• Journal of the Korean Applied Science and Technology
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• v.38 no.6
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• pp.1722-1734
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• 2021

The purpose of this study was that HPV prevention education based on the planned behavioral theory was designed to provide college students with HPV vaccine knowledge, cervical cancer knowledge, attitude toward HPV vaccination, subjective norms for HPV vaccination, perceived behavioral control for HPV vaccination, and HPV vaccination. This is an experimental study to confirm the effect on the intention to vaccinate and the behavior of HPV vaccination. The subjects were arbitrarily expressed as 32 subjects in the experimental group and 34 subjects in the control group. The collected data were analyzed by descriptive statistics, t-test, χ²-test, Fisher's exact test and repeated Measures ANOVA. As a result, the experimental group participating in HPV prevention education was compared to the control group who did not participate in HPV vaccine knowledge (t=5.66, p<.001), cervical cancer knowledge (t=4.13, p<.001), attitude (t=2.24, p=) .032 ), subjective norm (t=2.83, p=.008), perceived behavioral control (t=2.65, p=.013), and intention (t=3.91, p<.001) were significantly different. After 4 weeks of HPV prevention education intervention, there was a significant difference in the interaction between group and time course of HPV vaccination intention (F=6.95, p=.002). Therefore, it was confirmed that HPV prevention education is an educational program that can be applied to college students.

• Journal of Korea Entertainment Industry Association
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• v.14 no.8
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• pp.203-211
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• 2020

This study is a similar experimental study using parallax design before and after the non-equality control group conducted to investigate the effects of the Mental health guardian program for mentally disabled people on the awareness of rights, empowerment, and resilience of mentally disabled people. The mentally handicapped persons who participated in the mental health guardian program were significantly higher in the awareness of the rights of the handicapped compared to the mentally handicapped persons who did not participate. In terms of empowerment, there was no significant difference between the two groups. In terms of resilience, the experimental group significantly increased compared to the control group. Among the sub-areas of resilience, excluding spirituality, difficulty overcoming, self-competence, learning and self-financing, basic functions, overall life satisfaction, new potential, advocacy and fullness all significantly increased. It has been shown to be effective in increasing the resilience of the disabled. In this study, the reason why mental health guardian program is effective for awareness of rights and resilience is not a one-way education, but a participatory curriculum in which a person with mental disabilities who participated in the education finds and corrects the wrong news and creates a card news again. It seems to be because it did. As a result of this study, it seems that the mental health guardian program has contributed to enhancing the recognition of the rights of the mentally impaired and enhancing resilience.

• Journal of Life Science
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• v.32 no.2
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• pp.175-188
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• 2022

Relaxin has been demonstrated to have regulatory functions on both the smooth muscle and extracellular matrix (ECM) of blood vessels and fibrotic organs. The diverse mechanisms by which relaxin acts on small resistance arteries and fibrotic organs, including the bladder, are reviewed here. Relaxin induces vasodilation by inhibiting the contractility of vascular smooth muscles and by increasing the passive compliance of vessel walls through the reduction of ECM components, such as collagen. The primary cellular mechanism whereby relaxin induces arterial vasodilation is mediated by the endothelium-dependent production of nitric oxide (NO) through the activation of RXFP1/PI3K, Akt phosphorylation, and eNOS. In addition, relaxin triggers different alternative pathways to enhance the vasodilation of renal and mesenteric arteries. In small renal arteries, relaxin stimulates the activation of the endothelial MMPs and EtB receptors and the production of VEGF and PlGF to inhibit myogenic contractility and collagen deposition, thereby bringing about vasodilation. Conversely, in small mesenteric arteries, relaxin augments bradykinin (BK)-evoked relaxation in a time-dependent manner. Whereas the rapid enhancement of the BK-mediated relaxation is dependent on IK_Ca channels and subsequent EDH induction, the sustained relaxation due to BK depends on COX activation and PGI₂. The anti-fibrotic effects of relaxin are mediated by inhibiting the invasion of inflammatory immune cells, the endothelial-to-mesenchymal transition (EndMT), and the differentiation and activation of myofibroblasts. Relaxin also activates the NOS/NO/cGMP/PKG-1 pathways in myofibroblasts to suppress the TGF-β1-induced activation of ERK1/2 and Smad2/3 signaling and deposition of ECM collagen.

