• Journal of Korean Society for Quality Management
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• v.50 no.4
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• pp.665-677
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• 2022

Purpose: The purpose of this study is to analyze the current status and investigate relevant indicators so that R&D performance evaluation suitable for government-funded research institutes can proceed. A suitable performance evaluation model was presented based on the surveyed indicators. Based on the presented performance evaluation model, the importance was analyzed to calculate the weight for each indicator of the performance evaluation model. Methods: The method applied in this study presented a performance evaluation model based on the organizational performance evaluation cases of advanced overseas countries. By using the AHP(Analytic Hierarchy Process) technique, the weight of each indicator of the performance evaluation model was studied. Results: As a result of examining the indicators necessary for the evaluation model, focusing on overseas cases, 13 evaluation items were derived. A weight was calculated for the importance of the study results. And the scientific/technical research results showed the highest excellence. Conclusion: Key indicators of performance evaluation suitable for government-funded research institutes were derived and presented through detailed modeling in three stages. A realistic model that can objectively evaluate the performance of government-funded research institutes was proposed using the AHP technique.

• Genomics & Informatics
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• v.8 no.1
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• pp.50-57
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• 2010

Mercuric chloride, a model nephrotoxicant was used to elucidate time- and dose- dependent global gene expression changes associated with proximal tubular toxicity. Rat kidney cell lines NRK-52E cells were exposed for 2, 6 and 12 hours and with 3 different doses of mercuric chloride. Cell viability assay showed that mercuric chloride had toxic effects on NRK-52E cells causing 20% cell death (IC20) at $40{\mu}M$ concentration. We set this IC20 as high dose concentration and 1/5 and 1/25 concentration of LC20 were used as mid and low concentration, respectively. Analyses of microarray data revealed that 738 genes were differentially expressed (more than two-fold change and p<0.05) by low concentration of mercuric chloride at least one time point in NRK-52E cells. 317 and 2,499 genes were differentially expressed at mid and high concentration of mercuric chloride, respectively. These deregulated genes showed a primary involvement with protein trafficking (CAV2, CANX, CORO1B), detoxification (GSTs) and immunity and defense (HMOX1, NQO1). Several of these genes were previously reported to be up-regulated in proximal tubule cells treated with nephrotoxicants and might be aid in promoting the predictive biomarkers for nephrotoxicity.

• Biomolecules & Therapeutics
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• v.21 no.4
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• pp.307-312
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• 2013

Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to find out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed significant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.

• Journal of the Korean Society of Propulsion Engineers
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• v.22 no.1
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• pp.89-97
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• 2018

The test results of a 7-tonf-class engine for the third-stage engine of KSLV-II are presented. Hot-firing tests performed with two engineering model engines are classified into ground tests and high-altitude tests according to the test conditions. The operability verification of the engines were carried out through short and long duration tests. The full duration test performed for the durability verification of the engines revealed a few of items to be improved. Synthetically, encouraging data of adding power to engine development were obtained from the test results. New engines based on these results will be manufactured and consistently verified through hot-firing tests.

• Osong Public Health and Research Perspectives
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• v.9 no.6
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• pp.363-363
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• 2018

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.181-181
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• 2002

The herbal combination allergina has been used for the treatment of inflammatory diseases in South Korea. In this study, we investigated the immunosuppressive activities of allergina in more detail. Acute graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in patients undergoing allogeneic bone marrow transplantation.(omitted)

• Journal of Advanced Research in Ocean Engineering
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• v.4 no.4
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• pp.174-184
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• 2018

We herein propose a new design procedure of a flexible container ship model where the vertical bending and torsional vibration modes are similar to its prototype. To achieve similarity in torsional vibration mode shapes, the height of the shear center of the model must be located below the bottom hull, similar to an actual container ship with large opening decks. Therefore, we designed a ship model by imparting appropriate stiffness to the hull, using urethane foam without a backbone. We built a container ship model according to this design strategy and validated its dynamic elastic properties using a decay test. We measured wave-induced structural vibrations and present the results of tank experiments in regular and freak waves.

• Proceedings of the KIEE Conference
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• 2001.05a
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• pp.147-148
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• 2001

The construction of reliability evaluation according to their fields was promoted under the supervision of Agency for Technology and Standards for establishing the relevant institution & infrastructure that can fundamentally solve the reliability problems, the biggest obstruction when the developed electric components & materials come into the market. This paper describes the criterion of reliability evaluation and the evaluation facilities for the purpose of heightening the reliability of composite insulator estimated as the new material among the electric components & materials. We will understand the criterion of reliability evaluation with two parts as the performance evaluation based on various kinds of standards (especially IEC) and as the long-term reliability evaluation utilizing the accelerated aging & flashover test methods. Therefore we aim for constructing the criterion of reliability evaluation as the foundation for evaluation so as to support the industrial group based on KERI facilities.

• Geomechanics and Engineering
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• v.19 no.3
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• pp.283-293
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• 2019

Evaluating the stability of the excavation face of the cross-river shield tunnel with good accuracy is considered as a nonlinear and multivariable complex issue. Understanding the stability evaluation method of the shield tunnel excavation face is vital to operate and control the shield machine during shield tunneling. Considering the instability mechanism of the excavation face of the cross-river shield and the characteristics of this engineering, seven evaluation indexes of the stability of the excavation face were selected, i.e., the over-span ratio, buried depth of the tunnel, groundwater condition, soil permeability, internal friction angle, soil cohesion and advancing speed. The weight of each evaluation index was obtained by using the analytic hierarchy process and the entropy weight method. The evaluation model of the cross-river shield construction excavation face stability is established based on the idea point method. The feasibility of the evaluation model was verified by the engineering application in a cross-river shield tunnel project in China. Results obtained via the evaluation model are in good agreement with the actual construction situation. The proposed evaluation method is demonstrated as a promising and innovative method for the stability evaluation and safety construction of the cross-river shield tunnel engineerings.

• Journal of Korean Library and Information Science Society
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• v.53 no.4
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• pp.211-232
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• 2022

Research performance evaluation has been based heavily on quantitative criteria. Various limitations however were revealed and the demand for excellence in research quality was growing and the importance of qualitative evaluation factors was increasing as well. The study investigates and introduces cases for improving research evaluation that have appeared around the world since 2010. To extract qualitative factors that can be introduced in research achievement evaluation in Korea this study investigated and organized the performance evaluation cases of foreign universities and proposed the introduction of the evaluation method in Korea. Qualitative evaluation factors were extracted by analyzing achievement evaluation documents evaluation procedures and evaluation standards of top 10 universities around the world. As a results this study proposes the use of various performance evaluation documents mulch-faceted evaluation and multi-level performance evaluation process and various qualitative performance evaluation standards. In traditional bibliometrics, while the degree of citation was measured when generating research evaluation indicators, future indicators may reflect recommendation scores as indicators, or include industrial connectivity and utilization in education / industry. It is hoped that the performance evaluation method will be balanced through this paper and ultimately the professor's research achievement evaluation will be a process that can help individuals grow into excellent researchers and develop the research environment.