• IMMUNE NETWORK
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• v.19 no.1
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• pp.1.1-1.13
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• 2019

Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease characterized by production of autoantibodies to various nuclear antigens and overexpression of genes regulated by IFN-I called IFN signature. Genetic studies on SLE patients and mutational analyses of mouse models demonstrate crucial roles of nucleic acid (NA) sensors in development of SLE. Although NA sensors are involved in induction of antimicrobial immune responses by recognizing microbial NAs, recognition of self NAs by NA sensors induces production of autoantibodies to NAs in B cells and production of IFN-I in plasmacytoid dendritic cells. Among various NA sensors, the endosomal RNA sensor TLR7 plays an essential role in development of SLE at least in mouse models. CD72 is an inhibitory B cell co-receptor containing an immunoreceptor tyrosine-based inhibition motif (ITIM) in the cytoplasmic region and a C-type lectin like-domain (CTLD) in the extracellular region. CD72 is known to regulate development of SLE because CD72 polymorphisms associate with SLE in both human and mice and CD72^-/- mice develop relatively severe lupus-like disease. CD72 specifically recognizes the RNA-containing endogenous TLR7 ligand Sm/RNP by its extracellular CTLD, and inhibits B cell responses to Sm/RNP by ITIM-mediated signal inhibition. These findings indicate that CD72 inhibits development of SLE by suppressing TLR7-dependent B cell response to self NAs. CD72 is thus involved in discrimination of self-NAs from microbial NAs by specifically suppressing autoimmune responses to self-NAs.

• Reproductive and Developmental Biology
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• v.34 no.3
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• pp.229-233
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• 2010

Pluripotency and self-renewal capacity of human embryonic stem cells (hESCs) are retained by hESCs related genes as OCT4, SOX2 and NANOG. These genes are shown high expression level in diverse cancer cells and have potential role in the carcinogenesis. On the contrary to this, several genes which are up-regulated in the differentiated hESCs are involved to suppress the carcinogenesis or proliferation of cells. We discovered several genes in immortalized lung fibroblast (WI-38 VA13) by suppression subtractive hybridization. Among them, we focused chromosome 6 open reading frame 62 (C6orf62) which is uncharacterized, mapped to 6p22.3 and generated to Hepatitis B virus X-transactivated proteins (HBVx-transactivated proteins, XTP). Aim of this study was to characterize C6orf62 through analyzing of expression pattern in various cell lines. Expression of C6orf62 was significantly upregulated in diverse normal cell lines than cancer cell lines. And C6orf62 was up-regulated in differentiated hESCs (endothelial cells, neural cells) compared to those of undifferentiated hESCs. Also, C6orf62 in WI-38 cells was highly up-regulated during G1/S transition of the cell cycle. Taken together, C6orf62 is shown expression pattern similar to differentiated hESCs-associated genes which down-regulated in cancer cells. Therefore, we assume that C6orf62 may participate to suppress the proliferation and to induce differentiation through regulating the cell cycle.

• Journal of Gifted/Talented Education
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• v.13 no.1
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• pp.1-19
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• 2003

The purpose of this study is to investigate the self-efficacy of gifted students in the area of sciences. For this purpose, The Self-efficacy Beliefs Inventory was administered to 220 5th and 6th gifted students and high achievers. The research findings were as follows; First, there was no statistically significant difference in the general, academic, self regulated learning, and others’ expectation self-efficacy beliefs between gifted students and high achievers as well as among groups of gifted students. Second, the gifted students in mathematics were higher than other groups in the mathematics self-efficacy beliefs. Third, the high achievers were higher than other groups in the language art self-efficacy beliefs. Fourth, the gifted students in mathematics were higher than other groups in mathematics self-efficacy beliefs. Fifth, the gifted students in science were higher than other groups in science self-efficacy beliefs. Sixth, the gifted students in IT were higher than other groups in computer self-efficacy beliefs. Seventh, the gifted students in IT were lower than other groups in social self-efficacy beliefs.

