Browse > Article
http://dx.doi.org/10.7852/ijie.2013.27.1.209

The Effect of Silk Membrane Plus 3% 4-hexylresorcinol on Guided Bone Regeneration in a Rabbit Calvarial Defect Model  

Seok, Hyun (Department of Oral and Maxillofacial surgery, College of Dentistry, Gangneung-Wonju National University)
Lee, Sang-Woon (Department of Oral and Maxillofacial surgery, College of Dentistry, Gangneung-Wonju National University)
Kim, Seong-Gon (Department of Oral and Maxillofacial surgery, College of Dentistry, Gangneung-Wonju National University)
Seo, Dong-Hyun (Department of Biomedical Engineering, Institute of Medical Engineering and Yonsei-Fraunhofer Medical, Device Laboratory, Yonsei University)
Kim, Han Sung (Department of Biomedical Engineering, Institute of Medical Engineering and Yonsei-Fraunhofer Medical, Device Laboratory, Yonsei University)
Kweon, Hae Yong (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science)
Jo, You-Young (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science)
Kang, Tae Yeon (Gangneung Center, Korea Basic Science Institute)
Lee, Myung-Jin (Gangneung Center, Korea Basic Science Institute)
Chae, Weon-Sik (Gangneung Center, Korea Basic Science Institute)
Publication Information
International Journal of Industrial Entomology and Biomaterials / v.27, no.1, 2013 , pp. 209-217 More about this Journal
Abstract
The objective of this study was to evaluate the bone regeneration capability of silk membrane plus 3% 4-hexylresorcinol (3% 4-HR plus SM) in a rabbit calvarial defect model. Twenty New Zealand white rabbits were used in this study. Bilateral round shaped defects were created in the parietal bone (diameter: 8.0 mm). And the defects were covered with (1) 3% 4-HR plus SM, (2) collagen membrane (CM), (3) no graft material. After surgery, the animals were sacrificed at 4 weeks and 8 weeks. Bone regeneration was analyzed in each section by micro-computerized tomography (${\mu}$-CT). And Hematoxylin and eosin stains were used for histological analysis. As measured by ${\mu}$-CT analysis 4 weeks after surgery, the average of new bone formation in animals treated with 3% 4-HR plus SM was greater than that of animals treated with CM. and the difference was statistically significant. And well organized lamella bones were observed in the histological view of the 3% 4-HR plus SM group. Therefore, more bone regeneration was seen in animals treated with 3% 4-HR plus SM than in those treated with CM or uncovered control.
Keywords
4-Hexylresorcinol; Guided bone regeneration; Silk membrane;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Rothamel D, Schwarz F, Sager M, Herten M, Sculean A, Becker J (2005) Biodegradation of differently cross-linked collagen membranes: an experimental study in the rat. Clin Oral Impl Res 16, 369-378.   DOI   ScienceOn
2 Sanchez AR, Rogers RS, Sheridan PJ (2004) Tetracycline and other tetracycline- derivative staining of the teeth and oral cavity. Int J Dermatol 43, 709-715.   DOI   ScienceOn
3 Sanctis MD, Zucchelli G, Clauser C (1996) Bacterial colonization of bioabsorbable barrier material and periodontal regeneration. J Periodontol 67, 1193-1200.   DOI   ScienceOn
4 Schenk R, Buser D, Hardwick WR, Dahlin C (1994) Healing pattern of bone regeneration in membrane-protected defects: a histologic study in the canine mandible. Int J Oral Maxillofac Implants 9, 13.
5 Sofia S, McCarthy MB, Gronowicz G, Kaplan DL (2000) Functionalized silk-based biomaterials for bone formation. J Biomed Master Res 54, 139-148.
6 Song JY, Kim SG, Lee JW, Chae WS, Kweon HY, Jo YY et al. (2011) Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112, e26-e33.
