• Journal of Pharmacopuncture
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• v.11 no.4
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• pp.79-86
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• 2008

Objectives The purpose of this study is to report the effect of Hominis Placenta Pharmacopuncture(HPP) for patients with asthma. Methods We treated three patients who have asthma with HPP. To check the effect of HPP we used CAMSOM-V. To check the satisfaction of HPP we used Five-point Likert scale. Results After treatment symptoms were improved. CAMSOM-V decreased in all cases. The Likert scale points were checked 5 and 4 and 4. Conclusions In this study, we have found the meaning of the research that HPP, in the future will be efficacious against asthma.

• Journal of Oriental Neuropsychiatry
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• v.30 no.4
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• pp.357-369
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• 2019

Objectives: This study was designed to examine the effect of Hominis Placenta Pharmacopuncture on the change in behavior, sleep-related hormones, inflammatory cytokines, anti-oxidants, weight, blood, and serum on rats given chronic physical stress. Methods: Wistar rats older than age 10 weeks were used in this experiment. They were divided into six groups. The normal group was not given stress. The control group was given only chronic physical stress and no treatment. The positive control group was given chronic physical stress and treated with zolpidem. Three Hominis Placenta Pharmacopuncture (HPP) groups were given chronic physical stress, then treated with different concentrations of HPP; HPP-0.5× (0.5 times diluted), HPP-1× (undiluted) and HPP-2× (2 times condensed). The changes of values of Nestlet Shredding results, weight, Melatonin, Gamma-aminobutylic Acid (GABA), Tumor Necrosis Factor Alpha (TNF-α), Interleukin-6 (IL-6), Superoxide dismutase (SOD), glutathione peroxidase (GPx), AST, ALT, BUN, Creatinine, and leukocytes were observed during the experiment. Results: The changes in chronic physical stress of the rat model were as follow. The Nestlet Shredding result increased in the control group compared to the normal group (p<0.05), and decreased in the HPP-1× and HPP-2× compared to the control group (p<0.05). The amount of weight gain showed increasing tendency in the HPP-2× compared to the control group since the second week. The GABA increased (p<0.05) and Melatonin also showed certain increasing tendency in the HPP-1× and HPP-2× compared to the control group. The TNF-α and IL-6 increased in the control group compared to the normal group (p<0.01), and decreased in all the HPPs compared to the control group (p<0.05). The SOD level decreased in the control group compared to the normal group (p<0.01), and increased in all the HPPs compared to the control group (p<0.05). GPx, AST, ALT, Bun, Creatinine and leukocytes showed no noticeable difference among all groups. Conclusions: Hominis Placenta Pharmacopuncture was effective in increasing weight, GABA, Melatonin, SOD, and decreasing Nestlet Shredding and inflammatory cytokines, suggesting that it consequently facilitates in relieving physical stress.

• Journal of Pharmacopuncture
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• v.8 no.3
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• pp.87-97
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• 2005

Objectives : This study has been designed and performed to identify the effect on Bell's palsy according to the injection of herbal medicine induced from the Hominis Placenta. Methods : We measured the facial palsy changes of the patients who were admitted for Bell's palsy in the Oriental Medical hospital of Dongeui medical center from 03-01-2004 to 07-31-2004. Bell's palsy patients were divided into two groups. One group(A group) was injected with Hominis Placenta herbal acupuncture. The other group(B group) was injected with normal saline. Then effects of these treatment was evaluated by Yanagihara's unweighted grading system. Results : A group was marked more higher than B group in treatment outcome. we discovered that it is significant differences between two groups after 4 week. Conclusions : These results provided that A group is more effective than B group. For clearly proving the effect of Hominis Placenta herbal acupuncture on Bell's palsy, it is need more sample's number and more treatment's duration.

• Journal of Pharmacopuncture
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• v.4 no.1
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• pp.123-124
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• 2001

