• 한국미생물·생명공학회지
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• 제47권3호
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• pp.449-458
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• 2019

Hepatitis B treatments using immune therapy are gaining interest because of the improvements in dendritic cell performance for antigen presentation, which induces an appropriate immune response and raises patient survival rates. This research aims to produce a significant amount of the HBcAg antigen, which can induce an immune response and have a curative effect on HBV infection. In this study, the HBV subgenotype B3 of the HBcAg gene was used, which is dominant in Indonesia. Further, Lactococcus lactis bacteria was used as the host because of its safety and tightly regulated protein expression. The codon usage for the HBcAg gene was optimized to improve protein expression in L. lactis, which is important because a codon is not random between species. The HBcAg gene is attached to a pNZ8148 plasmid and transformed into the L. lactis NZ3900 expression host. The results confirm that a positive protein band (21 kDa) in two fractions of purified HBcAg was recognized by both western blotting and dot blot hybridization, even if the HBcAg optimized codon has higher GC contents than that suggested for L. lactis expression. Overall, this research strengthens the broad use of L. lactis bacteria for any protein expression, including higher protein expression of codon optimized HBcAg gene compared to non-optimized genes. Furthermore, the improvement in the codon optimization of the HBcAg gene significantly increases the total protein expression by 10-20%, and the expression level of the codon optimized HBcAg increases 1.5 to 3.2-times that of the native HBcAg.

• Journal of the Optical Society of Korea
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• 제10권3호
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• pp.112-117
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• 2006

We experimentally investigated the transmission characteristics of 400 Gbit/s (10 Gbit/s ${\times}$ 40 channels) WDM signals with 100 GHz channel spacing over 323 km of installed NZ_DSF. The installed fiber has optical properties of 0.28 dB/km attenuation, 4.3 ps/nm/km dispersion, $0.083ps/nm^2/km$ dispersion slope and less than $0.05ps/km^{1/2}$ PMD coefficient. In this experiment, two cases of dispersion compensation schemes, the lumped type and the distributed type, were compared. The results implied that the distributed type dispersion compensation in which dispersion compensation devices are inserted at the end of the each span showed better transmission performance than the lumped one in which dispersion compensation devices are located at the transmitter and receiver sites. From the analysis of the experimental results, we verified that different transmission performance comes from the power penalty induced by XPM in the distributed scheme is lower than the lumped scheme case.

• 대한수학회보
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• 제48권3호
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• pp.617-625
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• 2011

In [6], it was shown that hyponormality for Toeplitz operators with polynomial symbols can be reduced to classical Schur's algorithm in function theory. In [6], Zhu has also given the explicit values of the Schur's functions ${\Phi}_0$, ${\Phi}_1$ and ${\Phi}_2$. Here we explicitly evaluate the Schur's function ${\Phi}_3$. Using this value we find necessary and sufficient conditions under which the Toeplitz operator $T_{\varphi}$ is hyponormal, where ${\varphi}$ is a trigonometric polynomial given by ${\varphi}(z)$ = ${\sum}^N_{n=-N}a_nz_n(N{\geq}4)$ and satisfies the condition $\bar{a}_N\(\array{a_{-1}\\a_{-2}\\a_{-4}\\{\vdots}\\a_{-N}}\)=a_{-N}\;\(\array{\bar{a}_1\\\bar{a}_2\\\bar{a}_4\\{\vdots}\\\bar{a}_N}\)$. Finally we illustrate the easy applicability of the derived results with a few examples.

• 대한수학회보
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• 제51권1호
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• pp.77-82
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• 2014

We prove that if ${\mid}a_1{\mid}$ is large and ${\mid}a_0{\mid}$ is small enough, then every approximate zero of power series equation ${\sum}^{\infty}_{n=0}a_nx^n$=0 can be approximated by a true zero within a good error bound. Further, we obtain Hyers-Ulam stability of zeros of the polynomial equation of degree n, $a_nz^n$ + $a_{n-1}z^{n-1}$ + ${\cdots}$ + $a_1z$ + $a_0$ = 0 for a given integer n > 1.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.426-429
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• 1997

This paper describes the relationship among physiological, behavioral signal, and subjective evaluation depending on arousal level. Nz and reaction time hall similar pattern with KSS level, but eyeblink rate was different from these two parameters. Eyeblink rate increased slowly from KSS level 1 to 5, and had high increasing rate at KSS 7. But it showed steep descent at KSS level 9. From the result of reaction time test, since human performance was decreased rapidly above the KSS level 5, it is desirable to give a subject some stimulus such as sound or aroma to rise arousal level above the KSS level 3.

