• 생물정신의학
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• 제4권2호
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• pp.211-217
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• 1997

The Bcl-2 protein has been shown to block apoptosis induced by a variety of stimuli. We have performed the experiments which cell death can be blocked by the bcl-2 proto-oncogene under moderate(50-100mM) or high ethanol treatment(400-600mM). As a result of morphological changes, and MTT assay, cell death was blocked by Bcl-2 under 100mM ethanol. However, the results of DNA fragmentation and RT-PCR(ICE, and CPP32), immunoblotting(CPP32, and PARP) for SK-pcDNA3 cells(vector only) and SK-Bcl-2 cells(stably expressed bcl-2 gene) were showen to be no significant differences between two cell lines. These results suggested that cell death induced by ethanol was not followed by apoptosis mechanism, and was blocked by the bcl-2 proto-oncogene with moderate ethanol.

• 한국생활과학회지
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• 제21권4호
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• pp.679-693
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• 2012

The purposes of this study were to find the correlation of social maladaptation, depression, ego resilience and daily life satisfaction, and to explore the mediating role of ego resilience between social maladaptation, depression and daily life satisfaction. The subject of the survey was 184 intermarried Korean men. The data were analyzed with frequency, Pearson's correlation and structural equation modeling by SPSS and AMOS. Instruments were social maladapatation and depression of Shin(2001)'s Mental Health Scale, Block and Kremen(1996)'s Ego Resilience Scale, and Bradburn(1969)'s Structure of Psychological well-being, and Olson and Barnes(1982)' Quality of Life. The major findings were as follows: Social maladapataion and depression were negatively correlated with ego resilience and daily life satisfaction. Ego resilience was positively correlated with daily life satisfaction. Ego resilience mediated the effects of social maladaptation, depression and daily life satisfaction. Social maladaptation and depression influenced ego resilience. Ego resilience influenced positively daily life satisfaction. In conclusion, it is important to intervene intermarried Korean men's daily life satisfaction through special education program and counseling in order to build ego resilience.

• 한국식품영양과학회지
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• 제28권5호
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• pp.1180-1186
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• 1999

A wide ranges of chemicals released into the environment have potential to interfere with physiological and development process by disrupting endocrine pathways. Endocrine system embraces a multitude of mechanisms of action, including effect on growth, behavior, reproduction and immune function. These environmental endocrine disruptors are present in environment and pose potential health consequences to human and wildlife. The best known form in endocrine distruptors involves substances which mimic or block the action of natural hormone in the body. Endocrine disruptor have been variously defined as exogenous agents that interfere with the synthesis, secretion, transport, metabolism, binding action or elimination of the natural hormones in the body which are responsible for the maintenance of homeostasis, reproduction developmental and/or behavior. Many compounds polluted into the environment by human activity are capable of disrupting the endocrine system of animals, including fish, wildlife, and humans. Among these chemicals are pesticides, industrial chemicals, and other anthropogenic products. It has been alleged that several adverse effects on human health are linked with exposure to chemicals which are claimed to be endocrine disrupters, that is, increased incidence of testicular, prostate and female breast cancer, time dependent reductions in sperm quality and quantity, increased incidence of cryptorchidism (undescended testicles) and hypospadias(malformation of the penis), altered physical and mental de velopment in children. This observation is currently the only example of chemically mediated endocrine disruption which has resulted in a clear effect at the population level.

• 대한임베디드공학회논문지
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• 제17권5호
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• pp.265-272
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• 2022

As the risk of lung cancer has increased, early-stage detection and treatment of cancers have received a lot of attention. Among various medical imaging approaches, computer tomography (CT) has been widely utilized to examine the size and growth rate of lung nodules. However, the process of manual examination is a time-consuming task, and it causes physical and mental fatigue for medical professionals. Recently, many computer-aided diagnostic methods have been proposed to reduce the workload of medical professionals. In recent studies, encoder-decoder architectures have shown reliable performances in medical image segmentation, and it is adopted to predict lesion candidates. However, localizing nodules in lung CT images is a challenging problem due to the extremely small sizes and unstructured shapes of nodules. To solve these problems, we utilize atrous spatial pyramid pooling (ASPP) to minimize the loss of information for a general U-Net baseline model to extract rich representations from various receptive fields. Moreover, we propose mixed-up attention mechanism of reverse, boundary and convolutional block attention module (CBAM) to improve the accuracy of segmentation small scale of various shapes. The performance of the proposed model is compared with several previous attention mechanisms on the LIDC-IDRI dataset, and experimental results demonstrate that reverse, boundary, and CBAM (RB-CBAM) are effective in the segmentation of small nodules.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.863-870
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• 2022

