• 대한한방부인과학회지
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• 제22권3호
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• pp.246-256
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• 2009

Purpose: To report the effect of oriental medicine on 2 patients with secondary amenorrhea diagnosed as hypothalamic-pituitary failure. Methods: The patients who had secondary amenorrhea were treated with the oriental medical treatments such as herbal medication, herbal acupuncture and moxibustion therapy, and so forth. Results: After the oriental medical treatments, the patients could have their periods again, their menstrual condition was improved. Conclusion: This case report shows that the oriental medical therapy is effective for treating secondary amenorrhea diagnosed as hypothalamic-pituitary failure.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2022년도 추계학술대회
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• pp.97-97
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• 2022

The fruit of the Crataegus pinnatifida bunge has been known to have a role as a digestive stimulant, and is used for postpartum abdominal pain and women's menstrual pain. It is used for coronary artery disease, angina pectoris, hypertension and hyperlipidemia. Ascorbic acid, hydroquinone, retinoids, alpha-hydroxy acids, kojic acid, azelaic acid have been used for cosmetic whitening and medical depigmentation. To determine whether Crataegus pinnatifida bunge fruit also has whitening and depigmentation effect, tyrosinase inhibition assay was performed with American Crataegus pinnatifida Bunge ethanol extracts, Korean Crataegus pinnatifida Bunge (Cra) ethanol extracts and Arbutin as a positive control as previously described by Korean FDA guideline. Korean Cra fruit ethanol extracts were 1.87 fold more inhibitory function to tyrosinase activity than American Cra in the experimental condition that inhibitory function to tyrosinase activity of Korean Cra Arbutin is 81.8% when compared to that of the standard control Arbutin as 100%. These results suggest that ethanol extracts of Crataegus pinnatifida bunge have significant whitening effects and may provide the basis for development of cosmetic whitening agent and medical depigmentation applications.

• 한국전자통신학회논문지
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• 제8권7호
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• pp.1103-1110
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• 2013

본 연구는 인터넷시대에서 월경통 대상자의 보완대체요법에 대한 만족도를 파악하고자 하였다. 연구대상자는 광주시의 5개 보건소 방문자와 A 교회 여성 교인 중 18세 이상 55세 이하의 생리를 하고 있는 200명의 여성이며, 자료수집기간은 2010년 9월부터 2010년 10월 10일까지였다. 연구도구로는 안승덕(2003)의 설문지에서 사용한 문항을 기초로 한 설문지를 사용하였다. 자료분석은 SPSS 17.0을 이용, 빈도분석, 교차분석, 카이제곱검정을 하였고, 연구결과 월경통환자의 보완대체요법 이용률은 43.4%, 이용장소는 한의원이나 한약방이 56.3%, 대체요법의 종류도 한의원의 한약, 침술, 뜸, 부항(42.5%)의 비율, 이용시 지출비용(1년기준)은 50만원 미만 56.3%, 이용후의 만족도는 만족한다 51%의 분포도를 나타냈다. 결론적으로 사회활동이 많은 21세기에서 월경통 환자의 보완대체요법 이용률이 높아지고, 본인스스로 혹은 주위의 권유로 대체요법을 이용하며, 신뢰할 수 있는 의료기관인 한의원과 전통적 민간요법에 의존을 하는 것으로 나타났고, 보완대체요법에 대한 보험 혜택이 이루어지도록 연구와 협조가 필요할 것으로 사료된다.

• 대한한방부인과학회지
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• 제24권4호
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• pp.126-149
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• 2011

Purpose: KCDO-3(Korean Classification of Diseases(Oriental Medicine)-third edition) being used in January, 2010 accepted the KCD(Korean Classification of Diseases) and added disease pattern and syndrome of oriental medicine. But, the diagnoses of oriental medicine are too uncertain to express in A00-Z99(KCD). In this case, you should choose in U codes under the KCD use guidelines, but U codes are not capable of representing the symptoms too. So, we suggest the use criteria and consider the weakness of the U codes with medical records of patients who visited with amenorrhea or oligomenorrhea. Methods: We referred medical records of patients who visited oriental obstetrics and gynecology from January 1st to December 31st, 2010. From among them, we set up 122 patients who related with emmeniopathy as target group and searched codes distribution based on medical records. And we described that the process of choosing appropriate codes based on the medical records of 49 amenorrhea or oligomenorrhea patients. Results and Conclusions: The emmeniopathy is divided into menstrual disorder, amenorrhea and systemic disorders at the period of menstruation. And emmeniopathy is expressed in some codes such as N91, N92, N93, N94, U321, U77. When a patient visit hospital, a doctor should choose causal codes when there is confirmed diagnosis. Otherwise, a doctor chooses symptom codes. And if there are more than two diagnosis consistent with definition of chief condition, a doctor should code the first listed diagnosis as a chief condition. Because KCD-5 is classified according to western medical diagnosis, it is difficult to choose in KCD-5 when we diagnosed with disease pattern and syndrome of oriental medicine. But U codes are also deficient to express various condition of emmeniopathy. So we should add 'deficiency and detriment of the thoroughfare and conception vessels', 'prolonged menstruation' and various systemic disorders at the period of menstruation.