7 Um IC, Kweon HY, Park YH, Hudson S (2001) Structural characteristics and properties of the regenerated silk fibroin prepared from formic acid. Int J Biol Macromol 29, 91-97.   DOI   ScienceOn
8 Young C, Damon SR (1927) Laboratory: the use of hexylresorcinol in the treatment of typhoid carriers. Am J Public Health (N Y) 17, 279- 280.   DOI
9 Kodama T, Minabe M, Hori T, Watanabe Y (1989) The effect of various concentrations of collagen barrier on periodontal wound healing. J Periodontol 60, 205-210.   DOI
10 Kozubek A, Tyman JHP (1999) Resorcinolic lipids, the natural nonisoprenoid phenolic amphiphiles and their biological activity. Chem Rev 99, 1-26.   DOI   ScienceOn
11 Minabe M, Kodama T, Kogou T, Tamura T, Hori T, Watanabe Y, Miyata T (1989) Different cross-linked types of collagen implanted in rat palatal gingiva. J Periodontol 60, 35-43.   DOI
12 Lopez-Caballero M, Montero P, Gomez-Guillen M (2007) Spraying of 4-hexylresorcinol based formulations to prevent enzymatic browning in Norway lobsters (Nephrops norvegicus) during chilled storage. Food chemistry 100, 147-155.   DOI   ScienceOn
13 Lee SW, Park YT, Kim SG, Kweon HY, Jo YY, Lee HS (2012) The effects of tetracycline-loaded silk fibroin membrane on guided bone regeneration in a rabbit calvarial defect model. J Korean Assoc Maxillofac Plast Reconstr Surg 34, 293-298.   과학기술학회마을
14 Ling LJ, Hung SL, Lee CF, Chen YT, Wu KM (2003) The influence of membrane exposure on the outcomes of guided tissue regeneration: clinical and microbiological aspects. J Periodontal Res 38, 57-63.   DOI   ScienceOn
15 Minoura N, Tsukada M, Nagura M (1990) Physico-chemical properties of silk fibroin membrane as a biomaterial. Biomaterials 11, 430-434.   DOI   ScienceOn
16 Rabbani G, Gilman R, Kabir I, Mondel G (1985) The treatment of Fasciolopsis buski infection in children: a comparison of thiabendazole, mebendazole, levamisole, pyrantel pamoate, hexylresorcinol and tetrachloroethylene. Trans R Soc Trop Med Hyg 79, 513-515.   DOI   ScienceOn
17 Rakhmatia YD, Ayukawa Y, Furuhashi A, Koyano K (2013) Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications. J Prosthodont Res 57, 3-14.   DOI   ScienceOn
18 Retzepi M, Donos N (2010) Guided bone regeneration: biological principle and therapeutic applications. Clin Oral Impl Res 21, 567-576.   DOI   ScienceOn
19 Gottlow J (1993) Guided tissue regeneration using bioresorbable and non-resorbable devices: initial healing and long-term results. J Periodontol 64, 1157-1165.   DOI   ScienceOn
20 Iglhaut J, Aukhil I, Simpson D, Johnston M, Koch G (1988) Progenitor cell kinetics during guided tissue regeneration in experimental periodontal wounds. J Periodontal Res 23, 107-117.   DOI
21 Imbronito AV, Todescan JH, Carvalho CV, Arana-Chavez VE (2002) Healing of alveolar bone in resorbable and non-resorbable membraneprotected defects. A histologic pilot study in dogs. Biomaterials 23, 4079-4086.   DOI   ScienceOn
22 Iyidogan N, Bayindirli A (2004) Effect of L-cysteine, kojic acid and 4-hexylresorcinol combination on inhibition of enzymatic browning in Amasya apple juice. Journal of Food Engineering 62, 299-304.   DOI   ScienceOn
23 Kim J, Kim CH, Park CH, Seo JN, Kweon HY, Kang SW, Lee KG (2010) Comparison of methods for the repair of acute tympanic membrane perforations: silk patch vs. paper patch. Wound Rep Reg 18, 132-138.   DOI   ScienceOn
24 Kim MK, Park YT, Kim SG, Park YW, Lee SK, Choi WS (2012) The effect of a hydroxyapatite and 4-hexylresorcinol combination graft on bone regeneration in the rabbit calvarial defect model. J Korean Assoc Maxillofac Plast Reconstr Surg 34, 377-383.   과학기술학회마을
25 Kim S-G, Hahn B-D, Park D-S, Lee Y-C, Choi E-J, Chae W-S et al. (2011a) Aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants. J Oral Maxillofac Surg 69, e354-e363.   DOI   ScienceOn
26 Kim S-G, Lee S-W, Park Y-W, Jeong J-H, Choi J-Y (2011b) 4-hexylresorcinol inhibits NF-${\kappa}$B phosphorylation and has a synergistic effect with cisplatin in KB cells. Oncol Rep 26, 1527-1532.
27 Kim UJ, Park J, Li C, Jin HJ, Valluzzi R, Kaplan DL (2004) Structure and properties of silk hydrogels. Biomacromolecules 5, 786-792.   DOI   ScienceOn
28 Aramwit P, Kanokpanont S, De-Eknamkul W, Srichana T (2009) Monitoring of inflammatory mediators induced by silk sericin. J Biosci Bioeng 107, 556-561.   DOI   ScienceOn
29 Altman GH, Diaz F, Jakuba C, Calabro T, Horan RL, Chen J et al. (2003) Silk-based biomaterials. Biomaterials 24, 401-416.   DOI   ScienceOn
30 Arai T, Freddi G, Innocenti R, Tsukada M (2003) Biodegradation of Bombyx mori silk fibroin fibers and films. J Appl Polm Sci 91, 2383- 2390.
31 Buser D, Dula K, Hess D, Hirt HP, Belser UC (2007) Localized ridge augmentation with autografts and barrier membranes. Periodontol 2000 19, 151-163.
32 Cao Y, Wang B (2009) Biodegradation of silk biomaterials. Int J Mol Sci 10, 1514-1524.   DOI   ScienceOn
33 Dal Pra I, Freddi G, Minic J, Chiarini A, Armato U (2005) De novo engineering of reticular connective tissue in vivo by silk fibroin nonwoven materials. Biomaterials 26, 1987-1999.   DOI   ScienceOn
34 Gosline JM, DeMont ME, Denny MW (1986) The structure and properties of spider silk. Endeavour 10, 37-43.   DOI
35 Gotfredsen K, Nimb L, Buser D, Hjørting-Hansen E (1993) Evaluation of guided bone generation around implants placed into fresh extraction sockets: an experimental study in dogs. J Oral Maxillofac Surg 51, 879-884.   DOI   ScienceOn