Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Embryonal Neuromesodermal Progenitors for Caudal Central Nervous System and Tissue Development

  • Shaker, Mohammed R. (Australian Institute for Bioengineering and Nanotechnology, The University of Queensland) ;
  • Lee, Ju-Hyun (Department of Anatomy, Brain Korea 21 Plus Program for Biomedical Science, Korea University College of Medicine) ;
  • Sun, Woong (Department of Anatomy, Brain Korea 21 Plus Program for Biomedical Science, Korea University College of Medicine)
  • Received : 2020.12.23
  • Accepted : 2021.01.28
  • Published : 2021.05.01
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Abstract

Neuromesodermal progenitors (NMPs) constitute a bipotent cell population that generates a wide variety of trunk cell and tissue types during embryonic development. Derivatives of NMPs include both mesodermal lineage cells such as muscles and vertebral bones, and neural lineage cells such as neural crests and central nervous system neurons. Such diverse lineage potential combined with a limited capacity for self-renewal, which persists during axial elongation, demonstrates that NMPs are a major source of trunk tissues. This review describes the identification and characterization of NMPs across multiple species. We also discuss key cellular and molecular steps for generating neural and mesodermal cells for building up the elongating trunk tissue.

Keywords

References

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