• Journal of Radiopharmaceuticals and Molecular Probes
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• 제6권1호
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• pp.53-58
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• 2020

Pretargeting is a two-component strategy often used for tumor targeting to enhance the tumor-to-background ratio in cancer diagnosis as well as therapy. In the multistep strategy, the highly specific unlabeled monoclonal antibodies (mAbs) with the reactive site is allowed to get localized at tumor site first, and then small and fastclearing radiolabeled chelator with counter reactive site is administered which covalently attaches to mAbs via inverse electron demand Diels-Alder reaction (IEDDA). The catalyst-free IEDDA cycloaddition reaction between 1,2,4,5-tetrazines and strained alkene dienophiles aid with properties like selective bioconjugation, swift and high yielding bioorthogonal reactions are emergent in the development of radiopharmaceutical. Due to its fast pharmacokinetics, the in vivo formed radioimmunoconjugates can be imaged at earlier time points by short-lived radionuclides like ¹⁸F and ⁶⁸Ga; it can also reduce radiation damage to the normal cells. Ultimately, this review elucidates the updated status of pretargeting based on antibodies and IEDDA for tumor diagnosis (PET and SPECT) and therapy.

• The Transactions of the Korean Institute of Power Electronics
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• 제10권3호
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• pp.290-295
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• 2005

The incremental encoder has been mostly used to measure the speed and position of the motor. As the output signals of encoder are high frequency digital signals, they have much influence on radiation noises due to switching of the power semiconductor circuits. It is so difficult to suppress the noises with the conventional LPF. In this paper, the hardware digital filter for suppressing noises in the output signals of the encoder signals is developed. As both the clock frequency and counter in the digital filter for encoder are easily adjusted according to the kinds of noises, any noises in the encoder can be entirely eliminated. The performance of the digital filter has been verified by simulation and experimental results.

• Proceedings of the KSR Conference
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• 한국철도학회 2010년도 춘계학술대회 논문집
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• pp.6-12
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• 2010

The source of wayside noise for the train are the aerodynamic noise, wheel/rail noise, and power unit noise. The major source of railway noise is the wheel/rail noise caused by the interaction between the wheels and rails. The Structure borne noise is mainly a low frequency problem. The train noise and vibration nearby the elevated railway make one specific issue. The microphone array method is used to search sound radiation characteristics of elevated structure to predict the noise propagation from an elevated railway. In this paper, the train noise and structure borne noise by train are measured. From the results, we investigated the effect on the sound absorption tunnel for elevated railway.

• The Journal of Korean Institute of Communications and Information Sciences
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• 제25권1B호
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• pp.112-119
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• 2000

A two-color infrared (IR) seeker employs two detection-bands for efficient target tracking under countermeasures and background noises. This paper describes a study on the detection-band selections for the two-color seeker. To select the detection-bands, we analysis infrared radiation characteristics of a target, a flare, and background noises and then other characteristics closely related with the received power, such as the atmospheric transmission, acquisition range, background noise effect, and signal-to-noises. The analysis shows that the pertinent bands of two-color IR seeker are 3 um~5 um for target detection and 1.5 um~l.7 um for counter-countermeasures. The results of our study will play a significant role in the further study of two-color seekers.

• Proceedings of the KSRS Conference
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.1096-1098
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• 2003

SBC(Single Board Computer) is being developed for MSC(Multi-Spectral Camera) on KOMPSAT-2(Korea Multi-Purpose Satellite). SBC controls all the units of MSC system and gets commands and sends telemetry to and from spacecraft bus via 1553 communication channel. Due to the fact that SBC does very important roles for MSC system operation and SBC operates with 100% duty cycle, SBC is designed to have high reliability. SBC which has Intel 80486 as a main processor includes eight serial communication channels, one mil-std-1553 interface channel and several discrete interfaces. SBC incorporates 2Mbyte radiation hardened SRAM(Static Random Access Memory) and 1Mbyte flash memory. There are also PIC(Programmable Interrupt Controller), counter, WDT(Watch Dog Timer) in the SBC. In this paper, the design result of the SBC is presented.

• Journal of Mechanical Science and Technology
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• 제20권2호
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• pp.242-250
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• 2006

Detailed structures of the counterflow flames formed for different inlet fluid temperatures and different amount of additives are studied numerically. The detailed chemical reactions are modeled by using the CHEMKIN-II code. The discrete ordinates method and the narrow band based WSGGM with a gray gas regrouping technique (WSGGM-RG) are applied for modeling the radiative transfer through non-homogeneous and non-isothermal combustion gas mixtures generated by the counterflow flames. The results compared with those obtained by using the SNB model show that the WSGGM-RG is very successful in modeling the counterflow flames with non-gray gas mixture. The numerical results also show that the addition of $CO_2\;or\;H_2O$ to the oxidant lowers the peak temperature and the NO concentration in flame. But preheat of fuel or oxidant raises the flame temperature and the NO production rates. $O_2$ enrichment also causes to raise the temperature distribution and the NO production in flame. And it is found that the $O_2$ enrichment and the fuel preheat were the major parameters in affecting the flame width.