Unsatisfactory urban walking environment stresses urban residents, and may cause mental illness and chronic diseases by reducing walking activities. Therefore, establishing a high-quality walking environment that can promote walking activities in urban residents has emerged as an important issue. The walking environment consists of various components, such as trees, stairs, streetlights, benches, signs, fences, and facilities, and it is essential to understand which components and their settings act as satisfiers or dissatisfiers for pedestrians, to create a better quality walking environment. Therefore, this study investigated pedestrian satisfaction and dissatisfaction as a function of various environmental components through a survey using walking environment images. The results revealed that most of the walking environment components except the braille block and treezone exhibited significant correlations with pedestrian satisfaction. Particularly, safety-related component (e.g., adjacent roads, parked cars, traffic cushions, and car separation), and landscape-related components (e.g., trees and green), as well as the material settings of landscape facilities (e.g., wooden fences, benches, stairs, and walkway surfaces) correlated with pedestrian satisfaction. The results of this study can contribute to the extraction of useful features to evaluate pedestrian satisfaction as a function of the walking environment. The research outcome is expected to assist in the effective arrangement of walking environment components and their settings, which will ultimately contribute to significantly satisfactory walking environment and encourage walking activities.

• Asian-Australasian Journal of Animal Sciences
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• 제29권6호
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• pp.879-886
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• 2016

As is in all economic activities, the highest yield per unit area is the main goal in animal production, while addressing the temperamental needs of animals often is ignored. Animal welfare is not only an ethical fact; it also has an economic value. Spatial environmental enrichment contributes positively to animal welfare by addressing their behavioral and mental requirements. The present study was conducted to determine the effects of weaning and spatial environmental arrangements on behaviors of goat-kids. Experimental groups were arranged in structured and unstructured spatial environments. Roughage feeder, semi-automatic concentrate feeder, bunk, bridge, and wood block were placed in the structured environment. No equipment was placed in the unstructured environment and paddock sides were enclosed with an iron sheet to prevent bipedal stance and to provide environmental isolation. In the study 10 male and 10 female Turkish Saanen goat kids were used in each group. Spatial environmental arrangements did not have significant impacts on the growth performance of kids (p>0.05). All objects in the structured group were accepted by the kids. Average use ratios of roughage feeder, semi-automatic concentrate feeder, bunk, bridge and wood block were observed as 19.3%, 14.0%, 12.6%, 3.8%, and 0.7%, respectively. There were significant differences between before- and after-weaning in use of all objects except for underneath bridge ($p{\leq}0.05$). Concentrate feed consumption, locomotion, and resting behaviors in kids showed significant differences by structural group and growth period. Roughage consumption was similar between groups, while it differed by growth period ($p{\leq}0.05$). Interaction frequency was significantly higher in structured group (p = 0.0023). Playing behavior significantly differentiated based on the growth period rather than on groups ($p{\leq}0.05$). Playing behavior significantly decreased after weaning. Abnormal oral activity was significantly higher in the structured group before weaning ($p{\leq}0.05$). Despite there being no installations facilitating climbing and bipedal stance, the kids of the unstructured group were able to exhibit 1/3 as much bipedal stance behavior as the kids of the structured group through leaning over slippery paddock wall or over their groupmates. Bipedal stance behavior of unstructured group was similar before and after weaning, while bipedal stance behavior before weaning was about 2 times that of after weaning in structured group. It was concluded that unstructured environmental arrangement limited the behavior repertoire of the goat kids.

