• Journal of Environmental Impact Assessment
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• v.31 no.5
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• pp.321-333
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• 2022

In this study, the concentration and distribution characteristics of BTEX (benzene toluene, ethylbenzene, and xylene) emitted from Daesan Petrochemical Industrial Complex were examined to determine their potential hazards to local residents. Residents living nearby the complex areas may be exposed to the chemicals through various media (air, water, and soil), especially by air. This study evaluated human health risks by inhalation using both deterministic and probabilistic risk assessment approaches. As a result of the deterministic risk assessment, the non-cancer risk was much lower than the regulation limit of hazard index (HI 1.0) for all the points. However, in case of cancer risk evaluation, it was found that the risk of excess cancer for benzene at point A located in the industrial complex was 2.28×10^-6, which slightly exceeded the standard regulatory limit of 1.0×10^-6. In addition, the probabilistic risk assessment revealed that the percentile exceeding the standard of 1.0×10^-6was found to be 45.3%. The sensitivity analysis showed that exposure time (ET) had the greatest impact on the results. Based on the risk assessment study, it implied that ethylbenzene, toluene, and xylene had little adverse effects on potential human exposure, but benzene often exceeded the cancer risk standard (1.0×10^-6). Further studies on extensive VOCs monitoring are needed to evaluate the potential risks of industrial complex areas.

• Korea Trade Review
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• v.41 no.3
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• pp.1-25
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• 2016

This study reviews international discussions about the trade-labor linkage and examines the labor chapters of FTAs enforced by the US and the EU from a comparative perspective. Since early 1990s, starting from the NAFTA, the US has included forceable labor provisions in its FTAs and this trend continues to the TPP which was concluded in October 2015. On the other hand, the EU's labor provisions in its FTAs have been composed of promotional elements on labor rights based on cooperations and dialogues. These different features of labor provisions in the US and European FTAs are mainly due to the motives of the FTAs of the US and the EU respectively as well as their domestic situations with regards to domestic law and institutional set-ups. The coordination of labor provisions involves a long-term institutional as well as regulatory convergence which triggers not only economic but also social changes, compared to a relatively short-term effect of tariff elimination. For Korea which has been a FTA partner country both with the US and the EU, it is significant to keep the different characteristics in the labor provisions in mind, particularly in the process of its implementation. Concerning the implementation of Korea-US FTA, it might be problematic if Korean law and its regulatory practice on labor-management relations do not comply with that of the US. The Korea-EU FTA case can also have an indirect impact on Korea's labor laws since it stipulates in its provisions that both parties should have discussions not only within each government but also with the civil communities including NGOs. Thus, Korea should pay more attention to the true meaning in labor provisions of both FTAs in order to promote its firms to be equipped with the right labor-management system in their operations abroad.

• Knowledge Management Research
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• v.21 no.3
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• pp.197-213
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• 2020

This study analyzed the impact of information security service company certification on financial performance. The purpose of this study was to analyze the effect of the "Information Security Service Certification Company" system from a financial point of view for information security service certified & non-certified companies, and listed & unlisted companies. From a financial point of view, performance analysis was conducted using two-way ANOVA on sales, operating profit, and profit rate. This study verified whether there is a difference in management performance between an information security service certified company and an uncertified company. In the financial performance indicators of sales, operating profit, and profit rate, the information security service certification system showed an impact on financial performance because the information security service certification company showed better management performance than the uncertified company. The implications of this study are that the empirical performance analysis from the financial point of view of the information security service certified company system can be used as a basis for negative regulatory policies to revitalize the information security industry in the future, contributing to the growth of information security companies with excellent growth potential.

• Journal of the Korea Institute of Building Construction
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• v.22 no.1
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• pp.81-90
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• 2022

With apartment purchase prices rising, small and medium-sized cities have been highlighted as areas in which real estate speculation is overheated, and thus designated as target districts for adjustment. In addition, tax policy is constantly being adjusted in an attempt to stabilize real estate prices. The purpose of this study is to analyze the basic effect of tax policy on the purchase price of apartments in small and medium-sized cities. This study selected apartments in the Daejeon area that were constructed between 1990 and 2015. In addition, tax policy was divided into regulatory policy and easing policy based on tax increase and tax cut. This study analyzes the short-term difference of one year before and after the change in the purchase price of apartment houses. In addition, this study set the time when real estate policy was implemented and the actual transaction price of apartments in Daejeon as the analysis targets, and analyzed the correlation between tax policy and apartment sales prices through the NPV technique and T-test results. Through the study, it was found that most tax policies changed apartment purchase prices in the short term.

• Molecular & Cellular Toxicology
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• v.4 no.3
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• pp.260-266
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• 2008

Recently, there has been scientific discussion on the utility of -omics techniques such as genomics, proteomics, and metabolomics within toxicological research and mechanism-based risk assessment. Toxicogenomics is a novel approach integrating the expression analysis of genes (genomic) or proteins (proteomic) with traditional toxicological methods. Since 1999, the toxicogenomic approach has been extensively applied for regulatory purposes in order to understand the potential toxic mechanisms that result from chemical compound exposures. Therefore, this article's purpose was to consider the utility of toxicogenomic profiles for improved risk assessment, explore the current limitations in applying toxicogenomics to regulation, and finally, to rationalize possible avenues to resolve some of the major challenges. Based on many recent works, the significant impact toxicogenomic techniques would have on human health risk assessment is better identification of toxicity pathways or mode-of-actions (MOAs). In addition, the application of toxicogenomics in risk assessment and regulation has proven to be cost effective in terms of screening unknown toxicants prior to more extensive and costly experimental evaluation. However, to maximize the utility of these techniques in regulation, researchers and regulators must resolve many parallel challenges with regard to data collection, integration, and interpretation. Furthermore, standard guidance has to be prepared for researchers and assessors on the scientifically appropriate use of toxicogenomic profiles in risk assessment. The National Institute of Toxicological Research (NITR) looks forward to an ongoing role as leader in addressing the challenges associated with the scientifically sound use of toxicogenomics data in risk assessment.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4101-4106
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• 2013

