• 품질경영학회지
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• 제50권4호
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• pp.665-677
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• 2022

Purpose: The purpose of this study is to analyze the current status and investigate relevant indicators so that R&D performance evaluation suitable for government-funded research institutes can proceed. A suitable performance evaluation model was presented based on the surveyed indicators. Based on the presented performance evaluation model, the importance was analyzed to calculate the weight for each indicator of the performance evaluation model. Methods: The method applied in this study presented a performance evaluation model based on the organizational performance evaluation cases of advanced overseas countries. By using the AHP(Analytic Hierarchy Process) technique, the weight of each indicator of the performance evaluation model was studied. Results: As a result of examining the indicators necessary for the evaluation model, focusing on overseas cases, 13 evaluation items were derived. A weight was calculated for the importance of the study results. And the scientific/technical research results showed the highest excellence. Conclusion: Key indicators of performance evaluation suitable for government-funded research institutes were derived and presented through detailed modeling in three stages. A realistic model that can objectively evaluate the performance of government-funded research institutes was proposed using the AHP technique.

• Genomics & Informatics
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• 제8권1호
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• pp.50-57
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• 2010

Mercuric chloride, a model nephrotoxicant was used to elucidate time- and dose- dependent global gene expression changes associated with proximal tubular toxicity. Rat kidney cell lines NRK-52E cells were exposed for 2, 6 and 12 hours and with 3 different doses of mercuric chloride. Cell viability assay showed that mercuric chloride had toxic effects on NRK-52E cells causing 20% cell death (IC20) at $40{\mu}M$ concentration. We set this IC20 as high dose concentration and 1/5 and 1/25 concentration of LC20 were used as mid and low concentration, respectively. Analyses of microarray data revealed that 738 genes were differentially expressed (more than two-fold change and p<0.05) by low concentration of mercuric chloride at least one time point in NRK-52E cells. 317 and 2,499 genes were differentially expressed at mid and high concentration of mercuric chloride, respectively. These deregulated genes showed a primary involvement with protein trafficking (CAV2, CANX, CORO1B), detoxification (GSTs) and immunity and defense (HMOX1, NQO1). Several of these genes were previously reported to be up-regulated in proximal tubule cells treated with nephrotoxicants and might be aid in promoting the predictive biomarkers for nephrotoxicity.

• Biomolecules & Therapeutics
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• 제21권4호
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• pp.307-312
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• 2013

Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to find out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed significant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.

• 한국추진공학회지
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• 제22권1호
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• pp.89-97
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• 2018

한국형발사체 3단에 사용하기 위한 7톤급 엔진의 개발 시험 결과를 제시하였다. 2기의 engineering model 엔진을 가지고 수행된 연소시험은 시험조건에 따라 지상 시험과 고공 시험으로 구분된다. 엔진의 작동성 검증을 위해 수행된 short duration과 long duration 시험은 성공적으로 완료되었다. 내구성 검증을 위해 수행된 full duration 시험에서는 일부 개선 사항들이 발견되었다. 종합적으로, 엔진 개발에 힘을 더할 수 있는 고무적인 데이터들이 7톤급 엔진 시험으로부터 획득되었다. 이 결과를 바탕으로 새 엔진들이 제작되고, 제작된 엔진은 연소시험을 통해 지속적으로 검증될 예정이다.

• Osong Public Health and Research Perspectives
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• 제9권6호
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• pp.363-363
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• 2018

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.181-181
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• 2002

The herbal combination allergina has been used for the treatment of inflammatory diseases in South Korea. In this study, we investigated the immunosuppressive activities of allergina in more detail. Acute graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in patients undergoing allogeneic bone marrow transplantation.(omitted)

• Journal of Advanced Research in Ocean Engineering
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• 제4권4호
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• pp.174-184
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• 2018

