• BMB Reports
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• v.52 no.1
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• pp.42-46
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• 2019

Cellular senescence, a process of cell proliferation arrest in response to various stressors, has been considered to be important factor in age-related disease. Identification of senescent cells in tissues is limited and the role of senescent cells is poorly understood. Recently however, several studies showed the characterization of senescent cells in various pathologic conditions and the role of senescent cells in disease progression is becoming important. Senescent cells are growth-arrested cells, however, the senescence associated secretory phenotype (SASP) of senescent cells could modify the tissues' microenvironment. Here, we discuss the progress and understanding of the role of senescent cells in tissues of pathologic conditions and discuss the development of new therapeutic paradigms, such as senescent cells-targeted therapy.

• Journal of Distribution Science
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• v.9 no.1
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• pp.5-15
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• 2011

Research regarding corporate associations in marketing has generally been approached using the association theory. However, limited research investigates the effect of corporate associations on consumer loyalty to individual brands by examining the role of self connectedness with a corporate image. The activation of behavior-related constructs can influence individuals' behaviors without their intention or conscious awareness. A recently developed body of research suggests that self connection can play an important role in affecting subsequent behaviors. Although these effects have received considerable attention, the set of mechanisms involved in self connectedness and loyalty to individual brands is not clear. An active self account in which associative constructs can affect behavior by temporarily altering the active self-concept may lead to behavior or evaluation. If the exposure to a corporate brand can induce consumers' cognitive associations and goal-primed effects through the role of active self accounting, the connectedness between the consumer's self and the corporate brand could be developed and this connectedness could be explained by associative and connection models and the goal priming theory. Therefore, this study investigates the influence of corporate associations on loyalty to individual brands through connections between the corporate and the consumer's self. There are three main purposes of the research. First, theories regarding corporate associations will be explored. Second, theories of self-concept will be investigated and self connectedness with corporate brands will be explored. Third, the effects of the connectedness between the self and the corporation on corporate identification and loyalty to individual brands will be investigated. For the purposes of this research, the types of corporate associations are classified into corporate ability (CA) associations and corporate social responsibility (CSR) associations. Furthermore, the connectedness between the consumer's self and the corporate image are divided into two concepts: the connectedness between the individual self-concept and the corporate identity and the connectedness between social self-concept and the corporate identity. This study suggests the hypotheses that the types of consumer self connections with the corporate image could vary according to the types of corporate associations created and further that the connectedness between the corporate association and the consumer's self-concept have positive effects on loyalty to corporate individual brands. The results of testing these hypotheses are as follows. First, corporate ability associations enhance the connectedness between the consumer's individual self and corporate brands. That is, corporate ability associations influence individual connectedness between the corporate and individual self-concept positively from the viewpoint of the consumer's personal ability and branding success. In addition, corporate social responsibility associations have a positive effect on social connectedness between the corporation and the consumer's social self-concept. Second, the connectedness between the corporate brand and the consumer's self-concept affects identification with the corporation. The consumer's personal self and social self connectedness induces corporate identification. Third, individual self connectedness has a positive effect on loyalty to corporate individual brands, while social self connectedness does not. This also means that individual self connectedness with the corporate image or brand plays a more important role in forming individual brand loyalty than social self connectedness with the corporate does. In addition, social connectedness cannot influence individual brand loyalty until it passes through identification with the corporate. Fourth, consumers who experience identification with a corporate identity also show positive responses to corporate individual brands. That is, consumers also develop loyalties toward individual brands through the corporate identification because self-pursued goals that are induced by corporate associations can be achieved by consuming the individual brands that are sold by the corporate that the consumers identify with.

• Journal of Korean Academy of Nursing Administration
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• v.22 no.2
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• pp.129-136
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• 2016

Purpose: The aim of this study was to identify nurses' role in the delivery of health guidance service within the annual health guidance membership service. Methods: Dynamic job analysis process was applied with vertical job analysis and horizontal job analysis through a focus group workshop and expert survey. Results: As a result of this study, job description was established with 4 duties, 11 tasks, 60 task elements. Major duties consisted of 'professional nurse practice', 'coordination and cooperation', 'education and consultation', and 'administrative work and improvement'. A job process map was also framed. Conclusion: The results can be used to establish nurses' role in providing health care service. Ongoing research on nurse's role as a health guider will be a fundamental base for health care service development and will contribute to expansion of common health management services.

