• Archives of Pharmacal Research
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• v.28 no.5
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• pp.598-603
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• 2005

The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appen dicitis patients. Gentamicin was administered intravenously over 0.5 h every 8 h. Three specimens were collected at 48 h after the first dose from all patients at the following times, just before regularly scheduled infusion, at 0.5 h and 2 h after the end of 0.5 h infusion. Serum gentamicin levels were analyzed by fluorescence polarization immunoassay technique with TDxFLx. The standard deviation (SD) of the assay over its working range had been determined at the serum gentamicin concentrations of 0, 2, 4, 8, 12, and 16 ${\mu}g$/mL in quadruplicate. The polynominal equation of gentamicin assay error was found to be SD (${\mu}g$/mL) = 0.0246-(0.0495C)+ (0.00203C$^2$). There were differences in the influence of weight with gentamicin assay error on pharmacokinetic parameters of gentamicin using the nonlinear least squares regression analysis but there were no differences on the Bayesian analysis. This polynominal equation can be used to improve the precision of fitting of pharmacokinetic models to optimize the process of model simulation both for population and for individualized pharmacokinetic models. The result would be improved dosage regimens and better, safer care of patients receiving gentamicin.

• The Korean Journal of Emergency Medical Services
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• v.26 no.1
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• pp.139-150
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• 2022

Purpose: This protocol aims to improve the simplicity of the existing two-person cardiopulmonary resuscitation (CPR) by focusing on chest compressions and artificial respiration, and classifying the roles within the scope that can be observed. Methods: In this study, the protocol was developed by forming an expert group consisting of a professor from the emergency and rescue department, a professor from the nursing department, and a first aid officer from the fire department. In addition, if the number of panels is 15 and the derived content validity ratio (CVR) value exceeds 0.49, a reference point that satisfies content validity at 95% reliability is presented. Results: All 11 performance items exceeded the CVR value of 0.49 to meet the reference point, and the CVR range of this protocol is 0.625 to 1.000. Conclusion: In order to improve the quality of three-person CPR, verification of simulation models and continuous protocol revision should be conducted by individuals specializing in various fields.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.7
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• pp.490-499
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• 2017

In recent years, the introduction of complex systems analysis based on various variables has become more active in order to identify and analyze complex problems of Modern Society. Prediction of patients' spatial perception and usability according to the spatial arrangement of the outpatient department is a very important factor for providing high quality hospital service. For objective analysis, the standard program procedure and analysis index for the diseases of the elderly were prepared and the uniformity of the atmospheric space was evaluated through heat map analysis and quantitative analysis. In this study, 73 cells were installed and simulated to analyze the uniformity of the four alternatives according to the change of the arrangement of the medical care space, receiving space, and consultation space using the complex system analysis method for the nursing hospitals. The resulting density was derived. The results are as follows. 1)The layout of the reception space has the greatest influence on the total spatial density of the waiting space. 2) The uniformity of the waiting space can be increased by separating the examination space and the examination space. 3)The closer the location of the receiving space is from the entrance, the greater the density of the waiting space. Finally, this study applied discrete event simulation to the evaluation of uniformity of atmosphere space, and proved that the actor - based model can be utilized for utilization and evaluation as spatial analysis methodology.

• The Journal of the Korea Contents Association
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• v.16 no.4
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• pp.516-527
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• 2016

The purpose of this study was to test the effects of the Lasater's debriefing on critical thinking disposition, problem- solving skills and clinical judgement of nursing students. The study design was a nonequivalent control group non synchronized design. The subjects were 60 students for 12 groups. They were randomly assigned to the experimental group (n=30) or control group (n=30). Critical thinking and problem-solving skills were measured using a self-administered questionnaire. Clinical judgement was measured by a Lasater's clinical judgement rubric. The Results of the study was : After Lasater's debriefing, the level of students' critical thinking, problem-solving skills and clinical judgment in experimental group were higher than the level of control group. Through this experiment the rubric of Lasater debriefing is an effective tool for clinical judgment, therefore we know that the future of simulation training is needed to use the Lasater's clinical judgement rubric of debriefing in simulation training.

• Journal of the Korea Convergence Society
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• v.9 no.3
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• pp.257-263
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• 2018

Hyperthermia supplies RF high-frequency energy above 1MHz to the tumor tissue through the electrodes. And the temperature of the tumor tissue is increased to $42^{\circ}C$ or more to cause thermal necrosis. A mathematical model can be derived a human body model for absorption and transmission of electromagnetic energy in the human model and It is possible to evaluate the distribution of temperature fields in biological tissues. In this paper, we build the human model based on the adult standard model of the geometric shape of the 3D model and use the FVM code. It is assumed that Joule heat is supplied to the anatomical model to simulate the magnetic field induced by the external electrode and the temperature distribution was analyzed for 0-1,200 seconds. As a result of the simulation, it was confirmed that the transferred energy progressively penetrates from the edge of the electrode to the pulmonary tumors and from the skin surface to the subcutaneous layer.