Alterations of cyclin D1, one of the main regulators of the cell cycle, are known to be involved in various cancers. The CCDN1 G870A polymorphism causes production of a truncated variant with a shorter half-life and thus thought to impact the regulatory effect of CCDN1. The aim of the present study was to contribute to existing results to help to determine the prognostic value of this specific gene variant and evaluate the role of CCDN1 G870A polymorphism in brain cancer susceptibility. A Turkish study group including 99 patients with primary brain tumors and 155 healthy controls were examined. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. The CCDN1 genotype frequencies in meningioma, glioma and control cases were not significantly different (p>0.05). No significant association was detected according to clinical parameters or tumor characteristics; however, a higher frequency of AG genotype was recorded within patients with astrocytic or oligoastrocytic tumors. A significant association between AG genotype and gliobilastoma multiforme (GBM) was recorded within the patients with glial tumors (p value=0.048 OR: 1.87 CI% 1.010-3.463). According to tumor characteristics, no statistically significant difference was detected within astrocytic, oligoasltrocytic tumors and oligodentrioglias. However, patients with astrocytic astrocytic or oligoastrocytic tumors showed a higher frequency of AG genotype (50%) when compared to those with oligodendrioglial tumors (27.3%). Our results indicate a possible relation between GBM formation and CCDN1 genotype.

• Journal of Internet Computing and Services
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• v.13 no.6
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• pp.25-32
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• 2012

There is a growing controversy on whether and how to regulate real-time broadcasting services carried on smartphone. Some advocates strict regulation on them but the others minimal regulation. This study aims to suggest guiding rules for how to regulate broadcasting services in smartphone. For this, the study interviewed fourteen (14) executives of broadcasting companies, content providers, policy research center and regulatory body. The analysis indicates that linear channel service in smartphone is similar in form to traditional broadcasting but they should not be regulated at this moment. The supporting reasons are 1) regulating them is technically not effective, 2) they were already regulated in their primary service platforms, 3) they don't have a significant impact on a society. Consequently, the study suggests that the service providers are categorized as value added common carriers as defined in the Telecommunication Business Act.

• Journal of Family Resource Management and Policy Review
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• v.23 no.3
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• pp.89-107
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• 2019

This study aimed to examine the impact of academic background on full-time employment and on other important issues concerning job security and care faced by single-parent youths. The study alse aimed to verify the effect of related support on full-time employment. The analysis targeted 262 single parents under 24 years of age who were raising their children, and the main results were as follows: First, the ratio of adulthood was high for those who were employed, and the academic achievement of full-time workers was also significantly high. However, the rate of discontinuities in school was also high among those who were employed, especially those seeking full-time employment, whose desire to stay in school was higher than that of other difficulties of single, teenage parents. Second, the vocational education experience of single, teenage parents was 32 percent overall, and the rate of those seeking full-time employment was also relatively high, reaching 44 percent. However, the results of this study did not verify the direct effect of vocational education experience on full-time employment nor the interaction effect of the academic background. Therefore, a thorough review of the effectiveness of a vocational education program for young, single parents wishing to gain employment is necessary. Third, the overall rate of those who received a public nanny service was 31 percent, while the rate of full-time workers who experienced this service was significantly higher reaching 59 percent. In the research model verification, single parents who received a public nanny service were 3.8 times more likely to get a full-time job than those who did not, and receiving a public nanny service showed a regulatory effect between academic studies and full-time employment. The higher the academic level of the parents, the higher their possibility of full-time employment.

• Journal of Environmental Policy
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• v.8 no.3
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• pp.81-113
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• 2009

This study conducted a regulatory impact analysis regarding the introduction of the Korean version of REACH(Registration, Evaluation and Authorization of Chemicals). The direct cost of the Korean REACH is estimated at a total of 101 billion Korean won over the 11 year period. The cost includes pre-registration, testing, registration, Chemical Safety Assessment(CSA) and Chemical Safety Report(CSR), evaluation, and the authorization costs of 15,223 chemical substances produced and imported more than 1 ton per year in Korea in 2006. With regard to the benefit, the only public health benefit is included in the estimation. Based on the available foreign and domestic data, this study estimated that the economic values of public health benefits are in the range of 33.2~138.6 billion Korean won if only the savings of the National Health Expenditures are considered and it reaches 203.9~1,640.3 billion Korean won if the willingness to pay(WTP) for disease prevention is included. This study proved that the Korean REACH passed the cost/benefit criteria. The benefit-cost ratio of the Korean REACH, however, is estimated to be lower than its EU counterpart. Thus it is suggested that a rigorous study to reduce the costs to industry be required before the Korean government introduces the Korean REACH.

• IMMUNE NETWORK
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• v.14 no.3
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• pp.138-148
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• 2014

MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.