• Title/Summary/Keyword: Q-35

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Identification of Genomic Aberrations by Array Comparative Genomic Hybridization in Patients with Aortic Dissections

  • Suh, Jong-Hui;Yoon, Jeong-Seob;Kwon, Jong-Bum;Kim, Hwan-Wook;Wang, Young-Pil
    • Journal of Chest Surgery
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    • v.44 no.2
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    • pp.123-130
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    • 2011
  • Background: The aim of the present study was to identify chromosomal loci that contribute to the pathogenesis of aortic dissection (AD) in a Korean population using array comparative genomic hybridization (CGH) and to confirm the results using real-time polymerase chain reaction (PCR). Materials and Methods: Eighteen patients with ADs were enrolled in this study. Genomic DNA was extracted from individual blood samples, and array CGH analyses were performed. Four corresponding genes with obvious genomic changes were analyzed using real-time PCR in order to assess the level of genomic imbalance identified by array CGH. Results: Genomic gains were most frequently detected at 8q24.3 (56%), followed by regions 7q35, 11q12.2, and 15q25.2 (50%). Genomic losses were most frequently observed at 4q35.2 (56%). Real-time PCR confirmed the results of the array CGH studies of the COL6A2, DGCR14, PCSK6, and SDHA genes. Conclusion: This is the first study to identify candidate regions by array CGH in patients with ADs. The identification of genes that may predispose an individual to AD may lead to a better understanding of the mechanism of AD formation. Further multicenter studies comparing cohorts of patients of different ethnicities are warranted.

Quantitative Structure-Activity Relationships for Radical Scavenging Activities of Flavonoid Compounds by GA-MLR Technique

  • Om, Ae-Son;Ryu, Jae-Chun;Kim, Jae-Hyoun
    • Molecular & Cellular Toxicology
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    • v.4 no.2
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    • pp.170-176
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    • 2008
  • The quantitative structure-activity relationship (QSAR) of a set of 35 flavonoid compounds presenting antioxidant activity was established by means of Genetic Algorithm-Multiple Linear Regression (GA-MLR) technique. Four-parametric models for two sets of data, the 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity $(R^2=0.788,\;Q^2_{cv}=0.699\;and\;Q^2_{ext}=0.577)$ and scavenging activity of reactive oxgen species (ROS) induced by $H_2O_2 (R^=0.829,\;Q^2_{cv}=0.754\;and\;Q^2_{ext}=0.573)$ were obtained with low external predictive ability on a mass basis, respectively. Each model gave some different mechanistic aspects of the flavonoid compounds tested in terms of the radical scavenging activity. Topological charge, H-bonding complex and deprotonation processes were likely to be involved in the radical scavenging activity.

Effect of Tin Coating on the High Speed Seam Weldability of Thn Gage Sheet Steels (박판 강재의 고속 심 용접성에 미치는 Sn 도금의 영향)

  • 김기철;이목영
    • Journal of Welding and Joining
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    • v.16 no.5
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    • pp.86-92
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    • 1998
  • High speed wire seam weldability of tin coated thin gage sheet steels was investigated. Thickness and coating weight ranges of the test materials were 0.21~0.35mm and 1.1/1.1~2.8/11.2g/$m^2$, respectively. Test results indicated that the surface roughness value, Rz decreased as increasing the coating weight. The Rz was thought to be one of the important factors to influence the optimum welding condition range, $\triangle$Q. The $\triangle$Q showed close relationship with welding conditions such as welding pressure and travel speed. Higher welding pressure widened the $\triangle$Q while higher travel speed reduced the $\triangle$Q value. Results also demonstrated that tin coating weight should be optimized based on the weldability or the serviceability after welding. At th HAZ of sheet materials with thinner coating layer, tin depleted zone was produced since molten film of the coating material on the base metal agglomerated by the surface tension, which could result in reducing the corrosion resistance of the HAZ in the service environment.

