• Journal of the Korean Data and Information Science Society
• /
• 제7권2호
• /
• pp.235-245
• /
• 1996

확률변수 (X,Y)가 이변량 정규분포를 따르는 경우, 모상관계수 ${\rho}$에 관한 여러 가설들 중에서 $H_{0}:{\rho}={\rho}_{0}$인 경우에는 알려진 분포를 이용한 통계적 추론을 하기가 어렵다. 이러한 경우 Fisher에 의해 제안된 Z-변환을 이용한 근사적 검정법이 사용되어 오고 있으나 근사적인 방법이기 때문에 주어진 표본의 크기가 충분히 많지 않은 경우에는 적용에 무리가 있을 수 있다. 그래서 본 논문에서는 먼저 표본 상관계수 R의 분포를 모의실험을 통하여 직접 구하여 검정한 정확 검정법과, 붙스트랩(bootstrap) 방법을 이용하여 구한 붙스트랩 검정법을 제시하고, Fisher의 방법의 효율성과 실제성을 검토하고 제시된 방법들과 서로 비교하고자 한다.

• BMB Reports
• /
• 제51권5호
• /
• pp.230-235
• /
• 2018

Bone resorption by multinucleated osteoclasts is a multistep process involving adhesion to the bone matrix, migration to resorption sites, and formation of sealing zones and ruffled borders. Macrophage colony-stimulating factor (M-CSF) and osteopontin (OPN) have been shown to be involved in the bone resorption process by respective activation of integrin ${\alpha}v{\beta}3$ via "inside-out" and "outside-in" signaling. In this study, we investigated the link between signal modulators known to M-CSF- and OPN-induced osteoclast adhesion and spreading. M-CSF- and OPN-induced osteoclast adhesion was achieved via activation of stepwise signals, including integrin ${\alpha}v{\beta}3$, $PLC{\gamma}$, $PKC{\delta}$, and Rac1. Osteoclast spreading induced by M-CSF and OPN was shown to be controlled via sequential activation, consistent with the osteoclast adhesion processes. In contrast to osteoclast adhesion, osteoclast spreading induced by M-CSF and OPN was blocked via activation of $PLC{\gamma}/PKC{\alpha}/RhoA$ signaling. The combined results indicate that osteoclast adhesion and spreading are selectively regulated via $PLC{\gamma}/PKC{\alpha}-PKC{\delta}/RhoA-Rac1$ signaling.

• Bulletin of the Korean Chemical Society
• /
• 제32권12호
• /
• pp.4304-4308
• /
• 2011

Kinetic studies of the reactions of O,O-dimethyl Z-S-aryl phosphorothioates with X-benzylamines have been carried out in dimethyl sulfoxide at $85.0^{\circ}C$. The Hammett (log $k_2$ vs ${\sigma}_X$) and Br$\ddot{o}$nsted [log $k_2$ vs $pK_a$(X)] plots for substituent X variations in the nucleophiles are discrete with a break region between 4-Me and H, while the Hammett plots (log $k_2$ vs ${\sigma}_Z$) for substituent Z variations in the leaving groups are linear. The sign of the cross-interaction constant (${\rho}_{XZ}$) is positive for both the strongly and weakly basic nucleophiles. Greater magnitude of ${\rho}_{XZ}$ (= 2.54) value is observed with the weakly basic nucleophiles compared to with the strongly basic nucleophiles (${\rho}_{XZ}$ = 0.17). The deuterium kinetic isotope effects ($k_H/k_D$) involving deuterated benzylamines [$XC_6H_4CH_2ND_2$] are primary normal ($k_H/k_D$ > 1). The proposed mechanism is a stepwise with a rate-limiting leaving group expulsion from the intermediate involving a frontside nucleophilic attack with a hydrogen bonded, four-center-type transition state for both the strongly and weakly basic nucleophiles.

• 한국경영과학회지
• /
• 제22권1호
• /
• pp.101-121
• /
• 1997

Consider a Jackson type closed queueing network in which each queue has a single exponential server. Assume that N customers are moving among .kappa. queues. We propose a candidata procedure which yields a lower bound of the network throughput which is sharper than those which are currently available : Let (.rho.$_{1}$, ... .rho.$_{\kappa}$) be the loading vector, let x be a real number with 0 .leq. x .leq. N, and let y(x) denote that y is a function of x and be the unique positive solution of the equation. .sum.$_{i = 1}$$^{\kappa}$y(x) .rho.$_{i}$ (N - y(x) x $p_{i}$ ) = 1 Whitt [17] has shown that y(N) is a lower bound for the throughput. In this paper, we present evidence that y(N -1) is also a lower bound. In dosing so, we are led to formulate a rather general conjecture on 'quot;Migrating Critical Points'quot; (MCP). The .MCP. conjecture asserts that zeros of successive derivatives of certain rational functions migrate at an accelerating rate. We provide a proof of MCP in the polynomial case and some other special cases, including that in which the rational function has exactly two real poles and fewer than three real zeros.tion has exactly two real poles and fewer than three real zeros.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2000년도 춘계학술대회논문집B
• /
• pp.311-315
• /
• 2000

