• Genomics & Informatics
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• v.20 no.4
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• pp.47.1-47.13
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• 2022

Klebsiella pneumoniae is a gram-negative bacterium that is known for causing infection in nosocomial settings. As reported by the World Health Organization, carbapenem-resistant Enterobacteriaceae, a category that includes K. pneumoniae, are classified as an urgent threat, and the greatest concern is that these bacterial pathogens may acquire genetic traits that make them resistant towards antibiotics. The last class of antibiotics, carbapenems, are not able to combat these bacterial pathogens, allowing them to clonally expand antibiotic-resistant strains. Most antibiotics target essential pathways of bacterial cells; however, these targets are no longer susceptible to antibiotics. Hence, in our study, we focused on a hypothetical protein in K. pneumoniae that contains a DNA methylation protein domain, suggesting a new potential site as a drug target. DNA methylation regulates the attenuation of bacterial virulence. We integrated computational-aided drug design by using a bioinformatics approach to perform subtractive genomics, virtual screening, and fingerprint similarity search. We identified a new potential drug, koenimbine, which could be a novel antibiotic.

• Korean Journal of Exercise Nutrition
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• v.17 no.2
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• pp.43-48
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• 2013

This study aims to investigate changes in plasma lipid concentrations and appetite-regulating hormone levels after a 4% body fat reduction using a 9-week intervention involving aerobic exercise, a fat-oxidizing agent, and diet limitation. After the 9-week intervention, the aerobic exercise plus hydroxycitric acid (EX+HCA), exercise (EX), and diet limitation (DIET) groups achieved the target 4% body fat reduction from the baseline value. None of the plasma lipid indicators showed significant intergroup differences, indicating that plasma lipid levels are not influenced by body weight regulation. With regard to appetite-regulating hormones, no significant intergroup differences were observed in glucose, insulin, or glucagon-like peptide-1 levels, unlike ghrelin and leptin. Ghrelin levels in particular tended to decrease in the DIET group and increase in the HCA+EX and EX groups. Leptin levels significantly decreased in the HCA+EX and EX groups, whereas no differences were observed in the DIET group. Such results indicate that exercise alone without the administration of obesity diet supplements induces elevation in ghrelin levels and reduction in leptin levels, but that diet restriction alone does not influence changes in leptin levels. Taken together, we could not confirm any synergic effects arising from the use of a fat-oxidizing agent during an exercise program to control body weight. Furthermore, diet limitation unsupported by exercise had no effect on muscle mass reduction or appetite-regulating hormone levels; thus, it is not recommended as an effective body weight control method.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.07b
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• pp.570-573
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• 2002

Pb(Zr0.52Ti0.48)O3 (PZT) thin films were deposited on the Pt/Ti bottom electrode by rf magnetron sputtering method from target containing 5%, 25% and 50% Pb excess for applying ferroelectric random access memory (FRAM). PZT films were deposited at $300^{\circ}C$ and then they were crystallized by rapid thermal annealing (RTA) at $700^{\circ}C$. After RTA treatment, our results showed that all PZT films indicated perovskite polycrystalline structure with preferred orientation (110) and no pyrochlore phase was observed by X-ray diffraction (XRD) and by Scanning electron microscopy (SEM). A well-fabricated PZT film of excess Pb 25% capacitor showed a leakage current density in the order of $2.63{\times}10^{-7}A/cm^2$ at 100kV/cm, a remanent polarization of $3.385{\mu}C/cm^2$ and a coercive field of 41.32 kV/cm. The results showed that Pb excess of target affects to electrical properties of PZT thin film.

• Journal of Advanced Navigation Technology
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• v.2 no.1
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• pp.43-52
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• 1998

In this paper, we have investigated the effects of geographic information on the performance of multiple ground target tracking system using multiple sensors. Geographic information is utilized in two cases: association and masking target measurement. Virtually no improvement is observed to the overall performance of tracking system when we applied mobility to the association procedure. Masking target measurement based on mobility produces desirable result that the number of false tracks is reduced. Since geographic information can be regarded as an additional sensor in sensor fusion paradigm, careful usage is required.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.51 no.2
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• pp.272-278
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• 2015

