Browse > Article
http://dx.doi.org/10.4062/biomolther.2013.035

Dependence Potential of Quetiapine: Behavioral Pharmacology in Rodents  

Cha, Hye Jin (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Lee, Hyun-A (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Ahn, Joon-Ik (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Jeon, Seol-Hee (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Kim, Eun Jung (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Jeong, Ho-Sang (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Publication Information
Biomolecules & Therapeutics / v.21, no.4, 2013 , pp. 307-312 More about this Journal
Abstract
Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to find out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed significant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.
Keywords
Quetiapine; Dopamine system; Serotonin system; Drug dependence; Animal behavioral tests;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Acheson, S. K., Richardson, R. and Swarzwelder, H. S. (1999) Developmental changes in seizure susceptibility during ethanol withdrawal. Alcohol 18, 23-26.   DOI   ScienceOn
2 Adityanjee and Schulz, S. C. (2002) Clinical use of quetiapine in disease states other than schizophrenia. J. Clin. Psychiatry 63, 32-38.
3 Arango, C. and Bobes, J. (2004) Managing acute exacerbations of schizophrenia: focus on quetiapine. Curr. Med. Res. Opin. 20, 619-626.   DOI   ScienceOn
4 Bozarth, M. A. (1987) Conditioned place preference: a parametric analysis using system heroin injection. In Methods of assessing the reinforcing properties of abused drugs (M. A. Bozarth, Ed.), pp. 241-273. Springer, New York.
5 Brown, E. S., Nejtek, V. A., Perantie, D. C. and Bobadilla, L. (2002) Quetiapine in bipolar disorder and cocaine dependence. Bipolar Disord. 4, 406-411.   DOI   ScienceOn
6 Chung, C. S., Wang, J., Wehman, M. and Rhoads, D. E. (2008) Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats. Pharmacol. Biochem. Behav. 89, 137-144.   DOI   ScienceOn
7 Cohrs, S., Rodenbeck, A., Guan, Z., Pohlmann, K., Jordan, W., Meier, A. and Ruther, E. (2004) Sleep promoting properties of quetiapine in healthy subjects. Psychopharmacology 174, 421-429.
8 Doremus, T. L., Brunell, S. C., Varlinskaya, E. L. and Spear, L. P. (2003) Anxiogenic effects during withdrawal from acute ethanol in adolescent and adult rats. Pharmacol. Biochem. Behav. 75, 411-418.   DOI   ScienceOn
9 El-Kadi, A. O. and Sharif, S. I. (1994) The infl uence of various experimental conditions on the expression of naloxone-induced withdrawal symptoms in mice. Gen. Pharmacol. 25, 1505-1510.   DOI   ScienceOn
10 Erdogan, S. (2010) Quetiapine in substance use disorders, abuse and dependence possibility: a review. Turk. Psikiyatri Derg. 21, 167-175.
11 Goldstein, J. M. (1999) Quetiapine fumarate (Seroquel): a new atypical antipsychotic. Drugs Today 35, 193-210.   DOI
12 Gorelick, D. A., Gardner, E. L. and Xi, Z. X. (2004) Agents in development for the management of cocaine abuse. Drugs 64, 1547-1573.   DOI   ScienceOn
13 Hussain, M. Z., Waheed, W. and Hussain, S. (2005) Intravenous quetiapine abuse (letter). Am. J. Psychiatry 162, 1755-1756.   DOI   ScienceOn
14 Kapur, S., Zipursky, R., Jones, C., Shammi, C. S., Remington, G. and Seeman, P. (2000) A positron emission tomography study of quetiapine in schizophrenia. Arch. Gen. Psychiatry 57, 553-559.   DOI
15 Kest, B., Palmese, C. A., Hopkins, E., Adler, M. and Juni, A. (2001) Assessment of acute and chronic morphine dependence in male and female mice. Pharmacol. Biochem. Behav. 70, 149-156.   DOI   ScienceOn
16 Koob, G. F. (1999) Drug addiction: the yin and yang of hedonic homeostasis. Neuron 16, 893-896.
17 Koob, G. F. (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol. Sci. 13, 177-184.   DOI   ScienceOn
18 Koob, G. and Kreek, M. J. (2007) Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am. J. Psychiatry 164, 1149-1159.   DOI   ScienceOn
19 Landry, M. J., Smith, D. E., McDuff, D. R. and Baghman, O. L. (1992) Benzodiazepine dependence and withdrawal: identifi cation and medical management. J. Am. Board Fam. Pract. 5, 167-175.