• Journal of agricultural medicine and community health
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• v.47 no.2
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• pp.109-120
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• 2022

Objectives: The purpose of this study was to identify the effectiveness of COVID-19 vaccinations on deaths of the COVID-19 cases in some elderly long-term care facilities (LTCF) in Gwangju Metropolitan City. Methods: The study subjects were 659 COVID-19 cases in residents of 7 elderly LTCF, Gwangju, from 21 Dec. 2021 to 28 Jan. 2022. The used variables were confirmed dates for COVID-19, demographic characteristics, co-morbidities, presentation of symptoms, death and vaccination related characteristics including type of vaccine, doses and dates. Vaccination status were classified as not vaccinated, partially and fully vaccinated. The associations of vaccination status and deaths of COVID-19 cases were tested by chi-square test and multiple logistic regression analysis. Results: The rates of not vaccinated, partially vaccinated and fully vaccinated were 19.4%, 10.2% and 70.4%, respectively. The mortality rate of the cases was 6.4%. The death rate by vaccination status was 16.4% in not vaccinated, 15.4% in partially vaccinated and 2.6% in fully vaccinated, showing a statistically significant difference. The adjusted odds ratios (ORs) (95% confidence intervals, CIs) of death compared to fully vaccinated were 7.64 (3.87-16.34) in non-vaccinated, and 6.97 (3.44-14.14) in partially vaccinated. Conclusions: COVID-19 vaccination seems to work effectively in preventing deaths of COVID-19 cases of elderly LTCF residents. This finding support that fully vaccinations in high risk group such as elderly LTCF residents is very important for one of strategies of COVID-19 management.

• Journal of Korean Library and Information Science Society
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• v.53 no.3
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• pp.263-285
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• 2022

This study presented the factor analysis on constructing the new factors affecting the middle school students' online learning behaviors from the questionnaires employed among middle school students. A total of 204 students participated and the data were collected in South Korea. The sample of middle school ninth-grade students was selected and used through purposive sampling. Findings from the factor analysis provided evidence for the eight-factor solution for the 35-items accounting for 66.15% of the shared variance. A wide range of factors has been considered to identify students' online learning behaviors. The appropriate experience and use of e-learning in the middle school period is also important as it will be a critical stepstone for future education. This research provides information that has been taken into account for advancing online learning to enhance the quality of e-learning systems for middle school students. The study results provided eight new factors affecting the middle school students' online learning behaviors; that is 1) communication using social media as a learning tool, 2) intention to share information using ICT, 3) addiction of technology, 4) adoption of technology, 5) seeking information using ICT, 6) use of social media learning, 7) information search using ICT, and 8) immersion of technology. This study confirmed that middle school students prefer communication using social media as a learning tool, and value intention to share information using ICT for the most part. The data obtained based on factor analysis can highlight the online learning behaviors towards a mixture of social media learning and ICT to ensure a new educational platform for the future of e-learning. This research expects to be useful for both middle schools of online learning to better understand students' online learning behaviors and design online learning environments and information professionals to better assist students who particularly need digital literacy.

• Journal of Industrial Convergence
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• v.20 no.12
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• pp.1-9
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• 2022

The objective of this study was to analyze the factors affecting the stages of change of exercise in middle-aged men who work. 170 middle-aged men who work surveyed, 40 to 59 years old, is residing, Chung-Buk and Chung-Nam province, who understand the purpose of this study and agree to participate in this study. This study data is analyzed by using frequency, percentage, standard deviation, t-test, 𝑥² test and Logistic regression analysis. The study show that the exercise self-efficacy(𝛽=.965, p=.003) and the perceived health status(𝛽=.805, p=.025) among middle aged men who work have an effect on the stages of change of exercise meaningfully. That is, the exercise self-efficacy of middle aged men who work who have exercise behavior is 2.6 times higher than middle aged men at work who don't have exercise behavior, and the perceived health status is 2.2 times higher. This study suggests that the development of better exercise practice for middle aged men who work should be aimed at promoting exercise self-efficacy and perceived health status, Based on this, it is necessary to find ways to operate exercise programs at the workplace and community level.

• Korean Journal of Clinical Laboratory Science
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• v.54 no.4
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• pp.298-306
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• 2022

This study sought to evaluate the mechanism of cellular injury caused by ferrous sulfate (FeSO₄) and the protective effects of Parnassia palustris L. (PP) extract against FeSO₄-induced cytotoxicity of cultured C6 glioma cells. FeSO₄ is known to cause neurotoxicity and induce Parkinson's disease. The antioxidative effects of PP, such as superoxide dismutase (SOD)-like and superoxide anion-radical (SAR)-scavenging activities, as well as effects on cell viability, were studied. FeSO₄ significantly decreased cell viability in a dose-dependent manner and the XTT₅₀ value, the concentration of FeSO₄ which reduced the cell viability by half, was measured at 63.3 μM in these cultures. FeSO₄ was estimated to be highly cytotoxic by the Borenfreund and Puerner toxicity criteria. Quercetin, an antioxidant, significantly improved cell viability, damaged by FeSO₄-induced cytotoxicity. While evaluating the protective effects of the PP extract on FeSO₄-induced cytotoxicity, it was observed that the extract significantly increased cell viability compared to the FeSO₄-treated group. Also, the PP extract showed superoxide dismutase (SOD)-like and superoxide anion radical (SAR)-scavenging activities. Based on these findings, it can be concluded that FeSO₄ induced oxidative stress-related cytotoxicity, and the PP extract effectively protected against this cytotoxicity via its antioxidative effects. In conclusion, natural antioxidant sources such as PP may be agents useful for preventing oxidative stress-related cytotoxicity induced by heavy metal compounds such as the FeSO₄, a known Parkinsonism inducer.

