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http://dx.doi.org/10.7314/APJCP.2013.14.9.5207

Physical Inactivity, Water Intake and Constipation as Risk Factors for Colorectal Cancer among Adults in Jordan  

Tayyem, Reema Fayez (Department of Clinical Nutrition and Dietetic, The Hashemite University)
Shehadeh, Ihab Numan (Gastroenterology Division, KHCC)
AbuMweis, Suhad Sameer (Department of Clinical Nutrition and Dietetic, The Hashemite University)
Bawadi, Hiba Ahmad (Department of Nutrition and Food Technology, Hashemite University)
Hammad, Shatha Sabri (Department of Clinical Nutrition and Dietetic, The Hashemite University)
Bani-Hani, Kamal Eddin (Faculty of Medicine, Hashemite University)
Al-Jaberi, Tareq Mohammad (Jordan University of Science and Technology)
Alnusai, Majed Mohammed (Gastroenterology Division, Prince Hamza Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.9, 2013 , pp. 5207-5212 More about this Journal
Abstract
Background: Physical activity has been found to play a role in cancer prevention. The purpose of this matched case-control study was to investigate the association between physical activity levels, water intake, constipation and colorectal cancer (CRC). Materials and Methods: Two hundred and thirty-two patients diagnosed with CRC (125 male, 107 female) were enrolled in this case-control study. Cases were matched to 271 population controls (137 male, 134 female). Results: Drinking more than 4 cups of water daily decreased the risk of CRC by 33-42%; however, this effect was non-significant. Having constipation was found to be a significant risk factor for developing CRC with an OR=6.284 (95%CI=2.741-14.40). With reference to sedentary behavior, minimum activity (600-3000 Metabolic Equivalents Task (MET)) had 43% protection against CRC and the level of Health Enhancing Physical Activity OR was 0.58 (at 95%CI; 0.37-0.92). A significant negative association was found between CRC and physical activity levels expressed as both METs and MET-hours/week (p for trend=0.017 and 0.03, respectively). Among females, a significant trend of reduction in CRC by 62% was observed with increasing the level of physical activity expressed in MET (p for trend=0.04). Conclusions: The risk of CRC may be reduced by adopting a healthy lifestyle and practicing physically activity regularly, especially among females. Consuming adequate amounts of water and healthy bowel motility could also reduce the risk of CRC.
Keywords
Colorectal cancer; physical activity; water intake; constipation;
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1 Alharbi N, Alshammari M, Almutairi B, Makboul G, El-Shazly M (2012). Knowledge, awareness, and practices concerning breast cancer among Kuwaiti female school teachers. Alexandria J Med, 48, 75-82.   DOI   ScienceOn
2 Boutron-Ruault MC, Senesse P, Meance S, Belghiti C, Faivre J (2001). Energy intake, body mass index, physical activity, and the colorectal adenoma-carcinoma sequence. Nutr. Cancer, 39, 50-7.   DOI   ScienceOn
3 Breslow R, Sorkin J, Frey C, Kessler L (1997). Americans' knowledge of cancer risk and survival. Prev Med, 26, 170-7.   DOI   ScienceOn
4 Campbell P, Cotterchio M, Dicks E, et al (2007). Excess body weight and CRC risk in Canada: associations in subgroups of clinically defined familial risk of cancer. Cancer Epidemiol Biomarkers Prev, 16, 1735-44.   DOI   ScienceOn
5 Fu Z, Shrubsole M, Smalley W, et al (2012). Lifestyle factors and their combined impact on the risk of colorectal polyps. Am J Epidemiol, 176, 766-76.   DOI   ScienceOn
6 Clinton SK, Bostwick DG, Olson LM, Mangian HJ, Visek WJ (1988). Effects of ammonium acetate arid sodium cholate on N-methyl-N0-nitro-N-nitrosocolon colon carcinogenesis of rats. Cancer Res, 48, 3035-9.
7 Dobrila-Dintinjana R, Trivanovic D, Zelic M, et al (2012). Nutritional support in patients with CRC during chemotherapy: does it work? Hepatogastroenterology, 60, 475-80.
8 Friedenreich C, Orenstein M (2002). Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr, 132, 3456-64.   DOI
9 Giovannucci E (1995). Insulin and colon cancer. Cancer Causes Control, 6, 164-79.   DOI
10 Iber FL, Parveen S, Vandrunen M, et al (1993). Relation of symptoms to impaired stomach, small bowel, and colon motility in long-standing diabetes. Dig Dis Sci, 38, 45-50.   DOI
11 Kotake K, Koyama Y, Nasu J, Fukutomi T, Yamaguchi N (1995). Relation of family history of cancer and environmental factors to the risk of CRC: a case-control study. Jpn J Clin Oncol, 25, 195-202.
12 Kune GA, Kune S, Watson LF (1990). Body weight and physical activity as predictors of CRC risk. Nutr Cancer, 13, 9-17.   DOI   ScienceOn
13 Marchand L, Wilkens L, Kolonel L, Hankin J, Lyu LC (1997). Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of CRC. Cancer Research, 57, 4787-94.
