The Korean Journal of Applied Statistics (응용통계연구)

The Korean Statistical Society (한국통계학회)
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A Composite Trend Test with Symptom Occurrence and Severity Symptom Scores

증상 발현과 증상 심각성을 병합한 추세검정법

  • Choi, Se-Mi (Department of Biostatistics, Graduate School, The Catholic University of Korea) ;
  • Yang, Soo (College of Nursing, The Catholic University of Korea) ;
  • Song, Hae-Hiang (Department of Biostatistics, Graduate School, The Catholic University of Korea)
  • 최세미 (가톨릭대학교 대학원 의학통계학과) ;
  • 양수 (가톨릭대학교 간호대학) ;
  • 송혜향 (가톨릭대학교 대학원, 의생명과학교실 의학통계학과, 인간유전체 다형성 연구소)
  • Received : 20110300
  • Accepted : 20111000
  • Published : 2011.12.31
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Abstract

During clinical trials a researcher is frequently able to observe a disease symptom in a subject as well as a severity score for those who experienced a symptom after a fixed length of treatment. The traditional method to evaluate a decreasing trend in proportion, when there is an intrinsic order in the treatment groups (for example control and two or more treatment groups) is a Cochran-Armitage test, while the method to evaluate a decreasing trend in continuous non-normal data is a Jonckheere-Tersptra test. The Cochran-Armitage test emphasizes the dichotomous data of symptom occurrence and the Jonckheere-Tersptra test emphasizes the continuous non-normal data of severity symptom scores. In this paper we propose new test statistics that consider the combined evidence from a symptom occurrence and disease severity score. We illustrate these methods with example data of schizophrenic inpatients that demonstrated antipsychotic-drug induced constipation. A small-scale simulation is conducted to compare the new trend tests with other trend tests.

임상 연구자는 일정기간의 치료에 의해 환자에게 증상 발현 또는 증상 비발현을 관측할 뿐만 아니라 증상이 발현된 환자의 경우에는 증상 심각성 점수가 측정됨을 자주 본다. 예를 들어서 대조군을 비롯하여 치료의 정도에 차이가 있는 여러 치료군이 있을 때 발현율의 감소를 검정하는 전통적인 방법은 Cochran-Armitage 추세검정이며, 한편 비정규분포하는 연속자료의 감소를 검정하는 전통적인 방법은 Jonckheere-Terpstra 추세검정이다. 전자의 추세검정은 증상 발현의 이항자료만을 사용한 검정이 되며 한편 후자의 추세검정은 증상의 심각성 점수만을 사용한 검정이 된다. 본 논문에서는 증상 발현율과 증상의 심각성 점수로 나타나는 정보의 특성을 모두 감안한 추세검정법을 제안한다. 새로운 추세검정법을 항정신병 약제를 복용하는 정신분열증 입원환자로부터 수집된 자료에 적용하며 본 논문에서 취급하는 여러 다른 검정법과 비교한 효율성을 모의실험으로 알아본다.

Keywords

References

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