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Anti-inflammatory effects of Coptidis Rhizoma in chronic cold stress-exposed mice (만성 저온 스트레스 동물모델에서의 황련(黃連)의 항염증 효능 연구)

  • Choi, Jin Gyu;Huh, Eugene;Lee, Wonil;Kim, Yun-Kyung;Lee, Tae-Hee;Oh, Myung Sook
    • The Korea Journal of Herbology
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    • v.33 no.6
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    • pp.35-42
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    • 2018
  • Objectives : The aim of this study was to investigate whether the extract of Coptidis Rhizoma inhibits inflammation in chronic cold stress (CCS)-exposed mice or not. Methods : Coptidis Rhizoma extract (CRE) was made by reflux with distilled water. Male ICR mice (7 weeks old) were divided randomly into 5 groups: (1) control, (2) CCS, (3) CCS+CRE 100 mg/kg, (4) CCS+CRE 300 mg/kg, (5) CCS+CRE 1,000 mg/kg groups. Mice were orally administered once a day for 14 days starting from 1 day before CCS. Group (2)-(5) were exposed to CCS conditions that maintained at $4^{\circ}C$ for 2 h once a day for 14 days. The levels of serum cortisol and hypothalamic prostaglandin E1 (PGE1) and PGE2 were measured by enzyme-linked immunosorbent assay kit. The expression levels of several pro-inflammatory factors like heat shock protein 70 (HSP70), c-fos, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) were measured by western blot analysis in mouse hypothalamus. Results : Oral administration of CRE 1,000 mg/kg significantly suppressed the increase of serum cortisol levels in mice exposed to CCS. CCS-exposed mice had significantly increased the expression of HSP70, c-fos, and NF-kB in hypothalamus, while CRE treatment significantly attenuated the elevation of these pro-inflammatory factors. The ratio of PGE2/PGE1 was also higher in CCS-exposed mice than control group. CRE treatment significantly reduced the increase of PGE2/PGE1 ratio induced by CCS. Conclusion : These findings suggest that Coptidis Rhizoma may work as a potential agent to modulate inflammatory responses under the condition of cold adaptation formed by CCS.

The Effect of Education on Human tissue donation on Nursing students' Knowledge, Attitude and Perception of death (인체조직기증에 대한 교육이 간호대학생의 지식, 태도, 죽음에 대한 인식에 미치는 효과)

  • Park, Min-Ae;Yoon, Young-sub
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.3
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    • pp.15-23
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    • 2022
  • This study is a non-equivalent control group quasi-experimental design to test the effectiveness of educational programs on human tissue donation for nursing students to change the perception of human tissue donation. The subjects of the study were 75 nursing students located in U city, 38 in the experimental group and 37 in the control group. The data were analyzed using SPSS/WIN 23.0. The average age was 22.39±0.75 years old, women 84.2% and there was no difference in general characteristics and prior data between the two groups. Knowledge (F=-8.921, p<).001, Attitude (F=-5.414, p<).001, perception of death (F=-3.075, p=).004) showed a significant difference, and the educational intervention of nursing students developed to promote human tissue donation showed a positive effect on human tissue donation. When programs to be applied to educational institutions that train not only medical personnel but also experts in other fields must be developed, the establishment and stability of the human tissue donation culture will be solidified. It is also suggested that health care campaigns and education in public educational institutions should be conducted together.

Effects of fermented soybean meal with Bacillus velezensis, Lactobacillus spp. or their combination on broiler performance, gut antioxidant activity and microflora

