• Journal of Digital Convergence
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• v.12 no.3
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• pp.141-147
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• 2014

Diffusion model is popular research topic in marketing and economy particularly for the areas of model specification and market size forecasting. In particular, Bass model can explain Roger's innovation diffusion and product life cycle through easy mathematical representation and hence the model has been widely used for the explanation of adopting innovative new products and technologies. Nonetheless, there're only a couple of pioneering researches about semiconductor market, using diffusion models. Consequently, we'd utilise NLS approach diffusion model to estimate the market potential of MOSFET, major switching device for power management of system, and explain the process to industry stakeholders and policy makers for delivery of managerial implication with pragmatic purpose.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.1
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• pp.88-95
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• 2015

This paper presents the study of the efficient localization algorithm for non-linear least square estimation. Although non-linear least square(NLS) estimation algorithms are more accurate algorithms than linear least square(LLS) estimation, NLS algorithms have more computation loads because of iterations. This study proposed the efficient algorithm which reduced complexity for small accuracy loss in NLS estimation. Simulation results show the accuracy and complexity of the localization system compared to the proposed algorithm and conventional schemes.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2004.10a
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• pp.81-82
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• 2004

• BMB Reports
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• v.45 no.9
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• pp.521-525
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• 2012

In addition to its pivotal role in neuronal survival, PI3K/Akt signaling is integral to neuronal differentiation and neurite outgrowth. However, the exact role of Akt in neuronal differentiation is still controversial. Here, we found that nuclear expression of CA-Akt resulted in unusual rapid neurite outgrowth and overexpression of KD-Akt caused multiple dendrite growth without specific axon elongation. Moreover, microarray data revealed that the expression of FOXQ1 expression was about 10-fold higher in cells with nuclear, active Akt than in control cells. Quantitative real-time PCR analysis showed that mRNA levels were upregulated in NLS-CA-Akt cells as compared to KD or EV cells. Furthermore, our FACS analysis demonstrated that overexpression of NLS-CA-Akt accumulate cells in the G1 phase within 24 h, fitting with the rapid sprouting of neuritis. Thus, our data implied that at least in this early time frame, the overexpression of nuclear, active Akt forced cells into neurite development through probably FOXQ1regulation.

• Microbiology and Biotechnology Letters
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• v.8 no.1
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• pp.19-25
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• 1980

Trials of investigating the effect of freezing and lyophilization, as the practical lactic starter preservation methods, on the viability and lactic acid producing activity of Lactobacillus bulgaricus NLS-4 have been carried out. After the treatments, both of viability and activity were decreased. However, when the initial cell cocentration was increared, the survival rate against freezing could be raised to 46% and the activity to 0.25% lactic acid whereas those against lyophilization were 22 ％ and 0.29% lactic acid, respectively. There were further increased maximally when the cell suspension was subjected to freezing and lyophilization after the addition of protective agents such as glycerol and the G. C. G. S. suspending medium.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2011.11a
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• pp.349-352
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• 2011

모바일 IPTV는 이동통신망을 이용하여 방송서비스를 제공한다. 이동통신망을 통해 원활하게 방송서비스를 제공하기 위해서는 극복해야 할 기술적인 장벽이 몇 가지 존재한다. 그 중 하나로, 사용자가 기지국과 기지국 사이를 이동하는 경우 통신망은 연속적으로 서비스를 제공하기 위해 상대 기지국에 사용자의 정보를 전달하는 핸드오버 절차가 수행된다. 핸드오버 절차가 수행되면 시간의 지연이 발생하는데, 시간 지연은 방송 품질에 영향을 미칠 수 있다. 따라서 핸드오버의 발생에 따른 성능 분석은 원활한 방송 서비스를 제공하는데 있어 필수적인 과정으로 볼 수 있다. 본 논문은 핸드오버 성능을 분석하기 위하여 기본적인 무선 액세스 네트워크의 기능이 이미 구현되어 있는 NLS(Network-level Simulator)를 이용한 모의실험 방법을 제시한다. 하지만, 성능 분석에 필요한 기능이 모두 NLS에 포함되어 있지는 않다. 따라서 본 논문에서는 NLS 중 하나인 QualNet을 이용하여 핸드오버 성능 분석에 필요한 기능을 구현하는 방법을 예로 설명한다. 성능은 핸드오버 지연시간과 지연시간의 CDF(Cumulative Distribution Function) 로서 나타낸다.

