• Journal of Chest Surgery
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• 제50권4호
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• pp.255-262
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• 2017

Background: Transcatheter aortic valve replacement (TAVR) has been suggested as a less invasive treatment for high-risk patients with aortic valve disease. I n this study, we compared the outcomes of conventional surgical aortic valve replacement (AVR) and TAVR in elderly patients aged over 80. Methods: A total of 108 patients aged 80 years or older who underwent isolated AVR (n=35) or TAVR (n=73) from 2010 through 2015 at Asan Medical Center were identified. Early and late clinical outcomes, including echocardiographic findings, were evaluated in both groups. The mean follow-up duration was $766.4{\pm}528.7days$ in the AVR group and $755.2{\pm}546.6days$ in the TAVR group, and the average timing of the last follow-up echocardiography was at $492.6{\pm}512.5days$ in the AVR group and $515.7{\pm}526.8days$ in the TAVR group. Results: The overall early mortality was 2.8% (0 of 35, 0% in the AVR group vs. 3 of 73, 4.1% in the TAVR group). Permanent pacemaker insertion was significantly more common in the TAVR group (p=0.010). Renal failure requiring dialysis and new-onset atrial fibrillation was more frequent and the length of hospital stay was longer in the AVR group; however, this difference did not reach statistical significance. In the TAVR group, 14 patients (19.2%) were rehospitalized due to cardiac problems, and 13 patients (17.8%) had developed significant paravalvular leakage by the time of the last follow-up echocardiography. Conclusion: TAVR could be a good alternative to conventional surgical AVR in elderly patients. However, TAVR has several shortcomings, such as frequent significant paravalvular leakage or readmission, which should be considered in decision-making.

• Journal of Microbiology and Biotechnology
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• 제30권4호
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• pp.526-532
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• 2020

A bacterial strain, designated B301^T and isolated from raw chicken meat obtained from a local market in Korea, was characterized and identified using a polyphasic taxonomic approach. Cells were gram-negative, non-motile, obligate-aerobic coccobacilli that were catalase-positive and oxidase-negative. The optimum growth conditions were 30℃, pH 7.0, and 0% NaCl in tryptic soy broth. Colonies were round, convex, smooth, and cream-colored on tryptic soy agar. Strain B301^T has a genome size of 3,102,684 bp, with 2,840 protein-coding genes and 102 RNA genes. The 16S rRNA gene analysis revealed that strain B301^T belongs to the genus Acinetobacter and shares highest sequence similarity (97.12%) with A. celticus ANC 4603^T and A. sichuanensis WCHAc060041^T. The average nucleotide identity and digital DNA-DNA hybridization values for closely related species were below the cutoff values for species delineation (95-96% and 70%, respectively). The DNA G+C content of strain B301^T was 37.0%. The major respiratory quinone was Q-9, and the cellular fatty acids were primarily summed feature 3 (C_16:1 ω6c/C_16:1 ω7c), C_16:0, and C_18:1 ω9c. The major polar lipids were phosphatidylethanolamine, diphosphatidyl-glycerol, phosphatidylglycerol, and phosphatidyl-serine. The antimicrobial resistance profile of strain B301^T revealed the absence of antibiotic-resistance genes. Susceptibility to a wide range of antimicrobials, including imipenem, minocycline, ampicillin, and tetracycline, was also observed. The results of the phenotypic, chemotaxonomic, and phylogenetic analyses indicate that strain B301^T represents a novel species of the genus Acinetobacter, for which the name Acinetobacter pullorum sp. nov. is proposed. The type strain is B301^T (=KACC 21653^T = JCM 33942^T).

• 한국식품과학회지
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• 제28권4호
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• pp.696-701
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• 1996

