• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.10
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• pp.7006-7012
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• 2015

Urban regeneration can be an effective tool to promote sustainability and enhance quality of village. Urban regeneration can be considered to be the process of reversing economic, social and physical decay having reached the point where market forces alone will not suffice. For this study, 154 village activist trainees are surveyed. Using the survey results, factor analysis, multi-regression analysis is conducted to identify the factor's significance and to find improvement properties by composing the significance and the satisfaction level. The purpose of this study is to suggest strategy of urban regeneration through the effect of urban regeneration factor on recognition and satisfaction. The findings show that environmental regeneration factor is more influential than economic, social and cultural factors on recognition and satisfaction. This study provide a convenient set of indicators for strategic focus to help urban regeneration policy.

• KIEAE Journal
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• v.10 no.5
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• pp.13-22
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• 2010

The old city centers of local metropolitans have lost their functions as CBD in korea. Those old city centers have an only role as a gate connected to the new CBD. This study aims to present regeneration stratigies of old city centers through Osaka case study. This research has been focused on the physical and environmental factors in urban regeneration. There are 4 strategies for old city centers. First, the strategy to attract people to the old city centers is high-density and mixed-use development having functions like shopping, entertainment, residence. This kind of development makes local metropolitan cities compact cities to protect urban sprawl. Second, strategy to give old city centers an identity is to conserve traditional culture and structures and to revitalize retail market. Third is to make pedestrian-friendly street system. Osaka ism't pedestrian friendly but remodelling the connect the pedestrian path to the culture facilities. Fourth is to have water and green environment. Green space is the strong factor that pull people to old city centers.

• Journal of Information Technology Services
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• v.19 no.1
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• pp.1-16
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• 2020

Suncheon City Regeneration Project is known as the concept of cultural residents. Through the previous projects, the residents' capabilities have been improved, and the projects have been carried out according to their strategies. For this reason, participants in urban regeneration projects are important. The purpose of this study is to actually identify the 'rescue center' and 'direct relationship' with the analysis utilizing the characteristics of social networks NetMiner solution of the participants, who led the project, Suncheon. Surveys and interviews were conducted for participants, and the characteristics of social networks were analyzed in time series to quantify and visualize the results. As a result of the analysis, social networks were changed among the participants before and after the urban regeneration project. Initially, loose networks were denser over time, and initially networks formed only around participants were expanded over time. Network analysis has revealed that the system is strengthening with urban regeneration projects in the form of public and public-private cooperation. This highlights the need for a city-centered urban regeneration strategy centered on people and shows that a dense network of participants can be a success factor.

• Korean Institute of Interior Design Journal
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• v.25 no.5
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• pp.16-30
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• 2016

There is an increasing interest in and efforts for safe residential environment from crimes nationwide. Many cities are making efforts to create safe residential environment by enacting ordinances and guidances on safe design for preventing crimes and implementing demonstration projects. In line with the trends of the times toward 'improvement of living conditions' through urban regeneration, the importance of the Crime Prevention Through Environmental Design(CPTED) has recently emerged in the field of residential housing regeneration. Indeed, the CPTED is included as essential factor in the recent deteriorated residential area regeneration related projects. In this respect, the purpose of this study is to provide the basic data on the methodology of CPTED to be applied to the regeneration of deteriorated residential area in the future. To this end, this study selected three representative CPTED projects in Busan - 'Deokpo-dong Hope and Stepping Stone Village,' 'Chilsan-dong CPTED Happiness Village' and 'Sujeong-dong Crime Prevention and Safe Village' as objects of this study and then investigated and analyzed project contents, application of CPTED strategy, subjects who are implementing projects, and the time when they implement projects as the framework of my analysis. The findings from this study are as follows: First, the projects that were largely based on hardware should be improved by including software in the future. Second, the current Step 2 should expand into Step 3 Maintenance in applying CPTED strategy. Third, it is necessary to encourage exchange and cooperation between unit projects and subjects who are operating related projects.

• Archives of Plastic Surgery
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• v.48 no.5
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• pp.559-567
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• 2021

The potential to differentiate into different cell lines, added to the easy and cost-effective method of extraction, makes adipose-derived stem cells (ADSCs) an object of interest in lymphedema treatment. Our study's goal was to conduct a comprehensive systematic review of the use of ADSCs in lymphatic tissue engineering and regeneration. On July 23, 2019, using PubMed/MEDLINE, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, and Embase databases, we conducted a systematic review of published literature on the use of ADSCs in lymphatic tissue engineering and regeneration. There were no language or time frame limitations, and the following search strategy was applied: ((Adipose stem cell) OR Adipose-derived stem cell)) AND ((Lymphedema) OR Breast Cancer Lymphedema). Only original research manuscripts were included. Fourteen studies fulfilled the inclusion criteria. Eleven studies were experimental (in vitro or in vivo in animals), and only three were clinical. Publications on the topic demonstrated that ADSCs promote lymphangiogenesis, and its effect could be enhanced by modulation of vascular endothelial growth factor-C, interleukin-7, prospero homeobox protein 1, and transforming growth factor-β1. Pilot clinical studies included 11 patients with breast cancer-related lymphedema, and no significant side effects were present at 12-month follow-up. Literature on the use of ADSCs in lymphatic tissue engineering and regeneration demonstrated promising data. Clinical evidence is still in its infancy, but the scientific community agrees that ADSCs can be useful in regenerative lymphangiogenesis. Data collected in this review indicate that unprecedented advances in lymphedema treatment can be anticipated in the upcoming years.