The aim of this study is to find out the behavior and acoustic backscattering of the large jellyfish Nemopliema nomurai using hydroacoustics in situ. N. nomurai was distributed at depths ranging from 10~15 m during the day. Regarding the behavior of N. nomurai, there was no significant change in depth, and 3D tortuosity was not high. The vertical direction was ${\pm}10^{\circ}$ from the horizontal, and moving speed was $0.9{\sim}1.5\;m\;s^{-1}$. With regard to hydro-acoustical characteristics, the mean TS of N. nomurai ranged from -69.6~-56.0 dB at 38 kHz and -69.4~-54.5 dB at 120 kHz. TS variation (Max TS-Min TS) at 38 and 120 kHz was 0~10.2 dB and 0.2~16.0 dB, respectively. Mean TS and TS variation (Max TS-Min TS) of N. nomurai were higher at 120 kHz than at 38 kHz. The results showed that the use of hydroacoustics was effective in estimating the distribution depth, behavior, and acoustic characteristics of the target.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.30 no.3
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• pp.279-285
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• 2012

Albeit the use of terrestrial 3D laser scanner (TLS) in the parts of landslide monitoring, cultural heritage documentation, civil engineering, urban engineering, etc. is increasing more and more, there is no international standardization regulation about the accuracy evaluation of the geometric element values, target, instrument calibration and test procedures, etc. Accordingly, this study deals with the manufacturing of TLS performance test target and the evaluation of TLS distance measurement and shows its suitability as the test target.

• Journal of the Korea Society of Computer and Information
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• v.22 no.10
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• pp.83-92
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• 2017

Reconnaissance is performed gathering information from a series of scanning probes where the objective is to identify attributes of target hosts. Network reconnaissance of IP addresses and ports is prerequisite to various cyber attacks. In order to increase the attacker's workload and to break the attack kill chain, a few proactive techniques based on the network-based moving target defense (NMTD) paradigm, referred to as IP address mutation/randomization, have been presented. However, there are no commercial or trial systems deployed in real networks. In this paper, we propose a threat model and the request for requirements for developing NMTD techniques. For this purpose, we first examine the challenging problems in the NMTD mechanisms that were proposed for the legacy TCP/IP network. Secondly, we present a threat model in terms of attacker's intelligence, the intended information scope, and the attacker's location. Lastly, we provide seven basic requirements to develop an NMTD mechanism for the legacy TCP/IP network: 1) end-host address mutation, 2) post tracking, 3) address mutation unit, 4) service transparency, 5) name and address access, 6) adaptive defense, and 7) controller operation. We believe that this paper gives some insight into how to design and implement a new NMTD mechanism that would be deployable in real network.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.18 no.9
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• pp.1090-1097
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• 2007

The multibeam surveillance radar is a state-of art of 3D radar technology. It applies the stacked beam-on-received realized by a digital beamformer. In this paper, a design concept of beamformer and a method of target altitude extraction for multibeam surveillance radar in the normal environmental condition considering no multipath situations are proposed and investigated. The extraction algorithm based on antenna sine space coordinated system in a FFT digital beamformer is described. The proposed algorithm is simulated by 1 look-up table data and confirmed to have consistent results in accordance with a variety of target altitudes and a full radar frequency range.

• Journal of the Korean Magnetic Resonance Society
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• v.23 no.4
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• pp.104-107
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• 2019

Many proteins are expressed as an insoluble form during the production using Escherichia coli (E. coli) system. Although various methods are applied to increase their amounts of soluble expression, refolding is the only feasible way to obtain a target protein in some cases. Moreover, protein NMR experiments require ¹³C/¹⁵N-labeled proteins that can only be obtained from E. coli systems in terms of cost and technical difficulty. The finding of appropriate refolding conditions for a target protein is a time-consuming process. In particular, it is very difficult to determine whether the refolded protein has a native structure, when a target protein has no enzymatic activity and its refolding yield is very low. Here, we showed that 1-dimensional ¹H-¹⁵N heteronuclear single quantum correlation (1D ¹H-¹⁵N HSQC) experiment can be efficiently used to screen an optimal condition for the refolding of a target protein by monitoring both the structure and concentration of the refolded protein.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.6
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• pp.1151-1158
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• 2011

Proximity magnetic sensor is able to detect the object target accurately in close range and it has been widely used in the underwater guided weapon system because there is no countermeasures from the target. In order to increase the damage of target by shock wave due to explosion of the underwater guided weapon system, the maximum detection range of the proximity magnetic sensor needs to be increased. In this paper, we describe the techniques of the optimum transmitting and receiving coils design using the Finite Element Method for the output power enhancement of the transmitter and the sensitivity improvement of the receiver. Finally, the proposed design techniques of the transmitter and the receiver were verified using a experimental setup and a prototype.