14 Lee IM, Paffenbarger RS Jr, Hsieh C (1991). Physical activity and risk of developing CRC among college alumni. J Natl Cancer Inst, 83, 1324-9.   DOI
15 Lee RD, Nieman DC (2010). Nutritional Assessment. 5th ed. New York: McGraw Hill.
16 Meyerhardt J, Giovannucci E, Holmes M, et al (2006). Physical activity and survival after CRC diagnosis. J Clin Oncol, 24, 3527-34.   DOI   ScienceOn
17 McKeown-Eyssen G (1994). Epidemiology of CRC revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomarkers Prev, 3, 687-95.
18 McTiernan A (2008). Mechanisms linking physical activity with cancer. Nat Rev Cancer, 8, 205-11.   DOI   ScienceOn
19 Nakamura T, Imamura K, Kasai F, et al (1993). Fecal excretions of hydroxy fatty acid and bile acid in diabetic diarrheal patients. J Diabetes Complications, 7, 8-11.   DOI   ScienceOn
20 Narisawa T, Magadia NE, Weisburger JH, Wynder EL (1974). Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-Nnitrosoguanidine in rats. J Natl Cancer Inst, 53, 1093-7.   DOI
21 Nilsen T, Vatten L (2001). Prospective study of CRC risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis. Bri J Cancer, 84, 417-22.   DOI   ScienceOn
22 Peppone L, Hyland A, Moysich K, et al (2009). Examining the association between cigarette smoking and CRC using historical case-control data. Cancer Epidemiol, 33, 182-8.   DOI   ScienceOn
23 Roberts M, Millikan R, Galanko J, Martin C, Sandler R (2003). Constipation, laxative use, and colon cancer in a North carolina population. Am J Gastroenterol, 98, 857-64.   DOI
24 Peters RK, Garabrant DH, Yu MC, Mack T (1989). A casecontrol study of occupational and dietary factors in CRC in young men by subsite. Cancer Res, 49, 5459-68.
25 Reddy BS, Watanabe K, Weisburger JH, Wynder EL (1977). Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res, 37, 3238-42.
26 Shannon J, White E, Shattuck A L, Potter JD (1996). Relationship of food groups and water intake to colon cancer risk. Cancer Epidemiol Biomarkers Prev, 5, 495-502.
27 Sallis JF, Haskell WL, Wood PD (1985). Physical activity assessment methodology in the five-city project. Am J Epidemiol. 121, 91-106.   DOI
28 Sanchez-Lara K, Ugalde-Morales E, Motola-Kuba D, Green D (2013). Gastrointestinal symptoms and weight loss in cancer patients receiving chemotherapy. Br J Nutr, 109, 894-7.   DOI   ScienceOn
29 Simons C, Hughes L, Engeland M, et al (2013). Physical activity, occupational sitting time, and CRC risk in the Netherlands cohort study. Am J Epidemiol, 177, 514-30.   DOI   ScienceOn
30 Slattery M L, Edwards S, Curtin K, et al (2003). Physical activity and CRC. Am J Epidemiol, 158, 214-24.   DOI   ScienceOn
31 Steindorf K, Tobiasz-Adamczyk B, Popiela T, et al (2000). Combined risk assessment of physical activity and dietary habits on the development of CRC. A hospital-based casecontrol study in Poland. Eur J Cancer Prev, 9, 309-16.   DOI
32 Stewart BW, Kleihues P (2003). World cancer report. Geneva, World Health Organization/Lyon, International Agency for Research on Cancer.
33 Ugajin H (1989). The role of bile acids with physiological concentration in colon carcinogenesis. Nippon Shoukakibyo Gakkai Zasshi, 86, 1627-37.
34 Tang R, Wang J, LO S, Hsieh L (1999). Physical activity, water intake and risk of CRC in Taiwan: a hospital-based casecontrol study. Int J Cancer, 82, 484-9.   DOI
35 Wolin K, Tuchman H (2011). Physical activity and gastrointestinal cancer prevention. Recent Results Cancer Res, 186, 73-100.
36 Thune I, Lund E (1996). Physical activity and risk of CRC in men and women. Bri J Cancer, 73, 1134-40.   DOI
37 Whittemore A, Wu-Williams A, Lee M, et al (1990). Diet, physical activity, and CRC among Chinese in North America and China. J Natl Cancer Inst, 82, 915-26.   DOI
38 Wu AH, Paganini-Hill A, Ross RK, Henderson BE (1987). Alcohol, physical activity and other risk factors for CRC: a prospective study. Bri J Cancer, 55, 687-94.   DOI
39 Zarkovic M, Qin X, Nakatsuru Y, et al (1993). Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model. Carcinogenesis, 14, 1261-4.   DOI   ScienceOn
40 Slattery ML, Ballard-Barbash R, Edwards S, Caan BJ, Potter JD (2003). Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States). Cancer Causes Control, 14, 75-84.   DOI   ScienceOn