• The Korean Journal of Physiology and Pharmacology
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• v.20 no.5
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• pp.547-556
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• 2016

Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing $K^+$ channels (TASK-2) might be one of the candidates for the regulation of uterine circular smooth muscles in mice. In this study, we tried to show the mechanisms of relaxation via TASK-2 channels in marine myometrium. Isometric contraction measurements and patch clamp technique were used to verify TASK conductance in murine myometrium. Western blot and immunehistochemical study under confocal microscopy were used to investigate molecular identity of TASK channel. In this study, we showed that TEA and 4-AP insensitive non-inactivating outward $K^+$ current (NIOK) may be responsible for the quiescence of murine pregnant longitudinal myometrium. The characteristics of NIOK coincided with two-pore domain acid-sensing $K^+$ channels (TASK-2). NIOK in the presence of $K^+$ channel blockers was inhibited further by TASK inhibitors such as quinidine, bupivacaine, lidocaine, and extracellular acidosis. Furthermore, oxytocin and estrogen inhibited NIOK in pregnant myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed stronger inhibition of NIOK by quinidine and increased immunohistochemical expression of TASK-2. Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretch-activated channels in the longitudinal myometrium of mouse. Activation of TASK-2 channels seems to play an essential role for relaxing uterus during pregnancy and it might be one of the alternatives for preventing preterm delivery.

• Land and Housing Review
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• v.3 no.2
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• pp.127-136
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• 2012

The Korean government designated 10 innovation cities throughout the country in 2005 in order to resolve concentration on the capital region and to promote balanced development of localities. An innovation city is a future-type city equipped with environment for innovation and high-quality settlement environment in terms of residence, education and culture by accommodating public institutions and facilitating close cooperation among companies, universities and research institutes. Thus, for the early settlement and activation of innovation cities, this study suggested a plan to operate the current innovation city business centers from a mid- and long-term viewpoint rather than for a limited time. Through this study, we attempt to establish the roles of the centers so that they can play central roles in the move of public institutions, the development of industry-university-research institute clusters, the creation of innovations, and the spread of innovations, which are the goals of the development of public institutions, after the sites have been prepared.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.74-82
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• 2016

The term research institute spin-offs refers to new firms created by public research institutes. These spin-offs are different from other start-ups in two respects: on the one hand, they should be located in the Special Research and Development Zones and, on the other hand, these firms are supposed to commercialize the results of public R&D activities. These spin-off firms show higher rates of survival and job creation than general new firms, which means that their contribution to economic growth is not negligible. The present study analyzes the factors affecting research institute spin-offs using a random effect panel logit model and negative binomial model. From previous studies, four elements are identified as playing an important role in the commercialization of public R&D through spin-offs, namely their organizational character, research capability, technological character, and geographical location. The empirical results demonstrate that government research institutes with more researchers and patents are more likely to create new firms. In addition, the location of the institutes significantly affects the probability of their creating spin-offs and their number. When the technological stage and TLO size are considered, however, it turns out that the number of researchers and technological stage play important roles in the spin-offs.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.10
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• pp.309-317
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• 2019

This study examined the effects of cooperative art activities according to visiting a forest on fulfilling young children's leadership ability and happiness. To achieve this, a study was conducted on experimental and non-experimental groups of 20 young children in classes A and B at S kindergarten, and also a group of children of the same age in a similar environment. The 16-session forest experience play activity program was planned for conducting research on the children's leadership ability and happiness fullness when using the Nuri curriculum, and this was carried out on the experimental group for 2 months. The pre- and post-analyses were carried out on the non-experimental group after outdoor activities on the topic of the Nuri curriculum-related activities. The results were as follows. First, cooperative art activities through the forest experience had a positive effect on the children's reinvention ability, human relations, goal achievement and direction power, which are all sub-factors of their leadership. Second, cooperative art activities through the forest experience had a positive effect on positive emotions, commitment, personal relations, meaning and achievement, which are sub-factors of their total happiness. Overall, their cooperative art activities during the forest experience were judged to be facilitating factors that have a positive effect on their leadership and happiness fullness.

• Journal of Wetlands Research
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• v.21 no.1
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• pp.84-94
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• 2019

The Seocheon and Yubu Island mudflats in Geum Estuary are important stopover sites for migratory birds as energy supplementation area in the East Asia-Australasian Flyway. Benthic invertebrates in the tidal flats are important food resources for the migratory birds. In other words, benthic invertebrates in the tidal flats play an important ecological role in energy flow. This study was conducted to investigate the relationship between benthic invertebrate assemblages and environmental factors in Seocheon and Yubudo tidal flats in the Geum Estuary. As a result of the benthic invertebrate assemblage during the fall migration season, the total species number was 147, density and biomass were $1,772{\pm}1,342individuals/m^2$ and $445.1{\pm}807.6g/m^2$, respectively. Based on the appearance species and the density data, the result of analysis of mutual similarity among sampling sites was divided into two groups. Group A was the Macrophthalmus-Heteromastus community and Group B was the Spio-Urothoe-Mandibulophoxus community. Group B showed higher mean species number, density and biomass than Group A. The BIO-ENV analysis showed that the benthic invertebrate assemblages were most affected by the combination of sand content % and sediment sorting (${\rho}=0.500$). The variables of significant relationship with species number and biomass were sediment sorting (p=0.015) and the pore water DO(Dissolved Oxygen, p=0.003) in sediment, respectively.

