Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지

Translocation of VP1686 Upregulates RhoB and Accelerates Phagocytic Activity of Macrophage Through Actin Remodeling

  • Bhattacharjee, Rabindra N. (Akira Innate Immunity Project, Exploratory Research for Advance Technology, Japan Science and Technology Agency, Osaka University) ;
  • Park, Kwon-Sam (Food Science and Biotechnology Major, College of Ocean Science and Technology, Kusan National University) ;
  • Chen, Xiuhao (Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University) ;
  • Iida, Tetsuya (Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University) ;
  • Honda, Takeshi (Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University) ;
  • Takeuchi, Osamu (Akira Innate Immunity Project, Exploratory Research for Advance Technology, Japan Science and Technology Agency, Osaka University) ;
  • Akira, Shizuo (Akira Innate Immunity Project, Exploratory Research for Advance Technology, Japan Science and Technology Agency, Osaka University)
  • Published : 2008.01.31
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Abstract

Here, we report that Vibrio parahaemolyticus induces a rapid remodeling of macrophage actin and activates RhoB GTPase. Mutational analysis revealed that the effects depend on type III secretion system 1 regulated translocation of a V. parahaemolyticus effector protein, VP1686, into the macrophages. Remodeling of actin is shown to be necessary for increased bacterial uptake followed by initiation of apoptosis in macrophages. This provides evidence for functional association of the VP1686 in triggering an eat me-and-die signal to the host.

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References

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