• Title/Summary/Keyword: Safety Risk Assessment

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Analysis Method of N-Nitrosamines in Human Urine by LC-MS/MS System (LC-MS/MS 시스템을 이용한 소변 중 N-니트로사민류 분석법 확립)

  • Park, Na-Youn;Jung, Woong;Kho, Younglim
    • Journal of the Korean Chemical Society
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    • v.61 no.2
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    • pp.51-56
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    • 2017
  • N-nitrosamines are the nitroso compounds which are produced by nitrosation reactions of the secondary amine and nitrite under acidic conditions. Approximately 300 species of N-nitrosamine have been tested for carcinogenicity in laboratory experiments, with 90% of them demonstrated carcinogenic effects different animal species, including higher primates. In 1978, IARC classified NDMA and NDEA as Group 2A, and NDPA, NDBA, NPIP, NPYR and NMOR as Group 2B. In this study, we established pretreatment and analytical method for N-nitrosamines (NDMA, NDEA, NMEA, NDPA, NDBA, NPIP, NPYR and NMOR) in human urine for biological monitoring of N-nitrosamines. The analytes were extracted using solid phase extraction (SPE), then quantitative analysis was performed by LC-(APCI)-MS/MS. The accuracies of the established method were between 85.8~108.7% and precisions were lower than 20%. The limit of detection (LOD) were between 0.0002 (NDBA) and 0.0793 (NDMA) ng/ml. The linearity obtained was satisfying for the 8 N-nitrosamines, with a coefficient of determination ($r^2$) higher than 0.999. The mean concentrations of N-nitrosamines in the urine were 2.645 mg/g creatinine for NDMA, 0.067 mg/g creatinine for NDEA, 0.009 mg/g creatinine for NMEA, 0.011 mg/g creatinine for NDBA, 0.271 mg/g creatinine for NPIP and 0.413 mg/g creatinine for NPYR. NDPA and NMOR were not detected. It can be used as a instrumental methodology for evaluation and risk assessment of human exposure to N-nitrosamines for the further research.

A Study on the Management Improvement of Disaster Recovery Resources of Municipality with Field Survey (현장실태조사를 활용한 지자체 재난관리자원 관리 개선 연구)

  • Kim, Joon-Ha;Kim, Tae-Heon;Jung, Jae-Wook
    • Journal of the Society of Disaster Information
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    • v.16 no.1
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    • pp.155-162
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    • 2020
  • Purpose: The purpose of study was to identify problems in disaster recovery resource management and operation through on-site investigation and utilize them as improvement proposal for disaster recovery resources management by local governments. Method: Areas with high natural and social disasters recorded in historical and yearly records of natural and social disasters, related books, and annual reports for 20 years were selected. The DRSS data of the selected local governments were analyzed and the reserve warehouse were selected for field survey. Result: It is analyzed that the current situation in the city hall and district offices is somewhat insufficient due to heavy work by the working-level officials of local governments on the storage of disaster recovery resources. The actual amount of stockpiles and DRSS data are somewhat different or missing because the input method and criteria are not clear at present when inputting the current data. Conclusion: To improve the management of the disaster recovery resource reserve, it is deemed that education of DRSS and training of best practices for the operation of disaster management resources are urgently needed, and that a systematic management of stockpiles using disaster prevention experts will be required.

Monitoring and Risk Assessment of Pesticide Residues in Commercial Environment Friendly Fruits and Fruiting Vegetables (유통 친환경 과실류와 과채류 중 농약잔류 실태조사 및 안전성 평가)

  • Lee, Jae Yun;Noh, Hyun Ho;Park, So Hyun;Lee, Kwang Hun;Park, Hyo Kyoung;Hong, Su Myeong;Kim, Doo Ho;Kyung, Kee Sung
    • The Korean Journal of Pesticide Science
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    • v.16 no.4
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    • pp.308-314
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    • 2012
  • In order to monitor the residual pesticides in environment friendly agricultural commodities, fruits and fruiting vegetables. Twenty-five agricultural commodities were collected twice in May and August 2011 from nine environment friendly agricultural commodities-selling supermarkets and retail stores located in eight major cities in Korea. The number of each agricultural commodity collected, 555 samples in total, was 152 organic agricultural products, 202 pesticide-free agricultural products and 201 low-pesticide agricultural products. Pesticide residues in samples were analyzed by multiresidue method for 245 pesticides using a GC-ECD/NPD and an HPLC-DAD/FLD and the peaks suspected as pesticides were identified with a GC/MSD. As a result of pesticide residue analysis, three pesticides, bifenthrin, EPN and chlorpyrifos, were detected from four samples including apple, representing a detection rate of 0.72%. The residue levels of the four pesticide-detected samples were less than their maximum residue limits (MRLs) but one pesticide EPN detected from pear exceeded its legible criterion of one twentieth MRL. Estimated daily intakes of the pesticides detected from fruits and fruiting vegetables were less than 0.76% of their maximum permissible intake.

