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http://dx.doi.org/10.18325/jkmr.2016.26.4.23

Systematic Review on Herbal Treatment for Obesity in Adults  

Han, Kyungsun (Department of Rehabilitation Medicine of Korean Medicine, Dongguk University)
Lee, Myeong-Jong (Department of Rehabilitation Medicine of Korean Medicine, Dongguk University)
Kim, Hojun (Department of Rehabilitation Medicine of Korean Medicine, Dongguk University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.26, no.4, 2016 , pp. 23-35 More about this Journal
Abstract
Objectives This systematic review is to support the effectiveness of herbal medicine for the treatment of simple obesity in adults. Methods A total of 8 electronic databases were searched in English, Chinese and Korean. Standard methodologies for the systematic review were used to search, analyze and synthesize data based on NECA's guideline for undertaking systematic review and meta-analyses for intervention. Results After screening 1781 potential articles, we identified 13 randomized controlled trials (RCTs). We conducted a meta-analysis for the study using Bangpungtongsung-san and Taeeumjowi-tang to evaluate the effectiveness of herbal medicines on weight loss compared to placebo control. Both herbs showed positive effect in weight, body mass index and waist circumference. In an analysis comparing herbal effects considering constitutions showed that proper treatment can lower adverse events. Conclusions Our results provide evidence that herbal medicine can be an effective treatment for the obesity compare to placebo or to conventional medicine without serious adverse events. Further study is needed to evaluate effectiveness of herbal medicines considering personalized treatment and its safety.
Keywords
Obesity; Herb; Korean traditional medicine; Weight loss;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Bae J, Chung S, Lee J, Kim S, Shin H. Clinical study on the efficacy of Yanghae (Bangpungtongseoung-san) in the treatment of obesity. J Oriental Rehab Med. 2003;13(1):37-46.
2 Shin D, Cho G, Lee H, Moon M, Kang D, Yun Y, Park D, Jung S, Lee H. Clinical study of Bangpoongtongsungsan on body weight change in subjects with obesity. Herbal Formula Science. 2008;16(2):133-44.
3 Kim H, Ahn H, Oh E, Kim YL. Effect of Taeeumjoweetang on the body composition, serum lipid level and antioxidant enzyme activity of obese female college students. J of Sasang Constitutional Medicine. 2011;23(3):391-401.
4 Lim SY, Park SW, Joo JH, Kim SR, Kim DJ, Choi WS. The effects of Taeeumjowei-tan (Taiyintiaowei-tang) on obesity in sasang constitution. J East-West Med. 2012;37(4):109-16.
5 Lee JM. Dong-Yi-Soo-Se-Bo-Won. 1st edition. Seoul: Jipmundang. Seoul, Korea: Jae Ma Lee, 1894.
6 Smith SR, Weissman NJ, Anderson CM, Sanchez M, Chuang E, Stubbe S, Bays H, Shannahan WR. Multicenter, placebo-controlled trial of lorcaserin for weight management. N Engl J Med. 2010;363:245-56.   DOI
7 Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation. 2005;111(11):1448-54.   DOI
8 Kim KS, Park SW. Drug therapy for obesity. Korean J Obes. 2012;21(4):197-202.   DOI
9 Filippatos TD, Derdemezis CS, Gazi IF, Nakou ES, Mikhailidis DP, Elisaf MS. Orlistat-associated adverse effects and drug interactions. Drug safety. 2008; 31(1):53-65.   DOI
10 Kim KC, Kim T, Kang WM, Kim YM, Ahn SM. Appropriate timing of bariatric surgery in obese type 2 diabetes patients. Korean J Obes. 2015;24(3):132-6.   DOI
11 The society of Korean medicine rehabilitation. Korean Rehabilitation Medicine Volume 4. Seoul: Kunja publishing company. 2015:295-313.
12 Park J, Bose S, Hong S, Lee D, Yoo J, Lim C Lee M, Kim H. Impact of GNB3-C825T, ADRB3-Trp64Arg, UCP2-3' UTR 45 bp del/ins, and $PPAR{\gamma}$-Pro12Ala Polymorphisms on Bofutsushosan Response in Obese Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial. J Med Food 2014;17(5):558-570.   DOI
13 Kang K, Moon J, Kang B, Kim B, Choi S. The comparison of pattern identification diagnosis accodring to symptom scale based on obesity pattern identification questionnaire. J Korean Med Obes Res. 2009;9(1):37-44.
14 NECA's guidance for undertaking systematic reviews and meta-analyses for intervention. National Evidence-based Healthcare Collaborating Agency. 2011:65-91.
