• Journal of the Chungcheong Mathematical Society
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• v.26 no.2
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• pp.393-402
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• 2013

For 0 < $p$ < ${\infty}$, ${\alpha}$ > -1 and 0 < $r$ < 1, we show that if $f$ is in the space of Dirichlet type $\mathfrak{D}^p_{p-1}$, then ${\int}_{1}^{0}M_{p}^{p}(r,f^{\prime})(1-r)^{p-1}rdr$ < ${\infty}$ and ${\int}_{1}^{0}M_{(2+{\alpha})p}^{(2+{\alpha})p}(r,f^{\prime})(1-r)^{(2+{\alpha})p+{\alpha}}rdr$ < ${\infty}$ where $M_p(r,f)=\[\frac{1}{2{\pi}}{\int}_{0}^{2{\pi}}{\mid}f(re^{it}){\mid}^pdt\]^{1/p}$. For 1 < $p$ < $q$ < ${\infty}$ and ${\alpha}+1$ < $p$, we show that if there exists some positive constant $c$ such that ${\parallel}f{\parallel}_{L^{q(d{\mu})}}{\leq}c{\parallel}f{\parallel}_{\mathfrak{D}^p_{\alpha}}$ for all $f{\in}\mathfrak{D}^p_{\alpha}$, then ${\parallel}f{\parallel}_{L^{q(d{\mu})}}{\leq}c{\parallel}f{\parallel}_{\mathcal{B}_p(q)}$ where $\mathcal{B}_p(q)$ is the weighted Besov space. We also find the condition of measure ${\mu}$ such that ${\sup}_{a{\in}D}{\int}_D(k_a(z)(1-{\mid}a{\mid}^2)^{(p-a-1)})^{q/p}d{\mu}(z)$ < ${\infty}$.

• The Korean Journal of Physiology and Pharmacology
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• v.6 no.3
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• pp.139-142
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• 2002

To examine intracellular signaling of human $S1P_3\;(hS1P_3),$ a sphingosine 1-phosphate (S1P) receptor in plasma membrane, $hS1P_3$ DNA was transfected into RH7777 rat hepatoma cell line, and the inhibition of forskolin-induced cAMP accumulation and activation of MAP kinases by S1P were tested. In $hS1P_3$ transformants, S1P inhibited forskolin-induced activation of adenylyl cyclase activity by about 80% and activated MAP kinases in dose-dependent and pertussis-toxin (PTX) sensitive manners. In oocytes expressing $hS1P_3$ receptor, S1P evoked $Cl^-$ conductance. These data suggested that PTX-sensitive G proteins are involved in $hS1P_3-mediated$ signaling, especially the positive action of S1P in cell proliferation. The potential advantages of rat hepatoma cells for the research of sphingosine 1-phosphate receptor are discussed.

• The Journal of the Korea Contents Association
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• v.12 no.2
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• pp.358-368
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• 2012

The purpose of this study was to discover the factors affecting on physical activity levels of community-dwelling older adults in Korea. The data was analyzed on 12,322 older adults, aged 65 or above, from the 2008 National Elderly Survey. The results of this study were as follows: First, 29.9% of older men and 46.4% of older women were classified as physically inactivity. Second, age(OR=1.44, p<.001), education(OR=1.17, p=.026), location of residence(OR=1.19, p=.016), perceived health status(OR=2.18, p<.001), chronic disease(OR=1.23, p=.020), pain(OR=1.24, p=.011), ADL(OR=1.86, p<.001), fear of fall(OR=1.26, p=.003), depression(OR=1.78, p<.001) predicted physical activity levels in older men. Age(OR=1.54, p<.001), perceived health status(OR=1.63, p<.001), pain(OR=1.45, p<.001), falling experience(OR=1.24, p=.001), ADL(OR=1.72, p<.001), depression(OR=1.46, p<.001) predicted physical activity levels in older women. It is suggested that the findings of this study are helpful to develop effective physical activity interventions for older adults.

