• JSTS:Journal of Semiconductor Technology and Science
• /
• v.3 no.4
• /
• pp.217-222
• /
• 2003

A new two-dimensional analytical model for the potential distribution and drain-induced barrier lowering (DIBL) effect of fully depleted short-channel Silicon-on-insulator (SOI)-MESFET's has been presented in this paper. The two dimensional potential distribution functions in the active layer of the device is approximated as a simple parabolic function and the two-dimensional Poisson's equation has been solved with suitable boundary conditions to obtain the bottom potential at the Si/oxide layer interface. It is observed that for the SOI-MESFET's, as the gate-length is decreased below a certain limit, the bottom potential is increased and thus the channel barrier between the drain and source is reduced. The similar effect may also be observed by increasing the drain-source voltage if the device is operated in the near threshold or sub-threshold region. This is an electrostatic effect known as the drain-induced barrier lowering (DIBL) in the short-gate SOI-MESFET's. The model has been verified by comparing the results with that of the simulated one obtained by solving the 2-D Poisson's equation numerically by using the pde toolbox of the widely used software MATLAB.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1992.05a
• /
• pp.33-33
• /
• 1992

항혈전성 약물로서 그의 항 혈소판 작용력은 dipyridamole보다 강하나 심혈관계 등에 대한 부작용이 적어 clinical efficiency가 유의하게 높은 약물개발에 대한 연구는 임상적 응용성 뿐 아니라, 혈소판-응고기전의 규명에 기여할 것으로 사료되는 바 본 연구에서는 cyclic nucleotide phosphodiesterase(PDE-I)들의 항혈소판 작용을 검토하여 그들의 혈관 내피세포와 혈관평활 근세포의 중식에 대한 영향을 항혈소판성 작용을 보이며 혈관세포들의 증식에 없어서는 안되는 spermine의 그것과 비교 검색하였다. Johnson 등(1985)의 방법에 따라서 제조한 aequorin부하-가토혈소판의 thrombin(0.25 units: TB)에 대한 응집반응에서, pyridazinone 유도체인 KR30075, sodium nitroprusside(SNP), imazodan, isobutylmethylxanthine(IBMX), rolipram, 및 spermine의 응집억제성 $IC_{50}$/ (M)은 각각 2.21 $\times$ $10^{-7}$, 1.26 $\times$ $10^{-6}$, 6.96 $\times$ $10^{-6}$, 7.78 $\times$ $10^{-6}$, 8.11 $\times$ $10^{-4}$, 및 4.28 $\times$ $10^{-3}$ M으로써 이들은 TB-응고반응에 동반되는 혈소판 [Ca$^{++}$]$_{i}$-증가에 대한 각각의 $IC_{50}$/과 차이를 보이지 않았으며, 유의한 상관성을 보였다.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.21 no.8
• /
• pp.1024-1033
• /
• 1997

The past several years have witnessed an ever-increasing acceptance and adoption of parallel processing, both for high performance scientific computing as well as for more general purpose applications. Furthermore with increasing needs to perform the complex flow calculations in an efficient manner, the use of the message passing model on distributed networks has emerged as an important alternative to the expensive supercomputers. This work attempts to provide a generic framework to enable the parallelization of all CFD-related works using the master-slave model. This framework consists of (1) input geometry, (2) domain decomposition, (3) grid generation, (4) flow computations, (5) flow visualization, and (6) output display as the sequential components, but performs computations for (2) to (5) in parallel on the workstation clustering. The flow computations are parallized by having multiple copies of the flow-code to solve a PDE on different spatial regions on different processors, while their flow data are exchanged across the region boundaries, and the solution is time-stepped. The Parallel Virtual Machine (PVM) is used for distributed communication in this work.

• BMB Reports
• /
• v.29 no.4
• /
• pp.372-379
• /
• 1996

Components I and II (CI&II) are major phosphoproteins in the frog rod outer segments (ROS) of retina, whose phosphorylation is light- and cyclic nucleotide-dependent. Although it was reported that CI & II could be chemically cross-linked to ${\beta}{\gamma}-subunit$ of transducin (${\beta}{\gamma}_t$), it was not clear whether CI&II physically interact with ${\beta}{\gamma}_t$, under native conditions. CI&II extracted by hypotonic washing fo ROS membranes showed an overlapped migration with ${\beta}{\gamma}_t$, in sucrose density gradient centrifugation. The elution profile of CI&II in the peripheral membrane fractions from gel filtration chromatography also overlapped that of ${\beta}{\gamma}_t$. These hydrodynamic parameters indicate that the native molecular state of CI&II in the peripheral membrane fraction appears to be within a complex, most likely with ${\beta}{\gamma}_t$. CI&II coeluted with ${\beta}{\gamma}_t$, showed no phosphorylation by endogenous kinase which phosphorylates a serine of CI&II in other fractions. The purified CI&II were not able to inhibit trypsin-activated cGMP-phosphodiesterase, and CI&II were not recognized by a monoclonal antibody against the ${\gamma}-subunit$ of transducin, indicating that CI&II are not y-subunit of PDE or transducin. Thus, it is likely that native CI&II, which undergo a light-dependent phosphorylation/dephosphorylation cycle, can associate with ${\beta}{\gamma}$, in frog photoreceptor membranes, and the complex formation has an inhibitory effect on the endogenous phosphorylation of CI&II.

