• Biomolecules & Therapeutics
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• 제22권1호
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• pp.41-46
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• 2014

Enterovirus 71 (EV71) is the predominant cause of hand, foot and mouth disease (HFMD). The antiviral activity of hederasaponin B from Hedera helix against EV71 subgenotypes C3 and C4a was evaluated in vero cells. In the current study, the antiviral activity of hederasaponin B against EV71 C3 and C4a was determined by cytopathic effect (CPE) reduction method and western blot assay. Our results demonstrated that hederasaponin B and 30% ethanol extract of Hedera helix containing hederasaponin B showed significant antiviral activity against EV71 subgenotypes C3 and C4a by reducing the formation of a visible CPE. Hederasaponin B also inhibited the viral VP2 protein expression, suggesting the inhibition of viral capsid protein synthesis.These results suggest that hederasaponin B and Hedera helix extract containing hederasaponin B can be novel drug candidates with broad-spectrum antiviral activity against various subgenotypes of EV71.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.561-568
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• 2014

Background: The skin is the largest body organ that regulates excretion of metabolic waste products, temperature, and plays an important role in body protection against environmental physical and chemical, as well as biological factors. These include agents that may act as oxidants or catalysts of reactions producing reactive oxygen species (ROS), reactive nitrogen species (RNS), and other oxidants in skin cells. An increased amount of the oxidants, exceeding the antioxidant defense system capacity is called oxidative stress, leading to chronic inflammation, which, in turn, can cause collagen fragmentation and disorganization of collagen fibers and skin cell functions, and thus contribute to skin diseases including cancer. Moreover, research suggests that oxidative stress participates in all stages of carcinogenesis. We report here a summary of the present state of knowledge on the role of oxidative stress in pathogenesis of dermatologic diseases, defensive systems against ROS/RNS, and discuss how physical activity may modulate skin diseases through effects on oxidative stress. The data show duality of physical activity actions: regular moderate activity protects against ROS/RNS damage, and endurance exercise with a lack of training mediates oxidative stress. These findings indicate that the redox balance should be considered in the development of new antioxidant strategies linked to the prevention and therapy of skin diseases.

• 품질경영학회지
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• 제31권4호
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• pp.1-18
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• 2003

Quality is a critical competitive factor in today's environment because of the impact of quality on costs and delivery. Many companies regard quality as a key concept of company strategy in order to achieve the competitive edge. Measuring and reporting quality cost is the first step in quality management program. The supposition of quality cost model is that investment in prevention activities will bring rewards from reduced failure costs, and that further investment in prevention activities will show profits from reduced appraisal costs. In this study, the degree of quality cost deviation is conceptualized. This means a deviation between the ideal and present ranking in the amounts of quality cost categories. This study analysed that the effect of its deviation on quality management activity and performance variables. However, there are no difference in these variables. The major reason is that most of companies are endeavoring for quality management but operating quality cost system unsystematically. The review against a prevention and appraisal activity is necessary.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 하계학술대회 논문집 A
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• pp.56-59
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• 2001

In this paper, we explained the prevention activity for the fault of transmission facilities, And also considered the methods to lessen faults through the analysis of faults to be occurred in the west and south of chung-nam province (Cheong-yang power transmission branch office) for several years recently, and then proposed a suitable countermeasure and direction for the fault prevention activity.

• 산업경영시스템학회지
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• 제34권4호
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• pp.89-97
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• 2011

Traditional quality control for manufacturing or service sector is not suitable for the quality control of a project as the project is one-time task constrained by time, cost, and quality. To meet the internal and external customers' requirements, quality costs approach to the project will be effective. Hence, we propose PONC (price of nonconformance) estimation procedure and a mathematical model, which are focused on activity-based prevention in the execution step and warranty step of EPLC (extended project life cycle). This procedure and model will help project manager develop preventive action plan for project quality costs minimization from nonconformance risk activities and PONC estimates information.

• 한국식품영양과학회지
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• 제28권6호
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• pp.1412-1423
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• 1999

This review contains a discussion of the physiological activity of the components of Allium vegetables. Organosulfur compounds in Allium vegetables, such as ajoene, diallyl sulfides and S allylcysteine, have cancer preventive activity in chemically induced animal cancer models. They also have inhibitory effects on proliferation of cancer cells in vitro. Allium vegetables have lipid and cholesterol lowering effect, and platelet aggregation inhibitory activity that help the prevention of cardiovascular diseases. Sulfur con taining compounds, especially allicin and ajoene, have antimicrobial activities against gram negative, positive bacteria and fungi. Moreover, Allium organosulfur compounds such as S allylcysteine showed reducing effects on the senescence related symptoms including cognition. Allium organosulfur compounds have significant importance in food industry as both biologically active ingredients and savory.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5207-5212
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• 2013

