• 벤처창업연구
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• 제6권2호
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• pp.133-147
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• 2011

본 연구에서는 최근 꾸준한 성장세를 보이고 있는 의료산업의 국내벤처기업에 대한 신용 평가를 위해 먼저 기업의 재무 요인과 비재무 요인을 구분하여 평가지표를 개발한 다음 Saaty(1980)의 계층분석과정(Analytic Hierarchy Process; AHP)방법론을 적용하여 각 지표의 중요도(가중치)를 산출함으로써 의료벤처기업의 신용평가모형을 제시한다. 재무요인의 상위지표로는 수익성, 안전성, 활동성, 성장성, 생산성을 선택하였고, 각 상위지표에 대해서는 2개씩의 하위지표를 정하여 모두 10개의 지표를 설정하였다. 또 비재무적 요인의 상위지표로는 경영자 능력, 기술성, 시장성, 사업성, 신뢰성의 5개 영역을 정하고, 각 영역에 대해 2-5개의 하위지표를 정하여 모두 17개의 지표를 설정하였다. 신용평가지표에 대한 평가를 위해 원주의료기기클러스터 내 소재하고 있는 금융기관 및 보증기관의 심사역을 대상으로 설문조사를 한 후 이를 분석하여 평가지표에 대한 가중치를 산출하였다.

• Archives of Plastic Surgery
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• 제37권3호
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• pp.245-249
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• 2010

Purpose: High-pressure injection injury is caused by accidental injection of the high-pressure injection devices in industry. The initial benign appearance of the wound fools patients into delays in an adequate treatment. And it can result in disastrous outcomes such as necrosis and amputation. To avoid the poor prognosis, the injuries require a prompt surgical intervention. The purpose of this article is to recognize the poor outcome of the highpressure injection injury and to introduce an adequate treatment in need. Methods: We have 4 cases of the high-pressure injection injuries in the hand from April, 2005 to March, 2009. Average age is 39 years (30 - 49 years old), 2 cases are the palm of dominant hand, 1 case is the thumb of dominant hand, and 1 case is the palm of non-dominant hand, respectively. We followed up these patients for 20 months on average. In 3 cases, the immediate, aggressive surgical intervention was carried out, but the other one was delayed in early adequate treatment. The wounds were covered by local advancement flap, anterolateral thigh free flap, conservative treatment with antibiotics and dressing. Results: No pathogens after culture were found nor any findings of fracture in imaging study. Conservative treatment, local advancement flap and anterolateral thigh free flap for the open wound resulted in a desirable aesthetic outcome. In a long-term follow up, functional capability of the patient was also satisfactory. Conclusion: Upon initial evaluation, most high-pressure injection injuries present as innocuous wounds with very few symptoms and result in delaying the proper management. And the majority of high-pressure injection injuries will produce significant morbidity to the hand, amputation. And the initial aggressive surgical debridement was needed to prevent the poor outcome. The key to success in treating high-pressure injection injuries of the hand is the prompt aggressive surgical intervention.

• International Journal of Industrial Entomology and Biomaterials
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• 제27권1호
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• pp.209-217
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• 2013

The objective of this study was to evaluate the bone regeneration capability of silk membrane plus 3% 4-hexylresorcinol (3% 4-HR plus SM) in a rabbit calvarial defect model. Twenty New Zealand white rabbits were used in this study. Bilateral round shaped defects were created in the parietal bone (diameter: 8.0 mm). And the defects were covered with (1) 3% 4-HR plus SM, (2) collagen membrane (CM), (3) no graft material. After surgery, the animals were sacrificed at 4 weeks and 8 weeks. Bone regeneration was analyzed in each section by micro-computerized tomography (${\mu}$-CT). And Hematoxylin and eosin stains were used for histological analysis. As measured by ${\mu}$-CT analysis 4 weeks after surgery, the average of new bone formation in animals treated with 3% 4-HR plus SM was greater than that of animals treated with CM. and the difference was statistically significant. And well organized lamella bones were observed in the histological view of the 3% 4-HR plus SM group. Therefore, more bone regeneration was seen in animals treated with 3% 4-HR plus SM than in those treated with CM or uncovered control.