참치통조림 업계에서 부산물로 얻어지는 자숙액을 효율적으로 이용하기 위해 효소가수분해하여 분말엑기스를 제조하고 제조된 분말엑기스의 정미성분을 검토하였다. 두부와 내장을 제거한 2kg이하의 참치 2.3톤을 $93-95^{\circ}C$에서 45분간 증자하여 유출되는 약 $6^{\circ}brix$의 자숙액을 효소처리(pH; 6.19, 온도; $50^{\circ}C$, 효소농도; 0.5%, 처리시간; 1시간)하였다 이를 $80-85^{\circ}C$에서 5분간 처리하여 효소를 실활시키고 활성탄을 가하여 감압, 여과한 다음 이 여액 500ml 분무건조하여 백색의 분말엑기스 18 g을 얻었다. 이 분말엑기스의 유리아미노산 함량은 2,711.5 mg/100g이었고 이중 taurine이 19.4%를 차지하여 가장 많았고 다음으로 glutamic acid (13.8%), phenylalanine (11.7%) 및 alanine (10.5%)의 순으로 많았다. 이들 4종의 아미노산이 전체 유리 아미노산의 55.4%를 차지하였다. 한편 구성 아미노산의 함량은 30,758.1 mg/100g이었으며 이중 glutamic acid가 13.1%로 가장 많았다. 핵산관련물질 중에서는 inosine이 $76.29\;{\mu}mole/g$으로서 양적으로 가장 많았다. 엑기스 질소중 양적으로 가장 많은 것은 핵산관련물질 질소로 전 엑스분 질소의 41.2%를 차지하였으며 다음으로 유리 아미노산 질소의 순이었다. TMAO와 TMA는 미량 존재하였으며, betaine은 72.2 mg/100g으로서 전엑스분 질소의 4.9%를 차지하였고, 총 creatinine은 전엑스분 질소의 3.5%을 차지하였다 omission test 결과 분말엑기스의 맛에는 유리 아미노산, 유기산, 핵산관련물질의 순으로 기여도가 높았고, 유리 아미노산은 지미의 주된 물질임과 동시에 자극성의 맛이나 신맛을 완화시키는 역할을 하는 것으로 판단되었다.

• Journal of Hospice and Palliative Care
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• 제17권2호
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• pp.75-84
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• 2014

목적: 본 연구는 호스피스 환자 가족돌봄제공자의 수면의 질, 불안, 희망 및 건강상태의 관계를 확인하여 이들의 건강상태를 높이기 위한 중재를 위한 기초 자료를 제시하기 위함이다. 방법: 연구대상자는 D시에 소재한 3개 호스피스 병동에 입원한 환자를 주로 돌보는 가족 118명이다. 수집된 자료는 SPSS program version 18.0을 이용하여 서술통계, One-way ANOVA, Pearson correlation coefficients, 단계적 다중회귀분석 등을 실시하였다. 결과: 호스피스 환자의 가족돌봄제공자는 각각 4점 만점인 척도로 측정한 결과 수면의 질은 평균평점 2.55, 불안은 1.91, 희망은 2.78, 건강상태는 2.68로 나타났다. 회귀분석 결과 건강상태에 유의한 영향을 미치는 주요 요인은 수면의 질(${\beta}=0.526$), 성별(${\beta}=-0.195$), 불안(${\beta}=-0.232$) 및 희망(${\beta}=0.169$)으로 나타났다. 모형의 설명력은 59.8% (F=44.510, P<0.001)이었고, 그 중에서 수면의 질이 47.3%를 차지하였다. 결론: 결론적으로 호스피스 환자를 돌보고 있는 가족의 건강상태를 높이기 위해서 간호사는 수면의 질을 높이고, 불안을 감소시키고, 희망을 높이는 방안을 모색해야 할 것이다.

• 대한치과의사협회지
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• 제55권8호
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• pp.516-526
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• 2017

Objective: To suggest diagnostic reference levels (DRLs) for dental panoramic radiography in adults and children through the nationwide survey in Korea. Materials and Methods: Two hundred twelve dental institutions on a national basis were visited. The radiographic examination protocols were surveyed and their patient doses at the clinical exposure setting for adult and children (5- and 10-year old) were measured at 244 panoramic radiographic equipment. The measured DAP were analyzed and compared according to age group, the size of hospital, the type of radiographic system, the installation duration of equipment. Results: The mean exposure parameters were 70.1 kV, 9.2 mA, 14.4 second for adult and 66.6 kV, 7.9 mA, 13.8 second for 10-year old child and 65.5 kV, 7.3 mA, 13.7 second for 5-year old child. The mean and third quartile patient DAPs were $138.3mGy\;cm^2$ and $151.0mGy\;cm^2$ for adult, $99.5mGy\;cm^2$ and $104.8mGy\;cm^2$ for 10-year old child and $89.5mGy\;cm^2$ and $95.5mGy\;cm^2$ for 5-year old child. The mean patient dose at the university dental hospital was lower than that at the dental clinic (p<0.05). The mean patient dose of direct digital radiography type was higher than that of film-based type. However, the difference did not show statistically significance. Conclusion: DRLs for dental panoramic radiography in adult, 10- and 5-year old child were suggested to be $151mGy\;cm^2$, $105mGy\;cm^2$, and $96mGy\;cm^2$ in Korea based on this nationwide survey.

