• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.1
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• pp.672-679
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• 2018

This paper describes a methodology for shape design using an optimal design system, whereas generally a three dimensional analysis is required for such designs. An automatic finite element mesh generation technique, which is based on fuzzy knowledge processing and computational geometry techniques, is incorporated into the system, together with a commercial FE analysis code and a commercial solid modeler. Also, with the aid of multilayer neural networks, the present system allows us to automatically obtain a design window, in which a number of satisfactory design solutions exist in a multi-dimensional design parameter space. The developed optimal design system is successfully applied to evaluate the structures that are used. This study used a stress gauge to measure the maximum stress affecting the parts of the side housing bracket which are most vulnerable to cracking. Thereafter, we used a tool to interpret the maximum stress value, while maintaining the same stress as that exerted on the spot. Furthermore, a stress analysis was performed with the typical shape maintained intact, SM490 used for the material and the minimizing weight safety coefficient set to 3, while keeping the maximum stress the same as or smaller than the allowable stress. In this paper, a side housing bracket with a comparably simple structure for 36 tons was optimized, however if the method developed in this study were applied to side housing brackets of different classes (tons), their quality would be greatly improved.

• Microbiology and Biotechnology Letters
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• v.30 no.3
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• pp.235-240
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• 2002

Streptomycetes is a group of Gram-positive soil bacteria that growas a branching vegetative mycelium leading to the formation of spores, and display a physiological differenti-ation related to the synthesis of many secondary metabolites including antibiotics. Their complex life cycle and multicellular differentiation require various levels of regulation and types of signal transduction systems including eukaryotic-type serine/threonine protein kinases and prokaryotic-type histidine/aspartic acid protein kinases. Akt kinase that was found in cells is a sorine/threonine kinase controlling signal pathway for multi-tude of important cellular events. The activation or inactivation of Akt kinase in the cell is one of the critical regulatory points to deliver cell proliferation, differentiation, survival or apoptosis signal. To find the regula-tory protein homologous to Akt in Streptomyces, the fluorescien-labeled synthetic peptide (FITC-TRRSR-TESIT) was designed from the consensus sequence of target proteins for Akt kinase. From the difference of the mobility between the nonphosphorylated and phosphorylated synthetic peptides on Agarose gel electro-phoresis, the Akt-phosphorylating activity was monitored. The cell-free extract prepared from Streptomyces griseus IFO 13350 and the Akt homologous protein was purified by ammonium sulfate fractionation and many steps of column chromatographies such as, DEAE-Sepharose, Mono Q, Resource Phenyl-Soporose and Gel permeation column chromatographies. As a result, the protein phosphorylating the fluorescien-labeled Akt substrate was identified and it's molecular weight was estimated as 39 kDa on SDS-PAGE.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.42 no.1
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• pp.9-26
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• 2005

In the pursuit of ever higher levels of performance, recent computer systems have made use of deep pipeline, dynamic scheduling and multi-issue superscalar processor technologies. In this situations, branch prediction schemes are an essential part of modem microarchitectures because the penalty for a branch misprediction increases as pipelines deepen and the number of instructions issued per cycle increases. In this paper, we propose a novel branch prediction scheme, direction-gshare(d-gshare), to improve the prediction accuracy. At first, we model a neural network with the components that possibly affect the branch prediction accuracy, and analyze the variation of their weights based on the neural network information. Then, we newly add the component that has a high weight value to an original gshare scheme. We simulate our branch prediction scheme using Simple Scalar, a powerful event-driven simulator, and analyze the simulation results. Our results show that, compared to bimodal, two-level adaptive and gshare predictor, direction-gshare predictor(d-gshare. 3) outperforms, without additional hardware costs, by up to 4.1% and 1.5% in average for the default mont of embedded direction, and 11.8% in maximum and 3.7% in average for the optimal one.

