, the researcher surveyed incumbent juvenile counselors, and the data from this survey were put to hierarchical regression analysis. The key findings of this study were as follows; First, as for the impact of the competence of juvenile counselors upon exhaustion, it turned out to have an explanatory power of 58.4% (F=17.125, p<.001). Second, as for the impact of the working environment of juvenile counselors upon their exhaustion, it has an explanatory power of 70.3% (F=19.339, p<.001). Third, when the competence and environment were input in sequential order, the impact on exhaustion had an explanatory power of 81.0% (F=27.368, p<.001). These findings indicated that the competence and working environment of juvenile counselors did have an impact on their exhaustion. Therefore, it is necessary to take measures to prevent exhaustion by developing programs for juvenile counselors to enhance their competence, government-initiated support policies, and better employment conditions and opportunities for promotion, etc.

Research and consideration on the evaluation of usability formation of focused ultrasonic stimulation systems (집속형 초음파 자극 시스템의 사용적합성 형성평가에 대한 연구 및 고찰)

  • Kim, Jun-tae;Kim, Ju-hee;Joo, Kyu-tai;Kim, Kyung-ah;Ryu, Ok-su;Jo, Jae-hyun;Jeong, Jin-Hyoung
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.15 no.2
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    • pp.164-177
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    • 2022
  • Medical device usability evaluation refers to the evaluation of medical devices through actual users before the final prototype production is completed. IEC 62366, one of the international safety standards for electronic medical devices, is a standard that must be applied to obtain medical device licenses in major advanced countries such as Europe and the United States. In Korea, through the Ministry of Food and Drug Safety's notice, from January 2021, sequential application by grade has been implemented. In this study, 15 participant specialists were recruited through the Incheon G University Hospital Medical Device Convergence Center for formative evaluation during user suitability evaluation of the focused ultrasound stimulation system being developed by Icleo Co., Ltd., and the test was conducted through joint scenario development. . In the result of task performance, the performance rate was 90.67%, and after the completion of the performance, 86.67% of 'Easy user interface' and 94% of 'Identification/Readability/Understanding of information' questions in the participant survey results analysis by question. The response rate was above average.

Hybrid CMA-ES/SPGD Algorithm for Phase Control of a Coherent Beam Combining System and its Performance Analysis by Numerical Simulations (CMA-ES/SPGD 이중 알고리즘을 통한 결맞음 빔 결합 시스템 위상제어 및 동작성능에 대한 전산모사 분석)

  • Minsu, Yeo;Hansol, Kim;Yoonchan, Jeong
    • Korean Journal of Optics and Photonics
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    • v.34 no.1
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    • pp.1-12
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    • 2023
  • In this study, we propose a hybrid phase-control algorithm for multi-channel coherent beam combining (CBC) system by combining the covariant matrix adaption evolution strategy (CMA-ES) and stochastic parallel gradient descent (SPGD) algorithms and analyze its operational performance. The proposed hybrid CMA-ES/SPGD algorithm is a sequential process which initially runs the CMA-ES algorithm until the combined final output intensity reaches a preset interim value, and then switches to running the SPGD algorithm to the end of the whole process. For ideal 7-channel and 19-channel all-fiber-based CBC systems, we have found that the mean convergence time can be reduced by about 10% in comparison with the case when the SPGD algorithm is implemented alone. Furthermore, we analyzed a more realistic situation in which some additional phase noise was introduced in the same CBC system. As a result, it is shown that the proposed algorithm reduces the mean convergence time by about 17% for a 7-channel CBC system and 16-27% for a 19-channel system compared to the existing SPGD alone algorithm. We expect that for implementing a CBC system in a real outdoor environment where phase noise cannot be ignored, the hybrid CMA-ES/SPGD algorithm proposed in this study will be exploited very usefully.

Yin-Yang and Five-Element Characteristics of Day Master on Four Time Pillars of Birth in Korean Population with Schizophrenia: A Consilience-Based Holistic Approach (조현병 환자군과 일반 인구군간 출생일간(出生日干)의 음양오행적 특성 비교: 통섭(統攝)적 측면에서의 접근)

  • Tae-Young Hwang;Ji-Eun Lee;Geum-Dan Yi;Yeoung-Su Lyu
    • Journal of Oriental Neuropsychiatry
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    • v.34 no.2
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    • pp.71-82
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    • 2023
  • Objectives: The existing reductionist approach has not reached complete understanding of the cause of schizophrenia. The objective of this study was to investigate yin-yang and five-element characteristics reflected on four time pillars of birth of patients with schizophrenia through comparison with the general population in the perspective of consilience-based holistic approach. Methods: This study was conducted using a random sequential recruitment method for the general population and individuals with schizophrenia aged 18 to 64 based on the exact date and time of birth using structured questionnaires. Relative positional relations of yin-yang and five-element with day master were primarily examined. In addition, the strength of day master with a score range of 0~100 points was assessed through operational score allocation. Results: Of 591 participants, 576 (346: general population, 230: individuals with schizophrenia) were analyzed. Between-group analyses showed no significant difference in the distribution of types of day master (χ2=10.41, df=9, p=0.318). However, significant between-group differences were shown in the distribution of the strength of day master (t=2.14, p=0.032) and frequency of restraining month branch (χ2=5.23, df=1, p=0.022). In logistic regression analysis, 10-point increase on the strength of day master decreased the probability of onset of schizophrenia over the age of 30 by 29.6% (p=0.002; 95% confidence interval, 0.566~0.876). Conclusions: Findings in this study suggest that four time pillars of birth might be associated with schizophrenia through yin-yang and five-element theory and synchronicity principle, implicating the plausibility of consilience-based holistic approach in the determination of risk factors or cause of schizophrenia.