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Coping Pattern of Menopause in Middle Aged Woman (중년여성의 폐경에 대한 대처유형)

  • Kim, Ae-Kyung
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.17 no.1
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    • pp.35-44
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    • 2010
  • Purpose: The purpose of this study was to explore the coping behaviors related to menopause experience in woman. Method: The research method used was Q-methodology. The statement of self-reference was derived from face to face interviews with 10 womens. Statements were categorized by the researcher according to semantics. From categories of the Q-population 27 of the self reference statement were selected and 39 of the women were selected with consideration of given to diversity in socio-demographic background. Based on a 1 to 9 point scale, the selected menopausal women were made to participated in the Q-sorting. Analysis of Q-type was obtained by use of the QUNAL program. Result: There are three type of menopause experience of Korean women. 1. The first type focused on active coping relate to menopause. 2. The second type focused on mind control related to menopause. 3. The third type focused on religious support related to menopause. Conclusion: It is suggested that the results of this study may contribute to the development strategies for the purpose of health promotion middle aged women.

PSEUDO-HERMITIAN MAGNETIC CURVES IN NORMAL ALMOST CONTACT METRIC 3-MANIFOLDS

  • Lee, Ji-Eun
    • Communications of the Korean Mathematical Society
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    • v.35 no.4
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    • pp.1269-1281
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    • 2020
  • In this article, we show that a pseudo-Hermitian magnetic curve in a normal almost contact metric 3-manifold equipped with the canonical affine connection ${\hat{\nabla}}^t$ is a slant helix with pseudo-Hermitian curvature ${\hat{\kappa}}={\mid}q{\mid}\;sin\;{\theta}$ and pseudo-Hermitian torsion ${\hat{\tau}}=q\;cos\;{\theta}$. Moreover, we prove that every pseudo-Hermitian magnetic curve in normal almost contact metric 3-manifolds except quasi-Sasakian 3-manifolds is a slant helix as a Riemannian geometric sense. On the other hand we will show that a pseudo-Hermitian magnetic curve γ in a quasi-Sasakian 3-manifold M is a slant curve with curvature κ = |(t - α) cos θ + q| sin θ and torsion τ = α + {(t - α) cos θ + q} cos θ. These curves are not helices, in general. Note that if the ambient space M is an α-Sasakian 3-manifold, then γ is a slant helix.

Nurses' Self-Image Perceived by Clinical Nurses: An Application of Q-Methodology (임상간호사가 지각한 간호사 자아상: Q 방법론적 접근)

  • Ha, Eun-Ho;Hyun, Kyoung Soon
    • Korean Journal of Adult Nursing
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    • v.26 no.1
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    • pp.117-128
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    • 2014
  • Purpose: The views, perceptions, and feelings of nurses themselves would be important to quality of nursing and professionalism, and turnover intentions. The purpose of this study was to identify nurses 'self-image to develop a customized program. Methods: The Q-methodology which is to create a typology was used. The 40 selected Q-statements from each of 35 participants were classified into a shape of normal distribution using a nine point scale. The collected data were analyzed using a PC-QUANL program. Results: Three types of nurses 'self-image were identified: 'proactive self-image', 'critical self-image', and 'adaptive self-image'. Two consensus items in three types were extracted: 'need to develop healing therapies to overcome the constant tension and exhaustion from work', and 'just think as a colleague than the senior-junior relationship. Conclusion: The results is the typology and this leads to further research.

Caring Types in Mothers of Children with Athma : Q Methodology (천식 환아 어머니의 돌봄 유형: Q 방법론 적용)

  • Oh Won Oak
    • Child Health Nursing Research
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    • v.6 no.1
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    • pp.89-102
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    • 2000
  • Asthma is one of the most common chronic disease of childhood. Although an improved understanding of the pathophysiology of asthma has had a positive impact on the treatment and management of the disease, there has been a gradual but significant increase in asthma mortality. Also, mother's caring type is the essential factor in management of the child with asthma. The purpose of this study is to identify and understand the caring patterns of mathers of children with Athma by Q methodology. As a research method, 35 Q-statements were collected through individual interviews and review of related literatures. 37 subjects were interviewed and the data were analyzed by the PC QUANL program with principal component analysis. The were 3 different caring types classified as follows : Type I was the therapeutic compliance obeying type, compliancing medication and preventing cold etc. Type II was the physical strengthening type, taking Chinese medicine and folk remedy etc. Type III was the environment control type, managing house and environment clearly and ventilating room air etc. Therefore, it needs considering above each type in nursing care of the family and children with asthma.

