• Journal of the Korean Society for Precision Engineering
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• v.32 no.8
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• pp.755-760
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• 2015

For proper wound healing, dermal contraction and remodeling are critical; during the natural healing process, differentiated fibroblasts called "myofibroblasts" typically undertake these functions. For severe wounds, however, a critical mass of dermal matrix and fibroblasts are lost, making self-regeneration impossible. To overcome this impairment, synthetic wound patches with embedded functional cells can be used to promote healing. In this study, we developed a polydioxanone (PDO)-based cell-embedded sheet on which dermal fibroblasts were cultured and induced for differentiation into myofibroblasts, whereby the following combinatorial physicochemical stimuli were also applied: aligned topology, electric field (EF), and growth factor. The results show that both the aligned topology and EF synergistically enhanced the expression of alpha smooth-muscle actin (${\alpha}$-SMA), a key myofibroblast marker. Our proof-of-concept (POC) experiments demonstrated the potential applicability of a myofibroblast-embedded PDO sheet as a wound patch.

• KIEAE Journal
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• v.13 no.2
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• pp.131-139
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• 2013

The aim of this dissertation is establishing internal indicator list for achieving policy goal of Carbon Neutrality Green City. First of all, it started to construct the basic system of planning indicator based on through comprehension of current studies such as advanced researches, government guidelines and green building certifications. And then it was set up final indicator list through inspecting FGI (Focus Group Interview), Verification of suitability, and Analysis of importance). As a result of this research, the planning indicator divided three steps and there were classified four fields in the top-level; Green Land and Ecology, Green Energy, Green Resource and Transportation, Green Living and Institution. According to the data, it deducted four items (ratio of green land, site plan, heat island and management of climate, base of nature ecology) and twelve index in the field of green land and ecology, three item(energy conservation and self-supporting, energy efficiency, new regeneration energy) and twelve index in the field of green energy and regeneration, five items(water resources utilize and circulation, other resource reduction and circulation, public transportation, green transportation plan) and fifteen index. Totally, Planning Indicators of forty nine were deducted. Therefore, there was the result of importance analysis that the indicators of plan and maintain management as the side of space for carbon neutrality were more appreciated than carbon reduction of individual building.

• Journal of the Korean housing association
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• v.14 no.6
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• pp.15-22
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• 2003

The regeneration of built-up areas is considered as one of the necessary measures for the effectiveness of urban growth management. In this vein, this study explores how to limit the number of people who leaves the built-up areas and to restore the area with the resident. For this, a residential area of the built-up area is analyzed in terms of why people in that area are moving out of the area and who fills in it after all. This study founds that narrow roads in a residential area and the changes in land use from residential purposes to commercial are major forces that push the people in the built-up area. In addition, the lack of welfare facilities, the pavement of roads, and pedestrian roads. education. crime. the lack of interaction between neighbors, and the quality of housing are all emerged contributing the loss of people in the built-up areas. It is recommended that all the factors here should be restored in an appropriate way. Another finding is that those who fill in the built-up area are largely over 50, self-employed, comparably wealthy, and having their own families. Hence, it is advised that the built-up area would be rearranged in order to attract those type of people in there.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.9
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• pp.43-54
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• 2018

Recently, residents' community center is trying to combine with various program and facilities as the residents self-government program's development. This is due to the reduction of administrative tasks, the computerization of programs, the importance of community participation activities, the activation of community, and the increase of welfare projects. Therefore, previous studies on program complexity have been actively carried out. Nevertheless, spaces and programs studies of considering regional characteristics are lacking. Therefore, the community centers' program and spaces need to change. Therefore, this study propose an improvement direction through analyzing the situation of the residents' community center. For this study, the precedent research and institutional limitations are examined. In addition, this study selected and analyzed the 15 local community center. Thirdly, interviews were conducted with users and officials of the 5 residents' community centers on major changes. Finally, This study suggests direction of program improvement and architectural design direction. As a result of this study, integrated management measures with overlapping agencies should be sought. Surplus space will have to be rearranged into a new program through prior examination. Above all, the proposed remodeling guidelines require user requirements to be reflected and designed with the residents.