The Role of Content Services Within a Firm's Internet Service Portfolio: Case Studies of Naver Webtoon and Google YouTube (기업의 인터넷 서비스 포트폴리오 내 콘텐츠 서비스의 역할: 네이버 웹툰과 구글 유튜브의 사례 연구)

  • Choi, Jiwon;Cho, Wooje;Jung, Yoonhyuk;Kwon, YoungOk
    • Journal of Intelligence and Information Systems
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    • v.28 no.1
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    • pp.1-28
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    • 2022
  • In recent years, many Internet giants have begun providing their own content services, which attract online users by offering personalized services based on artificial intelligence technologies. This study investigates the role of two firms' content services within the firms' online service network. We examine the role of Naver Webtoon, which can be characterized as a professional-generated content, within Naver's service portfolio, and that of Google YouTube, which can be characterized as a user-generated content, within Google's service portfolio. Using survey data on viewers' use of the two services, we analyze a valued directed service network, where a node denotes an online service and a relationship between two nodes denotes a sequential use of two services. We found that both Webtoon and YouTube show higher out-degree centrality than in-degree centrality, which implies these content services are more likely to be starting services rather than arriving services within the firms' interactive network. The gap between the out-degree and in-degree centrality of YouTube is much smaller than that of Webtoon. The high centrality of YouTube, a user-generated content service, within the Google service network shows that YouTube's initial role of providing specific-content videos (e.g., entertainment) has expanded into a general search service for users.

A Qualitative Study using the Grounded Theory on the Trauma Experiences of State Violence Victims (국가폭력 트라우마 경험에 대한 근거이론적 탐구)

  • Seok-Woong Kim;Young-Shin Kang
    • Korean Journal of Culture and Social Issue
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    • v.30 no.1
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    • pp.1-33
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    • 2024
  • This study analyzed the experiences of victims of state violence, discovered differences between state violence and general trauma, and proposed ways to help heal trauma. Participants were composed of state violence victims and their families in total, including 11 from the Jeju 43 Incident, 11 from the Yeos u·Sunchoen 10.19 Incident and 6 form May 18th Democratic Uprising. As a result of using the grounded theory to analyze data, a total of 170 concepts, 57 subcategories, and 20 categories were derived. The central phenomenon was direct damage caused by state violence. This included 'post-traumatic stress', 'social stigma', 'isolation from community', 'socio-economical issues' and 'family dissolution'. As a result of the process analysis, the participants experienced six phases: 'trauma', 'isolation', 'resistance', 'resignation', 'recovery', and 'growth.' Each phase is sequential but at the time mutually affect each other. Based on the results, this study verified the difference between state violence and general trauma, and emphasized social and cultural factors, such as community support, were important factors in healing state violence trauma. Besides, the implications and limitations as well as suggestions for future research were mentioned.

Antioxidant, Anti-inflammation, and Anti-aging Effects of Ethyl Acetate Fraction from Cynanchum paniculatum Extracts (산해박 분획물의 항산화, 항염증 및 항노화 활성 효과 연구)

  • Jae Yong Seo;Go Eun Kim;Ji Soo Ryu;A Reum Jang;Su An Sim;Jung No Lee;Seunghee Bae
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.50 no.1
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    • pp.85-93
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    • 2024
  • In this study, we prepared fractions from Cynanchum paniculatum (C. paniculatum) with ethyl acetate and identified the structure and content of paeonol, an indicator substance. Fractions were obtained by sequential solvent fractions using n-hexane, methylene chloride, ethyl acetate, n-butanol, and distilled water, and showed the highest paeonol content in ethyl acetate (EtOAc). The structure of the ethyl acetate fraction (EA) was confirmed by nuclear magnetic resonance (NMR) and the content was determined by high performance liquid chromatography (HPLC) analysis. The antioxidant activity of EA was tested through its ability to scavenge 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), and its ability to inhibit nitric oxide (NO) production in RAW 264.7 cells induced by lipopolysaccharide (LPS) was tested for its ability to inhibit NO production in a concentration-dependent manner. Furthermore, MMP-1 production induced by ultraviolet B (UVB) was decreased in a concentration-dependent manner by the EA, and the ability to produce procollagen type-I was increased in a concentration-dependent manner. In addition, as a result of conducting clinical trials using cosmetic formulations containing EA, the effect of improving wrinkles around the eyes was confirmed. Thus, it is expected that Cynanchum paniculatum can be used as a natural functional cosmetic material with antioxidant and anti-aging effects.