• Journal of Internet of Things and Convergence
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• v.9 no.1
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• pp.33-39
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• 2023

As the number of people with chronic diseases increases due to an aging society, it is urgent to prevent and manage their diseases. Although biometric authentication methods and Telemedicine Systems have been introduced to solve these problems, it is difficult to solve the security problem of medical information and personal authentication. Since smart healthcare includes personal medical information of subjects, the security of personal information is the most important field. Therefore, in this paper, we tried to propose a Telemedicine System using a smart wearable device ECG in the form of a wristband and face personal authentication in a private blockchain environment. This system targets various medical personnel and patients with chronic diseases in all regions, and uses a private blockchain that can increase data integrity and transparency, ECG and face authentication that are difficult to forge and alter and have high personal identification to provide a system with high security and reliability. composed. Through this, it is intended to contribute to increasing the efficiency of chronic disease management by focusing on disease prevention and health management for patients with chronic diseases at home.

• Journal of Chest Surgery
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• v.56 no.3
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• pp.155-161
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• 2023

Background: Surgical closure of an atrial septal defect (ASD) is infrequently indicated during infancy. We evaluated the clinical characteristics and outcomes of patients who underwent surgical ASD closure during infancy. Methods: A single-center retrospective review was performed for 39 patients (19 males) who underwent surgical ASD closure during infancy between 1993 and 2020. The median body weight percentile at the time of operation was 9.3. Results: During a median follow-up of 60.9 months, 4 late deaths occurred due to chronic respiratory failure. A preoperative history of bronchopulmonary dysplasia (BPD) was the only risk factor for late mortality identified in Cox regression (hazard ratio, 3.54; 95% confidence interval [CI], 1.75-163.04; p=0.015). The 5-year survival rate was significantly lower in patients with preoperative history of BPD (97.0% vs. 50.0%, p<0.001) and preoperative ventilatory support (97.1% vs. 40.4%, p<0.001). There were significant postoperative increases in left ventricular end-diastolic (p=0.017), end-systolic (p=0.014), and stroke volume (p=0.013) indices. A generalized estimated equation model showed significantly better postoperative improvement in body weight percentiles in patients with lower weight percentiles at the time of operation (<10th percentile, p=0.01) and larger indexed ASD diameter (≥45 mm/m², p=0.025). Conclusion: Patients with ASD necessitating surgical closure during infancy are extremely small preoperatively and remain small even after surgical closure. However, postoperative somatic growth was more prominent in smaller patients with larger defects, which may be attributable to an increase in postoperative cardiac output due to changes in ventricular septal configuration. The benefits of ASD closure in patients with BPD are undetermined.

• Journal of Life Science
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• v.33 no.5
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• pp.397-405
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• 2023

Although glutathione (GSH) has been shown to play an important role in the prevention of oxidative damage as an antioxidant, studies on immune regulation by it have not been properly conducted. In this study, we investigated whether luthione^®, a reduced GSH, has an immune enhancing effect in murine macrophage RAW 264.7 cells. The results of flow cytometry and immunofluorescence experiments indicated that luthione increased phagocytic activity, a representative function of macrophages, compared to the control cells. According to the results of the cytokine array, the expression of interleukin (IL)-5, IL-1β, and IL-27 was significantly increased in the luthione-treated cells. Luthione also enhanced the production of tumor necrosis factor-α and IL-1β through increased expression of their proteins, and increased release of the immune mediators such as nitric oxide (NO) and prostaglandin E₂ was associated with increased expression of inducible NO synthase and cyclooxygenase-2. In addition, the expression of cluster of differentiation 86, an M1 macrophage marker, was dramatically enhanced in RAW 264.7 cells treated with luthione. Furthermore, as a result of heat map analysis, we found that cytokine signaling 1/3-mediated signal transducer and activator of transcription/Janus tyrosine kinase signaling pathway was involved in the immunomodulatory effect by luthione. In conclusion, our data suggested that luthione could act as a molecular regulator in M1 macrophage polarization and enhance immune capacity by promoting macrophage phagocytic function.