Browse > Article

Influence of Herbal Medicine and Acupuncture Treatment on the Pregnancy Rate in Infertile Women before In Vitro Fertilization-Embryo Transfer  

Park, Young-Sun (Dept. of Oriental Obstetrics & Gynecology, College of Oriental Medicine, Daegu Haany University)
Baek, Jung-Han (Dept. of Oriental pediatrics College of Oriental Medicine, Daegu Haany University)
Publication Information
The Journal of Korean Medicine / v.32, no.5, 2011 , pp. 25-40 More about this Journal
Abstract
Objectives: This study was performed to assess whether herbal medicine and acupuncture before in vitro fertilizationembryo transfer (IVF-ET) is effective on clinical pregnancy. Methods: From May 2010 to January 2011, a prospective analysis study was performed in 38 patients planning to undergo IVF-ET after taking herb medicine and acupuncture treatment. This study investigated the pregnancy rate and analyzed the change of dysmenorrhea by visual analog scale (VAS), body heat and condition of premenstrual syndrome (PMS), vaginal discharge and menstruation status. Results: 1. During herbal medicine and acupuncture treatment, five patients (13.16%) naturally became pregnant and six patients (15.79%) withdrew. After treatment, 15 patients (39.47%) received IVF-ET, 12 patients (31.58%) did not. 2. The biochemical pregnancy rate was 26.67%, the clinical pregnancy rate 26.67%, miscarriage rate 25% and ectopic pregnancy rate was 0%. 3. After treatment, PMS, dysmenorrhea and dysmenorrhea VAS was significantly decreased and the overall menstrual status improved. 4. After treatment, temperature difference of CV17-CV12 and CV4-CV12 increased, but it was not a statistically significant difference. 5. After treatment, decrease of hemoglobin and protein and increase of total bilirubin and creatinine were statistically significant. All the blood test results were within normal levels which proves safety of treatment. Conclusions: This study suggests that herbal medicine and acupuncture treatment before IVF-ET shows similar pregnancy rates with existing rates, but contributes to increasing the possibility of natural pregnancy.
Keywords
infertility; IVF-ET; herbal medicine; acupuncture; Jokyungjongok-Tang;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 Yang NR, Cho JH, Lee JM, Lee CH, Jang JB, Lee KS. A Study On the Severity of Dysmenorrhea, Digestive Power according to the Shift Rotation. The Journal of Oriental Obstetrics & Gynecology. 2010;23(2):95-105.
2 Yang NR, Cho JH, Lee JM, Lee CH, Jang JB, Lee KS. A Study On the Severity of Dysmenorrhea according to Digestive Power, BMI in the High School Female. The Journal of Oriental Obstetrics & Gynecology. 2009;22(4):110-122.
3 Jang YH. Studies on Pharmacological Action of Chokyeong chongok tang. The Journal of Oriental Gynecology. 1987;1(1):39-46.
4 Lee SJ, Lim JY, Lee DK, Lee TK. Effect of Jokyong-Jongok-tang on the Fertilization and Maturation of Immature Oocytes in Bovine. The Journal of Oriental Obstetrics & Gynecology. 1999;12(2):134-147.
5 김준태, 남상수, 이재동, 최도영, 안병철, 박동석, 이윤호, 최용태. 불임에 응용된 침구치료혈에 관한 문헌적 고찰. 대한침구학회지. 1997;14(2):93-113.
6 United Nations Population Fund Thoraya Ahmed Obaid, Executive Director. State of World Population 2010 translated in Korean part 1. Planned Population Federation of Korea. 2010. available from: URL: http://www.ppfk.or.kr/
7 Korea Institute for Health and Social Affairs. Evaluation of national supporting program for infertility couples in 2007 and qualty control of infertility clinics. college of medicine, pochon CHA university. 2008. available from: URL: http://dl.nanet.go.kr/SearchDetailList.do
8 Huh J. Dong-ui-bo-gam. 1st ed. Seoul:Bubin. 2005: 1090-1093.
9 Kim HW, Kim YS, Lee KS. Correlation between women infertility and DITI. The Journal of Oriental Obstetrics & Gynecology. 2001;14(3): 33-39.
10 Cho JH, Kim DI, Park KB, Kang HC. The Correlation Analysis of Factors Related to PMS through Survey. The Journal of Oriental Obstetrics & Gynecology. 2006;19(4):174-204.
11 Korean Society for the study of obesity. Clinical Obesity Treatment. Seoul:Korea Medical Publishing co. 1995:309-319.
12 The Korean Acuouncture & Moxibustion Society. The acupuncture and moxibustion. Paju:Jipmoondang. 2008:24,63,80,83,257,337, 374.
13 Lee DK, Chang KH, Kim SH, Park YK, Ku PS. Maternal Age: A major factor affecting the outcome of In Vitro Fertilization. Korean Journal of Obstetrics and Gynecology. 1996;39(8):1489- 1496.