Purpose. Free radicals are implicated in the pathophysiology of aging, ischemic injury and neurodegenerative disorders. To deform]no whether Hominis Placenta extract prevents $H_2O_2$-induced apoptosis, we have performed morphological and biochemical analyses for the detection of apoptotic phenomena in the pineal tumor cell line $PGT-{\beta}$ We have also peformed cytochemical and immunocytochemical analyses for the detection of changes in nitric oxide synthase (NOS) activity and estimated the expression . of apoptotic genes using reverse transcription-polymerase chain reaction (RT-PCR) Methods. $PGT-{\beta}\;cells$ were pretreated with Hominis Placenta extracts $(0,\;10^{-2}\;{\mu}g/ml)$ for 2 hours and then exposed to $H_2O_2\;(0,\;50\;{\mu}M)$ for 3 hours. Appearance of apoptotic characteristics were monitored using 4, 6-diamidino-2-phenylindole dihydrochloride (DAPI) staining assay, terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay and flow cytometric analysis. NOS activity was measured by NADPH-diaphorase cytochemistry. Expression of inducible NOS (iNOS) and nuclear factor kappa B (NF k B) was assessed via immunocytochemistry. The expression of apoptotic genes was examined by RT-PCR. Results. After 3 flours of exposure to $H_2O_2$, it was shown that $PGT-{\beta}\;cells$ treated with $H_2O_2(50\;{\mu}M)$ exhibit classical apoptotic features and increases in NOS activity and caspase-3 expression. Treatment with Hominis Placenta extract resulted in a reduced occurrence of apoptotic features. DAPI staining, TUNEL and flow cytometric assays revealed decreases in the occurrence of nuclear fragmentation and in the sub-Gl fraction in the $PGT-{\beta}\;cells$ treated with Hominis Placenta extract. Cells treated with Hominis Placenta extract also showed lower activity of NADPH-diaphorase and immunoreactivities of both iNOS and NF k B than those of $H_2O_2$-treated cells which were not treated with Hominis Placenta extract. By RT-PCR, it was shown that the level of caspase-3 mRNA was derreased In the cells treated with Hominis Placenta . extract. Conclusions. This study shows that Hominis Placenta extract prevents $H_2O_2$-induced apoptosis in $PGT-{\beta}\;cells$; inhibitions of iNOS and caspnse-3 are possible mechanisms of the protection against apoptosis.

• Journal of Pharmacopuncture
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• v.8 no.1
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• pp.45-49
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• 2005

Purpose : The purpose of this study was to identify the effects of Hominis Placenta Herbal Acupuncture(HPA) combined with Acupuncture compared with Acupuncture therapy. Methods : Data was collected from October 1st 2004 to February 28th 2005. A total of 8 women participated in this study. Of all subjects, 4 and 4 subjects were assigned to the experimental and the control group respectively. Subjects were treated three times a week. We used Visual Analogue Scale(VAS) for evaluating the effects of HPA. Results : There showed statistically boardline significance between the experimental group and control group(p=0.057). Conclusion : The results showed HPA has significant effects on menstrual cramps.

• Journal of Pharmacopuncture
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• v.3 no.1
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• pp.89-99
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• 2000

This report was done to observe the effect of Hominis placenta herbal acupuncture on Bell's palsy. The study group comprised 16 patients who arrived at Woo-suk university oriental hospital from January, 1999 till January, 2000 for Bell's palsy. All patients were divided into two group. One was herbal acupunture group, and the other was control group. Acupunture group was done herbal acupuncture therapy on the facial acupuncture points. Followings are achievement and a term of each group. In herbal acupuncture group, 100% motor recovery was 7 case, 75% was 1 case, and 25% motor recovery term was $7.38{\pm}5.21$ days, 50% was $11.00{\pm}6.16$ days, 75% was $15.13{\pm}9.55$ days, 100% was $23.14{\pm}7.97$ days. In control group, 100% motor recovery was 4 case, 75% was 2 case, 25% below was 2 case and 25% motor recovery term was $11.17{\pm}4.96$days, 50% was $18.17{\pm}6.82$ days, 75% was $29.50{\pm}6.95$ days, 100% was $44.00{\pm}11.49$ days. The above results indicate that Hominis placenta herbal acupuncture is a useful effect on Bell's palsy. thus, continuous herbal acupunture study will be needed for more clinical application on Bell' palsy.

• Journal of Pharmacopuncture
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• v.4 no.2
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• pp.27-33
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• 2001

Objectives : The treatment of Bell's palsy must be divided into three states(acute, subacute and healing state). 41 cases of the patient suffering from Bell's palsy were treated and observed from january 2000 to July 2001. The usage of herbal acupunctures on that disease have been effective. So I propose a method of herbal acupunctures on Bell's palsy. Methods : By the states(acute, subacute and healing state) of Bell's palsy, SY(消炎) herbal acupuncture is used at the acute state, Hominis Placenta(紫河車) at the subacute, JGH(中氣下陷) at the healing state. Results : 1. At the acute state, SY(消炎) herbal acupuncture is effective to postauricular pain. 2. At the subacute state, Hominis Placenta(紫河車) herbal acupuncture is effective to decreasing pain and improving symptoms. 3. By the states(acute, subacute and healing state) of Bell's palsy, SY(消炎), Hominis Placenta(紫河車) and JGH(中氣下陷) herbal acupuncture is effective to improving symptoms of Bell's palsy.