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A Study on design inductor with PGS for improvement in Noise Figure of LNA (LNA 잡음 특성 개선을 위한 PGS 구조를 갖는 인덕터 설계에 관한 연구)

  • Ko, Jae-Hyeong;Kim, Dong-Hun;Kim, Hyeong-Seok
    • 한국정보통신설비학회:학술대회논문집
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    • 2008.08a
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    • pp.35-38
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    • 2008
  • In this paper, study noise performance of LNA to enhance Q-factor of input circuit by patterned ground shield is inserted inductor using TSMC 0.18um. Applied LNA technology is cascode method. The input matching circuit was constituted on-chip and wirebonding inductor. Taguchi's method is used for the best suited structure of PGS. We confirmed enhancement of Q-factor by inserted PGS into inductor. The input matching circuit enhanced Q-factor by inductor with PGS improve noise figure of LNA.

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Types of Students' Death Attitudes Majoring in Human Service Area : Q-Methodological Approach (휴먼서비스 전공분야 대학생의 죽음태도 유형 -Q 방법론적 접근-)

  • Jo Kae-Hwa;Lee Hyun Ji;Lee Yun Ju
    • Journal of Korean Academy of Nursing
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    • v.35 no.5
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    • pp.829-841
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    • 2005
  • Purpose: The purpose of this study was to analyze death attitudes of students majoring In the human service area, such as nursing science, education, and social welfare. Method: The Q-methodology which provides a method of analyzing the subjectivity of each item was used, The 38 selected Q-statements from each of 42 subjects were classified into a shape of normal distribution using a 9 point scale. The collected data was analyzed using a QUANL PC program. Result: Four types of death attitudes for research subjects in nursing, education, and social welfare areas were identified. Type I is fatalistic admission, Type II is pursuit of existential life, Type III is uncertainty of life after death, and Type IV is separation-connection between life and death. Conclusion: The results of the study indicate that different approaches of death educational programs are recommended based on the four types of death attitudes.

Electrical Properties of White OLEDs used such as $Zn(HPB)_2$ and Zn(HPB)q ($Zn(HPB)_2$와 Zn(HPB)q를 이용한 White OLEDs의 전기적 특성)

  • Jang, Yoon-Ki;Kim, Byoung-Sang;Kim, Doo-Seok;Lee, Burm-Jong;Kwon, Young-Soo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2006.06a
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    • pp.416-417
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    • 2006
  • Organic light emitting diodes (OLEDs) show a lot of advantages for display purposes. Because OLEDs provide white light emission with a high efficiency and stability, it is desirable to apply OLEDs as an illumination light source and back light in LCD displays. We synthesized new emissive materials, namely [2-(2-hydroxyphenyl)benzoxazole] ($Zn(HPB)_2$) and [(2-(2-hydroxyphenyl)benzoxazole)(8-hydoxyquinoline)] (Zn(HPB)q), which have a low molecular compound and thermal stability. We studied white OLEDs using $Zn(HPB)_2$ and Zn(HPB)q. The fundamental structures of the white OLEDs were ITO/PEDOT:PSS (23 nm)/NPB (40 nm)/$Zn(HPB)_2$ (40 nm)/Zn(HPB)q (20 nm)/$Alq_3$ (10 nm)/LiAl (120 nm). As a result, we obtained a maximum luminance of $15325\;cd/m^2$ at a current density of $997\;mA/cm^2$. The CIE(Commission International de l'Eclairage) coordinates are (0.28, 0.35) at an applied voltage of 9.75 V.

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