• 한국미생물·생명공학회지
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• 제46권3호
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• pp.194-200
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• 2018

Glycogen plays important roles in bacteria. Its structure and storage capability have received more attention recently because of the potential correlations with environmental durability and pathogenicity. However, the low level of intracellular glycogen makes extraction and structure characterization difficult, inhibiting functional studies. Bacteria grown in regular media such as lysogeny broth and tryptic soy broth do no accumulate large amounts of glycogen. Comparative analyses of bacterial media reported in literature for glycogen-related studies revealed that there was no consistency in the recipes reported. Escherichia coli $DH5{\alpha}$ is a convenient model organism for gene manipulation studies with respect to glycogen. Additionally, M9 minimal salts medium is widely used to improve glycogen accumulation, although its composition varies. In this study, we optimized the M9 medium by adjusting the concentrations of itrogen source, tryptone, carbon source, and glucose, in order to achieve a balance between the growth rate and glycogen accumulation. Our result showed that $1{\times}M9$ minimal salts medium containing 0.4% tryptone and 0.8% glucose was a well-balanced nutrient source for enhancing the growth and glycogen storage in bacteria. This result will help future investigations related to bacterial physiology in terms of glycogen function.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7757-7759
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• 2013

Physicians, in order to study the causes of cancer, detect cancer earlier, prevent or determine the effectiveness of treatment, and specify the reasons for the treatment ineffectiveness, need to access accurate, comprehensive, and timely cancer data. The cancer care environment has become more complex because of the need for coordination and communication among health care professionals with different skills in a variety of roles and the existence of large amounts of data with various formats. The goals of health care systems in such a complex environment are correct health data management, providing appropriate information needs of users to enhance the integrity and quality of health care, timely access to accurate information and reducing medical errors. These roles in new systems with use of agents efficiently perform well. Because of the potential capability of agent systems to solve complex and dynamic health problems, health care system, in order to gain full advantage of E- health, steps must be taken to make use of this technology. Multi-agent systems have effective roles in health service quality improvement especially in telemedicine, emergency situations and management of chronic diseases such as cancer. In the design and implementation of agent based systems, planning items such as information confidentiality and privacy, architecture, communication standards, ethical and legal aspects, identification opportunities and barriers should be considered. It should be noted that usage of agent systems only with a technical view is associated with many problems such as lack of user acceptance. The aim of this commentary is to survey applications, opportunities and barriers of this new artificial intelligence tool for cancer care information as an approach to improve cancer care management.

• Imaging Science in Dentistry
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• 제42권1호
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• pp.19-24
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• 2012

Purpose : Field of view and voxel resolution of cone beam computed tomography (CBCT) might affect the diagnostic capability. This study was performed to compare between the standard and HiRes zoom modes in the diagnosis of external root resorption (ERR) using CBCT. Materials and Methods : Sixty three small cavities (0.25 mm depth and 0.5 mm diameter) were simulated on the buccal, lingual, and proximal surfaces at three different levels of 16 roots of teeth. After covering the root with nail varnish, the roots were inserted in the sockets and the model was placed in a water-containing lacuna. CBCT scans were taken in both standard and HiRes zoom modes using NewTom VG (QR srl Company, Verona, Italy). Then, an observer assessed the images to determine the presence or absence of the cavities. This process was repeated by increasing the size and depth of cavities to 0.5 mm depth and 1 mm diameter. Data were analyzed by McNemar test. The sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio in evaluation of the simulated cavities were calculated. Results : There was a significant difference between the two imaging modes in diagnosing the shallow cavities (p=0.02).The sensitivity of the standard zoom in detecting the shallow cavities was lower than that of the HiRes zoom. The likelihood ratio of the HiRes zoom was higher in the diagnosis of both cavity types. Conclusion : This study suggested that a smaller voxel size in the HiRes zoom mode of CBCT is preferred for diagnosis of ERR.

• IMMUNE NETWORK
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• 제13권3호
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• pp.86-93
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• 2013

In the present study, we investigated if priming of autoreactive $CD8^+T$ cells would be inhibited by competitive peptides for major histocompatibility complex (MHC) class I binding. We used a mouse model of vitiligo which is induced by immunization of $K^b$-binding tyrosinase-related protein 2 (TRP2)-180 peptide. Competitive peptides for $K^b$ binding inhibited IFN-${\gamma}$production and proliferation of TRP2-180-specific $CD8^+T$ cells upon ex vivo peptide restimulation, while other MHC class I-binding peptides did not. In mice, the capability of inhibition was influenced by T-cell immunogenicity of the competitive peptides. The competitive peptide with a high T-cell immunogenicity efficiently inhibited priming of TRP2-180-specific $CD8^+T$ cells in vivo, whereas the competitive peptide with a low T-cell immunogenicity did not. Taken together, the inhibition of priming of autoreactive $CD8^+T$ cells depends on not only competition of peptides for MHC class I binding but also competitive peptide-specific $CD8^+T$ cells, suggesting that clonal expansion of autoreactive T cells would be affected by expansion of competitive peptide-specific T cells. This result provides new insights into the development of competitive peptides-based therapy for the treatment of autoimmune diseases.

