• Genomics & Informatics
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• v.17 no.4
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• pp.48.1-48.6
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• 2019

Over the last decade, genome-wide association studies (GWASs) have provided an unprecedented amount of genetic variations that are associated with various phenotypes. However, previous GWAS were mostly conducted in European populations, and these biased results for non-Europeans may result in a significant reduction in risk prediction for non-Europeans. An issue with the early GWAS was the winner's curse problem, which led to misleading results when constructing the polygenic risk scores (PRS). Therefore, more non-European population-based studies are needed to validate reported variants and improve genetic risk assessment across diverse populations. In this study, we validated 422 variants independently associated with glycemic indexes, liver enzymes, and type 2 diabetes in 125,872 samples from a Korean population, and further validated the results by assessing publicly available summary statistics from European GWAS (n = 898,130). Among the 422 independently associated variants, 284, 320, and 361 variants were replicated in Koreans, Europeans, and either one of the two populations. In addition, the effect sizes for Koreans and Europeans were moderately correlated (r = 0.33-0.68). However, 61 variants were not replicated in both Koreans and Europeans. Our findings provide valuable information on effect sizes and statistical significance, which is essential to improve the assessment of disease risk using PRS analysis.

• Journal of Acupuncture Research
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• v.28 no.4
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• pp.37-47
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• 2011

Objective : The purpose of this study is to evaluate the effect of sweet bee venom pharmacopuncture on the post-stroke hemiplegic shoulder pain. Methods : 40 patients with post-stroke hemiplegic shoulder pain were randomly divided into 2 groups : study group(sweet bee venom pharmacopuncture treatment group, n=21) and Control group(normal saline treatment group, n=19). They were monitored for 4 weeks, followed up with visual analog scale(VAS), pain rating score(PRS), painless passive shoulder range of movement(PROM) and Fugl-Meyer Motor assessment(FMMA) at before treatment(T0), after 2 weeks(T2) and after 4 weeks(T4). Results : 1. Study group and control group showed pain decrease, but study group showed more significant effectiveness in VAS and PRS than control group. 2. Although there is no significant difference in PROM between study group and control group, both groups showed increase of PROM, and study group had some effectiveness on abduction and flexion as the treatment progresses. 3. There is no significant difference in FMMA between study group and control group. Conclusions : This study suggests that sweet bee venom pharmacopuncture has significant analgesic effect on the post-stroke hemiplegic shoulder pain. And it seems that sweet bee venom pharmacopuncture can be applicable to improve PROM in hemiplegia patients with stroke. Further studies based on larger population and long term follow-up are needed to confirm this suggestion.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• autumn
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• pp.72-77
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• 2002

The development of a Pay Adjustment (PA) procedure for implementing Performance-related Specifications (PRS) is known to be a difficult task faced by most State Highway Agencies (SHAs) due to the difficulty in such areas as selecting pay factor items, modeling the relationship between stochastic variability of pay factor items and pavement performance, and determining an overall lot pay adjustment. This led to the need for an effective way of developing a scientific pay adjustment procedure by incorporating Life Cycle Cost Analysis (LCCA) embedded Monte Carlo approach. In this work, we propose a prototype system to determine a PA specifically using the data in the pavement management information systems at Wisconsin Department of Transportation (WisDOT) as an exemplary to other SHAs. It is believed that the PRS methodology demonstrated in this study can be used in real projects by incorporating the more accurate and reliable performance prediction models and LCC model.

• Journal of the Korean Society of Physical Medicine
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• v.2 no.1
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• pp.1-10
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• 2007

