• Genomics & Informatics
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• 제17권3호
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• pp.23.1-23.6
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• 2019

The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data.

• Journal of Yeungnam Medical Science
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• 제35권1호
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• pp.36-39
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• 2018

In the personalized medicine era, utilizing paraffin blocks in pathology archives for investigating human diseases has come into the limelight. This archived material with clinical data will reduce the research time and could prevent new patient recruitment to obtain tissue for research. However, the clause indicating the necessity of consent from human material providers in the Korean Bioethics and Safety Act has made the Institutional Review Board (IRB) deny permission to use paraffin blocks for research without consent, and alternatively to get the same before starting an experiment. Written consent may be waived off in studies using paraffin blocks with anonymous status or conditions not linked to personal information by applying the paragraph 3, article 16 of the current Bioethics and Safety Act. Also, the IRB should recommend researchers to preserve the blocks as medical records of patients in long-term archives.

• Journal of Oral Medicine and Pain
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• 제47권2호
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• pp.107-108
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• 2022

Artificial intelligence (AI) refers to the use of machines to mimic intelligent human behavior. It involves interactions with humans in clinical settings, and augmented intelligence is considered as a cognitive extension of AI. The importance of AI in healthcare and medicine has been emphasized in recent studies. Machine learning models, such as genetic algorithms, artificial neural networks (ANNs), and fuzzy logic, can learn and examine data to execute various functions. Among them, ANN is the most popular model for diagnosis based on image data. AI is rapidly becoming an adjunct to healthcare professionals and is expected to be human-independent in the near future. The introduction of AI to the diagnosis and treatment of oral diseases worldwide remains in the preliminary stage. AI-based or assisted diagnosis and decision-making will increase the accuracy of the diagnosis and render treatment more precise and personalized. Therefore, dental professionals must actively initiate and lead the development of AI, even if they are unfamiliar with it.

• Journal of Digestive Cancer Research
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• 제6권2호
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• pp.45-49
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• 2018

Colorectal cancer (CRC) is the third most common cause of cancer-related death in the world. Although the long-term outcome of patients with metastatic CRC is still poor, target therapy including anti EGFR agents and anti VEGF agents and immunotherapy including anti PD-1 antibody and anti CTLA-4 antibody have shown clinical benefits in the treatment of patient with metastatic CRC. In the future, the personalized treatment strategy based on the clinical characteristics and biologic features of patients with metastatic CRC will be necessary. In this review, we summarized the mechanisms and clinical evidences of target therapy and immunotherapy, and the guideline of clinical practice in patients with metastatic CRC.

• 한국컴퓨터정보학회논문지
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• 제16권12호
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• pp.59-69
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• 2011

최근 건강관리에 대한 국민의 관심이 높아지면서 헬스케어 서비스에 대한 인식과 이용률이 증가하고 있다. 하지만 기존의 헬스케어 서비스는 이동성의 불편함이 있으며, 정보입력의 신뢰성과 제공되는 정보의 정확성이 낮은 문제점을 가지고 있다. 본 연구는 이러한 문제점을 개선하여 스마트 폰을 활용한 m-Health 어플리케이션을 개발하였다. 이는 잘못된 생활습관으로 건강관리를 제대로 하지 못하는 20~30대를 대상으로 맞춤화된 식이추천, 심혈관 질환위험도 알림 등의 총 5가지 서비스를 제공한다. 또한 Importance-Performance Analysis(IPA)기법을 통해 일반적인 m-Health 서비스의 중요도와 본 서비스의 만족도를 비교분석하여 장점 및 문제점을 파악하였다. 개발된 어플리케이션의 IPA분석결과 m-Health 서비스를 효과적으로 제공받기 위해 필요한 12가지 항목 중 '정보 입력의 정확성 및 신뢰성', '컨텐츠 신뢰성', '건강에 적합한 서비스 추천' 등의 6가지 속성이 중요도와 만족도가 높은 영역에 속하였다. 그리고 '정보의 보안성'은 중요도는 높지만 만족도가 낮은 영역에 속하였다. 결론적으로 본서비스의 장점을 지속적으로 잘 유지하기 위해 Personal Heath record(PHR) 정보 연동과 함께 제공되는 서비스의 업 데이트 및 정보의 보안성 강화를 위한 연구를 진행할 예정이다.

• 사상체질의학회지
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• 제30권1호
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• pp.14-23
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• 2018

Objectives Because of growing interest in personalized medicine, constitutional medicine also becomes more important. Constitutional medicine has already developed in many countries. In this study, we tried to investigate five type personality (Wutairen), a kind of Chinese constitutional medicine. Methods We did a research on five type personality using CNKI (http://www.cnki.net) up to Jan 15, 2018. Total 204 papers were searched with the keyword "Wutairen". We excluded 170 papers away from the subject or clinically studied. As a result, 34 papers were selected and analyzed. Results and Conclusions Five type personality (Wutairen) originated from Huangdi Neijing-Lingshu. There are 5 types: greater Yin person (Taiyin), lesser Yin person (Shaoyin), greater Yang person (Taiyang), lesser Yang person (Shaoyang) and Yin-yang balanced person. These are classified according to Yin-Yang content. Each type has different characteristic, treatment and prevention. Five type personality theory considers internal factors more important than external factors. Also, it considers the balance of Yin-Yang important.