• Korean Journal of Biological Psychiatry
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• v.26 no.1
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• pp.8-13
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• 2019

Objectives Disrupted integrities of the fornix and stria terminalis have been suggested in schizophrenia. However, very few studies have focused on the fornix and stria terminalis comparing first-episode schizophrenia (FESZ), chronic schizophrenia (CS), and healthy controls (HCs) with the application of diffusion-tensor imaging (DTI) technique. The objective of this study is to compare the connectivity of the fornix and stria terminalis among FESZ, CS, and HCs. Methods We included the 44 FESZ patients, 39 CS patients and 20 HCs in this study. Voxel-wise statistical analysis of the fractional anisotropy (FA) data was performed using Tract-Based Spatial Statistics to analyze the connectivity of fornix and stria terminalis. In addition, the Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS) were used to evaluate clinical symptom severities. Results There were no significant differences between the FESZ, CS, and HCs in age, sex, education years. The SAPS and SANS scores of the schizophrenia groups showed no significant differences. FA values of the right fornix cres/stria terminalis in the CS group were significantly lower than those in FESZ and HCs. There were no significant differences of FA values of the right fornix cres/stria terminalis between the FESZ and the HCs. Pearson correlation analyses revealed that significant correlation between FA values of the right fornix cres/stria terminalies of the the FESZ group and positive, negative symptom scales, and FA values of the right fornix cres/stria terminalis of the CS group and negative symptom scales. Conclusions This study shows that FA values of the fornix and stria terminalis in the CS were lower than in the FESZ and the HCs. These results suggest that the fornix and stria terminalis can play a role in pathophysiology of schizophrenia. Thus current study can broaden our understanding of the pathophysiology of schizophrenia.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.2
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• pp.218-227
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• 2019

The term practical means that you actually use what you learn. Unlike that meaning, however, the curriculum is operated by specific majors of some professors. And we can be seen in many colleges. Jazz is a prime example. Jazz is a genre only for some maniacs and there is not much places to play on the pop scene. But this genre is now packaged as representative studies of practical music. This affects even cram schools, preparing for college entrance exams, while high school students are also learning, playing and preparing Jazz to take the exams. Of course, Jazz is a field of music, but it is a very sad reality, considering it can never be the mainstream of popular music. It has been 20 years since the department of practical music was established at a four-year university. The number of graduates will also be very large. Now that the role of a university is related to employment, it's time to look at how the graduates are getting jobs and whether they are working in music. And it will also be important to ensure that the curriculum of the department is reasonably managed to connect with employment in reality. Practical learning will be not only respond immediately to market changes but establishment and operation of education courses should be carried out accordingly. In this study, we will discuss curriculum of vocal at universities, concrete examples of operations, and reasonable vocal courses that can be connected to employment.

• Journal of Music and Human Behavior
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• v.15 no.2
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• pp.23-39
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• 2018

The purpose of this research was to investigate the effects of respiratory rehabilitation using a wind instrument for patients suffering from spinal cord injuries. From January 15, 2018 to April 15, 2018, we conducted ten 1-hour sessions of a harmonica program with eight patients with spinal cord injuries with average age of 37 years who could not perform abdominal breathing by themselves. We measured and compared patients' breathing capacity before and after the 10 sessions. Designed particularly for patients with spinal cord injuries resulting in a limited range of neck movement, the study used a 10-hole diatonic harmonica whose length was relatively short. For those patients who had difficulty using their hands, a harmonica holder was provided. Participants were trained to play simple tunes. They were guided to use abdominal breathing to make sounds, with emphasis on those parts requiring long and strong breathing. The results showed that for all eight patients both their breathing volume and their inspiratory volume increased following participation in the harmonica program. Also, the program had psychological benefits (e.g., more life satisfaction and less sadness) and additional physical benefits (e.g., less dizziness due to low blood pressure and better phlegm spitting). This study offers a unique way to help patients with spinal cord injuries to improve their breathing capacity, which may also be associated with a greater quality of life.

• The Journal of Sustainable Design and Educational Environment Research
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• v.18 no.1
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• pp.49-61
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• 2019

In this study, interviews are held with the faculties of two elementary schools on narrow sites located in Seoul to examine the existing problems of the elementary school on narrow site and the need for the new facilities of the elementary school on narrow site in order to derive the implications for the planning guidelines of such school construction. As a result of the survey, it was found that the substitutes of the playground installed in the elementary school on narrow site were not suitable for physical play activities, physical education class activities, and other curriculum operations. In order to secure an adequate physical activity an space for elementary schools, faculty members were demanding that the entire floor or rooftop of the school building be spatialized for physical activities. Additionally, problems such as noise generation and the lack of special rooms and public space were occurring in the elementary schools on narrow sites and are being deteriorated by accommodating an over number of students, and therefore policies are required to ensure that the appropriate number of students are maintained in the case of the schools on narrow sites.

• The Korean Journal of Applied Statistics
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• v.33 no.6
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• pp.823-832
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• 2020

The analgesic effects of music in people with glasses on perceived pain through cold-pressor task (CPT) is assessed based on three-sequence, three-period, crossover trial with three treatment conditions(music-listening, news-listening, and no-sound) to each subject. Fifty subjects are divided into three sequence groups by randomization, and CPTs under the pre-assigned treatment conditions at each period are performed. Pain responses after each CPT, subjects' pain tolerance (PT) in time scale and pain intensity (PI) and pain unpleasantness (PU) in visual analog scale (VAS) are measured. After classifying the group by whether or not to wear glasses, which is the phenotype of the myopia gene, pain responses are compared by F-tests and Tukey's multiple comparisons. CPT pain responses in group with glasses during the music intervention are significantly different from responses during the news intervention and the control conditions, respectively. This study investigates the pain responses of music intervention in the group wearing glasses, which can be seen as a phenotype of the nearsighted gene, and this result would play a role in explaining the biopsychosocial model of the pain mechanism.