• Korean Journal of Occupational Health Nursing
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• v.31 no.4
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• pp.198-206
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• 2022

Purpose: This study is investigate the role conflict, professional self-concept, and job satisfaction degree of the physician assistant nurses, and to grasp the factors affecting job satisfaction. Methods: Data were collected from September to October, 2018 and 156 physician assistant nurses working at one certified tertiary hospital, four general hospitals, using self-report questionnaires. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheffe's test, Pearson's correlation coefficient and stepwise multiple regression. Results: The degree of job satisfaction of the subject was 2.76 out of 5. The influential factors in the job satisfaction of the subjects were professional self-concept (β=.51, p<.001), and role conflict (β=-.29, p<.001), affected job satisfaction by 53.5%. Conclusion: In order to improve the job satisfaction of physician assistant nurses, the role conflict should be solved and a plan to form a positive self-concept should be sought. Therefore, through the identification of the roles that are appropriate to the situation in Korea and the legal and institutional positioning, they will need to be recognized and developed.

• Journal of Distribution Science
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• v.21 no.5
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• pp.63-73
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• 2023

Purpose: This study proposes a model for future research agendas on knowledge management activities as a source of increasing sustainable competitive advantage. Based on the literature, the role of knowledge management in sustainable competitive advantage does not necessarily have a significant effect but involves other variables. For this reason, future research proposals on the role of knowledge management on sustainable competitive advantage and other relevant variables need to be carried out. Research design, data, and methodology: This research uses a literature study. The model development stage is (1) relevant research studies, (2) identification of relevant theories and related variables, (3) developing and making a hypothesis (4) proposed model. Results: From the literature study, it was found that knowledge management plays a role in increasing managerial competence, market orientation, and innovation. Furthermore, managerial competence, market orientation, and innovation significantly affect sustainable competitive advantage. However, other studies have found a different relationship. Conclusions: This study proposes a research model on the role of knowledge management, managerial competence, market orientation, and innovation to improve sustainable competitive advantage. The study results can be used for further research based on the proposed model and as a reference for company owners and management to increase competitive advantage.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.15-21
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• 2010

Previously standardization study for identifying 5 types of pattern identification of stroke patients has been performed and the Korean standard of pattern identification (II) was developed. In the present study we investigated the interactions between total indices designated by the Korean standard of pattern identification(KSPI II) and indices for PI of Cold-Heat and Deficiency-Excess. Indicators for Cold-Heat and Deficiency-Excess are isolated from 58 indices through the survey of oriental medicine doctors and their relationship with KSPI-II indices was analyzed by corresponding analysis method using data of 1581 stroke patients. Means and standard deviations indicated that 2 Cold indices, 14 Heat indices, 12 Deficiency indices, and 5 Excess indices were included for Cold-Heat and Deficiency-Excess pattern identification. The results of corresponding analysis shows the relationship of 57 indices and 4 types of pattern identification (excluding 1 index and 1 pattern among 58 indices and 5 patterns) using the cross-tabulation which was obtained from the clinical data. Most of Cold and Heat index were divided to dimension 1(inertia 51.9%) obtained from the result of corresponding analysis. Deficiency and Excess index were partially associated with dimension 2(inertia 31.7%). These data suggest that pattern identification of Cold-Heat plays an role in the standardization of pattern identification in stroke, although further studies are required by various trials such as analysis of surveys and clinical data.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5605-5611
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• 2012

