• 농촌계획
• /
• 제5권1호
• /
• pp.66-75
• /
• 1999

The study intends to find out contents and impacts of rural development projects implemented by government in Ucheon myon-center village (Hoingseong-county) between 1989-1995. The projects in concern are Rural Industrial Estate Project(1989-90) and Rural Collective Village Project(1992-93), The restructuring of village plan introduced new construction and renewal of buildings that are required for a myon-center in general has to be. The study reveals some morphological patterns the village has and needs to be adjusted. As a conclusion, it proposes a conception of self-containment for a myon-center development. It is necessary that a project plan strategy should be based upon harmonious exploitation between old and new, flexible planning, and sense of technological alternatives.

• BMB Reports
• /
• 제49권1호
• /
• pp.3-10
• /
• 2016

microRNAs (miRNAs) are key regulators of cell state transition and retention during stem cell proliferation and differentiation by post-transcriptionally downregulating hundreds of conserved target genes via seed-pairing in their 3' untranslated region. In embryonic and adult stem cells, dozens of miRNAs that elaborately control stem cell processes by modulating the transcriptomic context therein have been identified. Some miRNAs accelerate the change of cell state into progenitor cell lineages—such as myoblast, myeloid or lymphoid progenitors, and neuro precursor stem cells—and other miRNAs decelerate the change but induce proliferative activity, resulting in cell state retention. This cell state choice can be controlled by endogenously or exogenously changing miRNA levels or by including or excluding target sites. This control of miRNA-mediated gene regulation could improve our understanding of stem cell biology and facilitate their development as therapeutic tools. [BMB Reports 2016; 49(1): 3-10]

• Molecules and Cells
• /
• 제41권2호
• /
• pp.83-92
• /
• 2018

The biological significance and deregulation of the Hippo pathway during organ growth and tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core kinases, MST1/2 and LATS1/2, are tumor suppressors that inhibit the oncogenic nuclear function of YAP/TAZ and TEAD. In addition to earlier studies that highlight the role of Hippo pathway in organ size control, cell proliferation, and tumor development, recent evidence demonstrates its critical role in cancer stem cell biology, including EMT, drug resistance, and self-renewal. Here we provide a brief overview of the regulatory mechanisms of the Hippo pathway, its role in cancer stem cell biology, and promising therapeutic interventions.

• Molecules and Cells
• /
• 제40권5호
• /
• pp.322-330
• /
• 2017

This study investigated the role of cancer/testis antigen DDX53 in regulating cancer stem cell-like properties. DDX53 shows co-expression with CD133, a marker for cancer stem cells. DDX53 directly regulates the SOX-2 expression in anti-cancer drug-resistant $Malme3M^R$ cells. DDX53 and miR-200b were found to be involved in the regulation of tumor spheroid forming potential of Malme3M and $Malme3M^R$ cells. Furthermore, the self-renewal activity and the tumorigenic potential of $Malme3M^R$-CD133 (+) cells were also regulated by DDX53. A miR-200b inhibitor induced the direct regulation of SOX-2 by DDX53 We therefore, conclude that DDX53 may serve as an immunotherapeutic target for regulating cancer stem-like properties of melanomas.

• 한국응급구조학회지
• /
• 제18권1호
• /
• pp.55-66
• /
• 2014

Purpose : The purpose of the study is to investigate the knowledge, attitude, confidence, and experiences of community health practitioner(CHP) regarding cardiopulmonary resuscitation(CPR). Methods : The subjects were 333 CHP in G Province, C Province, and I Metropolitan City. A structured self-reported questionnaire was filled out by 209 participants from July 29, 2013 to September 30, 2013. Results : Confidence level toward CPR was intermediate, and knowledge and attitude level was very low. Seventeen participants performed CPR to cardiac arrest victim. Eleven patients among 25 patients had spontaneous recovery of circulation (ROSC). So the rate was very high. Conclusion : It is necessary to perform the efficient CPR in CHP. In order to improve the positive attitude and confidence in CHP, the renewal system must maintain every two years.

• Journal of Yeungnam Medical Science
• /
• 제26권1호
• /
• pp.1-14
• /
• 2009

Human bone marrow-derived mesenchymal stem cells (MSCs) are a rare population of undifferentiated cells that have the capacity of self renewal and the ability to differentiate into mesodermal phenotypes, including osteocytes, chondrocytes, and adipocytes in vitro. Recently, MSCs have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well analyzed. Many reports showed that transplanted MSCs enhanced regeneration as well as functional improvement of damaged organs and tissues. The wide differentiation plasticity of MSCs was expected to contribute to their demonstrated efficacy in a wide variety of experimental animal models and in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for differentiation in tissue repair. This review describes what is known about the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for further applications in regenerative medicine.