• The Journal of Information Systems
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• v.28 no.4
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• pp.1-25
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• 2019

Purpose The purpose of this study is to investigate cognitive mechanism of goal relations (Single-goal vs. Multiple-goals) and to-do list (Packing vs. Unpacking) and also verify the role of self-efficacy in the perspective of motivation belief. The perspective of cognitive mechanism is related to the effects of how the relations of multitasking environments affects to facilitating relation or conflicting relations. In pursuit of a single goal, judgement of task importance can be facilitated by unpacking effect due to relations of strongly associated project components including to-do list. On the other hands, in pursuit of multiple goals, judgement of task importance can be conflicted due to mutually exclusive relations of multiple goals. Additionally, the cognitive mechanism can be regulated from the role of self-efficacy, which contributes to motivation belief on how much a person is confident in achieving given tasks. In the end this research is to identify self-efficacy as boundary condition in inhibiting the effects of facilitation and conflict. Design/methodology/approach This study conducted Two-way ANOVA (Packing/ Unpacking * Single-goal/ Multiple-goals) to explore the effects of cognitive mechanism on task importance. After that we performed Three-way ANOVA, 2 (To-do list: Packing/ Unpacking) * 2 (Goal relation: Single-goal/ Multiple-goals) * 2 (Self-efficacy: Low self-efficacy/ High self-efficacy) to verify the role of self-efficacy between goal relations and to-do list. Findings In the cognitive mechanism, the task importance is not significantly different between in packed and in unpacked condition in pursuit of a single goal. But multitasking with multiple goals causes goal conflict, which means packed condition indicates significantly higher task importance than unpacked condition. Additionally, for a group with low self-efficacy unpacking leads to conflicting relation, which implies that packed condition is more efficient strategy than packed condition. On the other hands, in pursuit of mulitple goals, either packing or unpacking has no distinctive effects on task importance. However, participants with high self-efficacy are no longer affected by facilitating relation and conflicting relation as well in pursuit of either a single goal or multiple goals as well.

• Journal of Families and Better Life
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• v.29 no.2
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• pp.73-87
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• 2011

The purpose of this study is to investigate the influence of children's socia-demographic variables(i.e., gender, birth order, and the amount of time staying in kindergarten) on, leadership, self-regulation and children's peer play behaviors. The participants of this study are 336 children aged between five and seven in four classes in a private kindergarten and eight classes in a private preschool located in the capital region. The results revealed that, girls showed more leadership, self-regulation, and play interaction section than boys: whereas, boys showed higher response in play disruption and the lack of play disconnection. However, birth order, did not have a significant effect on the sub-domain of leadership, self-regulation competence, and peer play behaviors. As for the duration children stay in preschool or in preschool or kindergarten, children who spend half-day showed higher reaction in behavioral self-control and emotional taking abilities than children who stay in the preschool or kindergarten full day. On the other hand, self-esteem of full-time children was higher than half-time children. Children who were emotionally sensitive, knew how to lead their peer group, and those who were sociable and self-regulated presented to be more active in peer-interaction than others. Second, as the result of the correlation analysis reveals, children's leadership, self-regulation competence, peer play behaviors, and play interaction had a meaningful effect on the sub-variations of children's leadership and self-regulation and they showed significant influence upon play disruption and play disconnection. In addition, girls who were not able to manage or to inspect their behavior and had insensitive emotion demonstrated higher tendency to play disconnected. Children, who participated in full-day program with having difficulties in self-regulation or inspecting their behavior properly but had a strong leadership and insensitive showed play disruption highly.

• Korean Journal of Culture and Social Issue
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• v.12 no.2
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• pp.45-76
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• 2006

This article compares the psychological and behavioral profiles of adolescents on probation and high school students. A total of 253 adolescents on probation and 257 high school students completed an open-ended questionnaire developed by the present researchers and structured questionnaire that assessed moral disengagement and self-efficacy developed by Bandura (1995), delinquent behavior and academic achievement. Adolescents on probation reported that they engaged in delinquent behavior due to the fault of others and they were angry for being forced to be on probation. They are not likely to take responsibility and morally disengage from their delinquent actions. When compared to high school students, adolescents on probation are likely to report low self-efficacy, low academic grade, and less likely to feel proud of themselves. They are more likely to meet their friends in Internet and video game rooms and less likely to focus on academic achievement. Results of ANCOVA indicate that adolescents on probation have higher scores on moral disengagement, social efficacy, but lower score on efficacy for self-regulated learning. They are more likely to run away from home and have lower academic grade. The results of the discriminant analysis indicate that running away from home, social efficacy and moral disengagement are predictive of adolescents on probation and academic achievement and efficacy for self-regulated learning are predictive of high school students.

