• Journal of Microbiology and Biotechnology
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• v.30 no.8
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• pp.1109-1115
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• 2020

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally, and the WHO has declared this outbreak a pandemic. Vaccines are an effective way to prevent the rapid spread of COVID-19. Furthermore, the immune response against SARS-CoV-2 infection needs to be understood for the development of an efficient and safe vaccine. Here, we review the current understanding of vaccine targets and the status of vaccine development for COVID-19. We also describe host immune responses to highly pathogenic human coronaviruses in terms of innate and adaptive immunities.

• Geomechanics and Engineering
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• v.22 no.1
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• pp.65-80
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• 2020

This paper presents a theoretical investigation on the response of the thermo-mechanical bending of FG plate on variable elastic foundation. A quasi-3D higher shear deformation theory is used that contains undetermined integral forms and involves only four unknowns to derive. The FG plates are supposed simply supported with temperature-dependent material properties and subjected to nonlinear temperature rise. Various homogenization models are used to estimate the effective material properties such as temperature-dependent thermoelastic properties. Equations of motion are derived from the principle of virtual displacements and Navier's solution is used to solve the problem of simply supported plates. Numerical results for deflections and stresses of FG plate with temperature-dependent material properties are investigated. It can be concluded that the proposed theory is accurate and simple in solving the thermoelastic bending behavior of FG thick plates.

• Journal of Information Technology Services
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• v.12 no.3
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• pp.151-163
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• 2013

It is no doubt that information technology is the key factor of national safety. Information technology is positively useful for national security such as crime prevention and detection, criminal investigation, disaster management, and national defense. However, it might be a threat to the security as we saw in the examples such as '3.4 DDoS attacks' and 'Nong-hyup Computer Network Failure.' Although the effect that information technology makes upon the national security is immense, the current legal system does not reflect these changes well. National security should be kept during 'prevention-response-recovery' process regardless it is in the online on offline. In addition, public administration for national security should be based on laws. However, the current legal system is lack of legislative basis on cyber and physical disaster, and the laws on the response to disaster might cause confusing. Therefore, this study examines the limitation of the current legal system on national security, and suggests directions for the development of the system based on the new establishment of the legal concept for 'national security'.

• Nuclear Engineering and Technology
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• v.52 no.8
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• pp.1847-1861
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• 2020

A design study was performed to improve the limit aseismic performance (LSP) of a primary heat transport system (PHTS) pump. This pump is part of the primary equipment of a prototype generation IV sodium-cooled fast reactor (PGSFR). The LSP is the maximum allowable seismic load that still ensures structural integrity. To calculate the LSP of the PHTS pump, a structural analysis model of the pump was developed and its dynamic characteristics were obtained by modal analysis. The floor response spectrum (FRS) initiated from a safety shutdown earthquake (SSE), 0.3 g, was applied to the support points of the PHTS pump, and then the seismic induced stresses were calculated. The structural integrity was evaluated according to the ASME code, and the LSP of the PHTS pump was calculated from the evaluation results. Based on the results of the modal analysis and LSP of the PHTS pump, design parameters affecting the LSP were selected. Then, ways to improve the LSP were proposed from sensitivity analysis of the selected design variables.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.24 no.4
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• pp.414-420
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• 2015

In this study, the linear quadratic Guassian loop transfer recovery (LQG/LTR) control technique was combined with an integrator and applied to an inchworm having piezoelectric actuators for precise motion tracking. The piezoelectric actuator showed nonlinear response characteristics, including hysteresis, due to its ferroelectric characteristics and the residual displacement phenomenon. This paper proposes a feedback control scheme using the LQG/LTR controller with an integrator to improve the ability to track the response to complex input signals and to suppress the phenomenon of hysteresis and residual vibration. Experimental results show that the developed feedback control system for an inchworm can track the various motion contours quickly without residual vibration or overshoot.