  • Tsai, C.F.;Lin, L.J.;Wang, C.H.;Tsai, C.S.;Chang, S.C.;Lee, T.T.
    • Animal Bioscience
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    • v.35 no.12
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    • pp.1892-1903
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    • 2022
  • Objective: A series of experiment were conducted to evaluate the effects of replacing a part of soybean meal (SBM) at 6% of broiler diets with fermented soybean meal (FSBM) obtained by single or two-stage fermentation by measuring growth performance, antioxidant activity in the jejunum and distal intestinal microflora. Methods: Soybean meal samples were prepared by single-stage fermentation using Bacillus velezensis (Bv) (FSBMB), or Lactobacillus spp. (as commercial control) (FSBML). Additional SBM sample was prepared by two-stage fermentation using Bv and subsequently using Lactobacillus brevis ATCC 367 (Lb) (FSBMB+L). Enzyme activity, chemical composition, trichloroethanoic acid-nitrogen solubility index (TCA-NSI) and antioxidant activity were measured. Then, in an in vivo study, 320 Ross308 broilers were divided into four groups with ad libitum supply of feed and water. Four groups were fed either a corn-soybean meal diet (SBM), or one of fermented SBM diets (FSBMB+L, FSBMB, and FSBML). Growth, serum characteristics, microflora, and the mRNA expression of selected genes were measured. Results: Compared to SBM, FSBMB+L contained lower galacto-oligosaccharide, allergic protein, and trypsin inhibitor, and higher TCA-NSI by about three times (p<0.05). Reducing power and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging ability correlated positively with the TCA-NSI content in FSBM. Growth performances were not significantly different among four groups. In jejunum of 35-day-old broilers, partial replacement of SBM by FSBMB+L increased the activity of superoxide dismutase and catalase (CAT), and the FSBMB group had the highest catalase activity (p<0.05). Partial replacement of SBM by FSBM increased relative mRNA expressions of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and peptide transporter 1 (PepT1) (p<0.05); however, FSBMB+L increased CAT mRNA level to 5 times of the control (p<0.05). Conclusion: Using Bv- and Lb-processed SBM through two-stage fermentation to partially replace 6% of diets will improve the gut's antioxidant activity under commercial breeding in broilers.

A Case of Multisystem Inflammatory Syndrome in Children (MIS-C) with Acute Myocarditis

  • Lim, Jin Gyu;Lee, Da Hye;Oh, Kyung Jin;Choi, Sujin;Song, Young Hwan;Lee, Joowon;Lee, Hyunju
    • Pediatric Infection and Vaccine
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    • v.28 no.3
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    • pp.173-180
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    • 2021
  • After initial reports of multisystem inflammatory syndrome in children (MIS-C) in April 2020 in Europe, this disease has been known to occur in children with recent history of coronavirus disease 2019 (COVID-19) and most cases have been reported in Europe and the Unites States of America. We report a case of a 14-year-old girl who was diagnosed with MIS-C with acute myocarditis and successfully treated with intravenous immunoglobulin (IVIG), methylprednisolone, and anakinra. At initial presentation, she had persistent high fever, generalized rash, generalized swelling, abdominal pain, and low blood pressure. She showed a remarkably elevated level of inflammation and cardiac enzyme markers and had a previous history of COVID-19 5 weeks before the initial presentation. After extensive work up, other infectious and non-infectious causes were excluded. She was diagnosed with MIS-C and initially treated with IVIG and high-dose methylprednisolone; however, despite treatment, her heart function deteriorated and coronary artery dilatation progressed. Therefore, anakinra, an interleukin-1 receptor antagonist, was administered on hospital day 6, after which her cardiac function exhibited improvement. She was discharged on hospital day 19 without any symptoms, and follow-up echocardiography after 1 month revealed fully recovered heart function with normal coronary arteries.

Using frequency and needs for walking sphere of neighborhood facilities by the elderly - Focused on the elderly who lived in Busan - (노인의 근린생활시설 이용정도와 도보권 시설요구 - 부산지역 거주 노인을 중심으로 -)

  • Oh, Chan Ohk
    • Korea Science and Art Forum
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    • v.20
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    • pp.279-292
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    • 2015
  • As the aging society is rapidly coming, the needs for the elderly-friendly living environments was also increasing. The purpose of this study was to examine how frequently 25 neighborhood facilities were used by the elderly and what facility they wanted to be arranged within their walking distance. The subject of this study were 158 elderlies who were their ages of more than 65 years and lived in Busan. The data were collected by using an one to one interview method. Findings were as follows; 1) The elderly used very frequently facility for the elderly such as a senior center, walking road, and park and green space. Also, bus stop, traditional market, and resting facilities were used relatively frequently. 2) Some neighborhood facilities were used not frequently, but periodically. 3) Using frequencies of some neighborhood facilities were different by the elderly's characteristics. 4) Among 25 neighborhood facilities, the facilities which the old persons wanted to be arranged within walking distance were medical clinics, facilities for the elderly, subway station, bus stop, traditional market, park and green space, walking road, and food market/convenience store.

