• 전자공학회논문지
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• 제51권9호
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• pp.190-199
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• 2014

본 논문에서는 섬모 번들 특성 모델과 통합 전정 유모세포 모델을 제안한다. 기존 전정기관 모델에 관한 연구는 외력이 없는 상태에서 전정 유모세포의 섬모 번들이 가지는 특성이나 시냅스에서 발생하는 활동전위만을 대상으로 진행되었으며 섬모번들의 고유 특성을 고려한 전정신경의 활동전위에 대한 연구는 이루어지지 않았다. 제안된 통합 전정 유모세포 모델은 외력을 반영하였고 서로 다른 규칙성을 가진 유모세포에 대해 각각의 섬모번들의 반강성 특성을 고려하였고 이를 기존의 외력없는 모델과 비교하였다. 그 결과 외부 자극의 변화에 따른 주파수 변화가 큰 불규칙적 신경섬유와 중간규칙적 신경섬유에서는 반강성 구간의 감소를 보였으나 그렇지 않은 규칙적 신경섬유에서는 기존의 반강성 특성과 유사한 특성을 보여주었다. 또한 제안된 전정 유모세포 모델을 통해 11개의 주파수 대역에서의 모델링 데이터와 기존의 동물 실험 데이터가 거의 일치함을 보여 주었다. 제안된 섬모 번들 특성 모델이 적절히 모델링되었음이 확인된다.

• 동의생리병리학회지
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• 제34권2호
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• pp.102-116
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• 2020

The purpose of this study was to analyze the research trends of randomized controlled trials on herbal medicine treatment for atopic dermatitis in China for the last 5 years. We searched for randomized controlled trials with the intervention of herbal medicine for the treatment of atopic dermatitis in the CNKI (China National Knowledge Infrastructure) from January 2014 to December 2018. For the screening of the paper, we used '特应性皮炎' and '异位性皮炎' which mean atopic dermatitis and search was limited to three areas within Medicine & Public Health: Traditional Chinese Medicine, Traditional Chinese Medicinal Herbs, Combination of Traditional Chinese Medicine with Western Medicine. Among the 136 searched studies, we selected a total of 34 studies and analyzed a year of publication, subject characteristics, study design and intervention, prescribed herbal medicine and herbs, pattern identification, evaluation criteria, and outcomes. Longmu decoction (龍牡湯) and Polia Sclerotium (茯笭) was the most frequently prescribed medicine and herb. The most commonly used pattern identification was Blood deficiency and Wind-dryness (血虛風燥), and among them, the most frequently prescribed herb is Rehmanniae Radix (生地黃). In most studies using the total effectiveness and SCORAD index as an outcome measure, the herbal medicine treatment group showed statistically better results than the control group. As a result of the safety assessment, the herbal medicine treatment group was reported having significantly fewer side effects compared to the control group. Hence, it was confirmed that the intervention including herbal medicine had a significant effect on atopic dermatitis. This study would be able to provide the basis of clinical research on atopic dermatitis and applied to the treatment of atopic dermatitis.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권1호
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• pp.34-40
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• 2013

Purpose: We investigated the positivity rate and the time period to the positive color change of the urease test in children and adults and assessed the correlation of the urease test to histopathologic findings. Methods: From 1995 to 2000, endoscopic biopsies of the antrum and body were collected from 811 children and 224 adults and subjected to urease tests and histopathology. Results: The positivity rate of the urease test was 49.4% for 0-4 years, 48.4% for 5-9 years, 47.3% for 10-15 years, and 62.5% for 20-29 years in the antrum. The positivity rate was 85.1% in 0-4 years, 82.3% in 5-9 years, 74.7% in 10-15 years, and 74.1% in 20-29 years for the body. In the antrum, the highest positivity rate was <1 hour for the group aged 10-29 years and 6-24 hours in the group <10 years old (p<0.0001). In the body, the highest positivity rate was <1 hour in adults and 6-24 hours in children (p<0.0001). The proportions of the positive reactions within 1 hour were similar for the antrum and the body. In the cases of more severe chronic gastritis, active gastritis, and Helicobacter pylori infiltration, a positive urease test reaction occurred more quickly (p<0.0001). Conclusion: There were significant differences in urease tests according to age and sampling site. The discrepancy between the antrum and the body was greater in younger children. These results might be related to the low density and patchy distribution of bacteria in children and in the body.