Monitoring and Risk Assessment of Pesticide Residues in Agricultural Products Collected from Wholesale and Traditional Markets in Cheongju (청주지역 유통 농산물 중 잔류농약 모니터링 및 안전성 평가)

  • Noh, Hyun-Ho;Kang, Kyung-Won;Park, Young-Soon;Park, Hyo-Kyung;Lee, Kwang-Hun;Lee, Jae-Yun;Yeop, Kyung-Won;Lee, Eun-Young;Jin, Yong-Duk;Kyung, Kee-Sung
    • The Korean Journal of Pesticide Science
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    • v.14 no.1
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    • pp.1-9
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    • 2010
  • In order to survey residual characteristics of pesticides in the agricultural products selling at markets and to assess their safety, a total of 120 agricultural products were collected from the wholesale and traditional markets in Cheongju and analyzed the pesticide residues in them by multiresidue analysis method using GLC, HPLC and GC-MSD. Three pesticides, procymidone, penconazole, and tetraconazole, were detected from 4 samples such as onion, leek, tomato, and green pepper. Fungicide penconazole was detected from the onion collected from wholesale market. Fungicide procymidone was detected from leek and tomato and fungicide tetraconazole was detected from green pepper. Pesticide residues were detected from 3.3% of the total samples. The estimated daily intakes (EDIs) of the pesticides detected were less than 0.1% of their acceptable daily intakes (ADIs), representing that residue levels of the pesticides detected were evaluated as safe.

Quality Evaluation of Edible Ices on the Microbiological Risk Factors (빙과류의 미생물학적 위해요소에 대한 품질 평가)

  • Kim, Tae-Woong;Choi, Jae-Ho;Kim, Jai-Moung;Ding, Tian;Rahman, S.M.E.;Bahk, Gyung-Jin;Oh, Deog-Hwan
    • Journal of Food Hygiene and Safety
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    • v.24 no.1
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    • pp.86-93
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    • 2009
  • This study was conducted to determine microbiological assessment on edible ices, which is one of mandatory items for HACCP application, and to provide basic scientific data for the improvement of HACCP system. In HACCP applied edible ice companies, the contamination levels of total counts, yeast and mold, and coliform from raw materials, mixed samples before sterilization, mixed samples after sterilization, and final products of edible ices were lower than those of non-HACCP applied edible ice companies. Foodborne pathogens, such as L. monocytogenes, Salmonella spp., B. cereus, B. aureus, Y. enterocolitica were not detected in all samples of edible ices from HACCP applied edible ice companies, but S. aureus was isolated1 from 1 raw material, 1 mixed samples before sterilization and 1 final product of edible ices from non-HACCP applied edible ice companies, respectively.

Analysis of risk management system of GM crops in China for the development of global GM crops (글로벌 GM 작물 실용화를 위한 중국의 GM 작물 안전관리제도 분석)

  • Lee, Shin-Woo;Cho, Kwang-Soo;Wang, Zhi;Kwak, Sang-Soo
    • Journal of Plant Biotechnology
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    • v.39 no.3
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    • pp.127-132
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    • 2012
  • We analysed the current status of development of GM crops and national biosafety framework including legislation-related agricultural GMO in China to provide the policy for the development of global GM crops in Korea. In China, several GM crops including cotton, petunia, tomato, sweet pepper, poplar, and papaya have been approved for commercialization and they have been cultivated at more than 4 million ha. In addition, GM rice and GM maize have also obtained approval for productive testing in 2009. China will be the first country to approve GM rice for commercialization. Prior to commercialization in China, all GM crops must be approved by government authority for biosafety assessment specified by national legislation including restricted field testing, enlarged field testing, productive testing and safety certificate. According to China's legislation, agricultural GMOs have been classified by research and testing, production and processing. All GMOs must go through 3 steps of field testing (restricted, enlarged and productive). Prior to conducting each field testing, it has to be approved by government authority. It is assumed that at least one to two years will be taken for each step of field testing (total 4 to 8 years to obtain the final safety certificate) along with a large amount of budget.

A Study on the Necessity and Direction of Regulations on the Emission of Hazardous and Noxious Substances from Marine Industrial Facilities (해양산업시설의 위험유해물질 해양배출 규제체계 개선의 필요성과 규제방향에 대한 연구)

  • Lee, Moonjin;Kim, Kyewon;Kang, Wonsoo
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.27 no.6
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    • pp.737-743
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    • 2021
  • In this paper, the current status of marine industrial facilities, regulatory legal systems, and emission status of hazardous and noxious substances (HNS) in these facilities were analyzed, and the direction of improvement of the regulatory system was presented accordingly. As a result of the analysis, it is estimated that about 1,100 marine industrial facilities are subject to the Marine Environment Management Act of 2007. It is estimated that 190 kinds of hazardous substances are discharged from these marine industrial facilities and are highly likely to flow into the ocean, of which 20 are estimated to be discharged into the water system. However, due to the lack of relevant laws and regulation, it is difficult to clearly determine whether the discharged material corresponds to an exceptional discharged material, making it difficult to effectively enforce regulations in the field. For this reason, effective regulatory enforcement is difficult in the regulatory field. The marine environment management law should clearly stipulate the exceptional emission standards and types of substances, and clarify the selection system, risk assessment system, and emission information collection and monitoring system for related Hazardous and Noxious Substances.

