• Journal of Periodontal and Implant Science
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• 제43권4호
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• pp.177-182
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• 2013

Purpose: Diabetes and periodontal disease are two common diseases with high prevalence rates. Recent evidence has shown a bidirectional relationship between diabetes and periodontitis. The aim of this study was to investigate the effects of nonsurgical periodontal therapy on glycemic control in type 2 diabetes mellitus patients. Methods: Sixty subjects aged 35-45 years with blood sugar controlled by oral hypoglycaemic agents were randomly divided equally among 3 groups: group A (scaling, mouthwash, and brushing), group B (mouthwash and brushing), and group C (brushing only). Glycated haemoglobin (HbA1c), fasting blood sugar (FBS), probing pocket depth (PPD), gingival index (GI), plaque index (PI), and the relevant drug history were recorded at baseline and after 3 months of intervention. Comparison of the mean difference among the variables was performed by parametric and nonparametric tests, which were further evaluated using multiple regression analysis. Results: The mean differences between the PPD, FBS, HbA1c, GI, and PI in groups A and B were found to be statistically significant (P<0.001). Multiple regression analysis in group A showed that out of all the independent variables, GI and frequency of drug administration independently (b=0.3761 and b=0.598) showed a significantly greater impact on HbA1c ($R^2$=0.832, P<0.05). Conclusions: Nonsurgical periodontal therapy can effectively decrease HbA1c levels in type 2 diabetes mellitus patients on medication.

• Animal Bioscience
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• 제34권6호
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• pp.957-966
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• 2021

Objective: Ovarian follicular development, which dependent on the proliferation and differentiation of granulosa cells (GCs), is a complex biological process in which miRNA plays an important role. Our previous study showed that miR-458b-5p is associated with ovarian follicular development in chicken. The detailed function and molecular mechanism of miR-458b-5p in GCs is unclear. Methods: The luciferase reporter assay was used to verify the targeting relationship between miR-458b-5p and catenin beta-1 (CTNNB1), which is an important transcriptional regulatory factor of the Wnt/β-catenin pathway. The cell counting kit-8 (CCK-8) assay, flow cytometry with propidium iodide (PI) and annexin V-fluorescein isothiocyanate (FITC) labeling were applied to explore the effect of miR-458b-5p on proliferation, cell cycle and apoptosis of chicken GCs. Quantitative real-time polymerase chain reaction and Western blot were used to detect the mRNA and protein expression levels. Results: We demonstrated that the expression of miR-458b-5p and CTNNB1 showed the opposite relationship in GCs and theca cells of hierarchical follicles. The luciferase reporter assay confirmed that CTNNB1 is the direct target of miR-458b-5p. Using CCK-8 assay and flow cytometry with PI and Annexin V-FITC labeling, we observed that transfection with the miR-458b-5p mimics significantly reduced proliferation and has no effects on apoptosis of chicken GCs. In addition, miR-458b-5p decreased the mRNA and protein expression of CD44 molecule and matrix metallopeptidase 7, which are the downstream effectors of CTNNB1 in Wnt/β-Catenin pathway and play functional roles in cell proliferation. Conclusion: Taken together, the data indicate that miR-458b-5p regulates ovarian GCs proliferation through Wnt/β-catenin signaling pathway by targeting CTNNB1, suggesting that miR-458b-5p and its target gene CTNNB1 may potentially play a role in chicken ovarian follicular development.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2001년도 Proceedings ICPE 01 2001 International Conference on Power Electronics
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• pp.374-379
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• 2001

In this paper, a novel design algorithm of speed controller for an Induction motor with the inertia variation is proposed. The main contribution of our work is a very robust, reliable and stable procedure for setting of the PI gains against the specified range of the inertia variation of an induction motor using Kharitonovs robust control theory. Therefore, the basic segment of controller design, the variation of induction motor inertia is estimated by the RLS (Recursive least square) method. PI based speed controller is widely used in industrial application for its simple structure and reliable performance. In addition the Kharitonov robust control theory is used for verification stability of closed-loop transfer function. The performance of this proposed design method is proved by digital simulation and experimentation with high performance DSP based induction motor driving system.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 춘계학술대회 논문집 전기기기 및 에너지변환시스템부문
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• pp.101-103
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• 2003