• 대한한방부인과학회지
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• 제19권3호
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• pp.231-245
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• 2006

Purpose : To investigate and compare the characteristics of menstruation in the shift workers and the day workers, and present guidelines for health promotion of the shift-working women. Methods : Questionnaires including general health condition and QSCC II were distributed to shift-working women and day-working women in one university hospital in Gyeonggi-do and 36 questionnaires of shift-working women and 33 of day-working women were analyzed. Results : Day workers were about 5 years older than shift workers on average. There was more irregularity of menstrual cycle and period in day-working group but it is thought to incorrect because of the age problem. There were more women who have dysmenorrhea in day-working group, but the proportion of dysmenorrhea which continues more than 72 hours -which is very suggestive of secondary dysmenorrhea- was higher in shift-working group. Average VAS of dysmenorrhea was nearly the same in two groups. The life of shift-working group was lesser satisfactory than that of day-working group. There were more sleep disturbances in the shift-working group. Sasang constitution was analyzed in both group using QSCC II, and Taeumin were more in shift-working group. Conclusion : As the number of shift-working women increases, needs for oriental medical treatments would increase because it is more natural and lesser invasive managements which women are very interested in. So it is thought to be necessary to understand health problems of shift-working women, and prepare guidelines for managements and treatments to promote the health of shift-working women.

• 대한한의학회지
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• 제32권5호
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• pp.25-40
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• 2011

Objectives: This study was performed to assess whether herbal medicine and acupuncture before in vitro fertilizationembryo transfer (IVF-ET) is effective on clinical pregnancy. Methods: From May 2010 to January 2011, a prospective analysis study was performed in 38 patients planning to undergo IVF-ET after taking herb medicine and acupuncture treatment. This study investigated the pregnancy rate and analyzed the change of dysmenorrhea by visual analog scale (VAS), body heat and condition of premenstrual syndrome (PMS), vaginal discharge and menstruation status. Results: 1. During herbal medicine and acupuncture treatment, five patients (13.16%) naturally became pregnant and six patients (15.79%) withdrew. After treatment, 15 patients (39.47%) received IVF-ET, 12 patients (31.58%) did not. 2. The biochemical pregnancy rate was 26.67%, the clinical pregnancy rate 26.67%, miscarriage rate 25% and ectopic pregnancy rate was 0%. 3. After treatment, PMS, dysmenorrhea and dysmenorrhea VAS was significantly decreased and the overall menstrual status improved. 4. After treatment, temperature difference of CV17-CV12 and CV4-CV12 increased, but it was not a statistically significant difference. 5. After treatment, decrease of hemoglobin and protein and increase of total bilirubin and creatinine were statistically significant. All the blood test results were within normal levels which proves safety of treatment. Conclusions: This study suggests that herbal medicine and acupuncture treatment before IVF-ET shows similar pregnancy rates with existing rates, but contributes to increasing the possibility of natural pregnancy.

• 지역사회간호학회지
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• 제24권3호
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• pp.264-272
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• 2013

Purpose: The aim of this study was to investigate coping styles for dysmenorrhea and explore factors related with their coping styles according to different health loci of control in middle schoolers. Methods: Data were collected by using a structured questionnaire for 572 students from three middle schools in Seoul from March 22 to April 2, 2010. The measurement included menstrual distress, coping method questionnaire and health locus of control. The data were analyzed by using t-test, ANOVA, Pearson's correlation coefficients, and multiple regression analysis. Results: Middle school students used the active behavioral coping style more often than the avoidance style. There was a significant difference in means within each coping style including levels of stress, levels of health, and regular exercise. There were also significant correlations between each coping style and health locus of control. Regression analyses indicated that the health locus of control factor is the most powerful factor in each coping style. Conclusion: We observed that various coping methods are used for dysmenorrhea in middle school students. However, the active behavioral coping style is dominant in such a condition. Based on these results, we need to develop a health locus of control to improve coping styles for dysmenorrhea.

• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2002년도 국제심포지엄
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• pp.112-112
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• 2002

Under normal conditions, women produce a single dominant follicle that participates in a single ovuation each menstrual cycle. But Polycystic ovary syndrome(PCOS) conditions, folliculogenesis does not proceed normally. This condition leads to the accumlation of large numbers of small graffian follicles in which the theca interstitial cells (TIC) produce abnormally large amounts of androgen. PCOS is probably the most common endocrine disorder, affecting women of reprodutive age with 5-10% prevalence estimate. Chronic anovulation, hyperandrogenism, hirsutism, obesity, infertility and polycystic ovaries are clinical hallmarks of women with PCOS. Its etiology remains unknown. To investigate the gene expression pattern of ovary in PCO-induced rat, we used cDNA expression analysis. Total RNA was extracted from the ovary of PCO-induced rat and reverse-transcribed in the presence of［$\alpha$$^{32}$P］-dATP Which were hybridized to Atlas$^{TM}$ Rat Toxicology 1.2 array (Clontech) representing approximately 1176 rat genes. We compared gene expression between ovary of pco-induced immature female rats and control. Differential gene expression profiles were revealed (LIFR-alpha, ADRA1A, Heat shock 90-kDa protein A, PDGFRA). Reverse transcription-polymerase chain reaction(RT-PCR) was used to validate the relative expression pattern obtained by the cDNA array. The precise relationship between the altered expression of genes and PCO is a matter of further investigation. This study was supported by Korea Science and Engineering Foundation(KOSEF)

• 대한불안의학회지
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• 제12권2호
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• pp.113-118
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• 2016

Objective : Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) is known to reduce the quality of sleep and is associated with various psychiatric disorders. The aim of this study was to investigate the relationship of PMS with depression, sleep qulity and sleep pattern in Korean female adolescents. Methods : Out of 867 high school female students, 400 female subjects were included in this study. All participants completed self-report questionnaires that included demographic variables, shortened premenstrual assessment form (SPAF), patient health questionnaire-9 (PHQ-9), Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), insomnia severity index (ISI) and Korean translation of composite scale (CS). A total of 394 individuals who completed the questionnaires were analyzed. Results : As score of SPAF, 143 subjects was defined PMDD group. They had more prevalence of eveningness, more depressive symptom, poorer sleep quality, and more excessive sleepiness than non-PMDD groups. Although the PMDD groups showed more menstrual dysmenorrhea, no difference was found in bleeding duration and cycle. PMS symptom had correlations with depression, poorer sleep quality and excessive sleepiness during the daytime. There was no difference in sleep duration between two groups, but PMS might have a relationship with eveningness of chronotype. Conclusions : Among Korean female high school students, the PMS might have an association with depression and poor sleep quality, and it might lead to daytime impairment due to excessive sleepiness. An appropriate evaluation of PMS could be helpful in determining the mental health condition of adolescents.

• 정신신체의학
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• 제3권2호
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• pp.115-125
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• 1995

Reports about the prevalence of premenstrual symptoms state that occurs in 20 to 100% of most reproductive-age women. There is a close association between premenstrual syndrome and affective disorders as well as same some other psychiatric disorders. Late luteal phase dysphoric disorder (LLPDD) is a premenstrual condition defined in DSM-III-R by severe mood changes and other symptoms that repeatedly occur only in the luteal phase of the menstrual cycle. However, DSM-III-R does not specify how to compute the change from the follicular to the luteal phase or how to determine when the amount of change is great enough to warrant the diagnosis nor how to determine occupational or social functional impairment. This study was conducted to evaluate the nature, severity and magnitude of premenstrual syndrome in women with current psychiatric disorders by using prospective Daily Rating Form(DRF), and to measure symptom changes according to three scoring methods for diagnosing LLPDD. Our study obtains the data about premenstrual changes estimated by DRF from 22 women with psychiatric disorders who had met criteria for major depressive syndrome on the Premenstrual Assessment Form (PAF). The data was scored by each three methods and was determined to meet criteria A for LLPDD. The results are as follows: 1) the subjects, when scored according to the percent change method, effect size method and absolute severity method, met the DSM-III-R criteria A for LLPDD in 36.4% (8 subjects), 14% (3 subjects) and 4.5% (1 subject) of the cases respectively. 2) The items of irritability, anger and impatience were occurred most frequently on the DRF, when it was scored according to the three scoring methods. And the item of breast pain was next frequent according to the effect size method and the percent change method but according to the absolute severity method. 3) The PAF item of impaired social functioning was reported by 16 (73%) of the subjects. 4) 4 (18%) of the subjects met criteria A for LLPDD and reported impaired social functioning. The prevalency of LLPDD according to each method varied. The percent change method yielded the greatest (36.4%), and the absolute seventy method yielded the laest (4.5%), The effect size method yielded an intermediate frequency (14%). Therefore, for maximizing the diagnostic accuracy of LLPDD, a diagnostic procedure including a measure of change (e.q., effect size method, percent change method) as well as confirmed diagnosis by DRF, will be needed. Also, an accurate tool to evaluate impaired social functioning will be required.