• 한국식품과학회지
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• 제42권5호
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• pp.593-597
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• 2010

본 연구에서는 현미의 미강으로부터 생리활성이 있는 페놀산물질을 얻기 위해 다양한 추출법을 시도하였고, 얻어진 미강 페놀산 농축물의 성분 분석 및 항산화 활성에 대해 조사하였다. 미강 추출물 중 알칼리 가수분해를 시행한 다음 에틸아세테이트로 분획하여 얻은 RBE-II의 총 폴리페놀 함량과 항산화 활성이 가장 높은 것으로 조사되었고, 페놀산 성분의 농축 및 정제를 위해 Sep-pak $C_{18}$ Vac cartridge를 통과시켜 미강 페놀산 농축물(F1-RBE-II)을 얻었다. HPLC 분석을 통해 얻어진 페놀산 성분 중 ferulic acid가 가장 많았고, p-coumaric acid, sinapic acid, vanillic acid, 그리고 syringic acid가 존재하였으며, 그 구성성분이 주로 hydroxycinnamic acid 계열에 속한다는 것을 알 수 있었다. DPPH radical과 ABTS radical 소거능에서 미강 페놀산 농축물(F1-RBEII)는 강력한 항산화 활성을 나타냈으며, ${\beta}$-CLMS을 이용한 지질산화 유도반응에서도 우수한 peroxy radical 저해능을 발휘하여, 합성 항산화제인 BHA의 활성과 비교했을 때 높은 과산화 지질억제력을 보였다. 본 연구를 통해 미강 페놀산 농축물의 성분 및 강한 항산화 능력이 확인됨으로천연 항산화제 및 지방 산화 방지제로 개발하기에 부족함이 없는 것으로 사료된다.

• 영재교육연구
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• 제20권2호
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• pp.503-526
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• 2010

본 연구에서는 과학적 창의력과 정서적 감수성의 관계를 알아보고자 고등학교 과학발명반집단(n=13)과 일반 고등학생집단(n=13)을 대상으로 정서를 유발하는 시각자극을 제시하고 뇌활동성을 기능성자기공명영상(fMRI)을 이용하여 분석하였다. 국내외 창의력 경진대회 수상자들을 중심으로 구성된 과학발명반집단은 창의적 성격검사(WKOPAY, SAM) 점수가 상위 96%이내였으며 일반집단은 보통 수준이었다. 정서를 유발하는 시각자극(IAPS사진) 제시 시 뇌활동성을 분석한 결과 과학발명반집단은 일반집단에 비해 중간측두이랑(MTG)과 상측두이랑(STG) 영역 등에서 뇌활동성이 높게 나타났다. 창의적 성격검사점수와 뇌활동성 간의 상관도를 분석한 결과 MTG, STG 영역 등에서 유의적인 상관도(p<0.005)를 나타내었다. 특히 흥분의 측면보다는 기분(유쾌/불쾌)의 측면에서 유의적인 상관도를 보이는 영역이 많았다. 이러한 결과는 과학적 창의력이 높은 학생들이 일반 학생들에 비해 정서적 감수성이 발달되어 있다는 점을 보여주는 것으로 과학영재교육 대상자의 선발과 교육프로그램에서 정서적 측면이 고려되어야 함을 시사한다.

• 한국산림과학회지
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• 제104권4호
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• pp.519-526
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• 2015

본 연구는 대구 도동측백나무림을 보전하기 위한 기초 자료를 확보할 목적으로 식생군집 분류 및 임분 특성을 분석하였다. 유집 분석 결과, 굴참나무 군집(A), 굴참나무-신갈나무 군집(B), 소나무 군집(C), 측백나무 군집(D)으로 분류되었으며, D군집의 입지환경은 해발고도가 99.3 m, 경사도 $59^{\circ}$, 암석노출도는 68.3%, 흉고단면적은 $21.8m^2/ha$이며 사면방위는 북서사면이었다. MRPP-test 결과 적절한 군집으로 분류되었다. 중요치는 D군집에서 측백나무는 85.4%, 굴참나무 1.3%, 소나무 1.3%, 물푸레나무 3.6% 등으로 나타났으며, 대표수종의 흉고직경급 분석 결과 측백나무는 역J자형곡선으로 나타났다. 종다양도(H')는 0.600~0.834, 최대종다양도(H'max) 1.317~1.466, 균재도(J') 0.456~0.594, 우점도(D')는 0.405~0.544로 분석되었다. 지표종 분석 결과 목본류 4분류군, 초본류 9분류군으로 나타났다.

