• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.17 no.1
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• pp.131-142
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• 2004

The purpose of this research was to investigate cytotoxity of Sunbanhwalmyungeum extract. Cytotoxity was determined by MTT assay method. After tumor cell lines(G361, BI6F10, MDA, A549) transplantation, the extracts of SunBangHwalMyungEum and its composition oriental medicines were administered, cytotoxity was measured by absorbance. The results were obtained as follows. 1. Sunbanhwalmyungeum extract and its composition oriental medicines extracts showed the concentration was higher, the more cytotoxity increased. 2. Both water and ethanol extracts of Sunbanhwalmyungeum showed excellent cytotoxity against G361, B16F10, MDA, A549 and high cytotoxity over 80$\%$ against G361, B16F10, MDA except A549 at the concentration of 1000ppm. 3. In water extract, Rhei Radix et Rhizoma, Gleditsiae Spina, Trichosanthis Radix, Glycyrrhizae Radix, Ledebouriellae Radix showed excellent cytotoxity. In ethanol extract, Gleditsiae Spina, Citri Pericarpium, Trichosanthis Radix, Paeoniae Radix Rubra, Myrrha showed excellent cytotoxity. 4. Rhei Radix et Rhizoma, Gleditsiae Spina, Trichosanthis Radix, Paeoniae Radix Rubra showed high cytotoxity in both water and ethanol extrats. 5. In water extract, Glycyrrhizae Radix, Ledebouriellae Radix, Myrrha showed high cytotoxity against A361, Lonicerae Flos, Olibanum, Fritillariae cirrhosae Bulbus, Paeoniae Radix Rubra, Manitis Squama against B16F10, Paeoniae Radix Rubra, Manitis Squama against MDA, Rhei Radix et Rhizoma, Angelicae gigantis Radix against A549. 6. In ethanol extract, Lonicerae Flos, Trichosanthis Radix showed high cytotoxity against G361, Rhei Radix et Rhizoma, Angelicae gigantis Radix, Gleditsiae Spina, Olibanum, Angelicae dahuricae Radix, Fritillariae cirrhosae Bulbus, Paeoniae Radix Rubra, Glycyrrhizae Radix, Ledebouriellae Radix, Myrrha against B16F10, Rhei Radix et Rhizoma, Manitis Squama against MDA, Citri Pericarpium, Manitis Squama against A549.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.11 no.5
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• pp.731-737
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• 2000

In this paper we propose a decoding algorithm of Ungerboeck TCM/PSK in the concept of Radix-trellis, which has been applied to the decoding of convolutional codes for the high speed decoding. As an example we choose 16-state trellis coded 8-ary PSK. For Radix-4 and Radix-16 trellis decoding, we explain the path metric(PM) and the branch metric(BM) calculation. By using the simulation, we evaluate the bit error rate(BER) performance according to the number of binary digits for I-Q value, PM and BM registers. The proper number of binary digits of each register has been derived.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2001.11a
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• pp.199-199
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• 2001

• Journal of the Korea Institute of Information Security & Cryptology
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• v.12 no.2
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• pp.35-44
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• 2002

In this paper, an implementation method of RSA exponentiator based on Radix-$2^k$ modular multiplication algorithm is presented and verified. We use Booth receding algorithm to implement Radix-$2^k$ modular multiplication and implement radix-16 modular multiplier using 2K-byte memory and CSA(carry-save adder) array - with two full adder and three half adder delays. For high speed final addition we use a reduced carry generation and propagation scheme called pseudo carry look-ahead adder. Furthermore, the optimum value of the radix is presented through the trade-off between the operating frequency and the throughput for given Silicon technology. We have verified 1,024-bit RSA processor using Altera FPGA EP2K1500E device and Samsung 0.3$\mu\textrm{m}$ technology. In case of the radix-16 modular multiplication algorithm, (n+4+1)/4 clock cycles are needed and the 1,024-bit modular exponentiation is performed in 5.38ms at 50MHz.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.16 no.2
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• pp.96-118
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• 2003