A Study on the Eco-Toxicity of Silicone-Based Antifoaming Agents Discharging into Marine Environments (해양으로 배출되는 실리콘계 소포제의 생태독성 연구)

  • Kim, Tae Won;Kim, Young Ryun;Park, MiOk;Jeon, MiHae;Son, Min Ho
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.25 no.1
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    • pp.81-88
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    • 2019
  • In order to understand the effects of the main components of antifoaming agents on the marine benthic ecosystem when silicone-based antifoaming agents are discharged into marine environments, eco-toxicity testing was performed on silicone and alcohol-based antifoaming agent by using benthic amphipod (Monocorophium acherusicum) and luminescent bacteria (Vibrio fischeri). The toxic effects of Polydimethylsiloxane (PDMS) as a main component of silicone-based antifoaming agents on aquatic organisms were also researched. In the results of the eco-toxicity test, luminescent bacteria showed a maximum of 9 times more toxic effects than benthic amphipod for alcohol-based antifoaming agents, and silicone-based antifoaming agents showed a maximum of 400 times more toxic effects than alcohol-based. The $LC_{50}$ and $EC_{50}$ values of PDMS ranged from 10 to $44,500{\mu}g/L$ in phytoplankton, invertebrate, and fish. In the results of applying PBT (P: persistency, B: bioaccumulation, T: toxicity) characteristics as an index showing the qualitative characteristics of PDMS, persistency (P) and bioaccumulation (B) were confirmed. Thus, when PDMS is discharged to marine environments, it could accumulate in the upper trophic level through bioaccumulation and the food chain, which could have negative effects on benthic organisms. The results of this study may be used for objective and scientific risk assessment, considering the major components of antifoaming agents when investigating the effects of various discharged antifoaming agents in marine ecosystem.

Microbial Risk Assessment for Mixed Vegetable Salad and Fresh and Frozen Fruits Distributed in Korea (국내 유통 중인 혼합채소샐러드 및 신선·냉동과일의 미생물 오염실태 조사)

  • Park, Hyun-Jin;Lee, Jeong-Eun;Kim, Sol-A;Shim, Won-Bo
    • Journal of Food Hygiene and Safety
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    • v.36 no.4
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    • pp.324-330
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    • 2021
  • In this study, the microbial levels on mixed vegetable salads, fresh fruits, and frozen fruits distributed in Korea were comparatively analyzed by food group, region, and quarter. Samples were collected from big markets in large cities from 2018 to 2019 and used for microbiological analysis. The levels of aerobic bacteria for mixed vegetable salads, fresh fruits, and frozen fruits were 6.48, 5.07, and 3.78 log CFU/g, respectively. As a result of analyzing the quarterly contamination levels of aerobic bacteria, the first quarter contamination level was 5.12 log CFU/g while the second quarter showed 6.26 log CFU/g, the third quarter 5.73 log CFU/g, and the fourth quarter 4.42 log CFU/g. A higher number of aerobic bacteria was observed in the second and third quarters when the temperature was higher. There was no difference in the number of bacteria by region. The levels of the coliform group were 1.98 - 3.93 log CFU/g in all samples, and Escherichia coli was detected at 1.38 log CFU/g in 3 out of 27 mixed vegetable salads. Since the mixed vegetable salad and fresh fruit used in this study exceeded the standard (3 log CFU/g) for unheated foods and E. coli was detected in three fresh fruits, stricter hygiene management in the manufacturing stage of salads and fresh fruit is required.

A Study on the Flooding Risk Assessment of Energy Storage Facilities According to Climate Change (기후변화에 따른 에너지 저장시설 침수 위험성 평가에 관한 연구)

  • Ryu, Seong-Reul
    • Journal of the Society of Disaster Information
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    • v.18 no.1
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    • pp.10-18
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    • 2022
  • Purpose: For smooth performance of flood analysis due to heavy rain disasters at energy storage facilities in the Incheon area, field surveys, observational surveys, and pre-established reports and drawings were analyzed. Through the field survey, the characteristics of pipelines and rivers that have not been identified so far were investigated, and based on this, the input data of the SWMM model selected for inundation analysis was constructed. Method: In order to determine the critical duration through the probability flood analysis according to the calculation of the probability rainfall intensity by recurrence period and duration, it is necessary to calculate the probability rainfall intensity for an arbitrary duration by frequency, so the research results of the Ministry of Land, Transport and Maritime Affairs were utilized. Result: Based on this, the probability of rainfall by frequency and duration was extracted, the critical duration was determined through flood analysis, and the rainfall amount suggested in the disaster prevention performance target was applied to enable site safety review. Conclusion: The critical duration of the base was found to be a relatively short duration of 30 minutes due to the very gentle slope of the watershed. In general, if the critical duration is less than 30 minutes, even if flooding occurs, the scale of inundation is not large.