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.6.1-6.10
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• 2018

Bmal1 is one of the key molecules that controls the mammalian molecular clock. In humans, two isoforms of Bmal1 are generated by alternative RNA splicing. Unlike the extensively studied hBmal1b, the canonical form of Bmal1 in most species, the expression and/or function of another human-specific isoform, hBmal1a, are poorly understood. Due to the lack of the N-terminal nuclear localization signal (NLS), hBMAL1a does not enter the nucleus as hBMAL1b does. However, despite the lack of the NLS, hBMAL1a still dimerizes with either hCLOCK or hBMAL1b and thereby promotes cytoplasmic retention or protein degradation, respectively. Consequently, hBMAL1a interferes with hCLOCK:hBMAL1b-induced transcriptional activation and the circadian oscillation of Period2. Moreover, when the expression of endogenous hBmal1a is aborted by CRISPR/Cas9-mediated knockout, the rhythmic expression of hPer2 and hBmal1b is restored in cultured HeLa cells. Together, these results suggest a role for hBMAL1a as a negative regulator of the mammalian molecular clock.

• The Korean Journal of Nuclear Medicine
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• v.37 no.5
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• pp.288-300
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• 2003

Purpose: To obtain regional blood flow and tissue-blood partition coefficient with time-activity curves from ${H_2}^{15}O$ PET, fitting of some parameters in the Kety model is conventionally accomplished by nonlinear least squares (NLS) analysis. However, NLS requires considerable compuation time then is impractical for pixel-by-pixel analysis to generate parametric images of these parameters. In this study, we investigated several fast parameter estimation methods for the parametric image generation and compared their statistical reliability and computational efficiency. Materials and Methods: These methods included linear least squres (LLS), linear weighted least squares (LWLS), linear generalized least squares (GLS), linear generalized weighted least squares (GWLS), weighted Integration (WI), and model-based clustering method (CAKS). ${H_2}^{15}O$ dynamic brain PET with Poisson noise component was simulated using numerical Zubal brain phantom. Error and bias in the estimation of rCBF and partition coefficient, and computation time in various noise environments was estimated and compared. In audition, parametric images from ${H_2}^{15}O$ dynamic brain PET data peformed on 16 healthy volunteers under various physiological conditions was compared to examine the utility of these methods for real human data. Results: These fast algorithms produced parametric images with similar image qualify and statistical reliability. When CAKS and LLS methods were used combinedly, computation time was significantly reduced and less than 30 seconds for $128{\times}128{\times}46$ images on Pentium III processor. Conclusion: Parametric images of rCBF and partition coefficient with good statistical properties can be generated with short computation time which is acceptable in clinical situation.

• KSBB Journal
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• v.24 no.4
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• pp.403-409
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• 2009

H2AX, a crucial component of chromatin, is implicated in DNA repair, cell cycle check point and tumor suppression. The aim of this study was to identify direct binding partners of H2AX to regulate cellular responses to above mechanisms. Literature reviews and bioinformatical tools were attempted intensively to find binding partners of H2AX, which resulted in identifying two potential proteins, breast cancer-1 (BRCA1) and BRCA1-associated RING domain 1 (BARD1). Although it has been reported in vivo that BRCA1 co-localizes with H2AX at the site of DNA damage, their biochemical mechanism for H2AX were however only known that the complex monoubiquitinates histone monomers, including unphosphorylated H2AX in vitro. Therefore, it is important to know whether the complex directly interacts with H2AX, and also which regions of these are specifically mediated for the interaction. Using in vitro GST pull-down assay, we present here that BRCA1 and BARD1 directly bind to H2AX. Moreover, through combinational approaches of domain analysis, fragment clonings and in vitro binding assay, we revealed molecular details of the BRCA1-H2AX and BARD1-H2AX complex. These data provide the potential evidence that each of the BRCA1 nuclear localization signal (NLS) and BARD1 BRCA1 C-terminal (BRCT) repeat domain is the novel mediator of H2AX recognition.

• Proceedings of KOSOMES biannual meeting
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• 2009.06a
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• pp.105-111
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• 2009

Marine pollution prevention manager system has been operated for the purpose of preventing marine pollution from ships and marine facilities in Korea. As a new "marine environment management act" replacing an old "marine pollution prevention act" had entered into force from January 20, 2008, the works and business of the education and training courses for marine pollution prevention manager are scheduled to transfer from KIMFT(Korea Institute of Maritime and Fisheries Technology) and FHRDI(Fisheries Human Resource Development Institute) to KOEM(Korea Marine Environment Management Corporation) on January 1, 2011. The present state of the education and training for marine pollution prevention managers on board ships was surveyed and analyzed In order to prospect trainee demands for the education and training and to provide KOEM with basic data for establishing a new system for the education and training. The existing education and training courses of KIMFT for marine pollution prevention manager on board ships are classified into a regular course of 21 classes for 3 days, a reeducation course of 18 classes for 2 days and a NLS course of 17 classes for 2days. The annual numbers of trainees in 2008 were 516 persons for regular course, 1085 persons for reeducation course and 135 persons for NLS course in KIMFT. The trainee demands for the education and training were attempted to be predicted on a basis on annual increase rate of ships. The predicted demands for the education and training are changeable depending on the major factors such shipping market, naval architecture industry, etc.