• East Asian mathematical journal
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• v.19 no.1
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• pp.133-150
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• 2003

This paper will show that the relation (1.1) $$L^1({\Omega}){\subset}C_0(\bar{\Omega}){\subset}H_{p,q}$$ if 1/p'-1/n(1-2/q')<0 where p'=p/(p-1) and q'=q/(q-1) where $H_{p.q}=(W^{1,p}_0,W^{-1,p})_{1/q,q}$. We also intend to investigate the control problems for the retarded systems with $L^1(\Omega)$-valued controller in $H_{p,q}$.

• Journal of Life Science
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• v.21 no.2
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• pp.183-193
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• 2011

Migration and differentiation of mesenchymal stem cells are crucial for tissue regeneration in response to injury. Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates a variety of biological processes, including proliferation, survival, differentiation and motility. In the present study, we determined the role of S1P in migration and differentiation of human bone marrow-derived mesenchymal stem cells (BMSCs). S1P stimulated migration of BMSCs in a dose- and time-dependent manner, and pre-incubation of the cells with pertussis toxin completely abrogated S1P-induced migration, suggesting involvement of Gi-coupled receptors in S1P-induced cell migration. S1P elicited elevation of intracellular concentration of $Ca^{2+}$ ($[Ca^{2+}]_i$) and pretreatment with VPC23019, an antagonist of $S1P_1/S1P_3$, blocked S1P-induced migration and increase of $[Ca^{2+}]_i$. Small interfering RNA-mediated knockdown of endogenous $S1P_1$ attenuated S1P-induced migration of BMSCs. Furthermore, S1P treatment induced expression of $\alpha$-smooth muscle actin ($\alpha$-SMA), a smooth muscle marker, and pretreatment with VPC23019 abrogated S1P-induced $\alpha$-SMA expression. S1P induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), and pretreatment of cells with SB202190, an inhibitor of p38 MAPK, or adenoviral overexpression of a dominant-negative mutant of the p38 MAPK blocked S1P-induced cell migration and $\alpha$-SMA expression. Taken together, these results suggest that S1P stimulates migration and smooth muscle differentiation of BMSCs through an $S1P_1$-p38 MAPK-dependent mechanism.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.7
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• pp.1851-1859
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• 1998

We summarize the password-based authetication protocol K1P which was introduced in our easlier papers [1,2] and then propose three more extended protocols. These protocols preserve a design concept of K1P, i.e., security and efficiency, and canbe used for various purposes. They are a One-time key K1P, a Client public key K1P, and an Exponential key exchange K1P.

• Microbiology and Biotechnology Letters
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• v.23 no.2
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• pp.164-169
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• 1995

An endogenous cryptic plasmid, pBL1, which has been used to construct plasmid vectors for coryneform bacteria producing amino acids, was eliminated from Brevibacterium lactofermentum. The pBL1 was partially digested with Sau3AI and the resulting DNA fragments were subcloned into a suicide vector pEM1 which contains a kanamycin-resistant (km$^{r}$) gene. KM$^{r}$ B. lactofermentum transconjugants were obtained by conjugal transfer of the pEM1 derivatives containing pBL1 DNA fragments from Escherichia coli into B. lactofermentum. A km$^{r}$ transconjugant was analyzed to contain a plasmid pEB14, which occurred in vivo by homologous recombination between pBL1 and the conjugal-transferred plasmid. The pEB14 including the pEM1-derived km$^{r}$ gene was found to be lost concomitantly with km$^{r}$ phenotype, resulting in the construction of a pBL1-free strain of B lactofermentum. Based on transformation efficiencies and plasmid stability, the resultant pBL1- free strain is more useful than wild strain as a host cell for genetic manipulation. It could be concluded that foreign plasmid DNAs are efficiently isolated and analyzed from the pBL1-free strain because of the absence of endogenous pBL1 plasmid.

