• IMMUNE NETWORK
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• v.24 no.3
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• pp.21.1-21.16
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• 2024

IL-1, a pleiotropic cytokine with profound effects on various cell types, particularly immune cells, plays a pivotal role in immune responses. The proinflammatory nature of IL-1 necessitates stringent control mechanisms of IL-1-mediated signaling at multiple levels, encompassing transcriptional and translational regulation, precursor processing, as well as the involvement of a receptor accessory protein, a decoy receptor, and a receptor antagonist. In T-cell immunity, IL-1 signaling is crucial during both the priming and effector phases of immune reactions. The fine-tuning of IL-1 signaling hinges upon two distinct receptor types; the functional IL-1 receptor (IL-1R) 1 and the decoy IL-1R2, accompanied by ancillary molecules such as the IL-1R accessory protein (IL-1R3) and IL-1R antagonist. IL-1R1 signaling by IL-1β is critical for the differentiation, expansion, and survival of Th17 cells, essential for defense against extracellular bacteria or fungi, yet implicated in autoimmune disease pathogenesis. Recent investigations emphasize the physiological importance of IL-1R2 expression, particularly in its capacity to modulate IL-1-dependent responses within Tregs. The precise regulation of IL-1R signaling is indispensable for orchestrating appropriate immune responses, as unchecked IL-1 signaling has been implicated in inflammatory disorders, including Th17-mediated autoimmunity. This review provides a thorough exploration of the IL-1R signaling complex and its pivotal roles in immune regulation. Additionally, it highlights recent advancements elucidating the mechanisms governing the expression of IL-1R1 and IL-1R2, underscoring their contributions to fine-tuning IL-1 signaling. Finally, the review briefly touches upon therapeutic strategies targeting IL-1R signaling, with potential clinical applications.

• Communications of the Korean Mathematical Society
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• v.21 no.2
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• pp.261-272
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• 2006

In this paper, we define the sequence spaces: $[V,{\lambda},f,p]_0({\Delta}^r,E,u),\;[V,{\lambda},f,p]_1({\Delta}^r,E,u),\;[V,{\lambda},f,p]_{\infty}({\Delta}^r,E,u),\;S_{\lambda}({\Delta}^r,E,u),\;and\;S_{{\lambda}0}({\Delta}^r,E,u)$, where E is any Banach space, and u = ($u_k$) be any sequence such that $u_k\;{\neq}\;0$ for any k , examine them and give various properties and inclusion relations on these spaces. We also show that the space $S_{\lambda}({\Delta}^r, E, u)$ may be represented as a $[V,{\lambda}, f, p]_1({\Delta}^r, E, u)$ space. These are generalizations of those defined and studied by M. Et., Y. Altin and H. Altinok [7].

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.11a
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• pp.21-22
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• 2008

• Journal of Information Display
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• v.4 no.4
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• pp.4-7
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• 2003

The world largest 21.3" LTPS LCD has been successfully developed using SLS crystallization technology. Integration of gate circuit, transmission gate and level shifter was successfully performed in a large area display. Uniform and high performance of high quality grains of SLS technology make it possible to realize a uniform large size LTPS TFT-LCD with half the number of data driver IC's that is typically used in a-Si LCD. High aperture ratio of 65 % was achieved using an organic inter insulating method which lead to a high brightness of 500 cd/$cm^2$.