• Journal of the Korean Institute of Educational Facilities
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• v.28 no.2
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• pp.3-10
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• 2021

Community-based design is also becoming important in Korea recently. However, the existing design methods of the "conformity" method had the problem of excluding the participation of residents. Therefore, the "decision-making" method, in which residents participate in the design themselves, is drawing attention. Development of specific methods is important for residents to actively participate in "decision making." The theory of "Design Games" has long been studied as a method of community-based design in many countries. The old downtown areas of Jeju Special Self-Governing Province are increasing in number of buildings abandoned due to aging and declining. Abandoned buildings are causing many social problems. A decision-making method has been developed in Jeju for the regeneration design of abandoned buildings. This study conducted a design workshop involving residents on abandoned buildings in the old city center of Jeju City. The possibility and task of decision-making method were analyzed. As a result, participating residents were actively involved in decision-making. It also helped residents understand and learn about the attractions of the neighborhood. Meanwhile, there were also difficulties in communicating among some participants. This is a structural problem with this method. Studies have also shown that it is important for residents themselves to try to understand the neighborhood.

• Journal of Periodontal and Implant Science
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• v.37 no.3
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• pp.479-488
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• 2007

In spite of the attention given to the study of mesenchymal stem cells derived periodontal ligament (PDL), there is a lack of information about canine PDL cells. In this study, we characterized canine PDL cells to clarify their stem cell properties, including self renewal, proliferate rate, stem cell markers and multipotency. PDL cells were obtained from extracted premolars of canines, following a colony forming assay and proliferation rate of sub-confluent cultures of cells for self-renewal, immunostaining for STRO-1 and CD146/MUC18 and a differentiation assay for multipotency. Canine PDL cells formed single-cells colonies and 25% of the PDL cells displayed positive staining for BrdU. The cells expressed the mesenchymal stem-cell markers, STRO-1 and CD146/MUC18. Under defined culture conditions, the cells differentiated into osteoblasts and adipocytes, but the cells didn't differentiated into chondrocytes. The findings of this study indicated that the canine PDL cells possess crucial stem cells properties, such as self-renewal and multipotency, and express the mesenchymal stem cell markers on their surface. The isolation and characterization of canine PDL cells makes it feasible to pursue preclinical models of periodontal regeneration in canine.

• Journal of Periodontal and Implant Science
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• v.46 no.1
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• pp.10-21
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• 2016

Purpose: This study evaluated the predictive performance of a combination of self-report questionnaires, salivary hemoglobin levels, and age as a non-invasive screening method for periodontitis. Methods: The periodontitis status of 202 adults was examined using salivary hemoglobin levels, responses to 10 questions on a self-report questionnaire, and the Community Periodontal Index (CPI). The ability of those two variables and the combination thereof with age to predict the presence of CPI scores of 3-4 and 4 was assessed using logistic regression and receiver operating characteristic (ROC) curve analysis. Results: CPI scores of 3-4 and 4 were present among 79.7% and 46.5% of the sample, respectively. The area under the ROC curves (AUROCs) of salivary hemoglobin levels for predicting prevalence of CPI scores of 3-4 and 4 were 0.63 and 0.67, respectively (with sensitivity values of 71% and 60% and specificity values of 56% and 72%, respectively). Two distinct sets of five questions were associated with CPI scores of 3-4 and 4, with AUROCs of 0.73 and 0.71, sensitivity values of 76% and 66%, and specificity values of 63% and 69%. The combined model incorporating both variables and age showed the best predictive performance, with AUROCs of 0.78 and 0.76, sensitivity values of 71% and 65%, and specificity values of 68% and 77% for CPI scores of 3-4 and 4, respectively. Conclusions: The combination of salivary hemoglobin levels and self-report questionnaires was shown to be a valuable screening method for detecting periodontitis.

• Journal of Korean Society of Forest Science
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• v.105 no.1
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• pp.42-47
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• 2016