• 생명과학회지
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• 제30권5호
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• pp.483-490
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• 2020

유비퀴틴 시스템은 ubiquitin ligases와 deubiquitinases (DUBs)에 의해 타겟 기질의 ubiquitination 유무에 따라 안정화, 활성화, 국소화 및 상호작용을 변화시키고 암 발병의 관여하는 다양한 생물학적 과정을 조절한다. DUBs는 촉매 domain에 따라 6그룹으로 나뉘어지는데, 그 중에서 OTU 그룹 내 대부분의 DUB는 세포의 연속적 신호반응(cell signaling cascade)을 조절할 수 있다. 특이하게도 OTU 그룹에 속하는 otubain 1 (OTUB1)은 정규적(canonical) 활성과 비정규적(non-canonical) 활성을 모두 가지고 있다. 본 보고에서는 OTUB1의 canonical, non-canonical 활성 조절에 있어서 다양한 신호전달경로 및 OTUB1의 역할에 대해 기술하였다. OTUB1은 이 두 종류의 활성 경로를 통하여, OTUB1은 암 관련 신호 전달 체계에 중요한 FOXM1, ERα, KRAS 및 EMT를 조절하고 암세포 증식 및 전이 능력 향상 및 항암제에 대한 내성을 나타낸다. 또한 임상적으로 전이성 및 종양 분화도가 높은 암 조직에서 OTUB1의 발현이 높으며, 이에 따라 환자의 생존율이 감소하는 등 나쁜 예후를 나타낸다. 따라서, 임상적으로 적용할 수 있는 OTUB1 억제제의 개발이 이루어진다면 OTUB1은 종양 치료에 있어 중요한 진단마커이자 치료적인 타겟이 될 수 있다.

• Investigative Magnetic Resonance Imaging
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• 제9권2호
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• pp.134-139
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• 2005

목적 : 청각의 뇌기능 영상 검사 시 소음 감쇠기의 유용성을 알아보고자 하였다. 대상 및 방법 : 소음 감쇠기는 실리콘 이어폰, 귀마개 그리고 마스크로 구성하였다. 마스크와 귀마개는 방음효과가 크다고 알려져 있는 부드러운 재질의 폴리우레탄 시트와 폴리우레탄 폼을 사용하여 제작하였다. 500 Hz의 순음 자극에 대한 청각의 뇌기능 자기공명영상 실험은 4명의 지원자를 대상으로 다음의 세가지 경우로 구별하여 시행하였다: 첫째, 마스크와 귀마개, 이어폰을 모두 착용한 경우, 둘째, 귀마개와 이어폰만을 착용한 경우 그리고 마지막으로 소음 감쇠기를 착용하지 않은 경우 이다. 데이터 획득을 위하여 고성능 경사자계 시스템이 갖추어진 1.5 T 자기공명영상장치에서 BOLD 자기공명 영상기법을 사용하였다. 영상 데이터는 SPM 99 분석프로그램을 이용하여 분석하여 활성화 지도를 획득하였다. 결과 : 소음감쇠기의 모든 구성요소를 사용한 경우 활성화는 주로 일차 청각중추에서만 집중되어 나타나는 결과를 얻었다. 귀마개와 이어폰만을 착용했을 때는 청각의 뇌 활성화 영역이 일차 청각중추와 이차 청각 영역에 분산되어 나타는 결과를 얻었으며 마지막으로 소음감쇠기를 사용하지 않은 경우 청각영역이 오른쪽의 일부만이 활성화 되었다. 결론 : 마스크, 귀마개, 이어폰으로 구성된 소음 감쇠기는 청각의 뇌기능 영상 검사 시 매우 유용할 것으로 기대된다.