• Journal of the Korean Institute of Landscape Architecture
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• v.47 no.6
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• pp.45-52
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• 2019

As international criteria and standards are required in the fields of design and construction, landscape performance must also be considered not only for the value of the landscape but also for providing quality assurance and sustainability. Given the lack of research on landscape performance, the present research was purposed to analyze the importance of potential assessment categories and items using an analytical network process. A list of assessment items, which is composed of 20 items and 6 categories, was derived through a literature review and a preliminary survey of 11 landscape professionals. An ANP model was established and a survey was conducted among 30 landscape practitioners to determine the weight of priorities considering the criteria. The results of ANP showed that the categories of site selection, preservation and health, and convenience had high priorities while materials had the lowest importance score. For the assessment items, a monitoring plan was the highest importance, followed by cultural/ historic preservation, management cost reduction, and natural ground areas. Despite the difficulties in quantifying landscape achievements, most respondents agreed that there needs to be an evaluation system for landscape performance in order to assure the quality and sustainability of landscape development. More research and discussion are needed to develop an assessment system for landscape performance that is applicable to Korean context.

• Strategy21
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• s.41
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• pp.261-293
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• 2017

Nuclear power is a way of attaining an enormous amount of energy with relatively small amount of resources and after it has been introduced to the submarine since 1954, there are approximately 150 of nuclear powered submarine currently on a mission around the world. This is due to the maneuverability, mountability and covertness of nuclear submarines. However, there are other tasks, not only the high level of nuclear technology that are needed to be dealt with in order to construct nuclear powered submarine. The biggest task of all is to secure the enriched uranium. Accordingly, this research is about the way of enriching and securing the nuclear fuel that are used in the nuclear submarine with the characteristics, merits and demerits of the nuclear submarine. Due to the fact that the pressurized water reactor in South Korea is the reactor that was originally built for the development of nuclear powered submarine, many parts is designed to be suitable for the submarine propulsion. However, in order to apply this to submarine it is needed to consider additional requests such as the position of reactor, accident-coping system, radioactive covering, reactor output adjustment and ship's pitch and roll in order to apply this to submarine. Nuclear submarines have much higher speed based on the powerful propulsion in comparison with diesel-electric submarine and also have bigger loading area. Besides, there is no need to snorkel and they also have advantages in covertness with the multi-noise proof system. The nuclear technology in South Korea has seen the dramatic development since 1962 and in 1998 reached to the level that we have succeeded in the localization of nuclear plant and exported the world-class one-piece small-sized reactor (SMART) to UAE. To operate these reactors, we import the whole quantity of low-enriched uranium and having our own uranium enrich facility is not probable because of the budget and international regulations. With the ROK/US nuclear agreement revised on 2015 November, the enrichment of uranium that are available without special permission has changed up to 20%. According to the assumption that we use the 20% enrichment of Uranium on U.S. virginia class submarine, it is necessary to change the fuel after 11 years and it will cause additional cost of 1 billion dollars. But the replace period by the uranium's enrichment rate is not fixed so that it is possible to change according to the design of reactor. Therefore, I would like to make a suggestion on two types of design concepts of nuclear submarine that can be operated for 30 years without nuclear fuel change by using the 20% enriched uranium from ONNp.First of all, it is possible by increasing the size of reactor by 3 times and it results in the 1,000t increase of the weight. And secondly, it is by designing the one piece reactor to insert devices such as steam turbine, condenser into the inside of nuclear core like the Rubis class submarines of France.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.10 no.2
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• pp.23-38
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• 1990

In this study, decompositive optimization method of two levels was selected to optimize effectively the geometry of the truss which takes the multi-loading condition, and the allowable stress, bucking stress, displacement and natural frequency constraints into consideration. The algorithm of this study is made up of sectional optimization using the feasible direction method in level 1, and geometrical optimization employing Powell's one-direction search method which menimizes only objictive function in level 2. The results of this study acquired by beenning applied to structural model of the truss are as follows : 1. It is verified that the algorithm of this study effectively converges, independent of the initial geometry of the truss and the applied various constraints. 2. The optimum goemetry of the truss varies more considerably according to the constraints selected. 3. Under the condition of the same design, the weight of the truss can be decreased more considerably by means of optimizing even the geometry of truss than by means of optimizing the section of truss while fixing geometrical configuration of it, even though there might be a little difference according to the initial geometry of the truss and the design condition.