20 Koob, G. F., Maldonado, R. and Stinus, L. (1992) Neural substrates of opiate withdrawal. Trends Neurosci. 15, 186-191.   DOI   ScienceOn
21 Monnelly, E. P., Ciraulo, D. A., Knapp, C., LoCastro, J. and Sepulvedal (2004) Quetiapine for treatment of alcohol dependence. J. Clin. Psychopharmacol. 24, 532-535.   DOI   ScienceOn
22 Morin, A. K. (2007) Possible intranasal quetiapine misuse. Am. J. Health Syst. Pharm. 64, 723-725.   DOI   ScienceOn
23 Morris, S. A., Kelso, M. L., Liput, D. J., Mrshall, K. and Nixon, K. (2010) Similar withdrawal severity in adolescents and adults in a rat model of alcohol dependence. Alcohol 44, 89-98.   DOI   ScienceOn
24 Mucha, R. F., van der Kooy, D., O'Shaughnessy, M. and Bucenieks, P. (1982) Drug reinforcement studied by the use of place conditioning in rat. Brain Res. 243, 91-105.   DOI   ScienceOn
25 Narita, M., Akai, H., Nagumo, Y., Sunagawa, N., Hasebe, K., Nagase, H., Kita, T., Hara, C. and Suzuki, T. (2004) Implications of protein kinase C in the nucleus accumbens in the development of sensitization to methamphetamine in rats. Neuroscience 127, 941-948.   DOI   ScienceOn
26 Pae, C. U., Sohi, M. S., Seo, H. J., Serretti, A., Patker, A. A., Steffens, D. C. and Masand, P. S. (2010) Quetiapine XR: current status for the treatment of major depressive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 1165-1173.   DOI   ScienceOn
27 Pierre, J. M., Shnayder, I., Wirshing, D. A. and Wirshing, W. C. (2004) Intranasal quetiapine abuse (letter). Am. J. Psychiatry 161, 1718.   DOI   ScienceOn
28 Pinkofsky, H. B., Hahn, A. M., Campbell, F. A., Fueda, J., Daley, D. C. and Doualihy, A. B. (2005) Reduction of opioid-withdrawal symptoms with quetiapine. J. Clin. Psychiatry 66, 1285-1288.   DOI
29 Quetiapine fumarate. (2007) Food and Drug Administration: Electronic Orange Book. http://www.accessdata.fda.gov/scripts/cder/ob/default.cfm.
30 Pinta, E. R. (2007) Quetiapine addiction? Am. J. Psychiatry 164, 174-175.   DOI   ScienceOn
31 Ritzmann, R. F. (1981) Opiate dependence following acute injections of morphine and naloxone: the assessment of various withdrawal signs. Pharmacol. Biochem. Behav. 14, 575-577.   DOI   ScienceOn
32 Saelens, J. K., Granat, F. R. and Sawyer, W. K. (1971) The mouse jumping test - a simple screening method to estimate the physical dependence capacity of analgesics. Arch. Int. Pharmacol. Ther. 190, 213-218.
33 Sansone, R. A. and Sansone, L. A. (2010) Is seroquel developing an illicit reputation for misuse/abuse? Psychiatry 7, 13-16.
34 Sattar, S. P., Bhatia, S. C. and Petty, F. (2004) Potential benefi ts of quetiapine in the treatment of substance dependence disorders. J. Psychiatry Neurosci. 29, 452-457.
35 Smits, S. E. (1975) Quantitation of physical dependence in mice by naloxone-precipitated jumping after a single dose of morphine. Res. Commun. Chem. Pathol. Pharmacol. 10, 651-661.
36 Sumegi, A. (2008) Quetiapine in bipolar disorders. Neuropsychopharmacol. Hung. 10, 281-291.
37 Tauscher, J., Hussain, T., Agid, O., Verhoeff, N. P., Wilson, A. A., Houle, S., Remington, G., Zipursky, R. B. and Kapur, S. (2004) Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics. Am. J. Psychiatry 161, 1620-1625.   DOI   ScienceOn
38 Taylor, C. Z. (2002) Religious addiction: obsession with spirituality. Pastoral Psychol. 50, 291-315.   DOI   ScienceOn
39 Way, E. L., Loh, H. H. and Shen, F. H. (1969) Simultaneous quantitative assessment of morphine tolerance and physical dependence. J. Pharmacol. Exp. Ther. 167, 1-8.
40 Varlinskaya, E. I. and Spear, L. P. (2002) Acute effects of ethanol on social behavior of adolescent and adult rats: role of familiarity of the test situation. Alcohol Clin. Exp. Res. 26, 1502-1511.   DOI   ScienceOn
41 Weeks, J. R. (1972) Long term intraveneous infusion. In Methods in psychology (4th ed.) (R. D. Myers, Ed.), pp. 155-168. Academic press, New York.
42 Weisnam, R. L. (2003) Quetiapine in the successful treatment of schizophrenia with comorbid alcohol and drug dependence: a case report. Int. J. Psychiatry Med. 33, 85-89.   DOI   ScienceOn