• 전기전자학회논문지
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• 제6권1호
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• pp.65-71
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• 2002

본 연구에서는 최근 그 응용범위가 급격히 증가하고 었는 근거리 무선통신 방식인 블루투스를 이용한 생체신호 계측시스템을 사용하여 의료환경 적용시 블루투스의 실효성을 정성적으로 평가하였다. 이 연구를 위하여 블루투스를 사용한 생체신호 계측시스템을 개발하였고, 개발한 시스템을 사용하여 여러 가지 실제 의료환경과 유사한 구조의 공간에서 실험하였다. 실험결과 블루투스 무선통신방식이 송신부와 수신부가 같은 방안에 위치한 경우에는 신뢰성을 보였으나 송신부와 수신부가 벽에 의해 차단된 경우에는 거리에 따라 신뢰도가 급격히 감소됨은 발견하였다. 따라서 블루투스 통신방식을 실제 의료환경에서 사용할 때 구조 및 거리에 따른 전송장애에 대한 선행 평가가 이루어져야 하겠다.

• 한국방사선학회논문지
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• 제14권6호
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• pp.733-740
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• 2020

의료종사자의 피폭선량을 줄이기 위한 최근 연구에서, 방사선이 산란될 때 발생하는 광전효과를 이용하여 방사선치료실 입구에서의 선량을 줄이는 방법이 제안되었다. 이 방법은 특히 저에너지 광자에 효과적이기 때문에 본 연구에서는 몬테카를로 시뮬레이션을 이용하여 슬릿형태 구조물의 일반촬영실 산란 엑스선에 대한 차폐성능을 평가하였다. 두께 2 mm, 폭 50 mm, 길이 900 mm인 판을 2 mm 간격으로 수평 적재하는 형태의 슬릿형태 구조물은 알루미늄에 비해 철 또는 납으로 만드는 경우 차폐효과가 뛰어났다. 재질을 철로 한정한 경우 선원과 관심구역 사이에서 결정된 구조물의 설치위치는 차폐효과와 무관했으며, 판의 폭은 차폐효과에 비례했다. 폭 50 mm 철판을 사용한 경우 산란선이 직접 발생하는 바닥 및 환자의 높이를 제외하면 약 99.9% 또는 그 이상의 차폐효과가 있었다.

• 한국재료학회지
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• 제20권3호
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• pp.155-160
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• 2010

In this study, we investigated primary biocompatibility and osteogenic gene expression of porous granular BCP bone substitutes with or without strontium (Sr) doping. In vitro biocompatibility was investigated on fibroblasts like L929 cells and osteoblasts like MG-63 cells using a cell viability assay (MTT) and one cell morphological observation by SEM, respectively. MTT results showed a cell viability percent of L929 fibroblasts, which was higher in Sr-BCP granules (98-101%) than in the non-doped granules (92-96%, p < 0.05). Osteoblasts like MG-63 cells were also found to proliferate better on Sr-doped BCP granules (01-111%) than on the non-doped ones (92-99%, p < 0.05) using an MTT assay. As compared with pure BCP granules, SEM images of MG-63 cells grown on sample surfaces confirmed that cellular spreading, adhesion and proliferation were facilitated by Sr doping on BCP. Active filopodial growth of MG-63 cells was also observed on Sr-doped BCP granules. The cells on Sr-doped BCP granules were well attached and spread out. Gene expression of osteonectin, osteopontin and osteoprotegrin were also evaluated using reverse transcriptase polymerase chain reaction (RT-PCR), which showed that the mRNA phenotypes of these genes were well maintained and expressed in Sr-doped BCP granules. These results suggest that Sr doping in a porous BCP granule can potentially enhance the biocompatibility and bone ingrowth capability of BCP biomaterials.