Background: In the last two decades, pioneering research on anti-tumour activity of saffron has shed light on the role of crocetin, picrocrocin and safranal, as broad spectrum anti-neoplastic agents. However, the exact mechanisms have yet to be elucidated. Identification and characterization of the targets of bioactive constituents will play an imperative role in demystifying the complex anti-neoplastic machinery. Methods: In the quest of potential target identification, a dual virtual screening approach utilizing two inverse screening systems, one predicated on idTarget and the other on PharmMapper was here employed. A set of target proteins associated with multiple forms of cancer and ranked by Fit Score and Binding energy were obtained from the two independent inverse screening platforms. The validity of the results was checked by meticulously analyzing the post-docking binding pose of the picrocrocin with Hsp90 alpha in AutoDock. Results: The docking pose reveals that electrostatic and hydrogen bonds play the key role in inter-molecular interactions in ligand binding. Picrocrocin binds to the Hsp90 alpha with a definite orientation appropriate for nucleophilic attacks by several electrical residues inside the Hsp90-alpha ATPase catalytic site. Conclusion: This study reveals functional information about the anti-tumor mechanism of saffron bioactive constituents. Also, a tractable set of anti-neoplastic targets for saffron has been generated in this study which can be further authenticated by in vivo and in vitro experiments.

• Journal of the Korean Society of Costume
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• v.49
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• pp.155-172
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• 1999

The purpose of this study was to investigate the effect of children's personality traits and parental child-rearing attitudes on clothing attitudes and color evaluation of preschool children. The subjects for this study consisted of 360 five-year-old children who were attending a preschool and their parents in Cheju Island Korea. Employed mothers had significantly higher score on love acceptance attitude than unemployed mothers did. Female children had more conservative attitude on clothing sex-role than male children did There were no significant gender differences in parental child-rearing attitudes. There were significant relationships between gender and preferred clothing colors. Male children were more likely to prefer blue red, green, and prussian blue for the colors of clothing than were female children while female children liked pink yellow and orange more than male children. Boys selected blue and girls selected pink as the most preferred clothing color. Overall preschool children chose red as the most preferred color black as the most disliked color. The children's sex identification by clothing color was highly consistent with the conservative attitude of adults for all colors. That is preschool children identified pink red and yellow with female color while prussian blue blue and green with male color. Clothing interest of boys was influenced by the mother's state of employment and academic trait. The boys high in academic trait and whose mothers did not have job were high in clothing interest. Clothing management of boys was influenced by emotionality and love acceptance rearing Ttitude. Clothing independednce of boys was influenced by authority control rearing attitude Clothing sex-role of boys was influenced by familism trait. The boys high in familism trait had open-hearted attitude in clothing sex-role. Clothing interest of girls was influenced by academic trait clothing management by sociality clothing independence by emotionality and clothing satisfaction by familism trait. Therefore the more positive personality children had the higher clothing interest and the more desirable clothing attitudes they had.

• Journal of Convergence for Information Technology
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• v.9 no.12
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• pp.8-16
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• 2019

Customized sleep care service needs to be provided differently for individuals since individual has different degree of sleep disorder. Because the brainwave data shows unique waveform characteristics for each person, this characteristic can be used to identify individuals. Personal identification provides an important role in enabling customized services. When you blink, you can obtain brain wave characteristics by measuring the area of the frontal lobe. Therefore, a real-time personal identification algorithm based on blinking EOG for customized sleep care service is proposed in this paper. For evaluation, 10 individuals were tested for personal identification accuracy. The results of the experiment confirmed that a maximum accuracy of 93% were taken. Algorithms can be developed by reflecting characteristics such as changes in the external environment in the future.

• Journal of Digital Convergence
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• v.19 no.11
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• pp.39-44
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• 2021

Amid the growing interest of researchers in unethical pro-organizational behavior in recent years, this study validated the effects of organizational identification on unethical pro-organizational behavior while also verifying the mediating effect of organizational commitment in the relationship between organizational identification and unethical pro-organizational behavior. Based on the theory of good deeds and literature review, the hypothesis was established and a survey was conducted on employees engaged in manufacturing in southern area company in Korea. Analysis shows that organizational identifications has a significant positive effect on organizational commitment, and that organizational commitment has a significant positive effect on unethical pro-organizational behavior. organizational commitment has also been shown to play a partial mediating role in the relationship between organizational identification and unethical pro-organizational behavior. Finally, we discussed the significance and direction of future research.