• 한국정보디스플레이학회:학술대회논문집
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• 2003.07a
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• pp.241-244
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• 2003

The world largest 21.3" LTPS LCD has been successfully developed using SLS crystallization technology. Successful integration of gate circuit, transmission gate and level shifter was performed in a large area uniformly. Uniformity and high performance from high quality grains of SLS technology make it possible to come true a uniform large size LTPS TFT-LCD with half number of data driver IC's used in typical a-Si LCD. High aperture ratio of 65% was obtained using an organic inter insulating method, which lead a high brightness of 500cd/cm2.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.2
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• pp.34.1-34.1
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• 2018

We investigate the properties of bright galaxies with various morphological types in Abell 1139 and Abell 2589, using the pixel color-magnitude diagram (pCMD) analysis. The 32 bright member galaxies ($Mr{\leq}-21.3mag$) are deeply imaged in the g and r bands in our CFHT/MegaCam observations, as a part of the KASI-Yonsei Deep Imaging Survey of Clusters (KYDISC). We examine how the features of their pCMDs depend on galaxy morphology and infrared color. We find that the g - r color dispersion as a function of surface brightness (${\mu}r$) shows better performance in distinguishing galaxy morphology, than the mean g - r color does. The best set of parameters for galaxy classification appears to be a combination of the minimum color dispersion at ${\mu}r{\leq}21.2mag\;arcsec-2$ and the maximum color dispersion at $20.0{\leq}{\mu}r{\leq}21.0mag\;arcsec-2$: the latter reflects the complexity of stellar populations at the disk component in a typical spiral galaxy. Moreover, the color dispersion of an elliptical galaxy appears to be correlated with its WISE infrared color ([4.6]-[12]). This indicates that the complexity of stellar populations in an elliptical galaxy is related to its recent star formation activities. From this observational evidence, we infer that gas-rich minor mergers or gas interactions may have usually occurred during the recent growth of massive elliptical galaxies.

• Journal of Life Science
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• v.20 no.9
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• pp.1306-1313
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• 2010

The gene encoding esterase enzyme was cloned from a metagenomic library of cow rumen bacteria. The esterase gene (est1R) was 2,465 bp in length, encoding a protein of 366 amino acid residues, and the molecular weight of the enzyme was 61,166 Da. Est1R of rumen cosmid library shared 5.9% amino acid identity with Est1R (P37967) of PNB carboxylesterase, 6.1% with Est1R (1EEAA) of acetylcholinesterase and 6.1% with Est1R (1H23A) of chain A. BlastP in NCBI database analysis of Est1R revealed that it was not homologous to previous known lipases and esterases. Est1R showed optimum activity at pH 7.0 and $40^{\circ}C$. On the other hand, the enzyme was found to be most active without organic solvent, followed by 95% activity with methanol, and the enzyme activity was highly affected by hexane (lost 51% activity). Therefore, the novel esterase gene est1R is likely obtainable from cow rumen metagenome and may be utilized for industrial purposes.

• Communications of the Korean Mathematical Society
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• v.21 no.3
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• pp.491-496
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• 2006

In the paper, we study an n-dimensional compact Riemannian manifold (M, g) with the property that the lengthes of the images $c({\mathbb{R}})$ in M of any geodesic curves $c({\mathbb{R}}){\mapsto}M$ are finite.

• Communications of the Korean Mathematical Society
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• v.21 no.1
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• pp.17-25
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• 2006

In this paper, we study the right regular representation $R_\Gamma$ of a finite group G on the vector space consisting of vector valued functions on ${\Gamma}/G$ with a subgroup r of G and give a trace formula using the work of M. -F. Vigneras.

• Carbon letters
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• v.27
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• pp.26-34
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• 2018

To formulate folate receptor (FR)-specific graphene-based electrochemical electrodes, a folic acid (FA) derivative attached with two pyrene molecules on the glutamate tail of FA was synthesized. The resulting pyrene-functionalized FA (FA-Py) presented the spontaneous noncovalent binding on chemically reduced graphene oxides (rGO) through an ${\pi}-{\pi}$ interaction. Ultrathin morphology, high water-resistance, and preservation of intact FR-specific pteroates from the rGO/FA-Py assembly allow this assembly to be exploited as robust and FR-specific electrochemical electrode materials. The limits of detecting rGO/FA-Py modified electrodes were found to be as low as 3.07 nM in FR concentrations in cyclic voltammetry analysis.