Effects of Uwhangchungsimwon on Arterial Stiffness (우황청심원이 정상인의 동맥경직도에 미치는 영향)

  • Rhee, Jun-woo;Moon, Sang-kwan;Park, Seong-uk;Jung, Woo-sang;Park, Jung-mee;Ko, Chang-nam;Cho, Ki-ho;Bae, Hyung-sup;Kim, Young-suk
    • The Journal of the Society of Stroke on Korean Medicine
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    • v.7 no.1
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    • pp.17-22
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    • 2006
  • Objectives : Uwhangchungsimwon (UC) is one of the famous herbal medicine frequently used for stroke, hypertension, and atherosclerosis, etc. Therefore, we intended to examine if UC could have therapeutic effect on arterial stiffness by assessing Cardio-Ankle Vascular lndex (CAVI). Methods : We enrolled 38 healthy male subjects (28±4.41 years old) and divided them into two groups (UC and control group). The UC group (N=22) were treated with 1 pill of UC and monitored by CAVI every hour for 6 hours. The control group(N=16) did not receive any medicine and were also monitored by CAVI the same manner as the UC group. In both group, we also assessed each subject's Yin-Yang pattern score by the diagnostic scoring system. In analysis, we compared the difference of CAVIs between the UC and the control group considering subject's Yin-Yang pattern. Results : There was no significant difference in the change of CAVI between the UC and the control group. After excluding Yang-pattern subjects in both group, however, we could observe that CAVI decreased significantly 5 hours after UC administration compared with the corresponding CAVI in the control group (P=0.025). In the repeated measure analysis, the between-subjects effect had statistical significance (P=0.035). Conclusion : According to these results, we suggest that UC have therapeutic effect on arterial stiffness especially after taking oriental medical diagnosis into consideration.

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A Study on the Vegetables Mentioned in the Bible (성서에 언급된 채소류에 관한 연구)

  • Woo, Ja-Won
    • Journal of the Korean Society of Food Culture
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    • v.22 no.1
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    • pp.1-9
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    • 2007
  • This paper is intended to study what kinds of the vegetables are mentioned in the Bible and how they were used in those days. While one hundred and twenty-eight different plants are mentioned in the Bible, there are today 2,384 plant species in modem Israel, most of which have been introduced in recent centuries. These plants obviously did not exist there in biblical times and were only recently introduced from Australia and South America, respectively. This article will study only the vegetables mentioned in the Bible and known to have existed in the old and new testament times. Since the first book devoted exclusively to biblical botany was that of Levinus Lemmens in 1566, the modem systematic study of biblical plants, began with F. Hasselquist, a student of Linnaeus, the founder of modem botany. In 1928, Immanuel Loew approached the subject differently, reviewing all known data pertaining to biblical plants. His work not only discussed biblical plants, but also plants in later Jewish literature, particularly the Talmud. The British scholar G. E. Post provided a broad field study of modem plants in Palestine, Syria, Lebanon, and Jordan. More recent major treatments of the subject include those of A. and H. Moldenke (1952), M. Zohary (1982), N. Hareuveni (1984), and Y. J. Choi(1996). Today, articles on specific biblical plants listed in the Bible can be found in any number of encyclopedias. This study attempts to provide a synthesis of the work of a number of scholars who studied the vegetables and plants mentioned in the Bible. As a preliminary study on the culture of food in the biblical period, this study has focused on the identity and features of the vegetables of the Bible. In only a limited number of instances, because of the paucity of the informations and the broad and generic descriptions of the plants, we can't be certain about the identification of the vegetables named in the Bible. In many instances the traditions established by the Greek, Aramaic, and English translations are helpful, although sometimes they are misleading. This paper subdivides the vegetables into broad areas, the general vegetables and the flavoring herbs. Vegetables formed very important part of the diet in the biblical times. Two main types were used: those whose nutritious seeds could be easily stored and those which were eaten freshly gathered from gardens. Pulse seeds provided a useful source of vegetable protein, while fresh green vegetables were vitamin rich. Pulses could be eaten boiled, or their dried seeds could be ground up into flour and then made into nutritious soups. Fresh vegetables were eaten either raw or lightly cooked, usually by boiling in water. The general vegetables in the Bible are herbs(garden rocket), cucumber(snake cucumber), watermelon, leeks, chicory, and onions. Also the flavoring herbs in the Bible are rue, dill, cummin, black cummin, frankincense, cinnamon, cassia, myrrh, black mustard, coriander, mint, saffron, ginger grass, syrian hyssop, aloes(eagle wood), manna which have the flavor, aroma, and medical values.

