• 한국산학기술학회논문지
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• 제16권10호
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• pp.7006-7012
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• 2015

본 연구는 도시재생에 실질적인 역할을 수행하는 마을활동가가 되기 위한 교육생들을 대상으로 도시재생 전략요인들을 구체적으로 파악하고자 하는데 목적이 있다. 그들이 인식하는 도시재생의 인식수준, 필요정도, 영향관계를 파악하기 위하여 직접설문을 실시하였다. 그 결과 도시재생 전략요인으로는 사회재생, 경제재생, 문화재생, 환경재생 4가지 요인으로 나누어졌으며, 이 요인들은 도시재생에 대한 인식수준, 필요정도, 자발적 참여 및 전반적 만족도와 참여의지에 대해 유의한 영향을 미치는 것으로 나타났다. 특히 행정적지원이 포함된 환경재생 요인이 모든 변수에 영향을 미치는 것으로 나타남에 따라 도시재생에 있어 행정을 포함한 환경적 지원의 중요성에 대하여 확인할 수 있었다. 이외에 지역공동체 중심의 사회재생 요인과 지역자원 활용 중심의 문화재생 요인들도 유의한 영향을 미치는 것으로 확인됨에 따라 향후 도시재생을 실천하기 위한 구체적 전략수립 검토 및 방향성 제시에 기초자료가 될 것으로 기대된다.

• KIEAE Journal
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• 제10권5호
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• pp.13-22
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• 2010

The old city centers of local metropolitans have lost their functions as CBD in korea. Those old city centers have an only role as a gate connected to the new CBD. This study aims to present regeneration stratigies of old city centers through Osaka case study. This research has been focused on the physical and environmental factors in urban regeneration. There are 4 strategies for old city centers. First, the strategy to attract people to the old city centers is high-density and mixed-use development having functions like shopping, entertainment, residence. This kind of development makes local metropolitan cities compact cities to protect urban sprawl. Second, strategy to give old city centers an identity is to conserve traditional culture and structures and to revitalize retail market. Third is to make pedestrian-friendly street system. Osaka ism't pedestrian friendly but remodelling the connect the pedestrian path to the culture facilities. Fourth is to have water and green environment. Green space is the strong factor that pull people to old city centers.

• 한국IT서비스학회지
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• 제19권1호
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• pp.1-16
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• 2020

Suncheon City Regeneration Project is known as the concept of cultural residents. Through the previous projects, the residents' capabilities have been improved, and the projects have been carried out according to their strategies. For this reason, participants in urban regeneration projects are important. The purpose of this study is to actually identify the 'rescue center' and 'direct relationship' with the analysis utilizing the characteristics of social networks NetMiner solution of the participants, who led the project, Suncheon. Surveys and interviews were conducted for participants, and the characteristics of social networks were analyzed in time series to quantify and visualize the results. As a result of the analysis, social networks were changed among the participants before and after the urban regeneration project. Initially, loose networks were denser over time, and initially networks formed only around participants were expanded over time. Network analysis has revealed that the system is strengthening with urban regeneration projects in the form of public and public-private cooperation. This highlights the need for a city-centered urban regeneration strategy centered on people and shows that a dense network of participants can be a success factor.

• 한국실내디자인학회논문집
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• 제25권5호
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• pp.16-30
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• 2016

There is an increasing interest in and efforts for safe residential environment from crimes nationwide. Many cities are making efforts to create safe residential environment by enacting ordinances and guidances on safe design for preventing crimes and implementing demonstration projects. In line with the trends of the times toward 'improvement of living conditions' through urban regeneration, the importance of the Crime Prevention Through Environmental Design(CPTED) has recently emerged in the field of residential housing regeneration. Indeed, the CPTED is included as essential factor in the recent deteriorated residential area regeneration related projects. In this respect, the purpose of this study is to provide the basic data on the methodology of CPTED to be applied to the regeneration of deteriorated residential area in the future. To this end, this study selected three representative CPTED projects in Busan - 'Deokpo-dong Hope and Stepping Stone Village,' 'Chilsan-dong CPTED Happiness Village' and 'Sujeong-dong Crime Prevention and Safe Village' as objects of this study and then investigated and analyzed project contents, application of CPTED strategy, subjects who are implementing projects, and the time when they implement projects as the framework of my analysis. The findings from this study are as follows: First, the projects that were largely based on hardware should be improved by including software in the future. Second, the current Step 2 should expand into Step 3 Maintenance in applying CPTED strategy. Third, it is necessary to encourage exchange and cooperation between unit projects and subjects who are operating related projects.