15 Lee J, Song Y, Lim H. Randomized, double blind, placebo-controlled study of Bofu-tsusho-san on obeses patients. J Korean Med Obes Res. 2010;10(1):1-16.
16 Park J, Bose S, Lim C, Kim H. Impact of GNB3, ADRB3, UCP2, and $PPAR{\gamma}$-Pro12Ala polymorphisms on Boiogito response in obese subjects : A randomized, double-blind, placebo-controlled trial. J Korean Med Obes Res. 2012;12(2):28-43.
17 Hioki C, Yoshimoto K, Yoshida T. Efficacy of Bofu-tsushosan, an oriental herbal medicine, in obese Japanese women with impaired glucose tolerance. Clin Exp Pharmacol P. 2004; 31:614-9.   DOI
18 Azusima K, Tamura K, Haku S, Wakui H, Kanaoka T, Ohsawa M Uneda K, Kobayashi R, Ohki K, Dejima T, Maeda A, Hashimoto T, Oshikawa J, Kobayashi Y, Nomura K, Azushima C, Takeshita Y, Fujino R, Uchida K, Shibuya K. Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: A multicenter, randomized, parallel-group controlled trial. Atherosclerosis. 2015;240:297-304.   DOI
19 Li J, Song Y, Lim H. Clinical trial of Taeeumjowui-tang (Taiyintiaowei-tang) on obese patients - Randomized, double bline, placebo-controlled study. J Oriental Rehab Med. 2010;20(4):197-213.
20 Park S, Nahmkoong W, Cheon CH, Park J, Jang B, Shin Y Kim K, Go H, Song Y, Ko S. Efficacy and safety of Taeeumjowi-tang in obese Korean adults: A double-blind, randomized and placebo-controlled pilot trial. Evid-Based Compl Alt. 2013;Article ID 498935:10pages.
21 Park J, Lee M, Kim H, Hong S, Lee D, Yoo J, Choi S, Moon J, Lim C, Lee J. Efficacy and Adverse Events of Bangpungtongseong-san (Bofutsusho-san) and Bangkihwangki-tang (Boiogiot-tang) by Oriental Obesity Pattern Identification on Obese Subjects : Randomized, Double Blind, Placebo-controlled Trial. J Korean Med Obes Res. 2011;12(2):265-278.
22 Leonon GB, Li KT, Chang Y, Yang AW, Costa CD, Li CG Cohen M, mann N, Xue CC. Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity : A randomized, Placebo-Controlled Clinical Trial. Evid-Based Compl Alt 2012;ID 435702:11pages.
23 Lang N, Yu J, Wen J. Qi Guben Recipe for treatment of simple obesity and its effects on serum inflammatory factors. Guangdong Medical Journal. 2015; 36(1):136-138.
24 Ignjatovic V, Ogru E, Heffernan M, Libinaki R, Lim Y, Ng F. Studies on the use of "slimax", a chinese herbal mixture, in the treatment of human obesity. Pharm Biol. 2000;38(1):30-5.   DOI
25 Tang H, Song N, Liu P. Clinical observation of efficacy on treatmnet of Tiaoquichanglong Decoction of Zhuang Medicine for overweight and obesity. Chinese journal of Experimental Traditional Medical Formulae. 2013;19(9):291-293.
26 Ma J, Yu H, Zhao N, Wang Y. Clinical research of TCM prescription Peilian Mahuang for simple obesity. Information on Traditional Chinese Medicine. 2014;31(1):46-49.
27 Park JH, Lee MJ, Song MY, Bose S, Shin BC, Kim HJ. Efficacy and safety of mixed Oriental herbal medicines for treating human obesity: A systematic review of randomized clinical trials. J Med Food. 2012;15(7):589-97.   DOI
28 Ryu S, Song M, Chung S. The effect of very low calorie diet with Chegamuiyiin-tang (Tijianyiyiren-tang) on body composition and size in obese women. J Oriental Rehab Med. 2006;16(4):1-14.
29 Kwon S, Jung W, Byun AR, Moon S, Cho K, Shin K. Administration of Hwang-Ryun-Haedok-Tang, a herbal complex, for patients with abdominal obesity: a case series. Explore. 2015;11(5):401-6.   DOI
30 Lim SY. Clinical study of Gambitang for 22 obese patients. J East-West Med. 2011;36(4):51-57.
31 Zeng H, Tang Q, Tang H, Zheng J, Wang Y. Meta analysis of the effectiveness of simple obesity by Chinese medicine. World Journal Complex Medicine. 2015;1(2):134-9.
32 Shin JY. Commentary on Bangyakhappyeon. 1st edition. Seoul:Seongbosa. 1994:208-9.