• Journal of the Korean Society for Industrial and Applied Mathematics
• /
• v.23 no.4
• /
• pp.301-327
• /
• 2019

The proper orthogonal decomposition (POD) method for time-dependent problems significantly reduces the computational time as it reduces the original problem to the lower dimensional space. Even a higher degree of reduction can be reached if the solution is smooth in space and time. However, if the solution is discontinuous and the discontinuity is parameterized e.g. with time, the POD approximations are not accurate in the reduced space due to the lack of ability to represent the discontinuous solution as a finite linear combination of smooth bases. In this paper, we propose to post-process the sample solutions and re-initialize the POD approximations to deal with discontinuous solutions and provide accurate approximations while the computational time is reduced. For the post-processing, we use the Gegenbauer reconstruction method. Then we regularize the Gegenbauer reconstruction for the construction of POD bases. With the constructed POD bases, we solve the given PDE in the reduced space. For the POD approximation, we re-initialize the POD solution so that the post-processed sample solution is used as the initial condition at each sampling time. As a proof-of-concept, we solve both one-dimensional linear and nonlinear hyperbolic problems. The numerical results show that the proposed method is efficient and accurate.

• Progress in Superconductivity and Cryogenics
• /
• v.15 no.1
• /
• pp.29-34
• /
• 2013

AMR (Active Magnetic Regenerative) refrigerators require the large variation of the magnetic field and a HTS magnet can be used. The amount of AC loss is very important considering the overall efficiency of the AMR refrigerator. However, it is very hard to estimate the precise loss of the HTS magnet because the magnetic field distribution around the conductor itself depends on the coil configuration and the neighboring HTS wires interact each other through the distorted magnetic field by the screening current Therefore, the AC loss of HTS magnet should be calculated using the whole configuration of the HTS magnet with superconducting characteristic. This paper describes the AC loss of the HTS magnet by an appropriate FEM approach, which uses the non-linear characteristic of HTS conductor. The analysis model is based on the 2-D FEM model, called as 'magnetic field formulation and edge-element model', for whole coil configuration in cylindrical coordinates. The effects of transport current and stacked conductors on the AC loss are investigated considering the field-dependent critical current. The PDE model of 'Comsol multiphysics' is used for the FEM analysis with properly implemented equations for axisymmetric model.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.15 no.4
• /
• pp.57-64
• /
• 2011

It has been suggested that turbulent effect should be considered for the study of highly unstable detonation of hydrocarbon fuels, as in the case of pulse detonation engine (PDE). A series of numerical study are carried out to understand the characteristics of the highly unstable detonation by considering viscosity, turbulence model and turbulence-combustion interaction model. Through studies of the different levels of modeling, it is understood that the viscosity and turbulence have negligible effects on low frequency characteristics, but tend to enhance the high frequency characteristics. It is also considered that the turbulence-chemistry interaction model should be taken the influence of the activation energy into account for detonation studies.

• Archives of Pharmacal Research
• /
• v.13 no.2
• /
• pp.136-141
• /
• 1990

The vasorelaxant effects of KR-30075 in guinea-pig pulmonary, bovine coronary and renal arterial strips contracted by either$K^+$depolarization, phenylephrine, or prostaglandin $F_{2a}$($PGF_{2a}$) were evaluated. KR-30075 was more potent than imazodan as a vasorelaxant against $PGF_{2a}$-induced contractions in bovine coronary and renal arteries, whereas against$K^+$induced contractions KR-30075 was less potent than imazodan in guieapig pulmonary arteries and more potent in bovine coronary arteries. KR-30075 was more potent against contractions induced by phenylephrine or $PGF_{2a}$ than the contractions induced by $K^+$ This profile of activity for KR-30075 was similar to that of imazodan and dissimilar from the calcium entry blocking agent nifedipine. There was no vascular selectivity of KR-30075 between bovine coronary and renal arterial strip preparations. In conclusion, this study shows that KR-30075 represents the vasorelaxant effects on guinea-pig pulmonary, bovine coronary and renal arteries without specific vascular selectivity. The vasorelaxant profile of KR-30075, with different sources of vascular smooth muscle, is unlike that of calcium entry blocking agent and more similar to the profile of the agent that inhibit cyclic nucleotide phosphodiesterase.

• Clean Technology
• /
• v.18 no.3
• /
• pp.320-324
• /
• 2012

In the present study, the discharge characteristics of a lithium-ion battery was evaluated to calculate the rate of heat generation under various discharge rates by mathematical modeling. The modeling and simulation of a pseudo-two dimensional ionic transport system for governing Butler-Volmer equation were carried out by using FEMLAB as a PDE (partial differential equation) solver, where the discharge rate was changed from 5 $A/m^2$ to 25 $A/m^2$. The computational results showed that the concentration of consumed solid-phase lithium at the surface of electrode was increased with increasing discharge rates. While the resulting diffusion limitation occurred shortly, it increased the rate of heat generation even more rapidly for the internal voltage to approach the cutoff voltage of the lithium-ion battery.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 2007.04a
• /
• pp.157-162
• /
• 2007

A new level set based topology optimization employing inner-front creation algorithm is presented. In the conventional level set based topology optimization, the optimum topology strongly depends on the initial level set distribution due to the incapability of inner-front creation during optimization process. In the present work, in this regard, an inner-front creation algorithm is proposed. in which the sizes. shapes. positions, and number of new inner-fronts during the optimization process can be globally and consistently identified by considering both the value of a given criterion for inner-front creation and the occupied volume (area) of material domain. To facilitate the inner-front creation process, the inner-front creation map which corresponds to the discrete valued criterion of inner-front creation is applied to the level set function. In order to regularize the design domain during the optimization process, the edge smoothing is carried out by solving the edge smoothing partial differential equation (PDE). Updating the level set function during the optimization process, in the present work, the least-squares finite element method (LSFEM) is employed. As demonstrative examples for the flexibility and usefulness of the proposed method. the level set based topology optimization considering lightweight design of 3D shell structure is carried out.