• Clinical and Experimental Reproductive Medicine
• /
• 제45권4호
• /
• pp.149-153
• /
• 2018

Stem cells are undifferentiated cells capable of self-renewal and differentiation into various cell lineages. Stem cells are responsible for the development of organs and regeneration of damaged tissues. The highly regenerative nature of the human endometrium during reproductive age suggests that stem cells play a critical role in endometrial physiology. Bone marrow-derived cells migrate to the uterus and participate in the healing and restoration of functionally or structurally damaged endometrium. This review summarizes recent research into the potential therapeutic effects of bone marrow-derived stem cells in conditions involving endometrial impairment.

• Journal of Korean Neurosurgical Society
• /
• 제64권3호
• /
• pp.359-366
• /
• 2021

Neuromesodermal progenitors (NMPs) constitute a bipotent cell population that generates a wide variety of trunk cell and tissue types during embryonic development. Derivatives of NMPs include both mesodermal lineage cells such as muscles and vertebral bones, and neural lineage cells such as neural crests and central nervous system neurons. Such diverse lineage potential combined with a limited capacity for self-renewal, which persists during axial elongation, demonstrates that NMPs are a major source of trunk tissues. This review describes the identification and characterization of NMPs across multiple species. We also discuss key cellular and molecular steps for generating neural and mesodermal cells for building up the elongating trunk tissue.

• 산업진흥연구
• /
• 제1권2호
• /
• pp.121-128
• /
• 2016

Cultural heritage means a great lot to a nation's social system and its people's behavior consciousness and plays an important role in its self-development and improvement. It is essential for a nation's self-education and renewal. Improper cultural heritage will be disastrous because it may fall a nation into a loss of terrible chaos. Only the proper cultural heritage can make it always self-awaking, self-correcting and remaining vital in life. This paper, from the perspective of Choi Bu's Pyohaerok, makes a thorough analysis of the unbalance heritage of Chinese ancient culture for thousands of years. For example, many fine traditions gradually vanished in our actual life or only take half their life in heritage nowadays, such as our ancient broad and profound Confucian etiquette, ancient exquisite brocade art and architecture, ancient advanced ship-building technology and many other advanced numerous technological inventions; however, too much unwanted cultural rubbish keeps constant prevailing and takes repeated successions in the life, such as the heavy-form-and-light-content management mode, borrowing power to do evil, neglecting technological inventions long time and generally believing in ghost theory,etc.. This paper mainly focuses on the partial successions of the bad cultural heritage and its bad influence on the country, and concludes that it is just that that makes the country more and more backward. Therefore, the paper makes some pondering over these issues and proposes some related ideas of country-building to attract others participation to deal with them.

• 한국산학기술학회논문지
• /
• 제16권9호
• /
• pp.5955-5967
• /
• 2015

본 연구는 도시정비사업 내 공공관리자제도의 평가 필요성을 인지하고, 공공 관리자 제도의 평가기준을 체계적이고 객관적으로 수립하고자 정책평가의 틀을 이용하여 선행연구와 전문가의 의견을 바탕으로 공공성, 전문성, 참여성, 합리성, 지속가능성이라는 다섯 가지의 방향 아래 사업계획 단계에서부터 운영, 참여, 사업의 사후평가단계까지 확장된 개념의 지속적인 평가요소를 구축하였다. 중요도 분석 결과, 평가 분야에서는 사후관리 및 지속성 분야가 가장 중요하게 도출되었으며, 세부 평가 요소로는 사업 시 안정적 경제구조 조성 유도와 투명한 운영체계 수립, 제반 비용 절감, 자족성 있는 지역발전의 유도 등의 항목이 중요한 요소로 분석되었다. 이상과 같은 분석결과를 통해 얻을 수 있는 시사점은 다음과 같다. 첫째, 공공관리자제도는 사업의 계획단계부터 사업 완료 이후 사후관리 부분까지 원칙을 세워서 그에 맞게 운영방안을 수립해야한다. 둘째, 공공관리자제도의 지속가능한 운영을 이끌어내기 위해서는 지속적인 재교육 및 주민의 사업 참여 활동이 필수적이다. 셋째, 공공관리자제도를 평가할 때의 종전의 물리적, 경제적 효과에 치중하여 이끌어내던 성과관리시스템에서 탈피하여 사업의 운영과정에서의 갈등관리 등 비 물리적 평가기준 등의 요소 또한 평가될 필요가 있다.