The effect of Glycyrrhizae Radix water extract, known as depigmenting agent, on melanin biosynthesis was investigated in cellular level by using B16 mouse melanoma cells. The inhibitory effect of Glycyrrhizae Radix water extract on melanogenesis was determined by mushroom tyrosinase assay traditionally using in vitro screening test. To determine whether Glycyrrhizae Radix water extract suppress melanin synthesis in cellular level, B16 mouse melanoma cells were cultured in the presence of different concentrations of Glycyrrhizae Radix water extract. Effects on cell proliferation, melanin biosynthesis, tyrosinase activity, DOPAchrome tautomerase activity, and expression level of mRNA for tyrosinase were examined. The maximum concentration of Glycyrrhizae Radix water extract that was not inhibitory to growth of the cells was 2 mgml. At that concentration, melanin synthesis was significantly inhibited without cytotoxicity after 5 days, compared with untreated cells. The treatment with Glycyrrhizae Radix water extract reduced tyrosinase and DOPAchrome tautomerase activity in a dose-dependent manner. However, the treatment with Glycyrrhizae Radix water extract did not affect significantly mRNA levels for tyrosinase. These results suggest that the inhibitory effect of Glycyrrhizae Radix water extract on melanogenesis is correlated with the suppression of tyrosinase and DOPAchrome tautomerase activity more than altering mRNA levels of tyrosinase.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.8
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• pp.2816-2830
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• 2022

Number Theoretic Transform (NTT) is a method to design efficient multiplier for large integer multiplication, which is widely used in cryptography and scientific computation. On top of that, it has also received wide attention from the research community to design efficient hardware architecture for large size RSA, fully homomorphic encryption, and lattice-based cryptography. Existing NTT hardware architecture reported in the literature are mainly designed based on radix-2 NTT, due to its small area consumption. However, NTT with larger radix (e.g., radix-4) may achieve faster speed performance in the expense of larger hardware resources. In this paper, we present the performance evaluation on NTT architecture in terms of hardware resource consumption and the latency, based on the proposed radix-2 and radix-4 technique. Our experimental results show that the 16-point radix-4 architecture is 2× faster than radix-2 architecture in expense of approximately 4× additional hardware. The proposed architecture can be extended to support the large integer multiplication in cryptography applications (e.g., RSA). The experimental results show that the proposed 3072-bit multiplier outperformed the best 3k-multiplier from Chen et al. [16] by 3.06%, but it also costs about 40% more LUTs and 77.8% more DSPs resources.

• The Journal of Korean Medicine
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• v.17 no.1 s.31
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• pp.111-131
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• 1996

For the development of antimetastatic agent 41 kinds of crude drugs were used for the evaluation of inhibitory effect of several crude drugs on cell adhesion of pulmonary cancer cells and platelet aggregation. Results were obtained as follows: 1. Water extracts of crude drugs inhibited cell adhesion of A549 to complex extracelluar matrix over 40 % of contol were Houttuyniae Herba, Mylabris, Rhei Radix et Rhizoma, Meliae Cortex, Ferula Resina, Oldenlandiae diffusae Herba at the higher concentration of $10^{-3}g／ml$ while those inhibiting cell adhesion of Bl6-Fo over 40 % of control were $10^{-5}g／ml$ of Houttuyniae Herba, Aurantii Fructus, Lithospermi Radix, Zedoariae Rhizoma. Prunellae Spica, Foeniculi Fructus, Rbei Radix, Scutellariae Radix, Meliae Cortex, Ferula Resina and Oldenlandiae diffusae Herba. 2. MeOH extracts of crude drugs at the concentration of $4{\times}10^{-4}g／ml$ inhibiting cell adhesion of A549 specifically to single extracelluar matrix over 40 % of control were Lithospermi Radix, Agrimoniae Herba, Rhei Radix and Ferula Resina to collagen I, Houttuyniae Herba, Lithospermi Radix, Bupleuri Radix, Salviae miltiorrhizae Radix, Orostachys Herba, Sappan Lignum, Meliae cortex ferula Resina and Coicis Semen to collagen Ⅳ, Mylabris, Agrimoniae Herba to laminin, Houttuyniae Herba and Meliae Cortex to fibronectin. 3. NeOH extracts of crude drugs at the concentration of $4{\times}10^{-4}g／ml$ inhibiting cell adhesion of B16-Fo specifically to single extracelluar matrix over 60 % of control were Lithospermi Radix, Salviae miltiorrhizae Radix, Meliae Cortex and Ferula Resina to collagen I, Lithospermi Radix, Bupleun Radix, Saiviae miltiorrhizae Radix, Ferula Resina and Acanthopanacis Cortex to collagen Ⅳ, Bupleuri Radix, Orostachys Herba to laminin, Houttuyniae Herba to fibronectin. 4. MeOH extracts of crude drugs inhibiting platelet aggregation over 40% of ADP control were at the concentration of $50{\mu}g/m{\ell}$ of Houttuyniae Herba, Angilicae gigantis Radix, Zedoariae Rhizoma. Coicis Semen and $100{\mu}g/m{\ell}$ of Ferula Resina, Orostachys Herba, Salviae miltiorrhizae Radix, Curcumac Radix, Carthami Flos, Lithospermi Radix, Gleditsiae Spina, Sappan Lignum, Acanthopanacis Cortex. These results suggest that several crude drugs including Ferula Resina, Houttuyniae Herba, Lithospermi Radix and Salviae miltiorrhizae Radix chiefly have more possibility to exert antimetastatic activity and require in vivo antimetastatic study.

