• Applied Biological Chemistry
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• v.32 no.2
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• pp.170-177
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• 1989

In order to seek the molecular basis of higher insecticidal activity of the carbamates with two methyl groups, m-xylyl-N-methylcarbamate(MXNMC) than the corresponding unsubstituted phenyl N-methylcarbamate(PNMC), these two derivatives have been studied by molecular orbital(MO) theoretically using extended $H\ddot{u}ckel$ theory(EHT), and analysis of regression and linear free energy relationship(LFER). The most stable stereo structure(Z, Z) shows that the phenyl group occupies vertical(${\theta}=90^{\circ}$) position on the plane of the N-methylcarbamyl group. Regression analysis shows that especially good correlation exists between the $pI_{50}$ values and the calculated MO quantities when the hydrogen atomic charge of metaposition and of m-methyl groups, and LUMO energy are taken as variables. The LFER analysis on the carbamylation indicates that field(F) effect(60%) is slightly larger than resonance(R) effect(40%) in PNMC(E>R), whereas, in case of MXNMC, R effect(98.6%) is much larger than F effect(1.4%)($R{\gg}F$). From the basis on the findings, the enhancement of insecticidal activity of MXNMC may be the result of hyperconjugation by m-methyl groups.

• Mass Spectrometry Letters
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• v.12 no.4
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• pp.179-185
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• 2021

Collision-induced dissociation (CID) combined with electrospray ionization mass spectrometry (ESI-MS) was used to obtain structural information on rat islet amyloid polypeptide (rIAPP) monomers (M) and dimers (D) observed in the multiply charged state in the MS spectrum. MS/MS analysis indicated that the rIAPP monomers adopt distinct structures depending on the molecular ion charge state. Peptide bond dissociation between L₂₇ and P₂₈ was observed in the MS/MS spectra of rIAPP monomers, regardless of the monomer molecular ion charge state. MS/MS analysis of the dimers indicated that D⁵⁺ comprised M²⁺ and M³⁺ subunits, and that the peptide bond dissociation process between the L₂₇ and P₂₈ residues of the monomer subunit was also maintained. The observation of (M+ b₂₇)⁴⁺ and (M+ y₁₀)³⁺ fragment ions were deduced to originate from the two different D⁵⁺ complex geometries, the N-terminal and C-terminal interaction geometries, respectively. The fragmentation pattern of the [M_rIAPP + M_hIAPP]⁵⁺ MS/MS spectrum showed that the interaction occurred between the two N-terminal regions of M_rIAPP and M_hIAPP in the heterogeneous dimer (hetero-dimer) D⁵⁺ structure.

• Journal of Energy Engineering
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• v.15 no.4 s.48
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• pp.243-249
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• 2006

An experimental study on the refrigerant-side pressure drop of slit fin an tube heat exchanger has been carried out. A comparison was made between the predictions of previously proposed empirical correlations and experimental data for the pressure drop on design conditions of condenser in micro-fin tube for R22 and Rl34a. Experiments were carried out under the conditions of inlet refrigerant temperature of $60^{\circ}C$ and mass fluxes varying from $150\;to\;250\;kg/m^{2}s$ for R22 and Rl34a. The inlet air conditions are dry bulb temperature of $35^{\circ}C$, relative humidity of 40% and air velocity varying from 0.68 to 1.43 m/s. Experiments show that pressure drop for R134a was $22{\sim}22.6%$ higher than R22 for the degree of subcooling $5^{\circ}C$ For the mass fluxes of $200{\sim}250\;kg/m^{2}s$, the deviation between the experimental and predicted values for the pressure drop was less than ${\pm}20%$ for R22 and Rl34a.

• Journal of the Korean Mathematical Society
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• v.47 no.3
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• pp.633-643
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• 2010

Let a be an ideal of a commutative Noetherian ring R, M a finitely generated R-module and N a weakly Laskerian R-module. We show that if N has finite dimension d, then $Ass_R(H^d_a(N))$ consists of finitely many maximal ideals of R. Also, we find the least integer i, such that $H^i_a$(M, N) is not consisting of finitely many maximal ideals of R.

• Journal of the Korean Ceramic Society
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• v.29 no.12
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• pp.949-955
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• 1992

R-curves, fracture resistance (KR) as a function of crack extension (Δa), of a gas-pressure sintered monolithic Si3N4 were determined by controlled flaw/strength technique. Rising R-curve behavior was observed, confirming the operation of microstructural toughening process during crack growth. The R-curve parameters, k and m in the equation, KR=k(Δa)m, were determined to 30.301 and 0.1146, respectively. Microstructural observation of growing crack revealed that the bridging in the crack wake by unbroken ligament of large elongated ${\beta}$-grains was the mechanism primarily for the rising R-curve behavior.

• Bulletin of the Korean Mathematical Society
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• v.32 no.2
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• pp.321-328
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• 1995

In this note all are commutative rings with identity and all modules are unital. Let R be a ring. An R-module M is called a multiplication module if for every submodule N of M there esists an ideal I of R such that N = IM. Clearly the ring R is a multiplication module as a module over itself. Also, it is well known that invertible and more generally profective ideals of R are multiplication R-modules (see [11, Theorem 1]).

