• Journal of Nutrition and Health
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• v.57 no.2
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• pp.171-184
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• 2024

Purpose: Although activating thermogenic adipocytes is a promising strategy to reduce the risk of obesity and related metabolic disorders, emerging evidence suggests that it is difficult to induce adipocyte thermogenesis in obesity. Therefore, this study aimed to investigate the regulation of adipocyte thermogenesis in diet-induced obesity. Methods: Adipose progenitor cells were isolated from the white and brown adipose tissues of control diet (CD) or high-fat diet (HFD) fed mice, and fully differentiated white and brown adipocytes were treated with β-agonists or 18-carbon fatty acids for β-adrenergic activation or peroxisome proliferator-activated receptor (PPAR) activation. Results: Compared to the CD-fed mice, the expression of uncoupling protein 1 (Ucp1) was lower in the white adipose tissue of the HFD-fed mice; however, this was not observed in the brown adipose tissue. The expression of peroxisome proliferator-activated receptor gamma (Pparg) was lower in the brown adipose progenitor cells isolated from HFD-fed mice than in those isolated from the CD-fed mice. Norepinephrine (NE) treatment exerted lesser effect on peroxisome proliferator-activated receptor-γ coactivator (Pgc1a) upregulation in white adipocytes derived from HFD-fed mice than those derived from CD-fed mice. Regardless which 18-carbon fatty acids were treated, the expression levels of thermogenic genes including Ucp1, Pgc1a, and positive regulatory domain zinc finger region protein 16 (Prdm16) were higher in the white adipocytes derived from HFD-fed mice. Oleic acid (OLA) and γ-linolenic acid (GLA) upregulated Pgc1a expression in white adipocytes derived from HFD-fed mice. Brown adipocytes derived from HFD-fed mice had higher expression levels of Pgc1a and Prdm16 compared to their counterparts. Conclusion: These results indicate that diet-induced obesity may downregulate brown adipogenesis and NE-induced thermogenesis in white adipocytes. Also, HFD feeding may induce thermogenic gene expression in white and brown primary adipocytes, and OLA and GLA could augment the expression levels.

• Journal of Computing Science and Engineering
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• v.2 no.2
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• pp.162-179
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• 2008

We have developed a tool for annotation of electronic health record (EHR) data. Currently we are in the process of manually annotating a corpus of Norwegian general practitioners' EHRs with mainly linguistic information. The purpose of this project is to attain a linguistically annotated corpus of patient histories from general practice. This corpus will be put to future use in medical language processing and information extraction applications. The paper outlines some of our practical experiences from developing such a corpus and, in particular, the effects of semi-automated annotation. We have also done some preliminary experiments with part-of-speech tagging based on our corpus. The results indicated that relevant training data from the clinical domain gives better results for the tagging task in this domain than training the tagger on a corpus form a more general domain. We are planning to expand the corpus annotations with medical information at a later stage.

• KIEAE Journal
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• v.5 no.1
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• pp.19-25
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• 2005

Rapid urbanization and social development have brought about changes in family structure. In urbanized areas, recently the number of dogs that are a majority of companion animals has increased significantly in Korea. Consequently, a lot of friction between the general public who are not fond of dogs and dog owners in public places such as parks has been happening. A lot of countries that are taking a lead role in animal welfare have built dog parks that the general public and dogs can enjoy together. This research starts with the realization that the concept of 'dog park' needs to be introduced in Korea as more and more Koreans own dogs and other pets. This research aims to provide guidance for dog park planning by drawing planning items and analyzing the needs of each item. Total 56 planning items including dog zone, dog playground, and dog training facility, are drawn in this research. There are differences in the needs according to sex, age and the amount of time they spent with their dogs, however overall there is the highest needs in separated area for dogs in parks.