• The Korean Journal of Pain
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• 제7권1호
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• pp.100-105
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• 1994

좌측 대퇴 절단부에서의 통증을 주소로 하고 다양한 증상을 강하제 호소하던 환자에서 통증의 원인 검색 중 신경종을 발견하여 그것을 적출한 후에 절단부의 통증 뿐아니라 미증호소도 함께 경감된 증례를 경험했다. 이러한 미증호소는 지속되는 통증 및 정확하지 않은 치료방법에 의해 증가 할 수도 있다고 생각된다. 본 증례에서와 같은 경우 정신적 배려를 충분히 해가면서 통증의 원인 검색 및 치료를 하는 것이 합리적일 것으로 사료된다.

• 동의신경정신과학회지
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• 제11권2호
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• pp.53-62
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• 2000

Background : The aim of this study was to evaluate the effect of Punsimgieumgamibang on insomnia and anxiety. which is widely used in mental diseases. Method : We admitted Punsimgieumgamibang into rats which illumination of the sleeping periodhas been reversed, and measured its activity rate during the sleeping period. Also we studied the effect of Punsimgieumgamibang on anxiety using analyses of Punsimgieumgamibang on anxiety using analyses of behavior of rats submitted to the elevated plus-maze test.Result : 1) The sleeping ratio of the Pusimgieumgamibang group was higher than the control group on the whole, and the difference of the groups in the third time block was significant statistically. 2) We could not find any statistical information in all of the 4 anxiety related behavior of the elevated plus-maze experiment. and there was a tendency to a higher measurement in the Punsimgieumgamibang group animals in the total arms visitation in the elevated plus-maze, open arms visitation, and the amount of time of stay in arms. Conclusion : It is suggested that Pusimgieumgamibang has effects on insomnia.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1063-1067
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• 2015

Background: Tumor associated fatigue (TAF) or cancer related fatigue (CRF) is not a new concept. Nonetheless, no real headway has been made in the quantitative analysis of its successful treatment via cognitive behavioral therapy. Since 20 to 30% of all breast cancer patients suffer from anxiety and/or depression within the first year of their diagnosis, this issue needs to be addressed and a standard treatment protocol has to be developed. This study focused on developing a simple, reproducible and short (8 weeks) protocol for the cognitive behavioral therapy support of tumor associated fatigue patients. Materials and Methods: Between the year 2011 and 2012, 23 breast cancer patients fulfilled the diagnosis TAF requirements and were introduced into this study. Our method focused on a psycho-oncological support group using a predetermined, highly structured and reproducible, cognitive behavioral therapy treatment manual. Eight weekly, 90 minute sessions were conducted and patients were evaluated before and after this eight session block. Tumor fatigue specific questionnaires such as the multidimensional fatigue inventory (MFI) as well as the hospital anxiety and depression scale (HADS) were used in order to quantitatively evaluate patient TAF. Results: Of the 23 patients enrolled in the study, only 7 patients fulfilled the TAF diagnostic criteria after the psycho-oncological group treatment. This represents a 70% reduction in diagnosable tumor associated fatigue. The HADS analysis showed a 33% reduction in patient anxiety as well as a 57% reduction in patient depression levels. The MFI scores showed a significant reduction in 4 of the 5 evaluate categories. With the exception of the "mental fatigue" MFI category all results were statistically significant. Conclusions: This study showed that a highly structured, cognitive behavioral therapy group intervention will produce significant improvements in breast cancer patient tumor associated fatigue levels after only 8 weeks.

• 한국재난정보학회 논문집
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• 제10권3호
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• pp.374-387
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• 2014

성폭력 범죄는 재범의 개연성이 높은 범죄이므로, 이에 대한 대책으로 도입된 것이 전자감독제도이다. 본 제도는 전자장치를 통해 피부착자의 위치를 24시간 파악할 수 있기 때문에 피부착자에게 심리적 정신적 압박감을 주어, 어느 정도는 범죄의 의도를 억제하는데 효과가 있다. 하지만 강력한 의지를 가진 범죄자들의 재범을 막는데 한계가 있다. 현재 연구 중인 차세대 지능형 전자발찌는 전자감독 대상자의 위치정보와 부착센서를 통한 행동 및 신체적 상태 변화 정보를 실시간으로 수집하고 분석한다. 이를 기반으로 범죄 발생의 징후를 사전에 예측하여 범죄의도를 사전에 차단하거나, 실행중인 범죄가 확대되기 전에 중지시키는 데 그 목적이 있다.