• 대한후두음성언어의학회지
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• 제29권1호
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• pp.30-36
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• 2018

Background and Objectives : The effect of palliative injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients on voice and swallowing function is uncertain and there are few previous studies of its suitability, benefits as a palliative treatment option. The purpose of this study is to confirm the objective results of voice and swallowing function after palliative office-based hyaluronic acid injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients. Materials and Method : 36 patients who had unilateral vocal cord paralysis from non-thyroidal, extralaryngeal neoplasms were included in this study. To evaluate the clinical outcome, we analyzed perceptual GRBAS grading, acoustic analysis, aerodynamic study, Electroglottography (EGG), Voice Handicap Index (VHI-30) about voice function and disability rating scale (DRS), gastric tube dependency, aspiration pneumonia about swallowing function and 36-Item Short Form Survey version 2 (SF-36v2) about quality of life. Results : In GRBAS scale, G (p<0.001), R (p=0.004), B (p=0.001), A (p=0.011), and S (p=0.007) showed significant improvement. Jitter, shimmer, speaking fundamental frequency, maximal phonation time, VHI-30, DRS score, gastric tube dependency, aspiration pneumonia, and SF-36v2 were significantly improved after injection (p=0.016, p=0.011, p=0.045, p=0.005, p<0.001, p<0.001 p=0.003, p<0.001, and p<0.001 respectively). Conclusion : From this study we concluded office-based hyaluronic acid injection can be used as a useful palliative treatment option in cancer-related ill patients with unilateral vocal cord paralysis. Palliative hyaluronic acid injection laryngoplasty avoids the need for tube feeding, thus reducing the risk of aspiration pneumonia. These outcomes are accompanied by significant improvement in voice quality.

• 대한두경부종양학회지
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• 제12권2호
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• pp.169-176
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• 1996

결핵의 진단은 특징적 병리조직양상, 항산균 염색에 의한 균 증명과 M. tuberculosis균 배양으로 이루어지나 형태적으로는 결핵이 의심되더라도 항산균이 조직표본이나 도말에서 검출되지 않거나 M. tuberculosis가 배양되지 않아 정확한 원인적 진단이 불가능할 경우가 많다. 이에 저자들은 경부 결핵성 임파선염으로 적출되어 보내어진 경부 임파선 조직의 신선한 조직이나 통상적으로 처리되어 제작된 파라핀 블록을 이용하여 M. tuberculosis에 특수한 반복성 DNA sequence인 IS986를 표적으로 한 primers을 사용하여 nested PCR방법을 이용하여 예민도가 높은 M. tuberculosis 검출로 빠른 시간 내에 결핵을 진단하고자 본 연구를 실시하였다. 최근 유전자 기술의 진보로 M. tuberculosis의 여러 항원들의 유전자가 클론화되고 그 염기 배열이 밝혀졌으며 이에 저자들은 결핵의 확진을 위하여 파라핀 포매조직을 대상으로 nested PCR에 의한 188bp의 DNA를 증폭한후 증폭한 DNA분절의 염기 배열을 결정한 후 Bst UI와 Hha I 효소를 이용한 소화과정을 거친 후 restriction fragment length polymorphism(RFLP)을 은염색에 의해 그 패턴에 의해 M. tuberculosis를 확인하고 또한 다른 종의 Mycobacteria를 배제시킬 수 있었다. 본 방법은 1$\sim$2일에 끝나며, 방사선물질을 사용하지 않으면서도 감도 및 특이성이 우수하여 일반 병리실힘실에서도 M. tuberculosis를 포함한 각종 항산균의 신속한 검출법으로 손쉽게 사용할 수 있다고 생각되어 이에 보고하였다.

• 대한후두음성언어의학회지
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• 제15권1호
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• pp.16-20
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• 2004