We herein propose a new design procedure of a flexible container ship model where the vertical bending and torsional vibration modes are similar to its prototype. To achieve similarity in torsional vibration mode shapes, the height of the shear center of the model must be located below the bottom hull, similar to an actual container ship with large opening decks. Therefore, we designed a ship model by imparting appropriate stiffness to the hull, using urethane foam without a backbone. We built a container ship model according to this design strategy and validated its dynamic elastic properties using a decay test. We measured wave-induced structural vibrations and present the results of tank experiments in regular and freak waves.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 춘계학술대회 논문집 전력기술부문
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• pp.147-148
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• 2001

The construction of reliability evaluation according to their fields was promoted under the supervision of Agency for Technology and Standards for establishing the relevant institution & infrastructure that can fundamentally solve the reliability problems, the biggest obstruction when the developed electric components & materials come into the market. This paper describes the criterion of reliability evaluation and the evaluation facilities for the purpose of heightening the reliability of composite insulator estimated as the new material among the electric components & materials. We will understand the criterion of reliability evaluation with two parts as the performance evaluation based on various kinds of standards (especially IEC) and as the long-term reliability evaluation utilizing the accelerated aging & flashover test methods. Therefore we aim for constructing the criterion of reliability evaluation as the foundation for evaluation so as to support the industrial group based on KERI facilities.

• Geomechanics and Engineering
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• 제19권3호
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• pp.283-293
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• 2019

Evaluating the stability of the excavation face of the cross-river shield tunnel with good accuracy is considered as a nonlinear and multivariable complex issue. Understanding the stability evaluation method of the shield tunnel excavation face is vital to operate and control the shield machine during shield tunneling. Considering the instability mechanism of the excavation face of the cross-river shield and the characteristics of this engineering, seven evaluation indexes of the stability of the excavation face were selected, i.e., the over-span ratio, buried depth of the tunnel, groundwater condition, soil permeability, internal friction angle, soil cohesion and advancing speed. The weight of each evaluation index was obtained by using the analytic hierarchy process and the entropy weight method. The evaluation model of the cross-river shield construction excavation face stability is established based on the idea point method. The feasibility of the evaluation model was verified by the engineering application in a cross-river shield tunnel project in China. Results obtained via the evaluation model are in good agreement with the actual construction situation. The proposed evaluation method is demonstrated as a promising and innovative method for the stability evaluation and safety construction of the cross-river shield tunnel engineerings.

• 한국도서관정보학회지
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• 제53권4호
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• pp.211-232
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• 2022

연구업적평가는 계량서지학을 중심으로 활용하여 정량적인 기준을 중심으로 이루어져 왔다. 하지만 정량평가만을 활용한 평가에 여러 한계점이 드러나고 연구품질의 우수성 평가에 대한 요구가 커지며 정성적인 평가 요소의 중요성이 커지고 있다. 이에 본 연구는 2010년 이후 전 세계에서 나타난 연구 평가 개선을 위한 사례를 조사하여 소개하고, 연구업적평가에 도입 가능한 정성적인 요소를 추출하기 위해 외국대학의 업적평가 사례를 조사·정리하여 국내 도입을 제안하였다. 전 세계 상위 10개 대학의 업적평가 서류, 평가 절차, 심사기준 등을 분석하여 정성적 평가 요소를 추출하였다. 결과로 본 연구는 업적평가 문서의 다각화, 다면 평가와 다단계 업적평가 과정, 다양한 질적 업적평가 기준에 대해 국내 도입을 제안한다. 전통적인 계량서지학에서 연구 평가 지표 생성 시 인용도를 측정하였다면, 미래 지표에서는 추천 점수를 지표로 반영하거나, 산업 연계성, 교육/산업에서의 활용도 등을 포함할 수 있다. 궁극적으로 본 논문을 통해 업적평가 방식이 균형을 이루고, 교수의 연구업적평가가 개인이 우수한 연구자로 성장하여 연구 환경 발전에 도움이 될 수 있는 과정으로 기능하게 되기를 희망한다.