• Archives of Plastic Surgery
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• 제48권5호
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• pp.559-567
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• 2021

The potential to differentiate into different cell lines, added to the easy and cost-effective method of extraction, makes adipose-derived stem cells (ADSCs) an object of interest in lymphedema treatment. Our study's goal was to conduct a comprehensive systematic review of the use of ADSCs in lymphatic tissue engineering and regeneration. On July 23, 2019, using PubMed/MEDLINE, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, and Embase databases, we conducted a systematic review of published literature on the use of ADSCs in lymphatic tissue engineering and regeneration. There were no language or time frame limitations, and the following search strategy was applied: ((Adipose stem cell) OR Adipose-derived stem cell)) AND ((Lymphedema) OR Breast Cancer Lymphedema). Only original research manuscripts were included. Fourteen studies fulfilled the inclusion criteria. Eleven studies were experimental (in vitro or in vivo in animals), and only three were clinical. Publications on the topic demonstrated that ADSCs promote lymphangiogenesis, and its effect could be enhanced by modulation of vascular endothelial growth factor-C, interleukin-7, prospero homeobox protein 1, and transforming growth factor-β1. Pilot clinical studies included 11 patients with breast cancer-related lymphedema, and no significant side effects were present at 12-month follow-up. Literature on the use of ADSCs in lymphatic tissue engineering and regeneration demonstrated promising data. Clinical evidence is still in its infancy, but the scientific community agrees that ADSCs can be useful in regenerative lymphangiogenesis. Data collected in this review indicate that unprecedented advances in lymphedema treatment can be anticipated in the upcoming years.

• 대한치과의사협회지
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• 제48권2호
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• pp.113-118
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• 2010

Titanium and titanium alloys are the most common materials used for dental and biomedical implants, owing to their biocompatibility and favourable mechanical properties. However infection of the region surrounding a dental implant by pathogenic microorganisms is a significant factor in implant failure. Prevention and control of microbial colonization of implant surfaces is considerable interest to the biomedical community. One important strategy is to render the implant surface antibacterial by impeding the formation of biofilm. A number of approaches have been proposed for this purpose. Therefore, we reviewed the researches of antibacterial coatings on titanium implants in this articles.

• 디지털융복합연구
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• 제14권7호
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• pp.397-402
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• 2016

본 연구는 그라피티(Graffiti)를 동두천 구시가지에 적용하여 도시를 재생시키고, 더 나아가 그것을 도시의 정체성으로 연결시키는 도시 문화콘텐츠 융합 디자인 방안에 대해 논의하였다. 연구를 위해 세 가지 방법을 이용하였다. 먼저 동두천의 정체성 배경과 문화자산을 조사해보고 정체성이 잘 드러나는 장소를 분석하였으며 그리고 관내 대학을 다니는 대학생들을 대상으로 인터뷰를 실시하였다. 조사 결과, 도시 정체성 강화 방안으로서 그라피티 활용에 대한 긍정적 반응을 얻었다. 동두천에 미군이 주둔하면서 만들어진 이국적 이미지는 도시의 정체성을 결정짓는 중요한 요인으로 평가된다. 락 페스티벌은 미군 주둔에 따른 문화적 영향으로 자리를 잡게 된 동두천의 대표적인 문화자산으로서 도시 정체성을 결정짓는 요소 중 하나이다. 이러한 문화자산과 자연스럽게 어울리고 도시 정체성을 더욱 강화할 수 있는 요소로서 그라피티라는 시각문화가 제시되었다. 연구 결과에서는 동두천시의 정체성 변화와 도시재생 효과, 그리고 무공해 문화 창조의 도시 이미지 부각 효과를 기대하면서 그라피티를 활용하는 방안에 대해 제안하였다.