• Proceedings of the KSPS conference
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• 2006.11a
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• pp.109-112
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• 2006

This paper presents a dialogue interface using the dialogue management system as a method for controlling home appliances in Home Network Services. In order to realize this type of dialogue interface, we first investigated the user requirements for Home Network Services by analyzing the dialogues entered by users. Based on the analysis, we were able to extract 15 user intentions and 22 semantic components. In our study, example dialogues were collected from WOZ (Wizard-of-OZ) environment to implement a reasoning model for generating meaningful responses for example-based dialogue modeling technique. An overview of the Home Network Control System using proposed dialogue interface will be presented. Lastly, we will show that the Dialogue Management System trained with our collected dialogues behaves properly to achieve its task of controlling Home Network appliances by going through the steps of natural language understanding, response reasoning, response generation.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.4
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• pp.463-470
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• 2014

A Verilog model is proposed for transmission lines to perform the all-Verilog simulation of high-speed chip-to-chip interface system, which reduces the simulation time by around 770 times compared to the mixed-mode simulation. The single-pulse response of transmission line in SPICE model is converted into that in Verilog model by converting the full-scale analog signal into an 11-bit digital code after uniform time sampling. The receiver waveform of transmission line is calculated by adding or subtracting the single-pulse response in Verilog model depending on the transmitting digital code values with appropriate time delay. The application of this work to a USB 2.0 high-speed PHY interface reduces the simulation time to less than three minutes with error less than 5% while the mixed-mode simulation takes more than two days for the same circuit.

• Molecular & Cellular Toxicology
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• v.2 no.1
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• pp.48-53
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• 2006

[ ${\alpha}-Naphthylisothiocyanate$ ] (ANIT) induces intrahepatic cholestasis, involving damage to biliary epitheial cells. This study investigates hepatic gene expression and histopathological alterations in response to ANIT treatment in order to elucidate early time response of ANIT-induced hepatotoxicity. ANIT was treated with single dose (3, 6, and 60 mg/kg) in corn oil by oral gavage. Serum biochemical and histopathological observation were performed for evaluation of hepatotoxicity level. Affymetrix oligo DNA chips were used for gene expression profile by ANIT-induced hetpatoxicity. Hepatic enzyme levels (ALT, AST, and ALP) were increased in 24 hr high dose group. In microscopic observations, moderate hepatocellular necrosis, were confirmed 24 hr high dose groups. We found that gene expression patterns were dependent on time and dose. Our selected genes were related inflammation and immunomodulation. In this study, ANIT-induced hepatotoxicity was involved in acute phase responses and provides evidence for role of neutrophil could be mechanism associated with ANIT-mediated hepatotoxicity.

• Earthquakes and Structures
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• v.13 no.6
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• pp.573-588
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• 2017

The earthquake input is required when the soil-structure interaction (SSI) analysis is performed by the direct finite element method. In this paper, the earthquake is considered as the obliquely incident plane body wave arising from the truncated linearly elastic layered half space. An earthquake input method is developed for the time-domain three-dimensional SSI analysis. It consists of a new site response analysis method for free field and the viscous-spring artificial boundary condition for scattered field. The proposed earthquake input method can be implemented in the process of building finite element model of commercial software. It can result in the highly accurate solution by using a relatively small SSI model. The initial condition is considered for the nonlinear SSI analysis. The Daikai subway station is analyzed as an example. The effectiveness of the proposed earthquake input method is verified. The effect of the obliquely incident earthquake is studied.

• Structural Engineering and Mechanics
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• v.71 no.2
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• pp.109-118
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• 2019

This paper presents the numerical simulation of membrane structure under impact load. Firstly, the numerical simulation model is validated by comparing with the test in Hao's research. Then, the effects of the shape of the projectile, the membrane prestress and the initial impact speed, are investigated for studying the dynamic response and failure mechanism, based on the membrane displacement, projectile acceleration and kinetic energy. Finally, the results show that the initial speed and the punch shape are related with the loss of kinetic energy of projectiles. Meanwhile, the membrane prestress is an important factor that affects the energy dissipation capacity and the impact resistance of membrane structures.