• Communications of the Korean Mathematical Society
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• v.38 no.3
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• pp.733-740
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• 2023

Let R be a commutative ring and M be an R-module. The dimension graph of M, denoted by DG(M), is a simple undirected graph whose vertex set is Z(M) ⧵ Ann(M) and two distinct vertices x and y are adjacent if and only if dim M/(x, y)M = min{dim M/xM, dim M/yM}. It is shown that DG(M) is a disconnected graph if and only if (i) Ass(M) = {𝖕, 𝖖}, Z(M) = 𝖕 ∪ 𝖖 and Ann(M) = 𝖕 ∩ 𝖖. (ii) dim M = dim R/𝖕 = dim R/𝖖. (iii) dim M/xM = dim M for all x ∈ Z(M) ⧵ Ann(M). Furthermore, it is shown that diam(DG(M)) ≤ 2 and gr(DG(M)) = 3, whenever M is Noetherian with |Z(M) ⧵ Ann(M)| ≥ 3 and DG(M) is a connected graph.

• Journal of the Korean Chemical Society
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• v.29 no.5
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• pp.522-532
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• 1985

The reactions of p-nitrophenyldiphenylphosphate (p-NPDPP) with anions of benzimidazole (BI) and its 2-alkyl derivatives (R-BI) are strongly catalyzed by the micelles of cetyltrimethyl ammonium bromide (CTABr). On the other hand, the first order rate constants $(k'_{R-BI^-})$ and the second order rate constants $(k_{m(R-BI^-)})$ of the reactions mediated by R-$BI^-$in the micellar pseudophase are much smaller than those mediated by $BI^-$. In order to explain the slower rates of the micellar reactions mediated by R-$BI^-$, we compared the concentration-ratios ([R-$BI^-$]/[$BI^-$]) with the first order rate constant-ratios $(k'_{R-BI^-}/k'_{BI^-})$ and the second order constant-ratios $(k_{m(R-BI^-)}/k_{m(BI^-)})$ for the reactions taking place in the micellar pseudophase. The rate constant-ratios were much smaller than the concentration-ratios. For example in a 5 ${\times}10^{-4}$M butyl-BI solution, the two ratios were 0.089 and 0.430 (for the first order) respectively, and in a $10^{-4}$M butyl-BI solution the former was 0.100 (for the second order). This predicts that the reactivities of R-$BI^-$ in the micellar pseudophase are much smaller than that of $BI^-$. Based on the values of several kinetic parameters measured for dephosphorylation of p-NPDPP mediated by R-$BI^-$, a schemetic model is proposed. Due to the hydrophobicity and the steric effect of the alkyl substituents, these groups would penetrate into the core of the micelle for stabilization by van der Waals interaction with long cetyl groups of CTABr. Consequently, the movements of R-$BI^-$ bound to the micelle should be restricted, leading to decreased collison frequencies between the nucleophiles and p-NPDPP. We refer this as an "anchor effect". This effect became more predominent when a larger alky group in R-BI was employed and when a greater concentration of R-BI was used.

• Journal of Yeungnam Medical Science
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• v.10 no.2
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• pp.432-444
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• 1993

Multidrug resistance(MDR) phenotype is frequently observed in animal and human cancer cell lines selected for in vitro resistance to a single chemotherapeutic agent. It is characterized by the diminished drug accumulation and is related to the drug efflux mechanism in resistant cells. In the present study, adriamycin resistant cells(L1210-$AdR_6$ : $10^{-6}M$ adriamycin, $-AdR_5$ : $10^{-5}M$) and vincristine resistant cells (L1210-$VcR_7$ : $10^{-7}M$ vincristine, $-VcR_6$ : $10^{-6}M$) were produced from mouse lymphoblastic leukemia cell line L1210. Growth profiles of survived cells were observed for 5 days with MTT(thiazolyl blue) assay and resistance was compared with $IC_{50}$(drug concentration of 50% survival reduction in absorbance). Resistant cells proliferated more slowly than sensitive cell. Doubling times were 29.7hr in L1210, 68.7hr in L1210-$AdR_5$ and 58.2hr in $-VcR_6$. MDRs expressed as resistance factor were as follows, L1210-$AdR_5$ was 76.4 times for vincristine, L1210-$VcR_6$ was 96.4 times for adriamycin. The cell membrane proteins with three different M.W. were recognized to be related resistance, 220, 158, and 88 kd in L1210-$AdR_5$, 158, 140 and 88 kd in L1210-$VcR_6$ by SDS-PAG electrophoresis. Cell surface membrane proteins were identified by radio-iodination and autoradiogram, their molecular weights were 158, 72.8, and 42.4 Kd in L1210-$VcR_6$.

• Development and Reproduction
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• v.15 no.4
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• pp.331-338
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• 2011

MicroRNAs (miRNAs) function as a key regulator of diverse cellular functions. To find out novel miRNAs that promote the differentiation of mouse embryonic stem cells (mESCs), we compared the miRNAs expression profiles of mESCs under self-renewal vs. differentiation states. We noticed that miR-222 was highly expressed during the differentiation of mESCs. Quantitative RT-PCR analysis revealed that expression of miR-222 was up-regulated during the embryonic bodies formation and retinoic acid -dependent differentiation. When miR-222 was suppressed by antogomiR-222, the differentiation of mESCs was delayed compared to control. Self-renewal marker expression or cell proliferation was not affected but the expression of lineage specific marker was suppressed by the treatment of miR-222 inhibitor during the differentiation of mESCs. Taken together, these results suggest that miR-222 functions to promote the differentiation of mESCs by regulating expression of differentiation related genes.