• Journal of applied mathematics & informatics
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• 제36권3_4호
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• pp.231-236
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• 2018

A polynomial, $p(z)=a_0z^n+a_1z^{n-1}+{\cdots}+a_{n-1}z+a_n$, with real coefficients is called a stable or a Hurwitz polynomial if all its zeros have negative real parts. We show that if a polynomial is a Hurwitz polynomial then so is the polynomial $q(z)=a_nz^n+a_{n-1}z^{n-1}+{\cdots}+a_1z+a_0$ (with coefficients in reversed order). As consequences, we give simple ratio checking inequalities that would determine unstability of a polynomial of degree 5 or more and extend conditions to get some previously known results.

• 호남수학학술지
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• 제15권1호
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• pp.75-85
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• 1993

For A and B, $-1{\leq}B<A{\leq}1$, let P[A, B] be the class of functions p analytic in the unit disk E with P(0) = 1 and subordinate to $\frac{1+Az}{1+Bz}$. We introduce the class $T_{\alpha}[A,B]$ of functions $f:f(z)=z+\sum\limits_{n=2}^{{\infty}}a_nz^n$ which are analytic in E and for $z{\in}E$, ${\alpha}{\geq}0$, $[(1-{\alpha}){\frac{f(z)}{z}}+{\alpha}f^{\prime}(z)]{\in}P[A,B]$. It is shown that, for ${\alpha}{\geq}1$, $T_{\alpha}[A,B]$ consists entirely of univalent functions and the radius of univalence for $f{\in}T_{\alpha}[A,B]$, $0<{\alpha}<1$ is obtained. Coefficient bounds and some other properties of this class are studied. Some radii problems are also solved.

• Journal of applied mathematics & informatics
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• 제36권5_6호
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• pp.567-574
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• 2018

Let $f:f(z)=z+{\sum^{{\infty}}_{n=2}}a_nz^n$ be analytic in the open unit disc E. Then f is said to belong to the class $M_{\alpha}$ of alpha-convex functions, if it satisfies the condition ${\Re}\{(1-{{\alpha})}{\frac{zf^{\prime}(z)}{f(z)}}+{{\alpha}}{\frac{(zf^{\prime}(z))^{\prime})}{f^{\prime}(z)}}\}$ > 0, ($z{\in}E$). In this paper, we introduce and study q-analogue of the class $M_{\alpha}$ by using concepts of Quantum Analysis. It is shown that the functions in this new class $M(q,{\alpha})$ are q-starlike. A problem related to q-Bernardi operator is also investigated.

• 대한수학회보
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• 제52권6호
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• pp.1937-1943
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• 2015

For $1{\leq}{\alpha}<2$, let $\mathcal{F}({\alpha})$ denote the class of locally univalent normalized analytic functions $f(z)=z+{\Sigma}_{n=2}^{\infty}{a_nz^n}$ in the unit disk ${\mathbb{D}}=\{z{\in}{\mathbb{C}}:{\left|z\right|}<1\}$ satisfying the condition $Re\(1+{\frac{zf^{{\prime}{\prime}}(z)}{f^{\prime}(z)}}\)>{\frac{{\alpha}}{2}}-1$. In the present paper, we shall obtain the sharp upper bound for Fekete-$Szeg{\ddot{o}}$ functional $|a_3-{\lambda}a_2^2|$ for the complex parameter ${\lambda}$.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2016년도 추계학술발표대회
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• pp.583-586
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• 2016

단백질과 RNA의 상호작용 데이터가 대량으로 늘어남에 따라, 단백질과 RNA의 결합부위를 예측하는 계산학적인 방법들이 많이 개발되고 있다. 하지만, 많은 계산학적인 방법들은 단백질에서 단백질과 RNA 결합부위를 예측한다는 한계점이 있었다. 본 논문에서는 RNA와 단백질의 서열정보를 모두 사용하여, 단백질과 결합하는 RNA 결합부위를 예측하는 기법과 그 결과를 논한다. WEKA random forest(http://www.cs.waikato.ac.nz/ml/weka/)를 이용하여 예측 모델을 개발하였고, RNA 서열의 서열 프로파일, 서열 composition, 결합 상대방의 단백질의 특성 등을 특정으로 표현하였다. Random forest 기법을 사용한 cross validation의 결과로서 1:1 모델에서 제일 높은 성능인 92.4% sensitivity, 92.0% specificity, 92.2% accuracy를 보였고, independent test에서는 72.5% sensitivity, 90.0% specificity, 2.1% accuracy를 보였다.