A Study of Influential Factors on Health Promoting Behaviors of the Elderly: Focusing on Senior Citizens Living in Seoul (노인의 건강증진행위 영향요인에 관한 연구: 서울지역 거주노인을 중심으로)

  • Kim, Hyesook;Junsoo, Hur
    • 한국노년학
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    • v.30 no.4
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    • pp.1129-1143
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    • 2010
  • The purposes of this study were to investigate the major determinants influencing on health promoting behaviors(HPB) of the elderly living in Seoul. The conceptual framework of the study was Pender's health promoting model and the ecological perspectives. The study was conducted with 495 elderly persons whom 60 years old. For the analysis of data, descriptive statistics and hierarchical regression were used for the statistical analysis with SPSS program. The results were as following: 1) The mean score of the HPB was 3.11(SD=0.41). 2) Hierarchical regression analysis found that ModelIV accounted for 55.7% of the variance in HPB. 3) The Major determinants on HPB among the elderly persons were prior related perceived benefits of action, social support, perceived self-efficacy, community environment, perceived health status, education, and age. In conclusions, first, we should develop to various levels of educational and supportive programs for the HPB among the elderly persons. Second, we should examine more with environment, the accessibility to senior welfare agencies. Third, we should be organized the self-help groups for the elderly persons to improve health promoting behaviors. Fourth, the government should established more secure environment for the HPB, and find better solutions that are provided by various social welfare agencies connected with the coordination of the services in the local communities. Finally, we should develop professional education training programs of the HPB for the practitioners in the field of Gerontological Social Work.

Factors Affecting Falls of Demented Inpatients (치매 입원환자의 낙상 영향 요인)

  • Kim, Sang-Mi;Lee, Seong-A
    • 한국노년학
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    • v.39 no.2
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    • pp.231-240
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    • 2019
  • The study aimed to identify risk factors for falls as well as hospitalization status according to disease and demographic characteristics of demented inpatients by investigating the in-depth Injury Patient Surveillance System data collected by Korea Centers for Disease Control and Prevention(KCDC). Older adults over 60 years old who were diagnosed with dementia were included(n=1,732). Their data were analyzed after being assigned to either a fall group or a non-fall group. STATA was used for statistical analyses, such as frequency analysis, chi-square (χ2) test, and logistics regression. It was found that 8.0% of the demented inpatients experienced falls. According to the analysis on category of fall and non-fall group were statistically significant difference in age and Charlson Comorbidity Index(CCI) and bone density deficiency. Based on the logistic regression analysis of factors affecting falls, older adults over 80 are 2.386 times more likely to fall and based on a target with a CCI of 0, the risk of falls is 0.421 times lower, finally based on those without bone density disorder, the fall risk for those with bone density disorder was 3.581 times higher. Therefore, we expect that the important about the factors relating to falls identified in this can not only be found valuable for educating inpatients with dementia and care-givers, but also be used as reference that supports clinical professionals to make decisions on falls management for patients with dementia.

Awareness of the Causes of Drug-Induced Liver Injury: A Case of Hepatotoxicity Resulting from Antipsychotics (사례로 본 한방임상에서 양약으로 인한 약인성간손상에 대한 인식 필요성)

  • Chang-gue Son
    • The Journal of Internal Korean Medicine
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    • v.44 no.4
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    • pp.751-756
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    • 2023
  • Objective: This study attempts to increase awareness of hepatotoxicity caused by antipsychotic drugs and to provide updated information on drug-induced liver injury (DILI) to physicians in Korean medicine (KM) clinics. Methods: This study presents a detailed case of a female patient diagnosed with DILI attributed to antipsychotic drugs, highlighting the improvement observed through laboratory findings. Results: A 56-year-old female patient with underlying disorders, including mixed connective tissue disease and depression, was under medical care. One day, she reported experiencing intense fatigue and distressing sensations, prompting the author to order blood tests. The levels of AST and ALT were significantly elevated by more than 2.5-fold, indicating hepatocellular DILI. The RUCAM score for antipsychotic drugs was 9, as no other medications, including herbal medicine, were being taken. Upon discontinuation of the antipsychotic drugs, the patient's laboratory findings returned to normal levels within 2 weeks, accompanied by a recovery of subjective symptoms. Conclusion: This study presents a noteworthy case of hepatotoxicity caused by antipsychotic drugs, serving as an illustrative example that highlights the crucial need for awareness among doctors of KM in clinical settings.