Purpose : To identify the effects of Hold-Relax of proprioceptive neuromuscular facilitation (PNF) on the functional improvement of patients with neck myofascial pain syndrome. Methode : The present research investigated 60 patients with neck myofascial syndrome, dividing them into a group doing Hold-Relax of proprioceptive neuromuscular facilitation and a group doing Stretching, This study examined degree of recovery from neck pain by comparing their neck myofascial pain syndrome before and after the treatment, and compared two groups to find difference in the degree of recovery from myofascial pain syndrome. Results : 1. For Hold-Relax of proprioceptive neuromuscular facilitation group, the pain rating score (PRS) were significantly decreased for six weeks treatment. 2. For Stretching group, the pain rating score (PRS) did not indicate significant decrease for six weeks treatment. 3. For Hold-Relax of proprioceptive neuromuscular facilitation group, range of motion of flexion, left rotation, right rotation indicated significant difference after pre test and after two week but no significant difference after four week. 4. For Stretching group, range of motion of flexion, left rotation, and right rotation except extension indicated significant difference after pre test and after two week but no significant difference after four week. Conclusion : The Hold-Relax of proprioceptive neuromuscular facilitation is considered to be effective in increasing joint range of motion of patient and decreasing pain. Accordingly physical therapists has to learn a wide range of patterns and to develop various treatment techniques.

• International Journal of Highway Engineering
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• v.18 no.3
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• pp.33-45
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• 2016

PURPOSES : Concrete pavement has been used in the construction of the Jungbu expressway in 1987. More than 60% of the pavement on the expressway is currently made of concrete, but most has been used far beyond their design life. Pavement life has been extended through routine maintenance or overlay. However, the structural capacity of the pavement has reached its limit, and extensive rehabilitation/reconstruction with long time traffic blocking should be considered. The three following issues on concrete rehabilitation/reconstruction will be discussed: (1) economic comparison of asphalt inlay and asphalt overlay, (2) economic comparison preventive overlay on a section which is currently good and routine overlay on the section which will be poor, and (3) economic analysis of early-strength concrete when it is used in concrete reconstruction. METHODS : First, various life cycle cost analysis tools were compared, and the proper tool for the extensive rehabilitation/reconstruction was selected. Second, a sensitivity analysis of the selected tool was performed to find the influential input variables, which should be carefully selected in the analysis. Third, three case studies, which can be issues in the rehabilitation/reconstruction of the expressway concrete pavement in Korea, were performed. RESULTS : Asphalt overlay without milling the deteriorated concrete showed 18~25% lower life cycle cost than the current asphalt inlay with milling. The good current preventive overlay on the section was economically justified within the scope of this study. The construction cost limit of the early strength concrete was suggested to be economical for 1, 3, and 7 days of construction alternative opening. CONCLUSIONS : CA4PRS was a viable tool for comparing various rehabilitation/reconstruction issue alternatives. Several concrete issues associated with the rehabilitation/reconstruction of the deteriorated concrete pavement were discussed as mentioned above.

• Journal of Pharmacopuncture
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• v.15 no.3
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• pp.39-44
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• 2012

Objective: The purpose of this study is to report the effects of Chukyu (spine-healing) pharmacopuncture treatment in patients with lumbago and skelalgia. Methods: This clinical study included 45 patients who were treated for lumbago and skelalgia at the Department of Acupuncture and Moxibustion, Dong-Eui University College of Oriental Medicine, from July 5, 2011, to January 31, 2012. Subjects were randomly divided into two groups: Chukyu (spine-healing)-pharmacopuncture-treated group (experimental group, n = 23) and normal saline-pharmacopuncture-treated group (control group, n = 22). Patients in the experimental group were treated with acupuncture and Chukyu (spine-healing) pharmacopuncture while those in the control group were treated with acupuncture and normal saline pharmacopuncture. To estimate the efficacy of controlling pain, we checked the visual analog scale [VAS], and to estimate the improvement of the symptoms, we evaluated by pain rating scale [PRS] and the Oswestry low-back pain disability index [ODI]. Results: A comparison of the experimental and the control groups showed more significant improvements in the VAS, PRS, and ODI for the experimental group than for the control group. Conclusions: Chukyu (spine-healing) pharmacopuncture can be used for effective treatment in patients with lumbago and skelalgia.