14 Kim JY, Lee DH, Lee KS. Influence of women's age on the outcome of in vitro fertilization and ovarian blood flow. Korean Journal of Obstetrics and Gynecology. 2008;51(4):413-419.
15 So WB. All diseases' causes and symptoms. 1st ed. Taipei:Jipmunseoguk. 1976:391.
16 Jin ST. Elaborate Seoksilbirok. 1st ed. Taipei: Taeyeongukpung. 1974:121-122.
17 Gong S. Gogeumuigam. 1st ed. Jiangxi:Jiangxi science and technology. 1990:293-294,312-314.
18 Paulus WE, Zhang M, Strehler E, El-Danasouri I, Sterzik K. Influence of acupuncture on the pregnancy rate inpatients who undergo assisted reproduction therapy. Fertil Steril. 2002;77(4): 721-4.   DOI   ScienceOn
19 Whang DY. Paginal translation of Bangyakhappyeon. 1st ed. Seoul:Namsandang. 1992:230.
20 Rosenthal L, Anderson B. Acupuncture and In Vitro Fertilisation: Recent Research and Clinical Guidelines. Journal of Chinese Medicine. 2007; 84:28-35.
21 Kim HJ, Kim YS, Lim EM. A Study on Correlation between Stress and Menstruation among Lowincome Women. The Journal of Oriental Obstetrics & Gynecology. 2009;22(4):136-149.
22 Hong MJ, Lee IS. Analysis on Sasang Constitutional Medicine of the OB & GY outpatients in Dong-Eui University Korean Medical Hospital. The Journal of Oriental Gynecology. 2001;14(1): 336-354.
23 Korea Institute for Health and Social Affairs. Analysis and evaluation of the national supporting program for infertility couples in 2008. Seoul national university college of medicine. available from: URL: http://dl.nanet.go.kr/SearchList.do
24 Cha JH, Kem YS, Lee EM. A Study on Menstrual Pattern and Dysmemorrhea Related Factors of First-year Women College Students. The Journal of Oriental Obstetrics & Gynecology. 2010; 23(4):117-129.
25 보건복지부. 2011년 보건복지부 업무계획. 2010. available from: URL: http://www.mw.go.kr/front/index.jsp
26 Kim SJ, Lee SI, Koo BH. Study on the Influence of Extraction Methods of Jo Gyeong Jong Og Tang on the Ovarian Changes in Rabbit. Journal of KyungHee Oriental Medicine College. 1978; 1:69-73.
27 Bae JK, Kim GW. Effect of Jokyungiongoktang on the Fluctuation of Gonadotropin and Sex Hormone Concentration. The Journal of Dong Guk Oriental Medicine. 1992;1(1):15-54.
28 Lee KS, Song BK. Studies on the Effects of Jokyungjongok-Tang on Ovarian Function. Journal of KyungHee Oriental Medicine College. 1983; 6:139-151.
29 Department of Obstetrics and Gynecology, Seoul national university college of medicine. Obstetrics and Gynecology. 1st ed. Seoul:Koonja. 1999:565- 5888.
30 Chol YM, Lee JR, Lee DR, Kim SK, Hwang JH, Han DW et al. The report of support project for infertile couple:2006. Korean Society of Obstetrics and Gynecology. Gynecology. 2007;93(0):122.
31 Sart & Asrm. Assisted reproductive technology in the United States and Canada: 1993 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 1995;64(1):13-21.
32 Jonathan S. Berek. Berek & Novak's Gynecology. 14th rev. ed. philadelphia:Lippincott Williams & Wilkins. 2007:1245.
33 Korean Society of Obstetrics and Gynecology. Gynecology. 3rd ed. Seoul:Koonja. 1997:625, 667-668.
34 Korean Society of Obstetrics and Gynecology. Gynecology. 4th ed. Seoul:Korea Medical. 2007: 431, 507-508, 514.
35 Korea Institute for Health and Social Affairs. A Study on utilization of health services and coping strategies for infertility in Korea. 2003. available from: URL: http://www.ppfk.or.kr/
36 Brugo-olmendo S, Chillik C, Kopolman S. Definition and causes of infertility. RBM online. 2001;2(1):41-53.
37 Edwards RG, Craft I. Development of assisted conception. Br Med Bull. 1990; 46(3):565-579.
38 Ynag R. The book of changes and Chinese medicine. 1st ed. Beijing: Beijing science and technology. 1994:728.
39 Wang B. Newly interpreted huang-jeh-nae-kyungso-moon. 1st ed. Seoul:Daesung Culture. 1994: 173-176.
40 Dieterle S, Ying G, Hatzmann W, Neuer A. Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection:a randomised, prospective, controlled clinical study. Fertil Steril. 2006;85(5):1347- 1351.   DOI   ScienceOn