A numerical investigation is made of time-dependent buoyant convection in a square of a non-Boussinesq fluid. The density-temperature$({\rho}-T)$ relation is modeled by a quadratic function, with the maximum density ${\rho}_M$ at temperature $T_M$. The horizontal walls of the square are insulated, and a pulsating temperature $T_H=T_M+{\Delta}T'\;sin({\omega}{\tau})$ is imposed on the hot vertical sidewall. The temperature at the cold wall $T_c$ is constant. Extensive numerical solutions to the governing Navier-Stokes equations are portrayed. Resonance is identified by monitoring the amplitude of the mid-plane Nusselt number, $A(Nu^*)$. The primary resonance frequency is found by matching ${\omega}$ to the nondimensional basic mode $N_1$ of internal gravity oscillations. Due to the quadratic$({\rho}-T)$ relationship, the effective pulsation frequency for density, $2{\omega}$, is meaningful, which brings forth the secondary resonance frequency, i.e., $2{\omega}=N_1$

• Bulletin of the Korean Chemical Society
• /
• 제23권3호
• /
• pp.381-384
• /
• 2002

Second-order-rate constants ($k_N$) have been measured spectrophotometrically for the reactions of 4-nitrophenyl 2-thiophenecarboxylate (1a) with a series of secondary alicyclic amines in H2O containing 20 mole % DMSO at 25.0 $^{\circ}C$ . The ester 1a is less reactive than 4-nitrophenyl 2-furoate (1b) but more reactive than 4-nitrophenyl benzoate (1c) except towards piperazinium ion. The Brønsted-type plots for the aminolyses of 1a, 1b and 1c are linear with a $\beta$nuc value of 0.92, 0.84 and 0.85, respectively, indicating that the replacement of the CH=CH group by a sulfur or an oxygen atom in the benzoyl moiety of 1c does not cause any mechanism change. The reaction of piperidine with a series of substituted phenyl 2-thiophenecarboxylates gives a linear Hammett plot with a large $\rho^-$ value ($\rho^-$ = 3.11) when $\sigma^- $ constants are used. The linear Brønsted and Hammett plots with large $\beta$nuc and $\rho^-$ values suggest that the aminolysis of 1a proceeds via rate-determining break-down of the addition intermediate to the products.

• Journal of Microbiology and Biotechnology
• /
• 제18권1호
• /
• pp.171-175
• /
• 2008

Here, we report that Vibrio parahaemolyticus induces a rapid remodeling of macrophage actin and activates RhoB GTPase. Mutational analysis revealed that the effects depend on type III secretion system 1 regulated translocation of a V. parahaemolyticus effector protein, VP1686, into the macrophages. Remodeling of actin is shown to be necessary for increased bacterial uptake followed by initiation of apoptosis in macrophages. This provides evidence for functional association of the VP1686 in triggering an eat me-and-die signal to the host.

• Journal of Microbiology and Biotechnology
• /
• 제5권6호
• /
• pp.335-340
• /
• 1995

Two types of Rhizoctonia solani esterases induced by cutin hydrolysate were partially purified by ammonium sulfate precipitation and gel filtration. The esterase I with hydrolyzing activity toward both ${\rho}-ni-trophenyl$ butyrate and ${\rho}-nitrophenyl$ palmitate and the esterase II with hydrolyzing activity toward only ${\rho}-ni-trophenyl$ butyrate were inhibited by ebelactone B, an esterase inhibitor produced by actinomycetes with $IC_{50}$ values of 0.01 and $0.09{\;}\mu\textrm{g}/l$, respectively. Spraying on rice seedling with ebelactone B at a concentration of $30{\;}\mu\textrm{g}/ml$ completely suppressed infection by R. solani. Ebelactone B could not protect the wounded rice seedling and did not show any inhibitory effect on the mycelial growth at a concentration of 1 mg/ml. These results indicate that ebelactone B, an esterase inhibitor protects rice plants from infection with R. solani by inhibition of penetration, not through fungitoxic or fungicidal effect.

• 한국세라믹학회지
• /
• 제40권10호
• /
• pp.1015-1020
• /
• 2003

$\rho$-알루미나 결합 진동성형용 알루미나 캐스터블 내화물의 매트릭스부분과 용응 슬래그와의 침식거동을 젭센(Jabsen)이 주장한 이론을 기초로 하고 킹거리(Kingery)가 제안한 반응 기구를 통해 규명하였다. 매트릭스 부분의 초기침식이 분자확산거동에 의하여 지배되며, 아레니우스 관계식과 잘 일치하고 있어 온도의존성 활성화 과정으로 받아들 수 있다. 슬래그와 경계층의 Ca 농도차이가 23.2%로서 경계층을 형성하기 위한 물질이동의 구동력이 되었다. 매트릭스의 침식정도가 뮬라이트 소결체보다 심하지만 킹거리의 침식반응 기구와 잘 일치하고 있어 캐스터블의 수명예측이 가능하다.

• Journal of Magnetics
• /
• 제16권2호
• /
• pp.192-195
• /
• 2011

The phase transition of vortex matter from solid to liquid was studied in iron-based superconductors. Based on the traditional vortex glass theory, we have examined the magnetoresistivity data of iron-based superconductors using our extended thermal activation model: $\rho(B,T)=\rho((T-T_g(B))/(T_c(0)-T_g(B)))^{v(z-1)}$. We predict that the magnetic field-dependent area S + $S_0$ which integrates $\rho$ with T is proportional to $B^{\beta}$, where ${\beta}$ is the vortex glass transition exponent. From our calculation, the vortex glass transition exponent is 0.33, close to the exponent of area $S_0$ + S is 0.31 in $SmO_{0.9}F_{0.1}FeAs$; the exponent of area S is 0.63, which is close to the irreversibility line exponent 2/3. Both of the results show the validity of our model. In addition, our model is shown to be effective in describing irreversibility behavior in layered superconductors.