• 한국조경학회지
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• 제46권4호
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• pp.1-10
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• 2018

본 연구는 유휴산업시설 재생공간 방문자들의 장소성이 방문만족도와 체류시간에 미치는 영향을 밝히는 것을 연구목적으로 한다. 이를 위하여 본 연구는 서울시 영등포구에 위치한 문래예술창작촌을 연구대상지로 선정하였으며, 방문자를 대상으로 설문조사를 진행하였다. 탐색적 요인분석 및 신뢰도분석, 다중회귀분석결과, 문래예술창작촌의 장소성 요인인 매력성, 의미성은 방문만족도와 체류시간에 정(+)의 영향을 미치는 것으로 나타났으며, 매력성이 가장 큰 영향을 미치는 것으로 나타났다. 그러나 역사성은 방문만족도와 체류시간에 유의미한 영향을 미치지 못 하는 것으로 나타났다. 또한, 방문만족도는 체류시간에 정(+)의 영향을 미치는 것으로 분석되었다. 이상의 연구결과는 유휴산업시설 재생공간의 장소성을 진단하고, 추후 도시공간 계획가 및 관리자가 유휴산업시설 재생공간을 활성화시킬 수 있는 장소마케팅 전략을 수립하는 데에 유용한 지침이 될 수 있을 것이다.

• The Korean Journal of Physiology and Pharmacology
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• 제15권2호
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• pp.83-88
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• 2011

A large body of evidence has indicated that induction of endogenous antioxidative proteins seems to be a reasonable strategy for delaying the progression of cell injury. In our previous study, cilostazol was found to increase the expression of the antioxidant enzyme heme oxygenase-1 (HO-1) in synovial cells. Thus, the present study was undertaken to examine whether cilostazol is able to counteract tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$)-induced cell death in endothelial cells via the induction of HO-1 expression. We exposed human umbilical vein endothelial cells (HUVECs) to TNF-${\alpha}$ (50 ng/ml), with or without cilostazol ($10{\mu}M$). Pretreatment with cilostazol markedly reduced TNF-${\alpha}$-induced viability loss in the HUVECs, which was reversed by zinc protoporphyrine IX (ZnPP), an inhibitor of HO-1. Moreover, cilostazol increased HO-1 protein and mRNA expression. Cilostazol-induced HO-1 induction was markedly attenuated not only by ZnPP but also by copper-protoporphyrin IX (CuPP). In an assay measuring peroxisome proliferator-activated receptor-${\gamma}$ (PPAR-${\gamma}$) transcription activity, cilostazol directly increased PPAR-${\gamma}$ transcriptional activity which was completely abolished by HO-1 inhibitor. Furthermore, increased PPAR-${\gamma}$ activity by cilostazol and rosiglitazone was completely abolished in cells transfected with HO-1 siRNA. Taken together, these results indicate that cilostazol up-regulates HO-1 and protects cells against TNF-${\alpha}$-induced endothelial cytotoxicity via a PPAR-${\gamma}$-dependent pathway.

• BMB Reports
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• 제52권4호
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• pp.239-249
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• 2019

Membrane-anchored full-length MET stimulated by its ligand HGF/SF induces various biological responses, including survival, growth, and invasion. This panel of responses, referred to invasive growth, is required for embryogenesis and tissue regeneration in adults. On the contrary, MET deregulation is associated with tumorigenesis in many kinds of cancer. In addition to its well-documented ligand-stimulated downstream signaling, the receptor can be cleaved by proteases such as secretases, caspases, and calpains. These cleavages are involved either in MET receptor inactivation or, more interestingly, in generating active fragments that can modify cell fate. For instance, MET fragments can promote cell death or invasion. Given a large number of proteases capable of cleaving MET, this receptor appears as a prototype of proteolytic-cleavage-regulated receptor tyrosine kinase. In this review, we describe and discuss the mechanisms and consequences, both physiological and pathological, of MET proteolytic cleavages.