• Journal of the Korean Chemical Society
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• v.25 no.6
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• pp.383-389
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• 1981

Thianthrene cation radical perchlorate reacts with N-arylsulfonamides such as p-toluenesulfonanilide, benzenesulfonanilide, N-(2-methylphenyl)benzenesulfonamide, and N-phenyl-p-toluenesulfonanilide to give 5-(p-N-p-toluenesulfonamidophenyl)-(1a), 5-(p-N-benzenesulfonamidophenyl)-(1b), 5-(4-N-benzenesulfonamido-3-methylphenyl)-(1c), and 5-(p-N-phenyl-N-p-toluenesulfonamidophenyl thianthrenium perchlorate (1d), respectively. In the meantime, 1d reacts further with thiathrene cation ratical to form diperchlorate(1e). The structure of 1a~1e is very similar to 5-(p-acetamidophenyl) thianthrenium perchlorate which has been obtained from the reaction with acetanilide. However, the discrepancy in the stoichiometry between two reactions indicates that the reaction with sulfonamide appears not to proceed with a single mechanism.

• Honam Mathematical Journal
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• v.16 no.1
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• pp.119-135
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• 1994

Let $Q_{n+p-1}(\alpha)$ denote the- dass of functions $$f(z)=z^{P}-\sum_{n=0}^\infty{a_{(p+k)}z^{p+k}$$ ($a_{p+k}{\geq}0$, $p{\in}N=\left{1,2,{\cdots}\right}$) which are analytic and p-valent in the unit disc $U=\left{z:{\mid}z:{\mid}<1\right}$ and satisfying $Re\left{\frac{D^{n+p-1}f(\approx))^{\prime}}{pz^{p-a}\right}>{\alpha},0{\leq}{\alpha}<1,n>-p,z{\in}U.$ In this paper we obtain sharp results concerning coefficient estimates, distortion theorem, closure theorems and radii of p-valent close-to- convexity, starlikeness and convexity for the class $Q_{n+p-1}$ ($\alpha$). We also obtain class preserving integral operators of the form $F(z)=\frac{c+p}{z^{c}}\int_{o}^{z}t^{c-1}f(t)dt.$ c>-p $F\left(z\right)=\frac{c+p}{z^{c}}\int_{0}^{z} t^{c-1}f\left(t \right)dt. \qquad c>-p$ for the class $Q_{n+p-1}$ ($\alpha$). Conversely when $F(z){\in}Q_{n+p-1}(\alpha)$, radius of p-valence of f(z) has been determined.

• Pediatric Infection and Vaccine
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• v.11 no.1
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• pp.59-72
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• 2004

Purpose : Rotaviruses are the major cause of gastroenteritis in infants and young children worldwide. It is important to get the epidemiologic data of rotavirus genotype for the application of rotavirus vaccine. So we tried to investigate the distribution of rotavirus genotypes with RT-PCR. Methods : A total of 120 rotavirus latex agglutinin test positive stool samples were collected continually from 120 children from Sep. 2000 to Apr. 2001. Rotavirus P(VP4), G (VP7) genotypes were determined by RT-PCR. Results : The genotype was identified in 116 stool samples of total 120 samples(96%). The incidence of G genotype was as follow; G1 17(14.2%), G2 74(61.7%), G4 1(0.8%), G9 1(0.8%). There were four cases of multiple genotypes; G1/G2, G1/G4, G1/G9, G8/G9 and genotype of G3, G8 were not found. Twenty three(19.2%) samples were nontypeable. The incidence of P was as follow; P[4] 77(64.2%), P[6] 22(18.3%), P4/P6 12(10%), P[4]/P[8] 1(0.8%) p[8] 1(0.8%). Seven(5.9%) samples were nontypeable. Conclusion : Various combinations of G and P genotypes were observed. Most rotavirus strains were P[4]G2 62(51.74%), followed by P[6]G2 7(5.8%), and P[6]G1 7(5.8%), P[4/P[6] G1 4(3%), P[4]/P[6]G2 4(3%), P[4]G1 3(2.5%), P[8]G2 1(0.8%), P[4]G4 1(0.8%) in Kyoungsangnamdo, Korea during 2000~2001.