• The Journal of the Korea Contents Association
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• v.17 no.2
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• pp.13-25
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• 2017

This study aims to analyze the impacts on self-regulated learning (SRL) and problem-solving (PS) competencies rather than learning achievement through the use of digital textbooks in the SMART learning environment. To achieve the objective, $3^{rd}$ and $4^{th}$ grade elementary and $1^{st}$ year middle school students were selected from 29 schools where the digital textbooks were utilized in the subjects of science in pilot schools in 2014. In this, One-Group Pretest-Posttest Designs were applied as a research method to analyze SRL and PS competencies. Additionally, the effect size of Cohen's d was presented in order to display the practical significance. The results showed the positive impacts on SRL and PS competencies, in spite of a small effect size of about 0.2 through the use of digital textbooks. ANCOVA was conducted to determine the difference in the impacts according to demographic variables. The results demonstrated that the difference in the impacts on both SRL and PS were statistically significant according to the grade and level. For SRL, both the elementary grade 4 and middle school students showed more significant differences than elementary grade 3. Moreover, for PS, the elementary grade 4 students showed the most significant difference.

• Journal of Gifted/Talented Education
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• v.24 no.3
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• pp.445-462
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• 2014

The purpose of the present study is to compare paper and pencil test utilized to identify gifted students so far to the recently introduced teacher observation-recommendation system. More specifically, this study compared intelligence, career patterns, and self- regulated learning abilities of gifted students who were identified through those two different identification system to explore the possibility of the newly introduced teacher observation-recommendation system. The results show that there was no significant difference in the aspect of overall IQ score. However, students who were identified through the observation-recommendation system showed significantly higher scores at some subscores of intelligence test, such as vocabulary application, comprehension, and schematization. In the aspects of career patterns, about 72% of gifted students who were identified through the previous paper and pencil test belonged to the 'investigative' category of Holland. But more diverse career patterns such as enterprising, social, realistic, conventional including investigative categories were found in those students who were identified by the observation-recommendation system. There were also significant differences in the self-regulated learning abilities between two groups of students. Practical implications of the study were discussed in depth.

• The Journal of Korean Philosophical History
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• no.32
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• pp.161-183
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• 2011

Lee Ik(李瀷) had put emphasis on the achievements by self-regulated academic learning through doubts, and at the same time that it was all-embracing. His academic attitude had set an example among the members of Seongho school(星湖學派), and his disciples had strived to emulate his style. The greatness of Seongho(星湖)'s study had been revealed by development of Seongho school(星湖學派) right after his death. He had argued that the six strokes of I-Ching should be read having it divided into inward and outward divine signs. He had stated his view clearly that the divine signs ranging from one stroke to six strokes were not connected, same as Shao yong(邵雍)'s method, but, the three strokes of inward divine sign as well as the three strokes of outward divine signs were independent from each other. Seongho(星湖) also had raised many questions about Shifa(筮法), and Bianyao(變爻) and Zhuzi(朱子)'s Shifa(筮法), or Yixueqimeng("易學啓蒙") "Kaobianzhan("考變占")". In view of the Shifa(筮法), Seongho(星湖) had helped Dasan(茶山) to present 'Shiguafa(蓍卦法)' by proposing different divination rule from Zhuzi(朱子)'s Method of Divination by Shiyi("筮儀"). Seongho(星湖) had not professed something significantly different from Zhuzi(朱子) in his I-xue. His study on I-xue had been accomplished under his goal of achievements by self-regulated academic learning through doubts. "Shiguakao("蓍卦攷")" is also same. I-xue of Seongho(星湖) had made a great contribution to form Dasan(茶山)'s I-xue in the later years.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.6
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• pp.3469-3477
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• 2014

This study examined the effects of a 4 week, 8 session LCSI programs on the self-efficacy, adjustment to college of undergraduates. The number of participants was 39 students at one region. For statistical analysis, descriptive statistics, paired t-test, and Pearson correlation were used with SPSS WIN 18.0. The results are summarized as follows. The self-efficacy and underlying factors of self-efficacy in self-confidence, sense of self-regulated, task difficulty increased significantly, and the underlying factors of adjustment to college life academically, socially, emotionally, physically, love of the university, and adjustment to college increased significantly. Therefore, the self-growth program using LCSI, self-efficacy and adjustment to college life appears to have significant effects, and the LCSI program is more useful to consider the characteristics of each person by applying a range of situations to plan and deliver, such as communication or subjects, and conflict management in a variety of situations.