To examine the natural regeneration in the natural mixed-broadleaved forest, flowering, fruiting, seed-fall, and seed viabilities of Acer pseudosieboldianum (Ap) were investigated in Mt. Jungwang, Gangwon-do, from 2009 to 2015. The flower of Ap consisted many male and bisexual flowers on the corymb. Flowering dates are differed between sex morph in the same inflorescence. Stamens are stop growing and disappeared after pollinated pistil begin to grow in bisexual flowers, and male flowers have vestial pistil. The flowers of Ap might be pollinated by Apis mellifera, Andrenidae spp. and Syrphinae spp. Ap had some mechanism to prevent from self pollination with heterodichogamy. Mean annual seedfall of Ap was 70,780 ea/ha (ranged 310~234,840 ea/ha). Annual seedfall of Ap varied severely, and the maximum was about 760 times the minimum. Annual seed production of Ap might be to a normal distribution. Rates of damaged or decayed seeds are highest 59.3%, and those of sound seeds are 23.9%, Those of undeveloped and empty seeds are 9.2% and 7.6%, respectively. The most important factors influencing sound seed production might be the density and activities of insect pollinators and sucking pest in the flowerwing period, middle-late May. Successful regeneration of Ap might be in masting year and on the gap sites with proper conditions to germinate and grow. To understand the natural regeneration of deciduous hardwoods, further study on the characteristics of flowering and fruiting, pre- and post-dispersal seed predation, and annual variation on these factor should be needed.

• Journal of Korean Society of Forest Science
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• v.103 no.2
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• pp.153-158
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• 2014

To examine the natural regeneration in the natural mixed-broadlived forest, flowering, fruiting, seed-fall, and seed viabilities of Acer ukurunduense Trautv. & C.A. Mey. (AU) were investigated in Mt. Jungwang, Gangwon-do, from 2009 to 2013. The flower of AU consisited many male and bisexual flowers on the raceme (unusual panicle) and the arrangement of two sex morphs are differed for each inflorescence. Flowering dates are differed between sex morph in the same inflorescence. Stamens are stop growing and disappeared after pollinated pistil begin to grow in bisexual flowers, and male flowers have vestial pistil. The flowers of AU might be pollinated by Apis mellifera, Thyris fenestrella seoulensis, Cerambycidae sp., Andrenidae sp. and Ctenophora sp., and had some mechanism to prevent feom self pollination. The number of flower buds per inflorescence is 189 on June 8, and that of young samaras per inflorescence is 41.2 on June 21. At last ripened samaras per inflorescence is reduced 33.4 on September 5. Mean annual seedfall of AU was 6,720 ea/ha (ranged 670~17,930). Rates of sound seeds are highest 43.2%, and those of damaged or decayed seeds are 41.8%,. Those of undeveloped and empty seeds are 10.2% and 4.8%, respectively. Successful regeneration of AU might be in masting year and on the gap sites with proper conditions to germinate and grow. To understand the natural regeneration of the species, Genus Acer, further study on the fruiting habit, pre- and post-dispersal seed viability, and annual variation on these factor should be needed.

• Journal of Korean Society of Forest Science
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• v.99 no.1
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• pp.153-162
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• 2010

Abies holophylla Maxim. is a shade tolerant species that has potential to be used for continuous cover forestry system. Stand structure and natural regeneration of A. holophylla stands in Yong-In area located in the central part of Korea was investigated to estimate the self sustainability of A. holophylla plantation. Species composition, diameter at breast height (DBH) and height distribution of trees larger than 2 cm DBH were measured in ten stands in three study sites of Jeongsu-ri, Daedae-ri, and Hodong. Species and coverage of shrub layer, and A. holophylla seedlings were also investigated. While A. holophylla in non-managed stands (Jengsuri and Daedae-ri study sites) had the importance value of 40% and showed continuous diameter and age distribution, A. holophylla in Hodong site had narrow bell-shaped DBH distribution mostly concentrating between 25-35 cm DBH classes, and single canopy structure. Abies holophylla stands in Hodong have experienced occasional thinning and selective cutting. The correlation coefficient between age-DBH was significant but low ($R^2$=0.2, P=0.03), and similar aged A. holophylla had diverse DBH values. Continuos DBH distribution and multi-canopy structure of A. holophylla stands in Jeongsu-ri site show that natural regeneration of A. holophylla has been continuously occurred in this area. Seedling density of A. holophylla was between 2000 and 33000/ha, however, the number of trees in 2-5 cm DBH class was only 40-150 trees/ha, implying that the survival rate of seedlings is not high. Continuous natural regeneration and 0.6 cm/year of diameter growth rate of A. holophylla indicate that this area could be an appropriate habitat for this species, and A. holophylla plantation in this region seem to persist suggesting the possibility of managing the stands for continuous cover forestry system as well as selective harvesting practices.