• 대한간호학회지
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• 제52권5호
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• pp.535-549
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• 2022

Purpose: The study aimed to design and develop an automated personalized self-care (APSC) program for patients with type 2 diabetes mellitus. The secondary aim was to present a clinical protocol as a mixed-method research to test the program effects. Methods: The APSC program was developed in the order of analysis, design, implementation, and evaluation according to the software development life cycle, and was guided by the self-regulatory theory. The content validity, heuristics, and usability of the program were verified by experts and patients with type 2 diabetes mellitus. Results: The APSC program was developed based on goal setting, education, monitoring, and feedback components corresponding to the phases of forethought, performance/volitional control, and self-reflection of self-regulatory theory. Using the mobile application, the participants are able to learn from educational materials, monitor their health behaviors, receive weekly-automated personalized goals and feedback messages, and use an automated conversation system to solve the problems related to self-care. The ongoing two-year study utilizes a mixed method design, with 180 patients having type 2 diabetes mellitus randomized to receive either the intervention or usual care. The participants will be reviewed for self-care self-efficacy, health behaviors, and health outcomes at 6, 12, 18, and 24 months. Participants in the intervention group will be interviewed about their experiences. Conclusion: The APSC program can serve as an effective tool for facilitating diabetes health behaviors by improving patients' self-care self-efficacy and self-regulation for self-care. However, the clinical effectiveness of this program requires further investigation.

• 한방재활의학과학회지
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• 제26권4호
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• pp.23-35
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• 2016

Objectives This systematic review is to support the effectiveness of herbal medicine for the treatment of simple obesity in adults. Methods A total of 8 electronic databases were searched in English, Chinese and Korean. Standard methodologies for the systematic review were used to search, analyze and synthesize data based on NECA's guideline for undertaking systematic review and meta-analyses for intervention. Results After screening 1781 potential articles, we identified 13 randomized controlled trials (RCTs). We conducted a meta-analysis for the study using Bangpungtongsung-san and Taeeumjowi-tang to evaluate the effectiveness of herbal medicines on weight loss compared to placebo control. Both herbs showed positive effect in weight, body mass index and waist circumference. In an analysis comparing herbal effects considering constitutions showed that proper treatment can lower adverse events. Conclusions Our results provide evidence that herbal medicine can be an effective treatment for the obesity compare to placebo or to conventional medicine without serious adverse events. Further study is needed to evaluate effectiveness of herbal medicines considering personalized treatment and its safety.

• 동의생리병리학회지
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• 제30권6호
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• pp.376-384
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• 2016

Systems biology is an emerging field aiming at a systems level understanding of living organisms and focusing on the characteristics of the whole network of them. The emergence of systems biology is partly because of the availability of huge amounts of data on organisms and the extensive support of computational technologies as the tools for understanding complex biological systems. The scientific understanding of Korean medicine has been obstructed because of the lack of proper methods examining the complex nature and the unique property of it. However, systems biology could give a chance understanding Korean medicine objectively and scientifically. Pattern classification is a unique tool of Korean medicine to diagnose and treat patients and systems biology would give a useful tool to interpret pattern classification. Various omics technologies has been used to explain the relations between pattern classification and biological factors and then many characteristics of pattern classification in various diseases have been discovered. Therefore, pattern classification could be a bridge to understand the features and differences of western medicine and Korean medicine and it could be a basis to develop pattern-based personalized medicine.

• 대한한의학회지
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• 제44권4호
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• pp.1-13
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• 2023

Objectives: Weight counseling is an inevitable process for patients with obesity who intend to lose weight; however, the contents of real-world counseling practices remain uncertain in Korean medicine (KM) practice. This study aimed to explore the structure and constituents of obesity counseling in KM. Methods: Qualitative methods were used to explore the structure of weight counseling and clinicians' approaches to weight counseling, particularly the advice and main constituents of weight counseling in KM. Nine KM clinicians (4 women, 5 men) from nine clinics completed face-to-face, individual and semi-structured interviews from September 2019 to February 2020 in Seoul, Daejeon, Cheonan, Seongnam, Asan, and Hwaseoug. The interviews were digitally recorded, transcribed verbatim, and categorized based on their constituents. Results: During weight loss counseling, the six principal constituents of KM identified were: planning with patients, motivation, correcting misinformation on weight loss, dietary and exercise advice, medication guidance, and customized guides for each type. Conclusion: Clinicians with in-depth knowledge about obesity prescribed personalized guidance for exercise, diet, and medication through an integrative approach. The study results provide an in-depth understanding of weight counseling in KM. These six constituents could guide the counseling provided by clinicians in obesity care.