• The Journal of Korean Medicine
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• v.24 no.3
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• pp.145-154
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• 2003

Background : Production of cytokines by bronchial epithelial cells may contribute to the local accumulation of inflammatory cells in patients with bronchial asthma. In many recent studies, molecular biological methods have been used to investigate the role of cytokines in pathogenesis and new therapeutic targets of asthma. Objective : We aimed to identify the dose-dependent inhibitory effects of Lonicerae Flos and Paeoniae Radix on the mRNA expression of IL-6, IL-16, and GM-CSF involved in the asthma model. Materials and Methods : In the study BEAS-2B cell lines, human epithelial cells were used. These cells were stimulated with tumor necrosis factor $(TNF)-\alpha$ for artificial inflammatory expression. ${\beta}-actin$ messenger RNA (mRNA) was used for internal standard. After 24 hours of Lonicerae Flos, Paeoniae Radix, total cellular RNAs were collected treating RNA zol directly on the living cells. Then the transcriptional activities of IL-6, 16, GM-CSF were measured by RT- PCR with electrophoresis. Results : In the Lonicerae Flos study, the mRNA expression of IL-6, IL-16 and GM-CSF was showed no inhibitory effect compared to the control group in all concentrations. In the Paeoniae Radix study, the mRNA expression of IL-6, IL-l6 and GM-CSF was showed no inhibitory effect compared to the control group in all concentrations. Conclusion : This study shows that Lonicerae Flus and Paeuniae Radix have no inhibitory effects on the mRNA expression of IL-6, IL-16 and GM-CSF in BEAS-2B cell lines, human epithelial cells. Advanced studies are required to investigate the other mechanisms of inhibitory effect by Lonicerae Flus and Paeoniae Radix in the asthma model.

• Journal of Digital Convergence
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• v.11 no.2
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• pp.287-297
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• 2013

In this paper, we propose an efficient variable-length radix-8/4/2 FFT architecture for OFDM systems. The FFT processor is based on radix-8 FFT algorithm and also supports radix-4 or radix-2 FFT computation. We are using efficient "In-place" memory access method to maintain conflict-free data access and minimize memory size. Also we replace a very large lookup table with a twiddle factor generator which consumes less area then a ROM-based lookup table. The proposed FFT processor performs variable-length FFT including 64, 256, 512, 1024, 2048, 4096 and 8192 points which cover all the required FFT lengths used in 802.11a, 802.16a, DAB, DVB-T, VDSL and ADSL.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.8
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• pp.5579-5585
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• 2015

In FFT(Fast Fourier Transform) implementation, DIT(Decimation-In-Time) and DIF (Decimation-In-Frequency) methods are mostly used. Among them, various DIF structures such as Radix-2/4/8 algorithm have been developed. Compared to the DIF, the DIT structures have not been investigated even though they have a big advantage producing a sequential output. In this paper, a butterfly structure for DIT Radix-8 algorithm is proposed. The proposed structure has smaller latency time because of Radix-8 algorithm in addition to the advantage of the sequential output. In case of 4096-point FFT implementation, the proposed structure has only 4 stages which shows the smaller latency time compared to the 12 stages of Radix-2 algorithm. The proposed butterfly can be used in FFT block required the sequential output and smaller latency time.