• International Journal of CAD/CAM
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• v.12 no.1
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• pp.20-28
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• 2012

Finite Element Analysis (FEA) is often used to identify local stress/strain concentrations where a component is likely to fail. In order to reduce the degree of strain concentration, component thickness can be increased in those regions, or a stronger material can be used. In short fiber reinforced composite materials, strength and stiffness can be increased through proper fiber alignment. The field-aided microtailoring (FAiMTa) process is one promising method for doing this. FAiMTa uses principles of dielectrophoresis to preferentially align particles or fibers within a matrix. To achieve the preferred fiber orientation, an interdigitated electrode network must be integrated into the mold halves which can be fabricated by additive manufacturing (AM) processes. However, the process of determining the preferred fiber arrangements and electrode locations can be very challenging. This paper presents algorithms to semi-automate the interdigitated electrode design process. The algorithm has been implemented in the Solidworks CAD system and is demonstrated in this paper.

• The Journal of Korean Physical Therapy
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• v.14 no.4
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• pp.475-486
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• 2002

Orthopaedic manual therapy(OMT) includes knowledge in arthokinematic, biological, behavioral, biomechanical, patholology, anatomy, and clinical science. it allows proper approach to patient evaluation and program development and relieves joint and soft tissue lesions. The OMT has sports injurys, traumatic, developmental, and neuromusculoskeletal disorders of acute and chronic states, and prevention of dysfunction as well as the development, improvement, restoration, or maintenance of joint and muscular mobility, stability, relaxation, strenth, endurance, balance, and functional skills. The purpose of this article has to define and clarify the change and development of basic concepts of orthopaedic manual therapy. OMT is ancient in origin. The book of ' Manipulation Past and Present ' contains pictures recording various types of joint mobilization by Hippocrates. Recently, there are many kinds of manual therapeutic maneuvers to assess and relieve joint and soft tissue lesions developed by James Cyriax, John McM Mennell, Brian R Mullign, Robin McKenzie, Freddy Kaltenborn, Geoffrey Maitland, and Ola Grimsby.

• Advances in aircraft and spacecraft science
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• v.10 no.3
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• pp.257-279
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• 2023

This manuscript is dedicated to deriving the closed form solutions of free vibration of viscoelastic nanobeam embedded in an elastic medium using nonlocal differential Eringen elasticity theory that not considered before. The kinematic displacements of Euler-Bernoulli and Timoshenko theories are developed to consider the thin nanobeam structure (i.e., zero shear strain/stress) and moderated thick nanobeam (with constant shear strain/stress). To consider the internal damping viscoelastic effect of the structure, Kelvin/Voigt constitutive relation is proposed. The perforation geometry is intended by uniform symmetric squared holes arranged array with equal space. The partial differential equations of motion and boundary conditions of viscoelastic perforated nonlocal nanobeam with elastic foundation are derived by Hamilton principle. Closed form solutions of damped and natural frequencies are evaluated explicitly and verified with prestigious studies. Parametric studies are performed to signify the impact of elastic foundation parameters, viscoelastic coefficients, nanoscale, supporting boundary conditions, and perforation geometry on the dynamic behavior. The closed form solutions can be implemented in the analysis of viscoelastic NEMS/MEMS with perforations and embedded in elastic medium.

• 대한상한금궤의학회지
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• v.15 no.1
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• pp.1-52
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• 2023

Objective : The objective of this study was to explore the meaning of Mai (脉) in the fifteen letters provisions of Gangpyeong-Shanghanlun through the comparative analysis of 10 cases and paleography. Methods : We have collected 10 cases that have been diagnosed and treated by Gangpyeong-Shanghanlun Mai (脉) provision. And then, comparative analysis has been done among those 10 cases. Based on result of case analysis, paleographic meaning of each Mai (脉) have been studied to redefine Gangpyeong-Shanghanlun Mai (脉)'s meaning. Results : After administration of Mai (脉) provision's herbal medicine, all 10 patients recovered their mobility problem and pain. From this result, we could fomulate the hypothesis that Mai (脉) in Gangpyeong-Shanghanlun could mean mobility problems. After through further paleography studies, we could elaborate each Mai (脉)'s clinical meaning and related diseases. Conclusions : Mai (脉) in Gangpyeong-Shanghanlun could mean mobility problems caused by various diseases, which include musculoskeletal pain, neuropathy, syncope, fatigue, developmental disability and major depressive disorder.

