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http://dx.doi.org/10.5714/CL.2018.27.026

Assembly of chemically reduced graphene oxide with folic acid functionalized with pyrene moieties and electrochemical sensing of folate receptors  

Kwon, Binhee (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation)
Park, Jongyeap (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation)
Jeong, Woojun (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation)
Jeong, Guembi (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation)
Ryu, Hyeong Seon (Department of Organic and Nano Engineering, Hanyang University)
Paoprasert, Peerasak (Department of Chemistry, Faculty of Science and Technology, Thammasat University)
Park, Sung Young (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation)
In, Insik (Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation)
Publication Information
Carbon letters / v.27, no., 2018 , pp. 26-34 More about this Journal
Abstract
To formulate folate receptor (FR)-specific graphene-based electrochemical electrodes, a folic acid (FA) derivative attached with two pyrene molecules on the glutamate tail of FA was synthesized. The resulting pyrene-functionalized FA (FA-Py) presented the spontaneous noncovalent binding on chemically reduced graphene oxides (rGO) through an ${\pi}-{\pi}$ interaction. Ultrathin morphology, high water-resistance, and preservation of intact FR-specific pteroates from the rGO/FA-Py assembly allow this assembly to be exploited as robust and FR-specific electrochemical electrode materials. The limits of detecting rGO/FA-Py modified electrodes were found to be as low as 3.07 nM in FR concentrations in cyclic voltammetry analysis.
Keywords
chemically reduced graphene oxide; noncovalent interaction; electrochemical sensing; folic acid; folate receptor;
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