Purpose : To assess perceptual, acoustic and aerodynamic measure of voice quality in patients with unilateral vocal cord paralysis before and after type I thyroplasty. Methods : The clinical records of patients operated type I thyroplasty in the Departement of otorhinoalryngolgy, Yongdong Severance hospital from November 2001 to November 2003 were reviewed. All patients uderwent a vocal function evaluation including perceptual, acoustic and aerodynamic measures of voice preoperative and on $60^{th}$ postoperative day. The perceptual and acoustic measures were obtained from recording of patients' reading a 'Sanchak' passage. The perceptual evaluation was performed by 2 speech pathologist using a 4-point rating scale. Acoustic parameters(voice range profile low(RAL), voice range profile high(RAH), average fundamental frequency(AFX), closed quotient, harmonic to noise ratio, jitter and shimmer) were investigated by Lx speech studio. Mean flow rate(MFR), subglottic pressure(Psub) and intensity were measured using the Phonatory function analyzer. The maximum phonation time was also measured. The data were statistically analyzed. A paired t-test (p<0.1) was used to compare preoperative and postoperative results. And multiple regression test was used to find which parameter was most correlated to improvement of postoperative voice quality. Results : Among aerodynamic parameters, Psub $(88.11mmH_2O{\rightarrow}58.7mmH_2O)$, MPT(7.87sec${\rightarrow}$12.53sec), MFR (359.8ml/sec${\rightarrow}$161.06ml/sec) were statistically improved. AFx(205.5Hz${\rightarrow}$163.27Hz), AQx(23.9%${\rightarrow}$48.3%), RAL, RAH. Jotter and shimmer were improved. In multiple regression test, AFx and AQx was noted as the two meost correlated parameters to improvement of postoperative breathiness. But general grade of voice quality was more correlated to Psub and shimmer. Conclusion : Vocal fold medialization procedures effectively reduce glottic gap. Increasing of contact area of both vocal folds induced improvement in aerodynamic parameters and leaded stabilizing of vocal fold vibration. That effect results in improvement in acoustic parameters (shimmer, jitter, signal-to-noise ratio, voice range profile) and voice quality.

• 동의신경정신과학회지
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• 제26권2호
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• pp.117-130
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• 2015

Objectives: Banhahoobak-tang has been used to treat plum-pit qi, chest and hypochondriac distension, moist or greasy tongue coat, and wiry slow or wiry slippery pulse. It might be used to control coughing and vomiting. We observed that Banhahoobak-tang extract (BHTe) had anti-psychological stress effect. The objective of this study was to determine the effect of BHTe on restoring the transcriptional regulation of genes related to psychological stress. Methods: After giving psychological stress to mice, BHTe was orally administered at 100 mg/kg/day for five days. After extracting whole brain tissue from the mice, the gene expression changes were determined by microarray. Transcription factor binding site (TFBS) analysis showed up- and down-regulated genes related to psychological stress were protected by BHTe and segregated according to the structure of TFBS. We performed text based Pubmed search to select significant target genes involved in psychological stress affected by BHTe. Results: 1. Serum corticosterone level was decreased in the BHTe administered group, although the psychological stress was increased. 2. The BHTe administered group had no significant change in noradrenaline content in brain tissue, but the psychological stress group had decreased level. 3. The BHTe administered group had increased time of staying at open-arm than the psychological stress group. 4. Microarray revealed that TANK and RARA genes were up-regulated genes while AES, CDC42, FOS, NCL, and PVR were down-regulated genes by psychological stress but restored by BHTe.

• 동의생리병리학회지
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• 제32권2호
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• pp.134-140
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• 2018

This study aims to evaluate healthcare providers' satisfaction and demands pertaining to the collaborative first-stage pilot project between Korean medicine and Western medicine. This survey was conducted via electronic mail among 33 healthcare providers participating in the pilot project. Likert type 5-point scale or Likert type 7-point scale was used to evaluate each item. The response of '${\geq}4$' on the 5-point scale, and '${\geq}5$' on the 7-point scale were analyzed as positive answers. A total of 27 healthcare providers (81.8%) responded, of which 9 were western medical doctors (33.3%) and 18 were Korean medical doctors (66.7%). In respect to satisfaction of the pilot project, 88.9% gave positive responses on improved patients' convenience, 59.3% on treatment efficiency and 55.6% on diagnosis efficiency. In terms of self-evaluation on the pilot project, 70.4% gave positive answers on changes in quality of collaborative treatment, 74.1% on cooperation of results, 63.0% on cooperation of structure and 51.9% on cooperation of process. In terms of demand for collaborative treatment or the pilot project, 'standardized manual' and 'simplification of administrative procedures' showed highest demand, resulting up to 88.9%, followed by 85.2% demanding more public relations and 63.9% demanding enlargement of participating hospitals. This survey revealed that healthcare providers are generally satisfied with patients' convenience and treatment effects. Further studies are needed to develop a standardized manual, simplified administrative procedures, and expanded pilot project contents.