• Journal of Pharmacopuncture
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• v.17 no.4
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• pp.15-21
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• 2014

Objectives: The purpose of this study was to investigate the current trends in research on pharmacopuncture in Korea since 2007. Methods: A literature review was performed by using the search engines 'Science and Technology Society Village', 'Korean Studies Information Service System', 'National Discovery for Science Leaders', and 'Oriental Medicine Advanced Searching Integrated System' in Korea from January 2007 to December 2013. Searched key words were 'pharmacopuncture', 'herbal acupuncture', 'aqua-acupuncture', and 'bee venom'. Finally, we selected 457 papers, including Korean experimental studies and clinical studies. Selected papers were classified according to year of publication, type of pharmacopuncture, disease & topic, research type and the publishing journal. Results: One hundred fifty pharmacopunctures were studied in 457 papers. Single compound pharmacopuncture was the most studied pharmacopuncture in experimental studies while animal-based pharmacopuncture was the most studied pharmacopuncture in clinical studies. Bee venom placed first among the various pharmacopunctures, followed by placenta, sweet bee venom, mountain-ginseng, and anti-inflammatory pharmacopunctures. Experimental research on pharmacopuncture has fallen since 2007 when 55 papers were published. However, clinical research has been increasing steadily. In clinical studies, case reports were numerous than randomized clinical trials (RCTs). Musculoskeletal diseases were the most frequently-treated diseases in studies on pharmacopuncture; among the musculoskeletal diseases, rheumatoid arthritis was the most frequently-treated disease in experimental studies and low back pain was the most frequently-treated condition in clinical studies. Since 2007, 45 different journals have published studies on pharmacopuncture, with the Journal of the Korean Acupuncture and Moxibustion Medicine Society having the largest number of papers on pharmacopuncture and the Journal of Pharmacopuncture the second largest number. Conclusion: The trends in research on pharmacopuncture published in studies from 2007 to 2013 were similar to those in studies published before 2006. Many studies on pharmacopuncture focused on bee venom and musculoskeletal diseases. Additional studies on diverse types of and indications for pharmacopuncture are needed.

• Journal of Oriental Neuropsychiatry
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• v.30 no.3
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• pp.265-274
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• 2019

Objectives: The purpose of this study was to research the trend related to pharmacopuncture for insomnia in China for further development of pharmacopuncture in Korea. Methods: This study reviewed and analyzed 21 Chinese journals related to pharmacopuncture 2013~2019 sourced with the following keywords in the China National Knowledge Infrastructure (CNKI). 'Shimian', 'Wuewei zhushe', 'Shuizhen', 'Xuewei yaowu zhushe', 'Yaowu xuewei zhushe', 'Xuewei zhuyao', 'Xuezhu', and 'Xueweiyaowu zhuru'. Results: The following results were obtained in this study. 1. A total of 21 papers were selected, comprised of clinical research and case reports. 2. Pharmacopuncture was often used for insomnia, and as the medicine of injection, Salvia, Gastrodin, Acanthopanax, Hominis Placenta, Qingkailing, Shenmai, Bozhi Glycopeptide, Fufang Danggui, Vitamin B12, and Chlorpromazine Hydrochloride were used. 3. In combined treatments, acupuncture, chiropractic, auricular sticking, and herbal medicine were used. 4. It was more effective compared to conservational acupuncture therapy. Conclusions: It was established that they have efficiency to treat insomnia with pharmacopuncture in China, but there were limitations in this study, so we need more research to identify new medicines for neuropsychiatric diseases.

• Journal of Oriental Neuropsychiatry
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• v.32 no.3
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• pp.141-154
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• 2021

Objectives: Pharmacopuncture is a Korean medicine treatment that combines acupuncture and herbal medicines. The aim of this study was to investigate the current usage status of pharmacopuncture for insomnia among Korean medicine doctors (KMDs). Methods: We conducted a self-reporting online survey targeting KMDs from February 23 to March 15, 2021 with cooperation of the Association of Korean Medicine. Responses of 957 KMDs were analyzed. Results: Types of pharmacopuncture mainly used in treatment for insomnia were placenta pharmacopuncture and Hwangryunhaedok-tang pharmacopuncture. Cephalic and facial region were preferred as the treatment site. For one treatment, total usage of pharmacopuncture was more than 0.5 cc but less than 1 cc. Among respondents, the largest number of respondents thought that clinical experience and patient symptoms were important as selection criteria of acupoints using Pharmacopuncture for insomnia. Average treatment duration of using Pharmacopuncture for insmonia was more than 4 weeks. Most KMDs preferred treatment for one to four times a week regarding the treatment cycle. The use of Pharmacopuncture for insomnia was recognized as having a good effect, although other KMDs were concerned about the insufficient evidence and the high cost due to non-reimbursement of pharmacopuncture therapy. Conclusions: In order to activate pharmacopuncture treatment for insomnia, it is necessary to secure effectiveness and safety through basic research, create evidence through clinical research, and reduce costs for patients.