• The Journal of the Korean dental association
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• v.48 no.2
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• pp.113-118
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• 2010

Titanium and titanium alloys are the most common materials used for dental and biomedical implants, owing to their biocompatibility and favourable mechanical properties. However infection of the region surrounding a dental implant by pathogenic microorganisms is a significant factor in implant failure. Prevention and control of microbial colonization of implant surfaces is considerable interest to the biomedical community. One important strategy is to render the implant surface antibacterial by impeding the formation of biofilm. A number of approaches have been proposed for this purpose. Therefore, we reviewed the researches of antibacterial coatings on titanium implants in this articles.

• Journal of Digital Convergence
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• v.14 no.7
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• pp.397-402
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• 2016

This study discusses on the city-culture contents convergence design strategy which can be linked to the identity of the city through applying the graffiti on old-town of Dongducheon. First, the background and cultural asset of Dongducheon were researched. Second, the places revealing the identities were investigated. Third, the interviews with the college students in the city were performed. As the result, we found that using graffiti gains positive reaction as the reinforcement factor for the city identification. The exotic image made up by US military presence is evaluated as an important factor for the city identification. The Rock Festival is a representative cultural event derived by the cultural influence from the US military and is one of the crucial elements for the city identification. In this study, graffiti was proposed as the visual expression which can be harmonized with this culture and be reinforced for the city identity. Results of the study concludes with the strategy for the application of graffiti with the expectation for the improvement of city image of Dongducheon through the change of identity, urban regeneration, and making of pollution-free culture.

• Journal of the Korean Institute of Landscape Architecture
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• v.46 no.4
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• pp.1-10
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• 2018

The purpose of this study is to analyze the influence of visitors' sense of place on regeneration space using idle industrial facilities on visitors' satisfaction and length of stay. For this purpose, this study selected Mullae Art Village in Seoul as a study site and conducted a questionnaire survey focused on visitors. The results of an exploratory factor analysis (EFA), reliability analysis and multiple regression analysis show that among the sense of place factors of Mullae Art Village 'Attractiveness' and 'Meaningfulness' have a positive influence on visitor satisfaction and length of stay. 'Attractiveness' was found to be the most influential factor. 'Historicity' was found to have no effects on visitor satisfaction and length of stay. In addition, visitor satisfaction has a positive influence on duration of stay. These results suggest that it is important to analyze the sense of place of idle industrial facilities. It will be a useful guide for urban space planners in revitalizing and establishing a marketing strategy for these spaces.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.2
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• pp.83-88
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• 2011

A large body of evidence has indicated that induction of endogenous antioxidative proteins seems to be a reasonable strategy for delaying the progression of cell injury. In our previous study, cilostazol was found to increase the expression of the antioxidant enzyme heme oxygenase-1 (HO-1) in synovial cells. Thus, the present study was undertaken to examine whether cilostazol is able to counteract tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$)-induced cell death in endothelial cells via the induction of HO-1 expression. We exposed human umbilical vein endothelial cells (HUVECs) to TNF-${\alpha}$ (50 ng/ml), with or without cilostazol ($10{\mu}M$). Pretreatment with cilostazol markedly reduced TNF-${\alpha}$-induced viability loss in the HUVECs, which was reversed by zinc protoporphyrine IX (ZnPP), an inhibitor of HO-1. Moreover, cilostazol increased HO-1 protein and mRNA expression. Cilostazol-induced HO-1 induction was markedly attenuated not only by ZnPP but also by copper-protoporphyrin IX (CuPP). In an assay measuring peroxisome proliferator-activated receptor-${\gamma}$ (PPAR-${\gamma}$) transcription activity, cilostazol directly increased PPAR-${\gamma}$ transcriptional activity which was completely abolished by HO-1 inhibitor. Furthermore, increased PPAR-${\gamma}$ activity by cilostazol and rosiglitazone was completely abolished in cells transfected with HO-1 siRNA. Taken together, these results indicate that cilostazol up-regulates HO-1 and protects cells against TNF-${\alpha}$-induced endothelial cytotoxicity via a PPAR-${\gamma}$-dependent pathway.

• BMB Reports
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• v.52 no.4
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• pp.239-249
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• 2019

Membrane-anchored full-length MET stimulated by its ligand HGF/SF induces various biological responses, including survival, growth, and invasion. This panel of responses, referred to invasive growth, is required for embryogenesis and tissue regeneration in adults. On the contrary, MET deregulation is associated with tumorigenesis in many kinds of cancer. In addition to its well-documented ligand-stimulated downstream signaling, the receptor can be cleaved by proteases such as secretases, caspases, and calpains. These cleavages are involved either in MET receptor inactivation or, more interestingly, in generating active fragments that can modify cell fate. For instance, MET fragments can promote cell death or invasion. Given a large number of proteases capable of cleaving MET, this receptor appears as a prototype of proteolytic-cleavage-regulated receptor tyrosine kinase. In this review, we describe and discuss the mechanisms and consequences, both physiological and pathological, of MET proteolytic cleavages.