Background: Physical activity has been found to play a role in cancer prevention. The purpose of this matched case-control study was to investigate the association between physical activity levels, water intake, constipation and colorectal cancer (CRC). Materials and Methods: Two hundred and thirty-two patients diagnosed with CRC (125 male, 107 female) were enrolled in this case-control study. Cases were matched to 271 population controls (137 male, 134 female). Results: Drinking more than 4 cups of water daily decreased the risk of CRC by 33-42%; however, this effect was non-significant. Having constipation was found to be a significant risk factor for developing CRC with an OR=6.284 (95%CI=2.741-14.40). With reference to sedentary behavior, minimum activity (600-3000 Metabolic Equivalents Task (MET)) had 43% protection against CRC and the level of Health Enhancing Physical Activity OR was 0.58 (at 95%CI; 0.37-0.92). A significant negative association was found between CRC and physical activity levels expressed as both METs and MET-hours/week (p for trend=0.017 and 0.03, respectively). Among females, a significant trend of reduction in CRC by 62% was observed with increasing the level of physical activity expressed in MET (p for trend=0.04). Conclusions: The risk of CRC may be reduced by adopting a healthy lifestyle and practicing physically activity regularly, especially among females. Consuming adequate amounts of water and healthy bowel motility could also reduce the risk of CRC.

• 한국운동역학회지
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• 제16권1호
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• pp.19-30
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• 2006

The purpose of this study was to examine the effect of foot orthotics on the overall comfort and muscle activity during running. The subjects were 10 members from the joggers' club which consisted of 2 women and 8 men. These individuals ran on the treadmill by 4.0m/s speed with and without the custom foot orthotics. The data concerning the overall comfort was collected by a questionairre that examined the overall comfort, heel cushioning, forefoot cushioning, medio-lateral control, arch height, heel cup fit, shoe heel width, forefoot width, and shoe length The MegaWin ver. 2.1(Mega Electronics lid, Ma. Finland) was used to gain electromyography signals of the muscle activity; Tibialis anterior, medial gastronemius, lateral gastronemius, vastus lateralis, vastus medialis, biceps femoris, and rectus femoris were measured. The results of the study were as follows. 1. During running the overall comfort was higher for the foot arthotic condition than the nonorthotic condition. Among the inquiries the overall comfort showed the biggest difference comparing the two conditions. and the shoe heel width showed the highest score for contort. 2 The muscle activity of the biceps femoris, and vastus lateralis in the stance period decreased. due to the foot orthotics. The muscle activity of the vastus medialis in the swing period also decreased and the muscle activity tibialis anterior in the stance and swing stance decreased as well During running, orthotics showed positive result in foot comfort. The foot comfort related to decreased stress, muscle activity, and foot arch strain. Overall comfort and the adequate decrease of muscle activity were associated with injury prevention and the best method to prevent injury semms to be the maintenance of foot comfort.

• 한국콘텐츠학회논문지
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• 제10권2호
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• pp.306-319
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• 2010

근래 범죄예방이 무엇보다 중요한 형사정책의 한 축으로 자리매김 하면서 경찰활동도 기존과 다른 변화를 추구하고 있다. 근세 이후 범죄통제경향의 변화에서도 알 수 있듯, 종국적으로는 범죄예방이 범죄통제의 최선이라는 경험을 바탕으로 경찰의 역할에 대한 새로운 시각의 등장과 더불어 나타난 것이 지역사회 경찰활동이다. 또한 경찰활동에서 강조되는 것은 경찰활동의 다양화 지역사회의 적극적 참여라고 할 수 있다. 우리는 이와 관련하여 국내에서 발간된 "범죄예방론" 등 관련 서적을 통하여 미국의 범죄예방활동과 지역사회경찰활동에서 운용되는 프로그램을 접하고 있다. 그런데 관련 서적에 소개된 프로그램들이 마치 미국 전 지역에서 동일하게 이루어지는 것으로 오해될 소지가 있다. 본 연구에서는 미국 캘리포니아주산마테오 카운티에 속한 도시 가운데 비교 연구가 용이한 두 도시를 선정, 이들 도시에서 발생한 주요 범죄현황을 살펴보고 실제 이루어지고 있는 지역사회경찰활동프로그램 또는 범죄예방프로그램 운용 사례를 살펴보고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6657-6662
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• 2013

Background: The objective of this study was to investigate antioxidant and anti-inflammatory activity of cabbage phytochemicals. Materials and Methods: Color coordinates were evaluated by colorimetry, and the antioxidant and anti-inflammatory activities were analyzed by spectrophotometer for some common cabbage varieties. Results: Red heads had the highest total antioxidant contents followed by Savoy, Chinese and green heads. The Chinese variety had the highest ABTS (2,2-azino-di-(3-ethylbenzthiazoline-sulfonic acid) antioxidant activity, was 5.72 ${\mu}mol$ TE/g fw (Trolox equivalent). The green variety had the highest DPPH (free radical scavenging activity) antioxidant activity, which was 91.2 ${\mu}mol$ TE/g fw. The red variety had the highest FRAP (ferric reducing antioxidant power) antioxidant activity, which was 80.8 ${\mu}mol$ TE/g fw. The total phenol amounts were 17.2-32.6 mM trolox equivalent antioxidant capacity (TEAC) and the total flavonoid amounts were 40.0-74.2 mg quercetin per gram. Methanolic extracts of different cabbage heads showed different anti-inflammatory activity values. Chinese, Savoy and green heads had the highest anti-inflammatory activity, while red heads had the lowest. Conclusions: The results suggest that these varieties of cabbage heads could contribute as sources of important antioxidant and anti-inflammatory related to the prevention of chronic diseases associated to oxidative stress, such as in cancer and coronary artery disease.