This paper presents the speed control of Brushless DC Motors using PI control. PI control is implemented by software using digital signal processor(DSP) TMS320F240 from Texas instruments. Considering the cost of BLDC Driver A. B. C phase hall IC's signal is used instead of incremental encoder. The Present paper describes, how to control a speed of BLDC Drive.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1987년도 전기.전자공학 학술대회 논문집(II)
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• pp.1317-1321
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• 1987

A new type of motor-driven Total Artificial Heart(TAH) system with rolling cylinder mechanism has been developed. Brushless DC motor was chosen as energy converter and controlled by PI controller according to the given velocity profile under the highly time-varying load. Computer simulation was also performed to calculate the optimal gains of PI controller which minimize the input power, one of the most important parameter in artificial heart system.

• 산업기술연구
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• 제22권B호
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• pp.185-190
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• 2002

This paper describes a design of an induction motor control system using a 2 degree-of-freedom PI controller to compensate the effects of disturbance without degrading tracking performance. On the basis of vector control principle, the control system is simulated by using the ACSL and implemented on a DSP system(TMS320C31). In designing the 2 DOF controller, we can tune the performance of either the tracking or disturbance rejection independently without affecting the other. With the experimental results, the 2 DOF controller has shown a better performance in command tracking and disturbance rejection than a conventional PI controller.

• Bulletin of the Korean Chemical Society
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• 제25권5호
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• pp.620-624
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• 2004

Optical emission studies were performed to investigate thermal and dynamical properties of a plume produced by laser ablation of a graphite target in a nitrogen atmosphere. Experimental spectra of $C_2(d^3{\Pi}_g{\to}a^3{\Pi}_u$, ${\Delta}_V$=1) and CN ($B^2{\Sigma}^+{\to}X^2{\Sigma}^+,{\Delta}_V=0)$ were simulated to obtain the vibrational and rotational temperatures of the electronically excited species at various laser fluences and distances from the target. The spectroscopic temperatures of both molecules were found to be nearly independent of the laser fluence. The temperature of CN molecules was peaked in the middle of the plume while that of $C_2$decreased with increase in the distance. At a given distance, the temperature of CN molecules was clearly higher than that of $C_2$.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4635-4639
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• 2013

Multi-drug resistance (MDR) is an essential aspect of human lung cancer chemotherapy failure. Recent studies have shown that vinorelbine is involved in underlying processes in human tumors, reversing the MDR inseveral types of cancer cells. However, the roles and potential mechanism are not fully clear. In this study, we explored effects of vinorelbine in multi-drug resistance reversal of human lung cancer A549/DDP cells. We found that vinorelbine increased drug sensitivity to cisplatin and intracellular accumulation of rhodamine-123, while decreasing expression of P-glycoprotein (P-gp), multi-drug resistance-associated protein (MRP1) and glutathione-S-transferase ${\pi}$ (GST-${\pi}$) in A549/DDP cells. At the same time, we also established downregulation of p-Akt and decreased transcriptional activation of NF-${\kappa}B$ and twist after vinorelbine treatment. The results indicated that vinorelbine might be used as a potential therapeutic strategy in human lung cancer.

• 전력전자학회논문지
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• 제5권2호
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• pp.163-169
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• 2000

전력변환시스템의 경제적인 설계를 위해서는 전력용 반도체소자의 전류정격을 모든 동작조건에서 최대한 이용하는 것이 매우 중요하다. 따라서 본 논문에서는 제안전압 한계의 변화, 연산지연시간, 시스템의 불확실성에 대해서도 오버슈트 없는 고속 전류제어 응답을 얻는 실용적인 디지털 전류제어기의 설계방법을 제안한다. 제안한 전류제어기는 수정된 시간지연보상기와 조건부 적분기를 갖는 고이득 PI제어기로 구성되어 있다. 제시된 시뮬레이션 및 실험 결과는 제안한 방법의 유효성을 보여준다.

• 한국수학교육학회지시리즈B:순수및응용수학
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• 제25권1호
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• pp.17-29
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• 2018

We find modular equations of degree 3 to evaluate some new values of the cubic continued fraction $G(e^{-{\pi}\sqrt{n}})$ and $G(-e^{-{\pi}\sqrt{n}})$ for $n={\frac{2{\cdot}4^m}{3}}$, ${\frac{1}{3{\cdot}4^m}}$, and ${\frac{2}{3{\cdot}4^m}}$, where m = 1, 2, 3, or 4.