Journal of Digestive Cancer Research

Korean Society of Gastrointestinal Cancer Research (대한소화기암연구학회)
권호 표지

Emerging Treatment in Metastatic Colorectal Cancer

전이성 대장암에서 표적치료와 면역치료

  • Jae Hyun Kim (Department of Internal Medicine, Kosin University College of Medicine) ;
  • Seun Ja Park (Department of Internal Medicine, Kosin University College of Medicine)
  • 김재현 (고신대학교 의과대학 내과학교실, 소화기내과) ;
  • 박선자 (고신대학교 의과대학 내과학교실, 소화기내과)
  • Received : 2018.06.26
  • Accepted : 2018.12.16
  • Published : 2018.12.31
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Abstract

Colorectal cancer (CRC) is the third most common cause of cancer-related death in the world. Although the long-term outcome of patients with metastatic CRC is still poor, target therapy including anti EGFR agents and anti VEGF agents and immunotherapy including anti PD-1 antibody and anti CTLA-4 antibody have shown clinical benefits in the treatment of patient with metastatic CRC. In the future, the personalized treatment strategy based on the clinical characteristics and biologic features of patients with metastatic CRC will be necessary. In this review, we summarized the mechanisms and clinical evidences of target therapy and immunotherapy, and the guideline of clinical practice in patients with metastatic CRC.

Keywords

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