• International Journal of Computer Science & Network Security
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• v.24 no.5
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• pp.79-88
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• 2024

The information retrieval domain deals with the retrieval of unstructured data such as text documents. Searching documents is a main component of the modern information retrieval system. Locality Sensitive Hashing (LSH) is one of the most popular methods used in searching for documents in a high-dimensional space. The main benefit of LSH is its theoretical guarantee of query accuracy in a multi-dimensional space. More enhancement can be achieved to LSH by adding a bit to its steps. In this paper, a new Dynamic Locality Sensitive Hashing (DLSH) algorithm is proposed as an improved version of the LSH algorithm, which relies on employing the hierarchal selection of LSH parameters (number of bands, number of shingles, and number of permutation lists) based on the similarity achieved by the algorithm to optimize searching accuracy and increasing its score. Using several tampered file structures, the technique was applied, and the performance is evaluated. In some circumstances, the accuracy of matching with DLSH exceeds 95% with the optimal parameter value selected for the number of bands, the number of shingles, and the number of permutations lists of the DLSH algorithm. The result makes DLSH algorithm suitable to be applied in many critical applications that depend on accurate searching such as forensics technology.

• Parasites, Hosts and Diseases
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• v.50 no.1
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• pp.29-35
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• 2012

The aim of the study is to characterize the phenotypes of $CD4^+$ $CD25^+$ T regulatory cells within the liver granulomas and association with both Foxp-3 gene expression and splenic cytokines. Naive C57BL/6 mice were intravenously injected with multiple doses of the soluble egg antigen (SEA) 7 days before cercarial infection. The immunized and infected control groups were sacrificed 8 and 16 weeks post-infection (PI). Histopathology, parasitological parameters, splenic phenotypes for T regulatory cells, the FOXP-3 expression in hepatic granuloma using real-time PCR, and the associated splenic cytokines were studied. Histopathological examination of the liver revealed remarkable increase in degenerated ova within hepatic granuloma which decreased in diameter at weeks 8 and 16 PI ($P$<0.01). The percentage of T regulatory cells ($CD4^+$ $CD25^+$) increased significantly ($P$<0.01) in the immunized group compared to the infected control at weeks 8 and 16 PI. The FOXP-3 expression in hepatic granulomas increased from 10 at week 8 to 30 fold at week 16 PI in the infected control group. However, its expression in the immunized group showed an increase from 30 at week 8 to 70 fold at week 16 PI. The splenic cytokine levels of pro-inflammatory cytokines, IFN-${\gamma}$, IL-4, and TNF-${\alpha}$, showed significant decreases ($P$<0.05) compared to the infected control group. In conclusion, the magnitude and phenotype of the egg-induced effects on T helper responses were found to be controlled by a parallel response within the T regulatory population which provides protection in worm parasite-induced immunopathology.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10433-10438
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• 2015

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children and represents approximately 25% of cancer diagnoses among those younger than 15 years of age. Aim and Objectives: This study investigated substitutions in the ATP synthase subunit 6 gene of mitochondrial DNA (mtDNA) as a potential diagnostic biomarker for early detection and diagnosis of acute lymphoblastic leukemia. Based on mtDNA from 23 subjects diagnosed with acute lymphoblastic leukemia, approximately 465 bp of the ATP synthase subunit 6 gene were amplified and sequenced. Results: The sequencing revealed thirty-one mutations at 14 locations in ATP synthase subunit 6 of mtDNA in the ALL subjects. All were identified as single nucleotide polymorphisms (SNPs) with a homoplasmic pattern. The mutations were distributed between males and females. Novel haplotypes were identified in this investigation: haplotype (G) was recorded in 34% in diagnosed subjects; the second haplotype was (C) with frequency of 13% in ALL subjects. Neither of these were observed in control samples. Conclusions: These haplotypes were identified for the first time in acute lymphoblastic leukemia patients. Five mutations able to change amino acid synthesis for the ATP synthase subunit 6 were associated with acute lymphoblastic leukemia. This investigation could be used to provide an overview of incidence frequency of acute lyphoblastic leukemia (ALL) in Saudi patients based on molecular events.