• Journal of the Korean Chemical Society
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• v.43 no.2
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• pp.193-198
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• 1999

The transfection efficiency of plasmid DNA was inspected using multi-cationic polymer, 5, 10, 25 and 50KD polyethylenimine (PEI). The optimal neutralization ratio of PEI/DNA complexes by agarose assay was 1.5-2.0 (nmol/nmol) without much difference in molecular weight of PEI.In vitro transfection assay, most of PEI-mediated plasmid delivery was better compared to the naked DNA. Especially, 25KD PEI at optimal condition gave higher transfection rather than the standard assay of DEAE-dextran or Lipofectin. To enhance the cell targeting delivery, the liposome formulations were introduced using phospholipids. As a result, PC/PE liposomes increased 2-2.5 times of the transfection efficiency of PEI single or PC/PE single delivery, but not the case of 25KD PEI. Moreover, the DOTAP/PE-introduced PEI delivery reduced the transfection of DOTAP/PE single delivery. All these results proved that the PEI can be used not only good transfectants and but also good DNA condensing agents in neutral/anionic liposome for cell targeting delivery.

• Applied Chemistry for Engineering
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• v.24 no.3
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• pp.219-226
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• 2013

Organic semiconductor-based soft electronics has potential advantages for next-generation electronics and displays, which request mobile convenience, flexibility, light-weight, large area, etc. Organic field-effect transistors (OFET) are core elements for soft electronic applications, such as e-paper, e-book, smart card, RFID tag, photovoltaics, portable computer, sensor, memory, etc. An optimal multi-layered structure of organic semiconductor, insulator, and electrodes is required to achieve high-performance OFET. Since most organic semiconductors are self-assembled structures with weak van der Waals forces during film formation, their crystalline structures and orientation are significantly affected by environmental conditions, specifically, substrate properties of surface energy and roughness, changing the corresponding OFET. Organo-compatible insulators and surface treatments can induce the crystal structure and orientation of solution- or vacuum-processable organic semiconductors preferential to the charge-carrier transport in OFET.

• Radiation Oncology Journal
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• v.30 no.3
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• pp.132-139
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• 2012

Purpose: The purpose of this prospective multi-institutional study was to evaluate the nutritional status of patients undergoing radiotherapy (RT) for treatment of head and neck, lung, or gastrointestinal cancer. Materials and Methods: A total of 1,000 patients were enrolled in this study at seven different hospitals in Seoul, Korea between October 2009 and May 2010. The nutritional status of patients after receiving 3 weeks of RT was evaluated using subjective global assessment (SGA). The nutritional status of each patient was rated as well nourished (A), moderately malnourished (B), or severely malnourished (C). Results: The mean age of patients in this study was $59.4{\pm}11.9$ years, and the male to female ratio was 7:3. According to the SGA results, 60.8%, 34.5%, and 4.7% of patients were classified as A, B, or C, respectively. The following criteria were significantly associated with malnutrition (SGA B or C; p < 0.001): loss of subcutaneous fat or muscle wasting (odds ratio [OR], 11.473); increased metabolic demand/stress (OR, 8.688); ankle, sacral edema, or ascites (OR, 3.234); and weight loss ${\geq}5%$ (OR, 2.299). Conclusion: SGA was applied successfully to assess the nutritional status of most patients. The prevalence of malnutrition in a radiation oncology department was 39.2%. The results of this study serve as a basis for implementation of nutrition intervention to patients being treated at radiation oncology departments.

• Journal of the Korean Wood Science and Technology
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• v.39 no.1
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• pp.41-52
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• 2011

This study was carried out to investigate the effect of energy saving and sound insulation of building materials mixed with charcoal. To investigate the functionality of building based on the difference of construction materials, three different experimental buildings were constructed. They were buildings built with the conventional construction materials (A), the charcoal construction materials (B), and the charcoal-sericite construction materials (C). The study showed that energy consumption could be reduced approximately 9.5% and 14.5% by replacing A with B and C, respectively. Especially, it is revealed that the lower outdoor temperature was, the higher energy saving effect was. Also, after shutoff the boiler switch the decrease rate of room temperature of the one using B was lower than those of others using A and C so that the room temperature at the building using B was higher by $3.5{\sim}4.2^{\circ}C$ in the 1 meter air above the ground and by $4.4{\sim}5.4^{\circ}C$ on the floor surface after 12 hours passed. In the building noise test the heavy-and light-weight impact sound of the plate, represented by criterion of noise between floors in multi-story building, tended to decrease in the test sample containing charcoal.