• Journal of radiological science and technology
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• v.33 no.3
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• pp.203-211
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• 2010

The purpose of this study is meant to develop an evaluation framework for PBL and S-PBL package, as well as verify reliability and propriety of developed framework. To achieve the purpose, existing researches and related documents were considered, and composed basic questionnaire which fits to the basic frame of the framework, 3 categories 15 items for PBL/S-PBL. Verifying its contents propriety, examined by 9 experts who professors in college and made 14 items for PBL, 15 items for S-PBL. To verify construct validity of basic frameworks, carried out factor analysis. Final evaluation framework questionnaire were 15 items selected, its PBL for 3 items in motivating, 7 items in integrity, 4 items in systematic and total 14 items, S-PBL for 4 items in motivating, 6 items in integrity, 5 items in systematic and total 15 items, and was verify to have adequate reliability with Cronbach's $\alpha$ is 0.9112 in PBL, 0.9166 of S-PBL.

• The Korean Journal of Applied Statistics
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• v.34 no.5
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• pp.685-696
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• 2021

The Korean Economically Active Population Survey (KEAPS) is a national survey that produces employment-related statistics. The main purpose of the survey is to find out the economic activity status (employed/ unemployed/ non-employed) of the people. KEAPS has a unique characteristics caused by the survey method. In this study, through understanding of structural non-response and utilization of past data, we would like to present an improved imputation model. The performance of the proposed model is compared with the existing model through simulation. The performance of the imputation models is evaluated based on the degree of mathing/nonmatching rates. For this, we employ the KEAPS data in November 2019. For the randomly selected ones among the total 59,996 respondents, the six explanatory variables, which are critical in determining the economic activity states, are treated as non-response. The proposed model includes industry variable and job status variable in addition to the explanatory variables used in the precedent research. This is based on the linkage and utilization of past data. The simulation results confirm that the proposed model with additional variables outperforms the existing model in the precedent research. In addition, we consider various scenarios for the number of non-responders by the economic activity status.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.3
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• pp.65-73
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• 2021

This study aimed to provide the basic data for the development of a simulation training program for new infectious diseases by analyzing the knowledge and educational needs of 119 paramedics regarding COVID-19 infection control. Data was obtained through a structured questionnaire survey of 186 paramedics from November 15th to 30th 2020. The study showed that 98 of the 119 paramedic subjects (52.7%) had not been educated regarding COVID-19. The knowledge level was 18.21±1.98 out of 25 points, with environmental control securing the lowest correct answers. The highest need for education was in the areas of prevention of transmission and spread, and employee safety control. The total average for educational needs was 3.81±.28 (4 point scale) with the highest educational need in the area of prevention of the spread and dispersion of the disease and employee safety management. There was a statistically significant difference in the knowledge of the general characteristics according to gender (t=-1.999, p=.047) and the educational demand was related to career (t=-1.999, p=.047) and, education levels (t=2.336, p=.021). Accordingly, it is necessary to plan a new infectious disease simulation education program that addresses the low-scoring areas and items with high educational needs which include the propagation path and spread prevention, environmental management, and employee safety management as per the findings of this study.

• The Korean Journal of Applied Statistics
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• v.24 no.6
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• pp.1045-1054
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• 2011

During clinical trials a researcher is frequently able to observe a disease symptom in a subject as well as a severity score for those who experienced a symptom after a fixed length of treatment. The traditional method to evaluate a decreasing trend in proportion, when there is an intrinsic order in the treatment groups (for example control and two or more treatment groups) is a Cochran-Armitage test, while the method to evaluate a decreasing trend in continuous non-normal data is a Jonckheere-Tersptra test. The Cochran-Armitage test emphasizes the dichotomous data of symptom occurrence and the Jonckheere-Tersptra test emphasizes the continuous non-normal data of severity symptom scores. In this paper we propose new test statistics that consider the combined evidence from a symptom occurrence and disease severity score. We illustrate these methods with example data of schizophrenic inpatients that demonstrated antipsychotic-drug induced constipation. A small-scale simulation is conducted to compare the new trend tests with other trend tests.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.10a
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• pp.915-918
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• 2016

Virtual testing devices are required due to rapid changes in the health care industry and the increase of the medical or nursing workforce. The importance of devices such as the simulator, blood vessels, and lab equipment for modeling blood flow to the heart is increasing too. In this study, we made heart pump by using a step motor and developed device which simulates arterial, venous blood pressure, and blood flow. We finally evaluated the function of proposed device. The proposed system is composed of the pump for simulating, the valve device to describe the resistance of the artery and vein, and a reducing device showing the characteristics of the venous system. We used BOXER pump for heart simulator and silicon tube for arterial and venous vessels, and designed a reducing device. We also used the pressure sensor to measure arterial blood pressure. For the evaluation of the proposed system, we selected a range of 50~100mmHg of the blood circuit 60 per minute and then compared the blood pressure of a person and the measured blood pressure.