• Korean Journal of Cognitive Science
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• v.11 no.3_4
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• pp.45-55
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• 2000

This study was conducted to examine whether conceptual representational system was implicitly accessed while processing semantically similar but perceptually dissimilar pictures either conceptually or perceptually, The results indicated that the priming effects for the semantically similar picture pairs were found in conceptually driven processing but the effect was not found in data-driven processing. In addition. the semantic priming effect was found with 24 hour delay between the stimuli, The comparison of the recognition ratio and priming effects indicated that the priming effect was largely affected by semantically similar pictures. but recognition was relatively u unaffected, The results suggest that both Perceptual Representational System (PRS) and Conceptual Representational System (CRS) be involved during conceptually driven processing, but both PRS and CRS function independently during explicit recognition.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.22 no.1
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• pp.61-72
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• 2012

Background: The purpose of this study was to analyze the associations between physical therapists' work-related musculoskeletal pain, quality of life (QoL), and presenteeism. Methods: Self-reported questionnaires were given to 402 physical therapists in Korea. Variables examined included the prevalence of pain sites related to work, pain intensity, pain pattern, pain frequency, pain duration, pain rating score (PRS), general characteristics, QoL, and presenteeism. Results: Of the 314 physical therapists who responded, 251 (79.9%) reported work -related musculoskeletal pain in at least one body part. The most affected regions included the wrist and hand (21.0%), shoulder (19.6%), and lower back (19.1%). On average patients, QoL and presenteeism differed significantly between physical therapists who reported pain and those who did not (P < 0.05). QoL showed a negative correlation with the work-related musculoskeletal pain (P < 0.01) and presenteeism (P < 0.01), while the presenteeism and work-related musculoskeletal pain showed positive one(P < 0.01). Factors influencing a physical therapist's QoL included presenteeism, Working venues (Convalescent hospital), Work status (Contra ct worker) and professional experience, while the presenteeism included QoL, work status (Intern), PRS, working venues (Convalescent hospital), Area of specialty (Pediatrics), age, sex and working hour. Conclusions: Results show that physical therapists appear to be at a higher risk for work-related musculoskeletal pain. Therefore, administrators need to use the intervention strategies to manage the presenteeism and QoL of physical therapists.

• Korean journal of aerospace and environmental medicine
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• v.31 no.2
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• pp.45-50
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• 2021

Background: Obesity is a major public health problem that is causally related to serious medical conditions. In this study, the public health implications of obesity based on body mass index (BMI) with anthropometric measures among adults in the Republic of Korea and Japan in 2019 were compared. Methods: A simple cross-section, nationally representative of the raw data from the National Health and Nutrition Examination Survey in 2019 between Korea and Japan were used. We analyzed the data of those categorized as obese with a BMI of ≥25 kg/m² according to the World Health Organization Expert Consultation. Results: The average values of BMI based on body height and body weight among males and females in Korea were 24.6±0.08 and 23.3±0.09, respectively; those in Japan were 23.9±0.08 and 22.6±0.08, respectively. The measured anthropometric values were obviously higher in Korean than in Japan (P<0.01). The prevalence rates (PRs) of obesity by sex in Korea were 41.4% among males and 27.3% females; those in Japan were 32.5% among males and 22.0% among females. The statistically significant results showed that the total obesity rate was higher in males than in females in both countries (P<0.01). The PRs of obesity in Korea were 41.4% in males and 27.3% in females; those in Japan were 32.5% in males and 22.0% in females. The statistically significantly PR of total obesity among Korean adults was greater than that among Japanese adults (P<0.01). Conclusion: The PR of obesity in Korea relative to that in Japan showed a gradually increasing trend. Obesity is a major problem, especially in the pilot group. Reducing the prevalence of obesity among pilots is important for reducing in-flight medical incapacitation and ensuring flight safety. Obesity management is necessary to prevent obesity-related diseases and promote pilot health.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2023.11a
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• pp.122-123
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• 2023

About 1 year and 7 months have passed since the Serious Accident Punishment Act was implemented, and although many studies have been conducted on the definition and policy of the Act, almost no research has been conducted on its impact on the logistics industry. In particular, research on the PDI (PRS) process within finished vehicle logistics is severely lacking ‥‥‥. The government is expecting to expand the scope of punishment and upgrade the safety management system through the Serious Accident Punishment Act, but if you check the industrial accident data issued by the Ministry of Employment and Labor in 2022, the number and rate of industrial accidents will increase compared to 2021