• 약학회지
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• 제49권6호
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• pp.518-526
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• 2005

Hwanggumgung (HGG) is a hair-care product which is composed of several plant extracts used in oriental medicine. This study was carried out to investigate effect of HGG on hair regrowth in a shaving model of C57BL6 mice. Five-week-old mice were acclimated for 1 week under 23$\pm$3$^{\circ}C$, 50$\pm10\%$ relative humidity and 12 h of a light/dark cycle before beginning experiment. There were four experimental groups including distilled water (D.W., control), 10$\%$ ethanol (EtOH, vehicle control), a positive control of 3$\%$ minoxidil (MXD), and HGG for female and male mice, respectively; Six-weeks old mice were trimmed by electric clippers so as not to damage the skin. The next day; mice without visible scraches were selected, randomized and separated in groups of 11 mice. The test compounds were topically treated with 0.15ml per mouse per day for 21 days. The hair regrowth was photographically and histologically determined during the experimental period of 21 days. Enzyme activities of $\gamma$-glutamyl transpeptidase and alkaline phosphatase were also determined using a rate assay method. There were no clinical signs in all experimental groups. The topical application of 3$\%$ MXD and HGG in female mice promoted hair regrowth earlier and faster than the control groups. In male mice, the topical application of 3$\%$ MXD and HGG also accelerated hair growth compared with the controls. Ten percent ethanol also promoted hair growth faster than D.W group. The histology of hair growth in experimental groups was strongly associated with the hair regrowth. 3$\%$ MXD and HGG promoted elongation of hair follicles compared with the controls in both female and male mice. Activities of alkaline phosphatase and $\gamma$-glutamyl transpeptidase, enzymes related to hair growth, significantly increased after treatments of 3$\%$ MXD and HGG for 2 weeks in both female and male mice (p < 0.05). These results suggest that HGG has hair growth promoting activities and it can be for treatment for alopecia.

• 대한치과보철학회지
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• 제39권5호
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• pp.526-546
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• 2001

Fiber-reinforced composite(FRC) was developed as a structural component for dental appliances such as prosthodontic framework. FRC provides the potential for fabrication of a metal-free, excellent esthetic prostheses. It has demonstrated success as a result of its simple fabrication, natural colour, and marginal integrity, and fracture resistance of veneering composite resin and the FRC material. Although it has lots of merits, clinical and objective data are insufficient. The purpose of this study was to evaluate the fracture strength and the marginal fitness of fiber reinforced composite bridge in the posterior region for clinical application. Sixteen bridges of each group. $Targis/Vectris^{(R)}$, $Sculpture-Fibrekor^{(R)}$, and In-Ceram, were fabricated. All specimens were cemented with Panavia 21 to the master dies. Strength evaluation was accomplished by a universal testing machine (Instron). The marginal fitness was measured by using the stereoscope (${\times}50$). The results were as follows. : 1. The fracture strength according to the materials was significantly decreased in order In-Ceram($238.81{\pm}82$), Targis Vectris($176.25{\pm}18.93$), Sculpture-Fibrekor($120.35{\pm}20.08$) bridges. 2. FRC resin bridges were not completely fractured, while In-Ceram bridges were completely fractured in the pontic joint. 3. The marginal accuracy was significantly decreased in order Targis/Vectris ($60.71{\mu}m$), Sculpture-Fibrekor($73.10{\mu}m$) In-ceram Bridge ($83.81{\mu}m$). 4. The fitness of occlusal sites had a lower value than the marginal sites(P<0.001), and the marginal gaps of inner site of the pontic were greater than that of outer sites of the pontic. Fiber reinforced composite bridges are new, esthetic prosthesis and can be clinically used in anterior regions and short span bridges. However, caution must be exercised when extrapolating laboratory data to the clinical situation because there are no long term clinical data regarding the overall success of the FRC.