• Nuclear Engineering and Technology
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• 제51권6호
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• pp.1616-1625
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• 2019

Measuring occurrence times of random events, aimed to determine the statistical properties of the governing stochastic process, is a basic topic in science and engineering, and has been the subject of numerous mathematical modeling approaches. Often, true statistical properties deviate from measured properties due to the so called dead time phenomenon, where for a certain time period following detection, the detection system is not operational. Understanding the dead time effect is especially important in radiation measurements, often characterized by high count rates and a non-reducible detector dead time (originating in the physics of particle detection). The effect of dead time can be interpreted as a suitable rarefied sequence of the original time sequence. This paper provides a limit theorem for a high rate (diffusion-scale) counter with extendable (Type II) dead time, where the underlying counting process is a renewal process with finite second moment for the inter-event distribution. The results are very general, in the sense that they refer to a general inter arrival time and a random dead time with general distribution. Following the theoretical results, we will demonstrate the applicability of the results in three applications: serially connected components, multiplicity counting and measurements of aerosol spatial distribution.

• Journal of Acupuncture Research
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• 제38권4호
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• pp.300-311
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• 2021

Background: So far there is no confidence in the basics of acupoint/meridian phenomena, specifically in spatial and temporal electrical manifestations in the skin. Methods: Using the skin electrodynamic introscopy, the skin areas of 32 × 64 mm² were monitored for spectral electrical impedance landscape with spatial resolution of 1 mm, at 2 kHz and 1 MHz frequencies. The detailed baseline and 2D test-induced 2 kHz-impedance phase dynamics and the 4-parameter time plots of dozens of individual points in the St32-34 regions were examined in a healthy participant and a patient with mild gastritis. Non-thermal stimuli were used: (1) (for the sick subject), microwaves and ultraviolet radiation applied alternately from opposite directions of the meridian; and (2) (for the healthy one) microwaves to St17, and cathodic/anodic stimulation of the outermost St45, alternately. Results: In both cases, the following phenomena have been observed: emergence of in-phase and/or antiphase coherent structures, exceeding the acupoint conditional size of 1 cm; collective movement along the meridian; reversible with a reversed stimulus; counter-directional dynamics of both whole structures and adjacent points; local abnormalities in sensitivity and dynamics of the 1 MHz and 2 kHz parameters indicating existence of different waveguide paths. Conclusion: It is assumed that these findings necessitate reconsideration of some basic methodological issues regarding neurogenic/acupuncture points as spatial and temporal phenomena; this requires development of an appropriate approach for identifying the acuzones patterns. These findings may be used for developing new approaches to personalized/controlled therapy/treatment.

• Nuclear Engineering and Technology
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• 제54권10호
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• pp.3811-3815
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• 2022

Ni-63 is pure beta source which emits low energy beta particles. The Ni-63 sources were fabricated to develop the beta-voltaic battery which converts decay energy into electrical energy for power generation. Activity distribution of the source was important factor of power producibility of the beta-voltaic battery. Liquid scintillation counter widely used for measurement of low energy beta emitters was not suitable to measure activity distribution. In this study, we used the peeled-off Gafchromic™ EBT3 film to measure the activity distribution of the Ni-63 source. Absorbed dose was increased proportionally to the source activity and exposure duration. The low energy beta particles could transport the energy into the active layer without the polyester protective layer. Also, Activity distribution was measured by using the peeled-off EBT3 film. Two-dimensional dosimetric distribution was suitable to measure the activity distribution. To use the peeled-off EBT3 film is user-friendly and cost-effective method for quality assurance of the Ni-63 sources for the beta-voltaic battery.

• Nuclear Engineering and Technology
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• 제56권4호
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• pp.1425-1430
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• 2024

This study develops superheated emulsion detectors that are both sensitive to fast neutrons, and thermal neutrons owing to the exergonic ⁶₃Li(n, α)³₁H capture reaction caused by the ⁶Li-containing compound dispersed throughout the gel-like medium. The experimental research was conducted on two SEDs. One detector was an ordinary Freon-12 detector and the other was a Freon-12 detector containing 3.4 % (by weight) LiCl. In order to investigate the sensitivity of lithium-containing SEDs to thermal neutrons, two types of SEDs were simultaneously exposed to various flux levels of thermal neutrons from ²⁴¹Am-Be neutron source inside a cylindrical tank filled with water. A Boron-lined proportional counter was used to estimate the thermal neutron flux and the relevant MCNP code was developed for flux and dose calculations in the prepared set-up around ²⁴¹Am-Be source. The results demonstrate that there is a proportional relationship between the variations of SED response and the change in thermal neutron flux and dose. Also, the sensitivity of SED was estimated.